|
品牌：FUJIFILM Wako
CAS No.：21967-41-9 储存条件：2-10℃ 纯度：90.0+% (HPLC) |
| 产品编号
(生产商编号) |
等级 | 规格 | 运输包装 | 零售价(RMB) | 库存情况 | 参考值 |
|
021-11201 |
for Biochemistry | 100mg | – | 1,460.00 | – | – |
* 干冰运输、大包装及大批量的产品需酌情添加运输费用
* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。
天然产物 黄酮类 Flavonoids
Scutellarin (Synonyms: 野黄芩苷) 纯度: ≥98.0%
Scutellarin 是从黄芩中分离到的黄酮类物质，在 HCC 细胞中，能够下调 STAT3/Girdin/Akt 信号通路，在破骨细胞中，能够抑制 RANKL 介导的 MAPK/NF-κB 信号通路。Scutellarin 具有抗 HIV-1IIIB，HIV-1(74V) 和 HIV-1KM018 的活性，EC50 分别为 26 μM，253 μM 和 136 μM。
Scutellarin Chemical Structure
CAS No. : 27740-01-8
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 10 mM * 1 mL in DMSO | ￥500 | In-stock | |
| 10 mg | ￥450 | In-stock | |
| 25 mg | ￥780 | In-stock | |
| 50 mg | ￥1400 | In-stock | |
| 100 mg | 询价 | ||
| 200 mg | 询价 |
* Please select Quantity before adding items.
| 生物活性 |
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 & Target[1] |
|
||||||||||||||||
| 体外研究 (In Vitro) |
Scutellarin treatment significantly reduces HepG2 cell viability in a dose-dependent manner, and inhibits migration and invasion of HCC cells in vitro. Scutellarin treatment significantly reduces STAT3 and Girders of actin filaments (Girdin) expression, STAT3 and Akt phosphorylation in HCC cells. Introduction of STAT3 overexpression restores the scutellarin-downregulated Girdin expression, Akt activation, migration and invasion of HCC cells. Furthermore, induction of Girdin overexpression completely abrogates the inhibition of scutellarin on the Akt phosphorylation, migration and invasion of HCC cells. Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling[1]. Scutellarin selectively enhances Akt phosphorylation[2]. Scutellarin is a putative therapeutic agent as it has been found to not only suppress microglial activation thus ameliorating neuroinflammation, but also enhance astrocytic reaction. Acutellarin amplifies the astrocytic reaction by upregulating the expression of neurotrophic factors among others thus indicating its neuroprotective role. Remarkably, the effects of scutellarin on reactive astrocytes are mediated by activated microglia supporting a functional “cross-talk” between the two glial types[3]. Scutellarin can suppress RANKL-mediated osteoclastogenesis, the function of osteoclast bone resorption, and the expression levels of osteoclast-specific genes (tartrate-resistant acid phosphatase (TRAP), cathepsin K, c-Fos, NFATc1). Further investigation indicates that Scutellarin can inhibit RANKL-mediated MAPK and NF-κB signaling pathway, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation[5]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
| 体内研究 (In Vivo) |
Scutellarin (50 mg/kg/day) significantly mitigates the lung and intrahepatic metastasis of HCC tumors in vivo. The numbers of the lung and intrahepatic metastatic tumors in the scutellarin-treated group are significantly less than that in the controls[1]. The rats treated with Scutellarin display a significant alleviation in neurobehavioral deficits compared to the SAH group. Scutellarin enhanced eNOS expression compared with SAH rats[4]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
| 分子量 |
462.36 |
||||||||||||||||
| Formula |
C21H18O12 |
||||||||||||||||
| CAS 号 |
27740-01-8 |
||||||||||||||||
| 中文名称 |
野黄芩苷；野黄芩甙；灯盏花乙素；高黄芩苷；高黄芩甙；印黄芩苷；黃芹素 |
||||||||||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
| 储存方式 |
|
||||||||||||||||
| 溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (216.28 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂： ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
|
||||||||||||||||
| 参考文献 |
|
| Cell Assay [1] |
HepG2 cells (1×105/well) are cultured in 96-well plates and treated in triplicate with scutellarin at concentrations of 5, 10, 20, 30, and 100 μM or vehicle alone for 24 h. The cellular viability is tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and is expressed as a percentage of proliferation versus controls. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
|---|---|
| Animal Administration [1] |
To establish an orthotopic liver xenograft model, individual mice are anesthetized with isoflurane and a small incision is made in their abdomen. Individual mice are injected with 2×106 SK-Hep1 cells in 30 μL Matrigel into their left lobe of the liver. Twenty-four hours after orthotopic liver implantation, the mice are randomized and injected intraperitoneally with scutellarin (50 mg/kg/day) or vehicle (0.9% NaCl, normal saline) daily for 35 consecutive days (n=10 per group). Subsequently, the mice are sacrificed, and their lungs and livers are excised, fixed in 10% buffered formalin and paraffin-embedded for hematoxylin and eosin staining. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 参考文献 |
|
天然产物 黄酮类 Flavonoids
Scutellarein (Synonyms: 野黄芩素; 6-Hydroxyapigenin; 4′,5,6,7-Tetrahydroxyflavone) 纯度: 99.75%
野黄芩素(Scutellarein) 是天然黄酮类化合物，具有抗炎功效。
Scutellarein Chemical Structure
CAS No. : 529-53-3
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| Free Sample (0.1-0.5 mg) | Apply now | ||
| 10 mM * 1 mL in DMSO | ￥1259 | In-stock | |
| 2 mg | ￥800 | In-stock | |
| 5 mg | ￥1200 | In-stock | |
| 10 mg | ￥1700 | In-stock | |
| 25 mg | ￥3700 | In-stock | |
| 50 mg | ￥5700 | In-stock | |
| 100 mg | 询价 | ||
| 200 mg | 询价 |
* Please select Quantity before adding items.
| 生物活性 |
Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz., has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 分子量 |
286.24 |
||||||||||||||||
| Formula |
C15H10O6 |
||||||||||||||||
| CAS 号 |
529-53-3 |
||||||||||||||||
| 中文名称 |
野黄芩素；金黄紫碱；黄岑配基；高黄芩素；野黄芩黄素 |
||||||||||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
||||||||||||||||
| 溶解性数据 |
In Vitro:
DMSO : ≥ 30 mg/mL (104.81 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂： ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
|
||||||||||||||||
| 参考文献 |
|