Podocarpusflavone A(Synonyms: 竹柏双黄酮 A;罗汉松双黄酮A)

天然产物 黄酮类 Flavonoids

Podocarpusflavone A (Synonyms: 竹柏双黄酮 A;罗汉松双黄酮A)

Podocarpusflavone A是一个 DNA topoisomerase I 抑制剂,有一定的抗增殖能力,在 MCF-7 细胞中能引起凋亡,正在发展成抗肿瘤药物。

Podocarpusflavone A(Synonyms: 竹柏双黄酮 A;罗汉松双黄酮A)

Podocarpusflavone A Chemical Structure

CAS No. : 22136-74-9

规格 价格 是否有货
1 mg ¥1600 询问价格 & 货期
5 mg ¥4000 询问价格 & 货期

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生物活性

Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor drugs[1].

IC50 & Target[1]

Topoisomerase I

119.425 μM (IC50)

分子量

552.48

Formula

C31H20O10

CAS 号

22136-74-9

中文名称

竹柏双黄酮 A;罗汉松双黄酮A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pen-Ho Yeh et al. Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii J Tradit Complement Med. 2012 Jul;2(3):220-6.

Amentoflavone(Synonyms: 穗花杉双黄酮; Didemethyl-ginkgetin)

天然产物 黄酮类 Flavonoids

Amentoflavone (Synonyms: 穗花杉双黄酮; Didemethyl-ginkgetin) 纯度: 98.88%

穗花杉双黄酮 (Amentoflavone) 是一种天然的双黄酮类化合物,具有很多生物活性,包括抗炎、抗氧化、神经保护等作用。

Amentoflavone(Synonyms: 穗花杉双黄酮; Didemethyl-ginkgetin)

Amentoflavone Chemical Structure

CAS No. : 1617-53-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥829 In-stock
5 mg ¥700 In-stock
10 mg ¥1100 In-stock
25 mg ¥1600 In-stock
50 mg ¥2900 In-stock
100 mg ¥4600 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. IC50 value: Target: In vitro: In irradiated v79 cells, Pretreatment with amentoflavone 24 hours prior to 8 Gy 60Co γ-ray irradiation significantly inhibited apoptosis, promoted the G2 phase, decreased the concentration of ROS and mitochondrial mass [2]. Amentoflavone dose-dependently inhibited the viability of SW480 cells, and a high concentration of amentoflavone (150 μmol/L) obviously induced apoptosis of the cells [3]. In vivo: In epilepsy models, amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons [1].

分子量

538.46

Formula

C30H18O10

CAS 号

1617-53-4

中文名称

穗花杉双黄酮;阿曼托黄酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (232.14 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8571 mL 9.2857 mL 18.5715 mL
5 mM 0.3714 mL 1.8571 mL 3.7143 mL
10 mM 0.1857 mL 0.9286 mL 1.8571 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.64 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.64 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (4.64 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Zhang Z, et al. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects. Neural Regen Res. 2015 Jul;10(7):1125-33.

    [2]. Xu P, et al. Amentoflavone acts as a radioprotector for irradiated v79 cells by regulating reactive oxygen species (ROS), cell cycle and mitochondrial mass. Asian Pac J Cancer Prev. 2014;15(18):7521-6.

    [3]. Yang Y, et al. [Amentoflavone induces apoptosis in SW480 human colorectal cancer cells via regulating β-catenin and caspase-3 expressions]. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1035-8.

Ginkgetin(Synonyms: 银杏双黄酮)

天然产物 黄酮类 Flavonoids

Ginkgetin (Synonyms: 银杏双黄酮) 纯度: 98.37%

Ginkgetin 是一种从银杏叶中分离得到的双黄酮。Ginkgetin 具有抗肿瘤,抗炎,神经保护,抗真菌的作用。Ginkgetin 也是一种有效的 Wnt 信号抑制剂,IC50 值为 5.92 μM。

Ginkgetin(Synonyms: 银杏双黄酮)

Ginkgetin Chemical Structure

CAS No. : 481-46-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥3116 In-stock
5 mg ¥2500 In-stock
10 mg ¥4200 In-stock
50 mg   询价  
100 mg   询价  

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相关化合物库:

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生物活性

Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].

IC50 & Target[2]

Wnt

5.92 μM (IC50)

体外研究
(In Vitro)

Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G2/M cell cycle arrest in Daoy cells[2].
Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner[3].
Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells[2].
Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner[1].
Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Daoy and D283 cell lines
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Inhibited the cell growth, with IC50s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively.

Apoptosis Analysis[3]

Cell Line: Osteosarcoma cells
Concentration: 20, 30, 40 μM
Incubation Time: 24 hours
Result: Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner.

Cell Cycle Analysis[2]

Cell Line: Daoy cells
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 24 hours
Result: Increased G2/M phase, compared with that of control, indicating a G2/M cell phase arrest.

Cell Cycle Analysis[2]

Cell Line: Daoy and D283 cell lines
Concentration: 10, 20 μM
Incubation Time: 3, 6, 12, 24 hours
Result: Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells.
Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner.

体内研究
(In Vivo)

Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway[4].
Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g)[4]
Dosage: 25, 50, 100 mg/kg
Administration: I.p. 2 hours after the onset of ischemia
Result: Reduced the neurological deficit score.
Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα.
Decreased the expressions of ICAM-1, COX-2, and iNOS.
Downregulated downstream inflammatory factor PGE2 and TNF-α expression.
Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.

分子量

566.51

Formula

C32H22O10

CAS 号

481-46-9

中文名称

银杏素;白果双黄酮;银杏双黄酮;银杏黄素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (220.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7652 mL 8.8260 mL 17.6519 mL
5 mM 0.3530 mL 1.7652 mL 3.5304 mL
10 mM 0.1765 mL 0.8826 mL 1.7652 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Hu WH, et, al. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12):1828.

    [2]. Ye ZN, et, al. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect. 2015 Mar 29;5(2):91-97.

    [3]. Xiong M, et, al. Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncol Rep. 2016 Feb;35(2):1034-40.

    [4]. Li Q, et, al. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2019 Apr;83(4):675-683.

    [5]. Lou J, et, al. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 2017 Oct 16;8(54):93131-93148.

8-Hydroxy-3,5,6,7,3′,4′-hexamethoxyflavone(Synonyms: 8-羟基-3,5,6,7,3′,4′-六甲氧基黄酮)

天然产物 黄酮类 Flavonoids

8-Hydroxy-3,5,6,7,3′,4′-hexamethoxyflavone (Synonyms: 8-羟基-3,5,6,7,3′,4′-六甲氧基黄酮)

8-Hydroxy-3,5,6,7,3′,4′-hexamethoxyflavone 是从陈皮中分离得到的一种多氧甲基黄酮。

8-Hydroxy-3,5,6,7,3

8-Hydroxy-3,5,6,7,3′,4′-hexamethoxyflavone Chemical Structure

CAS No. : 1000415-56-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

8-Hydroxy-3,5,6,7,3′,4′-hexamethoxyflavone is a polymethoxyflavone (PMF) isolated from pericarpium citri reticulatae.

分子量

418.39

Formula

C21H22O9

CAS 号

1000415-56-4

中文名称

8-羟基-3,5,6,7,3′,4′-六甲氧基黄酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Vaccarin E(Synonyms: 王不留行黄酮苷E)

天然产物 糖类和糖苷 Saccharides and Glycosides

Vaccarin E;(Synonyms: 王不留行黄酮苷E)

Vaccarin E 是可从 V. hispanica 分离得到的天然 C-黄酮碳苷。

Vaccarin E(Synonyms: 王不留行黄酮苷E)

Vaccarin E Chemical Structure

CAS No. : 2252345-81-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Vaccarin E is a natural C-glycosylflavone that could be isolated from V. hispanica[1].

分子量

904.82

Formula

C42H48O22

CAS 号

2252345-81-4

中文名称

王不留行黄酮苷E

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. GuohongZhou, et al. C-glycosylflavone with rotational isomers from Vaccaria hispanica (Miller) Rauschert seeds. Phytochemistry Letters Volume 19, March 2017, Pages 241-247.