天然产物 天然产物苯丙素类 Phenylpropanoids
Gomisin J (Synonyms: 戈米辛J) 纯度: ≥99.0%
Gomisin J 是一种在五味子 (Schisandra chinensis) 中发现的小分子量木脂素,具有血管舒张活性。 Gomisin J 通过激活 AMPK,LKB1 和 Ca2+/ 钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白-A (fetuin-A) 来调节脂肪生成,脂肪分解酶和炎症分子的表达来抑制脂质积累。 gomisin J 在研究非酒精性脂肪性肝病方面具有潜在的益处。
Gomisin J Chemical Structure
CAS No. : 66280-25-9
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥2478 | In-stock | |
1 mg | ¥990 | In-stock | |
5 mg | ¥2900 | In-stock | |
10 mg | ¥4900 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Gomisin J 相关产品
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生物活性 |
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2]. |
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IC50 & Target |
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分子量 |
388.45 |
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Formula |
C22H28O6 |
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CAS 号 |
66280-25-9 |
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中文名称 |
戈米辛J |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (257.43 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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