Dipsanoside B 是一种来自川续断 (Dipsacus asper) 的新型四环苷类葡萄糖苷。川续断是一种在中国广泛存在的多年生植物,被用于传统中药中已有数百年,可以作为补品,作为骨质细胞的分裂促进剂,以及胚胎安全剂等。
Dipsanoside B Chemical Structure
CAS No. : 889678-64-2
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
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生物活性
Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc[1].
分子量
1475.40
Formula
C66H90O37
CAS 号
889678-64-2
中文名称
续断苷 B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Tian, X.-Y. et al. Two Novel Tetrairidoid Glucosides from Dipsacus asper. Organic Letters, 2006,8(10), 2179–2182.
Dipsanoside A 是一种来自川续断 (Dipsacus asper) 的新型四环苷类葡萄糖苷。川续断是一种在中国广泛存在的多年生植物,被用于传统中药中已有数百年,可以作为补品,作为骨质细胞的分裂促进剂,以及胚胎安全剂等。
Dipsanoside A Chemical Structure
CAS No. : 889678-62-0
规格
价格
是否有货
1 mg
¥3050
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5 mg
¥9140
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生物活性
Dipsanoside A is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc[1].
分子量
1475.40
Formula
C66H90O37
CAS 号
889678-62-0
中文名称
续断苷A
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Tian, X.-Y. et al. Two Novel Tetrairidoid Glucosides from Dipsacus asper. Organic Letters, 2006,8(10), 2179–2182.
Dipsacoside B(Synonyms: 川续断皂苷乙;川续断皂苷 B) 纯度: 99.17%
Dipsacoside B 是一种主要的具有生物活性的皂素,可用作标志物。
Dipsacoside B Chemical Structure
CAS No. : 33289-85-9
规格
价格
是否有货
数量
5 mg
¥550
In-stock
10 mg
¥950
In-stock
50 mg
¥2400
In-stock
100 mg
询价
200 mg
询价
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Dipsacoside B 相关产品
•相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Glycoside Compound Library
Terpenoids Library
生物活性
Dipsacoside B is a major bioactive saponin, which can be used as a marker.
体内研究 (In Vivo)
A liquid chromatography-electrospray ionization-mass spectrometry method has been developed and validated for identification and quantification of four major bioactive saponins in rat plasma after oral administration of extraction of saponins from Flos Lonicerae, i.e., Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B. The retention time of Macranthoidin B, Macranthoidin A, Dipsacoside B, Macranthoside B and IS are 10.65, 12.11, 13.81, 23.31 and 5.47 min, respectively[1]. Taking Macranthoidins A, B, Dipsacoside B (saponins), sweroside (iridoids), and luteolin-7-O-d-glucoside (flavonoids) as markers, a method of ultra high performance liquid chromatography with triple quadrupole mass spectrometry is employed to determine their amounts in Lonicerae Flos, Lonicerae Japonicae Flos, and Lonicerae Japonicae Flos preparations[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1075.24
Formula
C53H86O22
CAS 号
33289-85-9
中文名称
川续断皂苷乙;川续断皂苷 B
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Chen CY, et al. Liquid chromatography-mass spectrometry analysis of macranthoidin B, macranthoidin A, Dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):159-65.
[2]. Zhang X, et al. Rapid quantitative analysis of adulterant Lonicera species in preparations of Lonicerae Japonicae Flos. J Sep Sci. 2015 Dec;38(23):4014-20.
Animal Administration [1]
Mice[1] Sprague-Dawley rats (220-250 g) are used. To calculate the administered dose of Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B, their contents in saponins extraction are quantitatively determined. One hundred milligrams of the dry powder is suspended in 100 mL 50% methanol (v/v), ultrasonically extracted for 40 min, and then cooled at room temperature; 50% methanol is added to compensate for the lost weight. Finally, 5 μL of this solution is injected into the HPLC system for analysis after filtration through a 0.45 μm membrane. The contents of Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B are found as 36.7, 6.59, 23.3 and 0.506 g/100 g extraction, respectively.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Chen CY, et al. Liquid chromatography-mass spectrometry analysis of macranthoidin B, macranthoidin A, Dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):159-65.
[2]. Zhang X, et al. Rapid quantitative analysis of adulterant Lonicera species in preparations of Lonicerae Japonicae Flos. J Sep Sci. 2015 Dec;38(23):4014-20.
Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway[1]. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB[2].
IC50 Target[2]
Caspase 3
;
分子量
929.10
Formula
C47H76O18
CAS 号
39524-08-8
中文名称
川续断皂苷 VI
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Niu Y, et al. Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway. Phytother Res. 2011 Nov;25(11):1700-6.
[2]. Li C, et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7.