标签归档：货期

6″-O-Acetyldaidzin

发表于由

天然产物 黄酮类 Flavonoids

6″-O-Acetyldaidzin 

6″-O-Acetyldaidzin 是大豆中的一个异黄酮糖苷。在大鼠肝微粒体中，6″-O-Acetyldaidzin 显著抑制脂质过氧化反应的 IC50 值为 8.2 μM。

6"-O-Acetyldaidzin

6″-O-Acetyldaidzin Chemical Structure

CAS No. : 71385-83-6

规格 价格 是否有货
1 mg ￥6800 询问价格 & 货期
5 mg ￥19800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

6″-O-Acetyldaidzin is an isoflavone glycoside isolated from soybeans. 6″-O-Acetyldaidzin significantly inhibits lipid peroxidation in rat liver microsome with an IC50 of 8.2 μM[1][2].

体外研究
(In Vitro)

6″-O-Acetyldaidzin exhibits inhibitory effect against lipid peroxidation in rat liver microsome with an IC50 of 8.2 μM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

458.41

Formula

C23H22O10
CAS 号

71385-83-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shigemitsu KUDOU, et al. Shigemitsu KUDOU, et al. Malonyl Isoflavone Glycosides in Soybean Seeds (Glycine max MERRILL). Agric. BioI. Chem., 1991;55 (9), 2227-2233.

    [2]. Lee SJ, et al. An antioxidant lignan and other constituents from the root bark of Hibiscus syriacus. Planta Med. 1999 Oct;65(7):658-60.

Sibirioside A

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Sibirioside A 

Sibirioside A 是从玄参中分离出来的一种苯丙烷糖苷。Sibirioside A 可用于糖尿病研究的相关研究。

Sibirioside A

Sibirioside A Chemical Structure

CAS No. : 173046-19-0

规格 价格 是否有货
1 mg ￥2860 询问价格 & 货期
5 mg ￥8570 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Sibirioside A is a phenylpropanoid glycoside isolated from Scrophulariae Radix. Sibirioside A has the potential for the treatment of diabetes[1].

分子量

472.44

Formula

C21H28O12
CAS 号

173046-19-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang YF, et al. Investigation of the In Vivo Metabolism of Sibirioside A and Angoroside C in Rats by HPLC-ESI-IT-TOF-MSn.Molecules. 2018 Oct 19;23(10).

Vincetoxicoside B(Synonyms: 白前苷 B)

发表于由

天然产物 黄酮类 Flavonoids

Vincetoxicoside B (Synonyms: 白前苷 B)

Vincetoxicoside B 具有抗真菌活性。

Vincetoxicoside B(Synonyms: 白前苷 B)

Vincetoxicoside B Chemical Structure

CAS No. : 22007-72-3

规格 价格 是否有货
5 mg ￥1580 询问价格 & 货期
10 mg ￥2690 询问价格 & 货期
20 mg ￥4570 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Vincetoxicoside B shows antifungal activity[1].

分子量

448.38

Formula

C21H20O11
CAS 号

22007-72-3
中文名称

白前苷 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yang YX, et al. Chemical constituents from the rhizome of Polygonum paleaceum and their antifungal activity. J Asian Nat Prod Res. 2017 Jan;19(1):47-52.

Saikosaponin G

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Saikosaponin G;

Saikosaponin G 是一种从柴胡中分离得到的三萜苷类化合物。

Saikosaponin G

Saikosaponin G Chemical Structure

CAS No. : 99365-19-2

规格 价格 是否有货
1 mg ￥3430 询问价格 货期
5 mg ￥10290 询问价格 货期

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生物活性

Saikosaponin G is a triterpene glycoside isolated from Bupleuri Radix[1].

分子量

780.98

Formula

C42H68O13
CAS 号

99365-19-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shimizu K, et al. Structural transformation of saikosaponins by gastric juice and intestinal flora. J Pharmacobiodyn. 1985 Sep;8(9):718-25.

Ombuoside

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Ombuoside;

Ombuoside 是从绞股蓝 (Gynostemma pentaphyllum) 分离得到的糖苷复合物。Ombuoside 具有抗微生物活性，对几种革兰氏阳性菌和革兰氏阴性菌以及白色念珠菌 (Candida albicans) 有抑制作用。 Ombuoside 具有清除自由基和 ROS 抗氧化作用。

Ombuoside

Ombuoside Chemical Structure

CAS No. : 20188-85-6

规格 价格 是否有货
1 mg ￥1000 询问价格 货期
5 mg ￥2500 询问价格 货期

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生物活性

Ombuoside is a glycoside ombuoside isolated from Gynostemma pentaphyllum.Ombuoside has antimicrobial activity against several strains of gram-positive and gram-negative bacteria and the yeast Candida albicans[1]. Ombuoside has antioxidant effects by scavenging free radicals and ROS[2].

分子量

638.57

Formula

C29H34O16
CAS 号

20188-85-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. J M Amaro-Luis, et al. Isolation, Identification and Antimicrobial Activity of Ombuoside From Stevia Triflora. Ann Pharm Fr. 1997;55(6):262-8.

    [2]. Uchralsaikhan Davaasambuu, et al. Ombuoside From Gynostemma Pentaphyllum Protects PC12 Cells From L-DOPA-Induced Neurotoxicity.Planta Med

Gymnemagenin

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Gymnemagenin 

Gymnemagenin 是从 G. sylvestre 中分离的三萜。 Gymnemagenin 有潜力用于糖尿病和肥胖症的研究，还具有抗病毒特性。

Gymnemagenin

Gymnemagenin Chemical Structure

CAS No. : 22467-07-8

规格 价格 是否有货
1 mg ￥1900 询问价格 & 货期
5 mg ￥5710 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Gymnemagenin is a triterpenoid isolated from G. sylvestre. Gymnemagenin is an agent for diabetes and obesity and also possesses antiviral properties[1][2].

体内研究
(In Vivo)

Gymnemagenin has a poor oral bioavailability (~ 14 %) in rats[2].
Gymnemagenin has a short half-life and a high clearance in rats[2].
Gymnemagenin metabolizes rapidly with a short apparent and intrinsic half-life (~ 7 min) and high intrinsic clearance[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

506.71

Formula

C30H50O6
CAS 号

22467-07-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Parthasarathy R, et al. Gymnemagenin-producing endophytic fungus isolated from a medicinal plant Gymnema sylvestre R.Br. Appl Biochem Biotechnol. 2014 Mar;172(6):3141-52.

    [2]. In Vitro Metabolic Stability and Permeability of Gymnemagenin and Its In Vivo Pharmacokinetic Correlation in Rats – A Pilot Study.

Andropanoside

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Andropanoside;

Andropanoside 是一种天然产物，对各种肝脏疾病具有保护活性，可用于各种肝脏疾病的研究。

Andropanoside

Andropanoside Chemical Structure

CAS No. : 82209-72-1

规格 价格 是否有货
1 mg ￥2860 询问价格 货期
5 mg ￥8570 询问价格 货期

* Please select Quantity before adding items.

生物活性

Andropanoside is a natural product and possesses a protective activity against various liver disorders[1].

分子量

496.59

Formula

C26H40O9
CAS 号

82209-72-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bhope SG, et al. Design and development of a stable polyherbal formulation based on the results of compatibility studies. Pharmacognosy Res. 2011 Apr;3(2):122-9.

LCKLSL

发表于由

LCKLSL;

LCKLSL 是一种 N 末端六肽，是一种竞争性的膜联蛋白 A2 (AnxA2) 抑制剂，可有效抑制组织纤溶酶原激活物 (tPA) 与 AnxA2 的结合。LCKLSL 还可抑制纤溶酶的产生，并具有抗血管生成的作用。

LCKLSLamp;;

LCKLSL Chemical Structure

CAS No. : 533902-29-3

规格 价格 是否有货
5 mg ￥2500 询问价格 货期
10 mg ￥4500 询问价格 货期
25 mg ￥8500 询问价格 货期

* Please select Quantity before adding items.

LCKLSL 的其他形式现货产品:

LCKLSL hydrochloride

生物活性

LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].

IC50 Target

Annexin A2 (AnxA2)[1]
体外研究
(In Vitro)

In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

675.88

Formula

C30H57N7O8S
CAS 号

533902-29-3
Sequence

Leu-Cys-Lys-Leu-Ser-Leu
Sequence Shortening

LCKLSL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mallika Valapala, et al. A Competitive Hexapeptide Inhibitor of Annexin A2 Prevents Hypoxia-Induced Angiogenic Events. J Cell Sci. 2011 May 1;124(Pt 9):1453-64.

Bakkenolide B

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Bakkenolide B 

Bakkenolide B 是从 petasites japonicas 叶片中分离出来的，具有抗过敏和抗炎作用。 Bakkenolide B 可用于研究哮喘。

Bakkenolide B

Bakkenolide B Chemical Structure

CAS No. : 18455-98-6

规格 价格 是否有货
1 mg ￥4600 询问价格 & 货期
5 mg ￥13200 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1].

体外研究
(In Vitro)

Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1].
Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Mouse peritoneal macrophages
Concentration: 0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml
Incubation Time: 1 h later stimulated with LPS
Result: Decreased iNOS and cox-2 protein expression.

体内研究
(In Vivo)

Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovalbumin-induced asthma mice[1]
Dosage: 1 mg/ml
Administration: Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30
Result: Exhibited anti-allergic effects in mice.

分子量

390.47

Formula

C22H30O6
CAS 号

18455-98-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lee KP, et al. Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves.J Ethnopharmacol. 2013 Jul 30;148(3):890-4.

Peptide 401

发表于由

Peptide 401;

Peptide 401 是一种有效的来源于蜂毒中的肥大细胞脱颗粒肽，抑制血管通透性。

Peptide 401amp;;

Peptide 401 Chemical Structure

CAS No. : 32908-73-9

规格 价格 是否有货
500 μg ￥2800 询问价格 货期
1 mg ￥4800 询问价格 货期
5 mg ￥16500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

IC50 Target

serotonin

;

Histamine Receptor

;

体内研究
(In Vivo)

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins)[1]. Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2587.22

Formula

C110H192N40O24S4
CAS 号

32908-73-9
Sequence

Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)
Sequence Shortening

IKCNCKRHVIKPHICRKICGKN-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (19.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3865 mL 1.9326 mL 3.8652 mL
5 mM 0.0773 mL 0.3865 mL 0.7730 mL
10 mM 0.0387 mL 0.1933 mL 0.3865 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92.

    [2]. Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4.