Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity[1][2].
IC50 & Target
Pancreatic lipase[2]
分子量
1131.26
Formula
C55H86O24
CAS 号
26339-90-2
中文名称
七叶皂苷B
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Abudayeh ZH, et al. Determination of Four Major Saponins in Skin and Endosperm of Seeds of Horse Chestnut (Aesculus Hippocastanum L.) Using High Performance Liquid Chromatography with Positive Confirmation by Thin Layer Chromatography. Adv Pharm Bull. 2015 Nov;5(4):587-91.
[2]. Hu JN, et al. Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae). Chem Pharm Bull (Tokyo). 2008 Jan;56(1):12-6.
4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity and reduces IL-6 level[1].
分子量
192.17
Formula
C10H8O4
CAS 号
529-84-0
中文名称
4-甲基七叶亭
运输条件
Room temperature in continental US; may vary elsewhere.
Escin IA 是从马蹄中七叶树分离出的一种三萜皂苷,抑制 HIV-1 蛋白酶,IC50 值为 35 μM,Escin IA 具有抗三阴乳腺癌转移活性,其作用机制包括下调 LOXL 表达抑制上皮间充质转化过程。
Escin IA Chemical Structure
CAS No. : 123748-68-5
规格
价格
是否有货
数量
10;mM;*;1 mL in DMSO
¥3559
In-stock
5 mg
¥1680
In-stock
10 mg
¥2860
In-stock
50 mg
;
询价
;
100 mg
;
询价
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Escin IA 相关产品
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生物活性
Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression[1][2].
分子量
1131.26
Formula
C55H86O24
CAS 号
123748-68-5
中文名称
七叶皂苷A
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Yang XW, et al. Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis. J Nat Prod. 1999 Nov;62(11):1510-3.
[2]. Wang Y, et al. Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression. Oncotarget. 2016 Apr 26;7(17):23684-99.
Escin, a natural compound of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent[1].
Clinical Trial
分子量
1131.26
Formula
C55H86O24
CAS 号
6805-41-0
中文名称
七叶皂苷;七叶皂甙
运输条件
Room temperature in continental US; may vary elsewhere.