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Nodosin

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Nodosin 

Nodosin 是从 Isodon trichocarpus Kudo 和I. Japonicus HARA 中分离出来的二萜类化合物。

Nodosin

Nodosin Chemical Structure

CAS No. : 10391-09-0

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生物活性

Nodosin is a diterpenoid isolated from Isodon trichocarpus Kudo and I. Japonicus HARA[1].

分子量

362.42

Formula

C20H26O6
CAS 号

10391-09-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fujita, E, et al. Terpenoids vii the structure and absolute configuration of nodosin a new di terpenoid from isodon d species inst nuclear magnetic resonance isodon trichocarpus d isodon japonicus d.

Sculponeatin O

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Sculponeatin O 

Sculponeatin O 是从植物 Isodon sculponeata 中分离得到的 ent-kaurane 二萜衍生物化合物。

Sculponeatin O

Sculponeatin O Chemical Structure

CAS No. : 1169806-00-1

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生物活性

Sculponeatin O is a ent-kaurane diterpene derivative compound isolated from the plant Isodon sculponeata[1].

分子量

440.61

Formula

C28H40O4
CAS 号

1169806-00-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang F, et al. New terpenoids from Isodon sculponeata. Chem Pharm Bull (Tokyo). 2009;57(5):525-527.

Mudanpioside J

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Mudanpioside J 

Mudanpioside J 是一种单萜苷，是牡丹皮的代谢产物。

Mudanpioside J

Mudanpioside J Chemical Structure

CAS No. : 262350-52-7

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生物活性

Mudanpioside J, a monoterpene glycoside, is a metabolite of cortex moutan[1][2].

分子量

630.59

Formula

C31H34O14
CAS 号

262350-52-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chaoni Xiao, et al. Revealing metabolomic variations in Cortex Moutan from different root parts using HPLC-MS method. Phytochem Anal. Jan-Feb 2015;26(1):86-93.

    [2]. Hsiou-Yu Ding, et al. Phytochemical and Pharmacological Studies on Chinese Paeonia Species.Journal ofthe Chinese Chemical Society, 2000, 47, 381-388

Scutebarbatine B

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Scutebarbatine B 

Scutebarbatine B 对三种人类癌症细胞系，即 HONE-1 鼻咽癌、KB 口腔表皮样癌和 HT29 结直肠癌细胞具有显著的细胞毒活性，IC50值在 3.5-8.1 mM。

Scutebarbatine B

Scutebarbatine B Chemical Structure

CAS No. : 905929-95-5

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生物活性

Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC50 values in the range 3.5-8.1 mM[1]<

分子量

557.63

Formula

C33H35NO7
CAS 号

905929-95-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dai SJ, Tao JY, Liu K, Jiang YT, Shen L. neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities. Phytochemistry. 2006;67(13):1326-1330.

Kansuiphorin C

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Kansuiphorin C 

Kansuiphorin C 通过调节肠道菌群及相关代谢功能改善恶性腹水。

Kansuiphorin C

Kansuiphorin C Chemical Structure

CAS No. : 133898-77-8

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生物活性

Kansuiphorin C ameliorates malignant ascites by modulating gut microbiota and related metabolic functions[1].

分子量

478.58

Formula

C29H34O6
CAS 号

133898-77-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Y, et al. Kansuiphorin C and Kansuinin A ameliorate malignant ascites by modulating gut microbiota and related metabolic functions. J Ethnopharmacol. 2020;249:112423. 

Huzhangoside D

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Huzhangoside D 

Huzhangoside D 是从铁线莲的根和根茎中分离得到的皂苷类化合物。

Huzhangoside D

Huzhangoside D Chemical Structure

CAS No. : 96315-53-6

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生物活性

Huzhangoside D is a saponin compound isolated from the roots and rhizomes of Clematis graveolens[1].

分子量

1353.49

Formula

C64H104O30
CAS 号

96315-53-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rattan R, et al. Triterpenoid Saponins from Clematis graveolens and Evaluation of their Insecticidal Activities. Nat Prod Commun. 2015;10(9):1525-1528.

Substance P(1-7)

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Substance P(1-7);

Substance P(1-7) 是神经肽P物质 (SP) 的片段。Substance P(1-7) 可对孤束核产生抑制和缓和作用。

Substance P(1-7)amp;;

Substance P(1-7) Chemical Structure

CAS No. : 68060-49-1

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Substance P(1-7) 的其他形式现货产品:

Substance P(1-7) TFA

生物活性

Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius[1].

体内研究
(In Vivo)

Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

900.04

Formula

C41H65N13O10
CAS 号

68060-49-1
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe
Sequence Shortening

RPKPQQF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Herrera-Marschitz M, et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20.

    [2]. Sakurada T, et al. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5.
Animal Administration
[1][2]

Rats[1]

Sprague-Dawley male rats weighing 250-300 g are anaesthetized with halothane and placed in a stereotaxic frame. An injection cannula, conically shaped with a penetration tip diameter of approximately 0.15 mm is loared into the SNR. Saline (0.2 μL), SP (0.007-0.7 nmol) or Substance P (1-7) (0.01-1 nmol) is injected into the left substantia nigra, pars reticulata (SNR) and the rat is placed in a rotometer. The substances are injected in a total volume of 0.2 μL over a period of 1 min. A group of animals is sacrificed by decapitation 1 hour after the injection, their brains are immediately removed and tissue samples are taken from left and right striatum, globus pallidum (GP) and substantia nigra (SN). Samples are assayed for SP and SP(1-7)[1].
Mice[2]
The accumulated response time (s) of reciprocal movements of hindlimb scratching, biting, fore- and hindpaw licking are measured in Male mice (STD strain, 23-28 g) during the whole period of aversive response and 20 min at maximum. Substance P (1-7) is tested for its ability to inhibit the aversive response produced by intrathecal injection of SP or SP(5-11) (0.1 nM/mouse). Substance P (1-7) (1, 2, 4 pmol) is then administered together with SP or SP(5-11)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Herrera-Marschitz M, et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20.

    [2]. Sakurada T, et al. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5.

6-O-Methacrylate

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

6-O-Methacrylate 

6-O-Methacrylate 一种从 Wedelia trilobata 的叶子中分离出的三叶酸酯。6-O-Methacrylate 显示出显着的抗疟活性，对恶性疟原虫的 IC50 值为 8.9 μg/mL。6-O-Methacrylate 还具有抗烟草花叶病毒 (TMV) 的活性。

6-O-Methacrylate

6-O-Methacrylate Chemical Structure

CAS No. : 950685-51-5

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生物活性

6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata. 6-O-Methacrylate displays marked antimalarial activity, with IC50 of 8.9 μg/mL against P. falciparum parasite. 6-O-Methacrylate also has anti-tobacco mosaic virus (TMV) activity[1][2].

体外研究
(In Vitro)

6-O-Methacrylate (10 μg/mL) shows anti-TMV activities in the pretreated tobacco plants with inhibition rate of 59.6%[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

450.48

Formula

C23H30O9
CAS 号

950685-51-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. That QT, et, al. Wedelolides A and B: novel sesquiterpene delta-lactones, (9R)-eudesman-9,12-olides, from Wedelia trilobata. J Org Chem. 2007 Sep 14;72(19):7102-5.

    [2]. Li Y, et, al. Eudesmanolides from Wedelia trilobata (L.) Hitchc. as potential inducers of plant systemic acquired resistance. J Agric Food Chem. 2013 Apr 24;61(16):3884-90.

Gardenoin J

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Gardenoin J 

Gardenoin J 是一种环烷三萜，是从 Gardenia thailandica 的分泌物中分离出来的。

Gardenoin J

Gardenoin J Chemical Structure

CAS No. : 1345109-46-7

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生物活性

Gardenoin J, a cycloartane triterpene, is isolated from the exudate of Gardenia thailandica.

分子量

488.70

Formula

C30H48O5
CAS 号

1345109-46-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. ThanesuanNuanyai,et al. Cycloartane triterpenes from the exudate of Gardenia thailandica Author links open overlay panel. Volume 4, Issue 1, 15 March 2011, Pages 26-29.

Regaloside F

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天然产物 糖类和糖苷 Saccharides and Glycosides

Regaloside F;

Regaloside F Regaloside F 是一种酚类甘油葡萄糖苷，存在于百合球茎中。

Regaloside F

Regaloside F Chemical Structure

CAS No. : 120601-65-2

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生物活性

Regaloside F is a phenolic glycerol glucoside that can be found in Lily bulbs[1].

分子量

430.40

Formula

C19H26O11
CAS 号

120601-65-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Qiu K, et, al. Protective effect of total glycosides from lily on H2O2-induced H9C2 cells mitochondrial damage and characterization of the chemical profiles by UHPLC-LTQ-Orbitrap-MSn. Journal of Functional Foods. Volume 71, August 2020.