Neurokinin B 属于速激肽家族。Neurokinin结合到一系列 G 蛋白偶联受体 (GPCR)-包括神经激肽受体 1 (NK1R),NK2R 和 NK3R,且介导其生物学作用。
Neurokinin B Chemical Structure
CAS No. : 86933-75-7
规格
是否有货
100 mg
;
询价
;
250 mg
;
询价
;
500 mg
;
询价
;
* Please select Quantity before adding items.
Neurokinin B 的其他形式现货产品:
Neurokinin B TFA
生物活性
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].
IC50 Target
Neurokinin receptor[1]
体外研究 (In Vitro)
Neurokinin B (NKB) belongs to the tachykinin family of peptides that initially included the neuropeptides substance P (SP), neurokinin A (NKA), and NKB and more recently, endokinins and hemokinins. Tachykinins bind a family of G-protein-coupled receptors (GPCRs)-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1210.42
Formula
C55H79N13O14S2
CAS 号
86933-75-7
Sequence
Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening
DMHDFFVGLM-NH2
中文名称
神经激肽 B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;
H2O
Peptide Solubility and Storage Guidelines:
1.;;Calculate the length of the peptide.
2.;;Calculate the overall charge of the entire peptide according to the following table:
;
Contents
Assign value
Acidic amino acid
Asp (D), Glu (E), and the C-terminal -COOH.
-1
Basic amino acid
Arg (R), Lys (K), His (H), and the N-terminal -NH2
+1
Neutral amino acid
Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)
0
3.;;Recommended solution:
Overall charge of peptide
Details
Negative (lt;0)
1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH4OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)
1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)
1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
[1]. Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47.
KKI-5 is a specific inhibitor of tissue kallikrein. KKI-5 can attenuate breast cancer cell invasion[1].
IC50 Target
Kallikrein Inhibitor
体外研究 (In Vitro)
The KKI-5 Peptide corresponds to aa386-391 of bovine kininogen-1 that encompasses the aa388-389 kallikrein proteolytic site. The synthetic KKI-5 can attenuate breast cancer cell invasion, therefore it is investigated for its role in invasion and metastasis of cancer cells.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
773.88
Formula
C35H55N11O9
CAS 号
97145-43-2
Sequence
Ac-Pro-Phe-Arg-Ser-Val-Gln-NH2
Sequence Shortening
Ac-PFRSVQ-NH2
中文名称
激肽释放酶抑制剂
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;
H2O
Peptide Solubility and Storage Guidelines:
1.;;Calculate the length of the peptide.
2.;;Calculate the overall charge of the entire peptide according to the following table:
;
Contents
Assign value
Acidic amino acid
Asp (D), Glu (E), and the C-terminal -COOH.
-1
Basic amino acid
Arg (R), Lys (K), His (H), and the N-terminal -NH2
+1
Neutral amino acid
Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)
0
3.;;Recommended solution:
Overall charge of peptide
Details
Negative (lt;0)
1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH4OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)
1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)
1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
[1]. Deshpande MS, et al. Mapping the binding site of tissue kallikrein: preparation and testing of all possible substrate analog inhibitors homologous with the sequence of kininogen between Ser386 and Gln392. J Med Chem. 1992 Aug 21;35(17):3094-102.
Neurokinin B TFA;(Synonyms: 神经激肽 B 三氟乙酸盐) 纯度: 96.64%
Neurokinin B TFA 属于速激肽家族。Neurokinin 结合到一系列 G 蛋白偶联受体 (GPCR)-包括神经激肽受体1 (NK1R),NK2R 和 NK3R,且介导其生物学作用。
Neurokinin B TFA Chemical Structure
CAS No. : 101536-55-4
规格
价格
是否有货
数量
1 mg
¥900
In-stock
5 mg
¥3600
In-stock
10 mg
¥6400
In-stock
25 mg
¥12500
In-stock
50 mg
;
询价
;
100 mg
;
询价
;
* Please select Quantity before adding items.
生物活性
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].
IC50 Target
Neurokinin receptor[1]
分子量
1438.47
Formula
C55H79N13O14S2.2C2HF3O2
CAS 号
101536-55-4
Sequence
Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening
DMHDFFVGLM-NH2
中文名称
神经激肽 B 三氟乙酸盐
运输条件
Room temperature in continental US; may vary elsewhere.