N-Acetylneuraminic acid(Synonyms: 唾液酸; NANA; Lactaminic acid)

天然产物 糖类和糖苷 Saccharides and Glycosides

N-Acetylneuraminic acid;(Synonyms: 唾液酸; NANA; Lactaminic acid) 纯度: ge;98.0%

N-Acetylneuraminic酸是一个在细胞膜的糖蛋白和哺乳细胞神经节甘脂的糖脂上普遍存在的唾液酸单糖,在神经传递, 白细胞血管渗出,病毒或细菌感染起着生物作用。

N-Acetylneuraminic acid(Synonyms: 唾液酸; NANA;  Lactaminic acid)

N-Acetylneuraminic acid Chemical Structure

CAS No. : 131-48-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in Water ¥550 In-stock
100 mg ¥500 In-stock
1 g ¥700 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

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N-Acetylneuraminic acid 相关产品

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  • Metabolism/Protease Compound Library
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  • Antiviral Compound Library
  • Human Endogenous Metabolite Compound Library
  • Anti-Cardiovascular Disease Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Gut Microbial Metabolite Library
  • Microbial Metabolite Library
  • Food-Sourced Compound Library

生物活性

N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies suggest that N-Acetylneuraminic acid is useful biologically in neurotransmission, leukocyte extravasation, viral or bacterial infections and carbohydrate-protein recognition.

IC50 Target

Human Endogenous Metabolite

;

分子量

309.27

Formula

C11H19NO9

CAS 号

131-48-6

中文名称

唾液酸;N-乙酰神经氨酸;醋纽拉酸;N-乙酰涎酸;氧-唾液酸;N-乙酰-神经氨 (糖) 酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, stored under nitrogen

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)

溶解性数据
In Vitro:;

H2O : ≥ 100 mg/mL (323.34 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2334 mL 16.1671 mL 32.3342 mL
5 mM 0.6467 mL 3.2334 mL 6.4668 mL
10 mM 0.3233 mL 1.6167 mL 3.2334 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Bondioli L et al. PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid. Biomaterials. 2010 Apr;31(12):3395-403.

    [2]. Kiefel MJ, et al. Synthesis and biological evaluation of N-acetylneuraminic acid-based rotavirus inhibitors. J Med Chem. 1996 Mar 15;39(6):1314-20.

Plantainoside D

天然产物 糖类和糖苷 Saccharides and Glycosides

Plantainoside D;

Plantainoside D 具有抑制 ACE 活性(IC50 2.17 mM)。同时 Plantainoside D 也是 IKK-β 抑制剂。

Plantainoside D

Plantainoside D Chemical Structure

CAS No. : 147331-98-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Plantainoside D shows ACE inhibitory activity with IC50 2.17 mM[1]. And plantainoside D is a promising IKK-β inhibitor[2].

IC50 Target

IKK-β

;

分子量

640.59

Formula

C29H36O16

CAS 号

147331-98-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Geng F, Yang L, Chou G, Wang Z. Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Plantago asiatica L. Phytother Res. 2010;24(7):1088-1094.

    [2]. Zhou P, Hua F, Wang X, Huang JL. Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases. Inflammopharmacology. 2020;28(1):19-37. 

STIEEQAKTFLDKFNHEAEDLFYQSSLASWN

STIEEQAKTFLDKFNHEAEDLFYQSSLASWN; 纯度: 95.28%

STIEEQAKTFLDKFNHEAEDLFYQSSLASWN 是一种血管紧张素转换酶 2 (ACE2) 相关肽,可用于研究 ACE2 的功能。

STIEEQAKTFLDKFNHEAEDLFYQSSLASWNamp;;

STIEEQAKTFLDKFNHEAEDLFYQSSLASWN Chemical Structure

规格 价格 是否有货 数量
5 mg ¥5300 In-stock
10 mg ¥9050 询价
50 mg ; 询价 ;
100 mg ; 询价 ;

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生物活性

STIEEQAKTFLDKFNHEAEDLFYQSSLASWN, an angiotensin-converting enzyme 2 (ACE2) related peptide, can be used to study the function of ACE2[1].

分子量

3649.88

Formula

C164H238N40O55

Sequence Shortening

STIEEQAKTFLDKFNHEAEDLFYQSSLASWN

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Robson B, et, al. COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance. Comput Biol Med. 2020 Jun;121:103749.

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ; 纯度: 96.51%

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ 是一种血管紧张素转换酶 2 (ACE2) 相关肽,可用于研究 ACE2 的功能。

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQamp;;

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ Chemical Structure

规格 价格 是否有货 数量
5 mg ¥8200 In-stock
10 mg ¥14250 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ 相关产品

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  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Anti-Cardiovascular Disease Compound Library
  • Angiogenesis Related Compound Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ is an angiotensin-converting enzyme 2 (ACE2) related peptide that can be used as a tool for understanding ACE2 functions.

分子量

4835.47

Formula

C213H342N58O66S2

Sequence Shortening

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 33.33 mg/mL (6.89 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2068 mL 1.0340 mL 2.0681 mL
5 mM 0.0414 mL 0.2068 mL 0.4136 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (0.52 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (0.52 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (0.52 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (0.52 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。