Neonuezhenide

天然产物 糖类和糖苷 Saccharides and Glycosides

Neonuezhenide;

Neonuezhenide 对自由基诱导的红血球溶血有较强的抗氧化作用。

Neonuezhenide

Neonuezhenide Chemical Structure

CAS No. : 96382-91-1

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生物活性

Neonuezhenide exhibits strong antioxidant effect against hemolysis of red blood cells induced by free radicals[1].

分子量

702.65

Formula

C31H42O18

CAS 号

96382-91-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. He ZD, et al. Antioxidative glucosides from the fruits of Ligustrum lucidum. Chem Pharm Bull (Tokyo). 2001;49(6):780-784.

Complanatoside B

天然产物 糖类和糖苷 Saccharides and Glycosides

Complanatoside B;

Complanatoside B 是一种具有抗炎作用的黄酮类化合物。

Complanatoside B

Complanatoside B Chemical Structure

CAS No. : 142473-99-2

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生物活性

Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects[1].

分子量

756.66

Formula

C33H40O20

CAS 号

142473-99-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hua Fan, et al. Phyllolobium chinense Fisch Flavonoids (PCFF) Suppresses the M1 Polarization of LPS-Stimulated RAW264.7 Macrophages by Inhibiting NF-κB/iNOS Signaling Pathway. Front Pharmacol. 2020 Jun 18;11:864.

LXW7

LXW7;

LXW7 是一种含 Arg-Gly-Asp (RGD) 的环状肽,是一种整合素 αvβ3 抑制剂,对 αvβ3 整联蛋白具有很高的结合亲和力,IC50 为 0.68 μM。LXW7 可增强 VEGFR-2 磷酸化和 ERK1/2 活化。具有抗炎活性。

LXW7amp;;

LXW7 Chemical Structure

CAS No. : 1313004-77-1

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LXW7 的其他形式现货产品:

LXW7 TFA

生物活性

LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect[1][2][3].

IC50 Target

IC50: 0.68 μM (αvβ3 integrin)[1]

体外研究
(In Vitro)

LXW7 specially binds to αvβ3 integrin (Kd=76±10 nM). LXW7 binds strongly to αvβ3-K562 cells, weakly to αvβ5-K562 cells and αIIbβ3-K562 cells, and no binding to K562 cells. LXW7 has great potential as a highly efficient peptide ligand for targeted imaging and drug delivery[1].
LXW7 acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

LXW7 (100 μg/kg; intravenous injection) significantly lowers infarct volumes and brain water content (BWC) LXW7-treated rats. The LXW7 treatment lowers the expression of pro-inflammatory cytokines[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-280 g) subjected to middle cerebral artery occlusion (MCAO)[3]
Dosage: 100 μg/kg
Administration: Intravenous injection
Result: Infarct volumes and BWC were significantly lower compared to those in the MCAO+PBS (control) group.

分子量

820.89

Formula

C29H48N12O12S2

CAS 号

1313004-77-1

Sequence Shortening

CGRGDDVC-NH2 (Disulfide bridge:Cys1-Cys8)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Xiao W, et al. The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct;9(10):2714-23.

    [2]. Hao D, et al. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086.

    [3]. Fang T, et al. LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats. Braz J Med Biol Res. 2016 Aug 1;49(9):e5287.

1,4-D-Gulonolactone

天然产物 糖类和糖苷 Saccharides and Glycosides

1,4-D-Gulonolactone;

1,4-D-Gulonolactone 是一种内源性代谢产物。

1,4-D-Gulonolactone

1,4-D-Gulonolactone Chemical Structure

CAS No. : 6322-07-2

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1 g ¥350 In-stock
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1,4-D-Gulonolactone 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Lipid Compound Library

生物活性

1,4-D-Gulonolactone is an endogenous metabolite.

分子量

178.14

Formula

C6H10O6

CAS 号

6322-07-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, stored under nitrogen

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)

溶解性数据
In Vitro:;

H2O : 250 mg/mL (1403.39 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.6136 mL 28.0678 mL 56.1356 mL
5 mM 1.1227 mL 5.6136 mL 11.2271 mL
10 mM 0.5614 mL 2.8068 mL 5.6136 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

Cerebroside C

天然产物 糖类和糖苷 Saccharides and Glycosides

Cerebroside C;

Cerebroside C 是一种鞘脂,是一种真菌代谢物。Cerebroside C 在水稻中可引起防御反应。

Cerebroside C

Cerebroside C Chemical Structure

CAS No. : 98677-33-9

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生物活性

Cerebroside C, a sphingolipid, is a fungal metabolite. Cerebroside C licits defense responses in rice[1].

IC50 Target

Microbial Metabolite

;

分子量

754.09

Formula

C43H79NO9

CAS 号

98677-33-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kenji Umemura,et al.Cerebroside elicitor confers resistance to fusarium disease in various plant specie. Phytopathology. 2004 Aug;94(8):813-8.

Clematichinenoside C

天然产物 糖类和糖苷 Saccharides and Glycosides

Clematichinenoside C;

Clematichinenoside C 是存在于裂叶铁线莲中的一种三萜皂苷.

Clematichinenoside C

Clematichinenoside C Chemical Structure

CAS No. : 177912-24-2

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生物活性

Clematichinenoside C is one of triterpenoid saponins found in Clematis parviloba[1].

分子量

1499.63

Formula

C70H114O34

CAS 号

177912-24-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yan LH, Xu LZ, Lin J, Yang SL, Feng YL. Triterpenoid saponins from the stems of Clematis parviloba. J Asian Nat Prod Res. 2009;11(4):332-338.

Eclalbasaponin I

天然产物 糖类和糖苷 Saccharides and Glycosides

Eclalbasaponin I;

Eclalbasaponin I 从 Eclipta prostrata L. (Asteraceae) 分离,具有抗肿瘤活性。 Eclalbasaponin I 抑制肝癌细胞 smmc-7721 的增殖,其 IC50 值为 111.1703 μg/ml。

Eclalbasaponin I

Eclalbasaponin I Chemical Structure

CAS No. : 158511-59-2

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生物活性

Eclalbasaponin I is isolated from Eclipta prostrata L with antitumor activity. Eclalbasaponin I inhibits the proliferation of hepatoma cell smmc-7721 with an IC50 value of 111.1703 μg/ml[1].

IC50 Target

IC50: 111.1703 μg/ml (smmc-7721 cells)

分子量

796.98

Formula

C42H68O14

CAS 号

158511-59-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Liu QM, et al. Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity. Food Chem Toxicol. 2012 Nov;50(11):4016-22.

RAD16-I

RAD16-I;

RAD16-I 是一种自组装多肽,是人类间充质干细胞 (hMSC) 增殖分化成软骨细胞的适宜微环境。RAD16-I是一种经过充分研究的离子互补肽,可被用作检查 SAPNFs 潜在的淀粉样染色性质。

RAD16-Iamp;;

RAD16-I Chemical Structure

CAS No. : 289042-25-7

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RAD16-I 的其他形式现货产品:

RAD16-I hydrochloride

生物活性

RAD16-I, a soft nanofibrous self-assembling peptide, is a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes[1]. RAD16-I is a well-studied ionic complementary peptide was used as a model to check potential amyloid-like staining properties of SAPNFs[2].

分子量

1712.78

Formula

C2H5D4NO

CAS 号

289042-25-7

Sequence Shortening

Ac-RADARADARADARADA-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Gerard Rubí-Sans, et al. Development of a Three-Dimensional Bioengineered Platform for Articular Cartilage Regeneration. Biomolecules. 2019 Dec 28;10(1):52.

    [2]. Yongzhu Chen, et al. Amyloid-like staining property of RADA16-I nanofibers and its potential application in detecting and imaging the nanomaterial. Int J Nanomedicine. 2018 Apr 23;13:2477-2489.

Rubinaphthin A

天然产物 糖类和糖苷 Saccharides and Glycosides

Rubinaphthin A;

Rubinaphthin A 是一种萘氢醌,存在于 Rubia yunnanensis 的根中。 Rubinaphthin A 对烟草花叶病毒 (TMV) 具有抑制活性。

Rubinaphthin A

Rubinaphthin A Chemical Structure

CAS No. : 448962-05-8

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生物活性

Rubinaphthin A is a naphthohydroquinone that can be found in the roots of Rubia yunnanensis. Rubinaphthin A exhibits inhibitory activity against tobacco mosaic virus (TMV)[1][2].

IC50 Target

tobacco mosaic virus[2]

体外研究
(In Vitro)

Rubinaphthin A (compound C) (200 μg/mL) shows inhibitory activity against TMV, with the inhibition rate of 51.49%[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

366.32

Formula

C17H18O9

CAS 号

448962-05-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Liou MJ, et, al. Constituents of the roots of Rubia yunnanensis. Chem Pharm Bull (Tokyo). 2002 Feb;50(2):276-9.

    [2]. Shen S, et, al. A novel and other bioactive secondary metabolites from a marine fungus Penicillium oxalicum 0312F1. Nat Prod Res. 2013;27(24):2286-91.

OM99-2

OM99-2;

OM99-2,一种八残基拟肽,人脑 memapsin 2 的紧密结合抑制剂,其 Ki 值为 9.58 nM。OM99-2 显著促进了 BACE1 抑制剂的开发,具有研究阿尔茨海默症的潜力。

OM99-2amp;;

OM99-2 Chemical Structure

CAS No. : 314266-76-7

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生物活性

OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer’s disease[3].

IC50 Target

Ki: 9.58 nM (memapsin 2)

体外研究
(In Vitro)

Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

892.99

Formula

C41H64N8O14

CAS 号

314266-76-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523.

    [2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4.

    [3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119.

    [4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422.