Physcion(Synonyms: 大黄素甲醚; Parietin; Rheochrysidin)

天然产物醌类Quinones

Physcion (Synonyms: 大黄素甲醚; Parietin; Rheochrysidin) 纯度: 99.10%

Physcion (Parietin) 是从中药大黄中得到的蒽醌类物质,为 6-磷酸葡萄糖酸脱氢酶 (6-phosphogluconate dehydrogenase) 抑制剂,IC50Kd 值分别为 38.5 μM 和 26.0 μM。Physcion (Parietin) 具有通便、保肝、抗炎、抗菌、抗增殖、抗肿瘤作用。

Physcion(Synonyms: 大黄素甲醚; Parietin;  Rheochrysidin)

Physcion Chemical Structure

CAS No. : 521-61-9

规格 价格 是否有货 数量
10 mg ¥500 In-stock
25 mg ¥1000 In-stock
50 mg ¥1750 In-stock
100 mg ¥3000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Physcion 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].

IC50 & Target

IC50: 38.5 μM (6-phosphogluconate dehydrogenase)[1]
Kd: 26.0 μM (6-phosphogluconate dehydrogenase)[1]

分子量

284.26

Formula

C16H12O5

CAS 号

521-61-9

中文名称

大黄素甲醚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

THF : 2.5 mg/mL (8.79 mM; ultrasonic and warming and heat to 60°C)

DMF : 1 mg/mL (3.52 mM; Need ultrasonic)

Acetone : < 1 mg/mL (insoluble)

Ethanol : < 1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.

    [2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.

Bavachinin(Synonyms: 补骨脂二氢黄酮甲醚; 7-O-Methylbavachin; Bavachinin A)

天然产物 黄酮类 Flavonoids

Bavachinin (Synonyms: 补骨脂二氢黄酮甲醚; 7-O-Methylbavachin; Bavachinin A) 纯度: 99.96%

Bavachinin(7-O-Methylbavachin)是一天然化合物,具有抗炎症和抗血管生成活性。

Bavachinin(Synonyms: 补骨脂二氢黄酮甲醚; 7-O-Methylbavachin;  Bavachinin A)

Bavachinin Chemical Structure

CAS No. : 19879-30-2

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥660 In-stock
5 mg ¥600 In-stock
10 mg ¥800 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Bavachinin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Lipid Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library

生物活性

Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity. IC50 value: Target: in vitro: Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated Aβ42-induced toxicity in a SH-SY5Y cell model [1]. Bavachinin, has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α [2]. in vivo: significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model [3].

分子量

338.40

Formula

C21H22O4

CAS 号

19879-30-2

中文名称

补骨脂二氢黄酮甲醚;甲基补骨脂黄酮A;补骨脂双氢黄酮甲醚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (369.39 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9551 mL 14.7754 mL 29.5508 mL
5 mM 0.5910 mL 2.9551 mL 5.9102 mL
10 mM 0.2955 mL 1.4775 mL 2.9551 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.15 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.15 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Chen X, et al. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. FEBS Lett. 2013 Sep 17;587(18):2930-5.

    [2]. Nepal M, et al. Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α. Eur J Pharmacol. 2012 Sep 15;691(1-3):28-37.

    [3]. Chen X, et al. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs. Cell Mol Immunol. 2013 Nov;10(6):497-505.

Negletein(Synonyms: 黄芩素-7-甲醚; 5,6-Dihydroxy-7-methoxyflavone)

天然产物 黄酮类 Flavonoids

Negletein (Synonyms: 黄芩素-7-甲醚; 5,6-Dihydroxy-7-methoxyflavone)

Negletein 是一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突向外生长。Negletein 通过抑制 TNF-αIL-1β 表现出抗炎活性,其 IC50 值分别为 16.4 和 10.8 μM。

Negletein(Synonyms: 黄芩素-7-甲醚; 5,6-Dihydroxy-7-methoxyflavone)

Negletein Chemical Structure

CAS No. : 29550-13-8

规格 价格 是否有货
5 mg ¥3360 询问价格 & 货期
10 mg ¥5710 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively[1].

IC50 & Target[1]

TNF-α

16.4 nM (IC50)

IL-1β

10.8 nM (IC50)

分子量

284.26

Formula

C16H12O5

CAS 号

29550-13-8

中文名称

黄芩素-7-甲醚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Phan CW, et al. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors. 2016 Nov 12;42(6):591-599.

    [2]. Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30.

5,7,3′,4′-Tetramethoxyflavone(Synonyms: 木犀草素四甲醚)

天然产物 黄酮类 Flavonoids

5,7,3′,4′-Tetramethoxyflavone (Synonyms: 木犀草素四甲醚) 纯度: 99.08%

5,7,3′,4′-Tetramethoxyflavone 是从 M. exotica 中分离得到的一种多甲氧基黄酮,具有多种生物活性,包括抗真菌、抗疟疾、抗分支杆菌和抗炎活性。5,7,3′,4′-Tetramethoxyflavone 可通过靶向 β-catenin 发挥软骨保护作用。

5,7,3

5,7,3′,4′-Tetramethoxyflavone Chemical Structure

CAS No. : 855-97-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥716 In-stock
5 mg ¥950 In-stock
10 mg ¥1400 In-stock
50 mg ¥2100 In-stock
100 mg ¥3500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

5,7,3′,4′-Tetramethoxyflavone 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Antifungal Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Antiparasitic Compound library
  • Food-Sourced Compound Library

生物活性

5,7,3′,4′-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3′,4′-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].

分子量

342.35

Formula

C19H18O6

CAS 号

855-97-0

中文名称

木犀草素四甲醚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 8.33 mg/mL (24.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9210 mL 14.6049 mL 29.2099 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL
10 mM 0.2921 mL 1.4605 mL 2.9210 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Wu L, et al. 5,7,3′,4′-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling in vivo and in vitro. Biochem Biophys Res Commun. 2014 Sep 26;452(3):682-8.

Ermanin(Synonyms: 堪非醇3,4′-二-O-甲醚)

天然产物 黄酮类 Flavonoids

Ermanin (Synonyms: 堪非醇3,4′-二-O-甲醚)

Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。Ermanin 有效抑制 iNOSCOX-2 活性,并抑制血小板聚集,具有抗炎,抗结核和抗病毒/细菌特性。

Ermanin(Synonyms: 堪非醇3,4

Ermanin Chemical Structure

CAS No. : 20869-95-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties[1][2].

IC50 & Target[1]

COX-2

 

iNOS

 

Bacterial

 

分子量

314.29

Formula

C17H14O6

CAS 号

20869-95-8

中文名称

堪非醇3,4′-二-O-甲醚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sandeep Appunni, et al. Targeting PknB, an Eukaryotic-Like serine/threonine Protein Kinase of Mycobacterium Tuberculosis With Phytomolecules. Comput Biol Chem. 2017 Apr;67:200-204.

    [2]. Jih-Jung Chen, et al. New Sesquiterpenoids and Anti-Platelet Aggregation Constituents From the Rhizomes of Curcuma Zedoaria. Molecules. 2016 Oct 17;21(10):1385.