Temporin A

Temporin A;

Temporin A 是从 Rana temporaria 皮肤中分离得到的一种短α螺旋抗菌肽。Temporin A 对广谱革兰氏阳性菌有效。Temporin A 直接与微生物的细胞膜相互作用,在抗菌浓度下对红细胞无毒。Temporin A 还具有抗真菌活性,可对抗酵母样白色念珠菌。

Temporin Aamp;;

Temporin A Chemical Structure

CAS No. : 188713-69-1

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生物活性

Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans)[1][1][3].

体外研究
(In Vitro)

Temporin A (TA) is a small, basic, highly hydrophobic, antimicrobial peptide amide (FLPLIGRVLSGIL-NH2) found in the skin of the European red frog, Rana temporaria. It has variable antibiotic activities against a broad spectrum of microorganisms, including clinically important Methicillin-sensitive and -resistant Staphylococcus aureus as well as Vancomycin-resistant Enterococcus faecium strains[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1396.76

Formula

C68H117N17O14

CAS 号

188713-69-1

Sequence Shortening

FLPLIGRVLSGIL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mäntylä T, Sirola H, Kansanen E, et al. Effect of temporin A modifications on its cytotoxicity and antimicrobial activity. APMIS. 2005;113(7-8):497-505.

    [2]. Wade D, et al. Antibacterial activities of temporin A analogs. FEBS Lett. 2000;479(1-2):6-9.

    [3]. Kamysz W, et al. Temporin A and its retro-analogues: synthesis, conformational analysis and antimicrobial activities. J Pept Sci. 2006;12(8):533-537.

Temporin L

Temporin L;

Temporin L 是一种有效的抗菌肽,对革兰氏阴性细菌 (Gram-negative bacteria) 和酵母菌株 (yeast strains) 具有活性。Temporin L 还具有抗内毒素的特性。

Temporin Lamp;;

Temporin L Chemical Structure

CAS No. : 188713-81-7

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生物活性

Temporin L is a potent antimicrobial peptide and is active against Gram-negative bacteria and yeast strains. Temporin L also has antiendotoxin properties[1][2].

分子量

1639.98

Formula

C83H122N20O15

CAS 号

188713-81-7

Sequence Shortening

FVQWFSKFLGRIL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Elisabetta Buommino, et al. The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L. ChemMedChem. 2019 Jul 3;14(13):1283-1290.

    [2]. Andrea Giacometti, et al. Interaction of antimicrobial peptide temporin L with lipopolysaccharide in vitro and in experimental rat models of septic shock caused by gram-negative bacteria. Antimicrob Agents Chemother. 2006 Jul;50(7):2478-86.

Mambalgin 1

Mambalgin 1;

Mambalgin-1 是从黑曼巴蛇毒液中分离出来的毒素。Mambalgin-1 是一种富含二硫的多肽,由 57 个氨基酸组成,属于三指毒素家族。Mambalgin-1 可以结合并稳定 ASICs (acid-sensing ion channels),形成生理上相关的闭通道构象。

Mambalgin 1amp;;

Mambalgin 1 Chemical Structure

CAS No. : 1609937-15-6

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生物活性

Mambalgin-1 is a toxin isolated from black mamba venom. Mambalgin-1 is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. Mambalgin-1 can bind to and stabilize ASICs (acid-sensing ion channels) in a physiologically relevant closed-channel conformation[1].

分子量

7283.22

Formula

C310H481N87O100S8

CAS 号

1609937-15-6

Sequence Shortening

LKCYQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK (Disulfide bridge:Cys3-Cys19;Cys12-Cys37;Cys41-Cys49;Cys50-Cys55)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sun D, et al. Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect. Cell Discov. 2018;4:27. Published 2018 Jun 5.

Lysobactin

Lysobactin;

Lysobactin 由土壤中发现的几种革兰氏阴性菌产生的,是一种有效的抗生素 (antibiotic),对金黄色葡萄球菌和肺炎链球菌具有功效。

Lysobactinamp;;

Lysobactin Chemical Structure

CAS No. : 118374-47-3

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生物活性

Lysobactin, produced by several genera of Gram-negative gliding bacteria found in soil, is a potent antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae[1].

分子量

1276.48

Formula

C58H97N15O17

CAS 号

118374-47-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wonsik Lee, et al. The Mechanism of Action of Lysobactin. J Am Chem Soc. 2016 Jan 13;138(1):100-3.

Myostatin-IN-1

Myostatin-IN-1;

Myostatin-IN-1 是一种有效的肌肉生成抑制素 (myostatin) 抑制剂 (myostatin、GDF-11、activin A 和 TGF-β1 的IC50 分别为 0.19 μM、0.63 μM、0.89 μM 和 1.6 μM)。Myostatin-IN-1 能增加小鼠胫骨前肌质量。Myostatin-IN-1 可用于研究骨骼肌中肌生成抑制素的长期失活。

Myostatin-IN-1amp;;

Myostatin-IN-1 Chemical Structure

CAS No. : 2757831-08-4

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生物活性

Myostatin-IN-1 is a potent myostatin inhibitor (IC50 of 0.19, 0.63, 0.89 and 1.6 μM for myostatin, GDF-11, activin A and TGF-β1, respectively). Myostatin-IN-1 increases the tibialis anterior muscle mass in mice. Myostatin-IN-1 can be used for researching the prolonged inactivation of myostatin in skeletal muscle[1].

IC50 Target

IC50: 0.19 μM (myostatin), 0.63 μM (GDF-11), 0.89 μM (activin A), 1.6 μM (TGF-β1)[1]

体外研究
(In Vitro)

Myostatin-IN-1 (MID-35) (50 µM; 400 min) possesses complete proteolytic stability, and can survive 99 and 97% of the intact form incubated for 400 min in trypsin or α-chymotrypsin solution[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Myostatin-IN-1 (0.75 mM; i.m.; single) can significantly induce the increase in tibialis anterior (TA) muscle mass in C57BL/6J mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (8 weeks)[1]
Dosage: 0.75 mM
Administration: i.m.; single
Result: Significantly induced the increase in tibialis anterior (TA) muscle mass in C57BL/6J mice.

分子量

2350.94

Formula

C118H184N34O17

CAS 号

2757831-08-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Takayama K, et al. Development of Myostatin Inhibitory d-Peptides to Enhance the Potency, Increasing Skeletal Muscle Mass in Mice. ACS Med Chem Lett. 2022;13(3):492-498. Published 2022 Feb 14.

Homodestcardin

Homodestcardin;

Homodestcardin 是一种基于去甲氧基环肽的免疫抑制剂。Homodestcardin 是一种真菌代谢物,对刀豆蛋白A (Con A) 激活具有显著的抑制活性,IC50 为 0.86 μM。

Homodestcardinamp;;

Homodestcardin Chemical Structure

CAS No. : 917382-84-4

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生物活性

Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM[1].

分子量

621.81

Formula

C32H55N5O7

CAS 号

917382-84-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ai Hua Zhang, et al. Discovery of a new class of immunosuppressants from Trichothecium roseum co-inspired by cross-kingdom similarity in innate immunity and pharmacophore motif. Chem Asian J. 2013 Dec;8(12):3101-7.

Trichomide A

Trichomide A;

Trichomide A 是一种有效的 SHP2 激活剂。Trichomide A 是一种天然的环缩肽。Trichomide A 在 Con A 激活的 T 细胞中对激活的 T 淋巴细胞介导的免疫反应具有免疫抑制活性。Trichomide A具有研究免疫相关皮肤病的潜力。

Trichomide Aamp;;

Trichomide A Chemical Structure

CAS No. : 1569195-36-3

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生物活性

Trichomide A is a potent activator of SHP2. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases[1].

分子量

637.81

Formula

C32H55N5O8

CAS 号

1569195-36-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Song Y, et al. Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. J Med Chem. 2022;65(4):3066-3079.

DSTYSLSSTLTLSK

DSTYSLSSTLTLSK;

DSTYSLSSTLTLSK 是人通用肽,可用于英夫利昔单抗定量检测。 Infliximab (Avakine) 是一种嵌合的单克隆 IgG1 抗体,特异性结合到 TNF-α。

DSTYSLSSTLTLSKamp;;

DSTYSLSSTLTLSK Chemical Structure

CAS No. : 177792-42-6

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DSTYSLSSTLTLSK 的其他形式现货产品:

DSTYSLSSTLTLSK TFA

生物活性

DSTYSLSSTLTLSK is a generic human peptide and can be used for infliximab quantitative detection[1]. Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.

分子量

1502.62

Formula

C64H107N15O26

CAS 号

177792-42-6

Sequence Shortening

DSTYSLSSTLTLSK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jing-Ya Shiao, et al. Development of efficient on-bead protein elution process coupled to ultra-high performance liquid chromatography-tandem mass spectrometry to determine immunoglobulin G subclass and glycosylation for discovery of bio-signatures in pancreatic disease. Chromatogr A. 2020 Jun 21;1621:461039.

Baccatin

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Baccatin 

Baccatin 是一种从 Sapium Sebiferum 的根中分离出来的化合物。

Baccatin

Baccatin Chemical Structure

CAS No. : 66107-60-6

规格 是否有货
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生物活性

Baccatin is a compound isolated from the roots of Sapium Sebiferum[1].

分子量

458.67

Formula

C29H46O4

CAS 号

66107-60-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Li-Shian Shi, et al. A New Ent-Trachylobane Diterpenoid from the Roots of Sapium Sebiferum.

Morelloflavone

天然产物 黄酮类 Flavonoids

Morelloflavone 

莫雷洛黄酮具有抗氧化、抗病毒和抗炎特性。

Morelloflavone

Morelloflavone Chemical Structure

CAS No. : 16851-21-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Morelloflavone has antioxidative, antiviral, and anti-inflammatory properties.

分子量

556.47

Formula

C30H20O11

CAS 号

16851-21-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pang X, et al. Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways. Cancer Res. 2009 Jan 15;69(2):518-25.