标签归档：产物

2-Hydroxyanthraquinone

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

2-Hydroxyanthraquinone  纯度: ≥98.0%

2-Hydroxyanthraquinone 是一种天然产物，具有抗肿瘤和免疫抑制活性。

2-Hydroxyanthraquinone

2-Hydroxyanthraquinone Chemical Structure

CAS No. : 605-32-3

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
500 mg ￥350 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

2-Hydroxyanthraquinone 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Fragment Library
  • Traditional Chinese Medicine Monomer Library

生物活性

2-Hydroxyanthraquinone, a natural compound, possesses antitumor and immunosuppressive activity[1].

分子量

224.21

Formula

C14H8O3
CAS 号

605-32-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (446.01 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.4601 mL 22.3005 mL 44.6010 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL
10 mM 0.4460 mL 2.2301 mL 4.4601 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.15 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (11.15 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (11.15 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. I Hilgert, et al. Antitumour and immunosuppressive activity of hydroxyanthraquinones and their glucosides. Folia Biol (Praha). 1977;23(2):99-109.

Kadsurin(Synonyms: 南五味子素)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Kadsurin (Synonyms: 南五味子素)

Kadsurin 是可从 Kadsura heteroclita (Schizandraceae) 茎中提取得到的天然产物，可显著降低小鼠肝脏中CCL4 诱导的脂质过氧化产物，如TBA-RS，共轭二烯和荧光产物。

Kadsurin(Synonyms: 南五味子素)

Kadsurin Chemical Structure

CAS No. : 51670-40-7

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Kadsurin, a natural compound from the stems of Kadsura heteroclita (Schizandraceae), results in significant decreases of CCL4– induced lipid-peroxidation products, such as thiobarbituric acid reactive substances (TBA-RS), conjugated dienes and fluorescent products in the liver of mice[1].

分子量

458.50

Formula

C25H30O8
CAS 号

51670-40-7
中文名称

南五味子素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. X W Yang, et al. Anti-lipid peroxidative effect of an extract of the stems of Kadsura heteroclita and its major constituent, kadsurin, in mice. Chem Pharm Bull (Tokyo). 1992 Feb;40(2):406-9.

3′-​O-​Acetylhamaudol

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

3′-​O-​Acetylhamaudol  纯度: 99.87%

3′-O-Acetylhamaudol 是从Angelica japonica 根部提取得到的，其抗肿瘤活性通过抗血管生成和激活肠上皮淋巴细胞实现。

3

3′-​O-​Acetylhamaudol Chemical Structure

CAS No. : 30358-88-4

规格 价格 是否有货 数量
5 mg ￥3160 In-stock
10 mg ￥5380 In-stock
20 mg ￥9140 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

3′-​O-​Acetylhamaudol 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Phenols Library

生物活性

3′-O-Acetylhamaudol, isolated from Angelica japonica roots, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation[1].

分子量

318.32

Formula

C17H18O6
CAS 号

30358-88-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Kimura Y, et al. Anti-tumor actions of major component 3′-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. Cancer Lett. 2008 Jun 28;265(1):84-97.

3′-Hydroxyxanthyletin

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

3′-Hydroxyxanthyletin 

3′-Hydroxyxanthyletin 是一种香豆素化合物，具有抗分枝杆菌活性。

3

3′-Hydroxyxanthyletin Chemical Structure

CAS No. : 165900-08-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

3′-Hydroxyxanthyletin is a coumarin compound with antimycobacterial activities[1][2].

体外研究
(In Vitro)

3′-Hydroxyxanthyletin against Mycobacterium tuberculosis H37RV in vitro with a MIC value of 16 μg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

244.24

Formula

C14H12O4
CAS 号

165900-08-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li-Wen Chen, et al. Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa. Chem Biodivers. 2010 Jul;7(7):1814-21.

    [2]. Satyajit D.Sarker, et al. An alkaloid, coumarins and a triterpene from Boronia algida. Phytochemistry. Volume 39, Issue 4, July 1995, Pages 801-804.

Tunicamycin V(Synonyms: Tunicamycin A)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Tunicamycin V;(Synonyms: Tunicamycin A) 纯度: ge;95.0%

Tunicamycin V (Tunicamycin A) 是一种核苷天然产物，可抑制细菌 phospho-N-acetylmuramyl-pentapeptide transferase (MraY)，IC50 为 0.35 μM。Tunicamycin V 具有抗菌活性。

Tunicamycin V(Synonyms: Tunicamycin A)

Tunicamycin V Chemical Structure

CAS No. : 66054-36-2

规格 价格 是否有货 数量
1 mg ￥11500 In-stock
5 mg ; 询价 ;
10 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35 μM. Tunicamycin V has antibacterial activties[1][2].

IC50 Target

IC50: 0.35 μM (phospho-N-acetylmuramyl-pentapeptide transferase (MraY))[1]
体外研究
(In Vitro)

Tunicamycins are nucleoside natural products isolated from the fermentation broths of Streptomyces lysosuperficus in 1971 and exhibit a variety of biological properties including antibacterial, antiviral, antifungal, and antitumor activities. Tunicamycins strongly inhibit UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase, the enzyme responsible for the first N-acetylglucosamination of the N-linked glycopeptide in endothelial reticulum (ER)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

830.92

Formula

C38H62N4O16
CAS 号

66054-36-2
中文名称

衣霉素V；衣霉素A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Kazuki Yamamoto, et al. Structural requirement of tunicamycin V for MraY inhibition. Bioorg Med Chem. 2019 Apr 15;27(8):1714-1719.

    [2]. Kazuki Yamamoto, et al. Total Synthesis of Tunicamycin V. Org Lett. 2018 Jan 5;20(1):256-259.

Oxypeucedanin

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Oxypeucedanin  纯度: 98.03%

Oxypeucedanin 是从 Angelica dahurica 中分离出来的呋喃香豆素衍生物。Oxypeucedanin 是一种选择性的开放通道阻滞剂，可抑制 hKv1.5 通道电流，IC50 值为 76 nM。Oxypeucedanin 延长心脏动作电位持续时间 (APD)，是一种潜在的抗心律失常试剂。Oxypeucedanin 通过抑制癌细胞迁移来诱导细胞凋亡 (apoptosis )。

Oxypeucedanin

Oxypeucedanin Chemical Structure

CAS No. : 737-52-0

规格 价格 是否有货 数量
5 mg ￥2020 In-stock
10 mg ￥3430 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Oxypeucedanin 相关产品

•相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Membrane Transporter/Ion Channel Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Covalent Screening Library
  • Anti-Cardiovascular Disease Compound Library
  • Medicine Food Homology Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Alzheimer’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Food-Sourced Compound Library

生物活性

Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].

IC50 & Target

IC50: HKv1.5 current; apoptosis[1]
分子量

286.28

Formula

C16H14O5
CAS 号

737-52-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (174.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4931 mL 17.4654 mL 34.9308 mL
5 mM 0.6986 mL 3.4931 mL 6.9862 mL
10 mM 0.3493 mL 1.7465 mL 3.4931 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.73 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.73 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Eun JS, et al. Effects of oxypeucedanin on hKv1.5 and action potential duration.Biol Pharm Bull. 2005 Apr;28(4):657-60.

    [2]. Yu Liu, et al. Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration

1,4-D-Gulonolactone

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

1,4-D-Gulonolactone;

1,4-D-Gulonolactone 是一种内源性代谢产物。

1,4-D-Gulonolactone

1,4-D-Gulonolactone Chemical Structure

CAS No. : 6322-07-2

规格 价格 是否有货 数量
1 g ￥350 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

* Please select Quantity before adding items.

1,4-D-Gulonolactone 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Lipid Compound Library

生物活性

1,4-D-Gulonolactone is an endogenous metabolite.

分子量

178.14

Formula

C6H10O6
CAS 号

6322-07-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, stored under nitrogen

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)
溶解性数据
In Vitro:;

H2O : 250 mg/mL (1403.39 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.6136 mL 28.0678 mL 56.1356 mL
5 mM 1.1227 mL 5.6136 mL 11.2271 mL
10 mM 0.5614 mL 2.8068 mL 5.6136 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。