N-Acetyl-α-Endorphin

N-Acetyl-α-Endorphin;

N-Acetyl-α-Endorphin 是α-Endorphin 在N末端乙酰化的形式,α-Endorphin是一种内源性阿片肽。

N-Acetyl-α-Endorphinamp;;

N-Acetyl-α-Endorphin Chemical Structure

CAS No. : 88264-63-5

规格 是否有货
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生物活性

N-Acetyl-α-Endorphin is an acetylated α-Endorphin at N-terminal. α-Endorphin is an endogenous opioid peptide.

分子量

1787.98

Formula

C79H122N18O27S

CAS 号

88264-63-5

Sequence

Ac-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr

Sequence Shortening

Ac-YGGFMTSEKSQTPLVT

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Acetyl Perisesaccharide C(Synonyms: 乙酰杠柳寡糖 C)

天然产物 糖类和糖苷 Saccharides and Glycosides

Acetyl Perisesaccharide C;(Synonyms: 乙酰杠柳寡糖 C) 纯度: 98.99%

Acetyl Perisesaccharide C 是一种寡糖。

Acetyl Perisesaccharide C(Synonyms: 乙酰杠柳寡糖 C)

Acetyl Perisesaccharide C Chemical Structure

CAS No. : 110764-09-5

规格 价格 是否有货 数量
1 mg ¥2450 In-stock
5 mg ¥4900 In-stock
10 mg ; 询价 ;
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Acetyl Perisesaccharide C 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Acetyl Perisesaccharide C is an oligosaccharide.

分子量

794.88

Formula

C37H62O18

CAS 号

110764-09-5

中文名称

乙酰杠柳寡糖 C

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

Acetyl-Calpastatin(184-210)(human) TFA

Acetyl-Calpastatin(184-210)(human) TFA;

Acetyl-Calpastatin(184-210)(human) TFA 是一种有效,选择性和可逆的钙蛋白酶 (calpain) 抑制剂,对 μ-钙蛋白酶和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。

Acetyl-Calpastatin(184-210)(human) TFAamp;;

Acetyl-Calpastatin(184-210)(human) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Acetyl-Calpastatin(184-210)(human) TFA is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively[1][2].

分子量

3291.65

Formula

C144H231F3N36O46S

Sequence

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

Sequence Shortening

Ac-DPMSSTYIEELGKREVTIPPKYRELLA-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3.

    [2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355.

N-Acetyl-Ser-Asp-Lys-Pro acetate(Synonyms: Ac-SDKP acetate)

N-Acetyl-Ser-Asp-Lys-Pro acetate;(Synonyms: Ac-SDKP acetate) 纯度: 98.93%

N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate 是血管紧张素转换酶 (ACE) N端活性位点的特异性底物。N-Acetyl-Ser-Asp-Lys-Pro acetate是多能干细胞增殖的天然抑制剂。N-Acetyl-Ser-Asp-Lys-Pro acetate 具有抗炎和抗纤维化特性。

N-Acetyl-Ser-Asp-Lys-Pro acetateamp;;(Synonyms: Ac-SDKP acetate)

N-Acetyl-Ser-Asp-Lys-Pro acetate Chemical Structure

规格 价格 是否有货 数量
1 mg ¥500 In-stock
5 mg ¥1000 In-stock
10 mg ¥1750 In-stock
25 mg ¥3800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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N-Acetyl-Ser-Asp-Lys-Pro acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Angiogenesis Related Compound Library
  • Peptide Library

生物活性

N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties[1][2].

分子量

547.56

Formula

C22H37N5O11

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (182.63 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8263 mL 9.1314 mL 18.2628 mL
5 mM 0.3653 mL 1.8263 mL 3.6526 mL
10 mM 0.1826 mL 0.9131 mL 1.8263 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Peng H, et al. Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension. Hypertension. 2003;42(6):1164-1170.

    [2]. Sharma U, et al. Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol. 2008;294(3):H1226-H1232.

Acetyl-Hirudin (54-65) (sulfated)

Acetyl-Hirudin (54-65) (sulfated);

Acetyl-Hirudin (54-65) (sulfated) 直接与凝血酶-rHCII(L444R) 结合,破坏 rHCII 的 N 末端酸性结构域与凝血酶的阴离子结合异位点 I 之间的相互作用,有助于稳定复合物。

Acetyl-Hirudin (54-65) (sulfated)amp;;

Acetyl-Hirudin (54-65) (sulfated) Chemical Structure

CAS No. : 125441-00-1

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生物活性

Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1].

分子量

1590.60

Formula

C68H95N13O29S

CAS 号

125441-00-1

Sequence

Ac-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-{Try(SO3H)}-Leu-Gln

Sequence Shortening

Ac-GDFEEIPEE-{Try(SO3H)}-LQ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272(13):8243-9.

Acetyl tetrapeptide-15

Acetyl tetrapeptide-15;

Acetyl tetrapeptide-15 是一种合成肽,用于敏感皮肤的化妆品中。Acetyl tetrapeptide-15 衍生自 endomorphin-2 (Tyr-Pro-Phe-Phe-NH2),一种具有选择性镇痛作用的人类 μ-阿片类激动剂。Acetyl tetrapeptide-15 通过内啡肽样通路提高 μ-阿片受体中的神经元兴奋性阈值,降低皮肤高反应性产生的炎症性、慢性和神经性疼痛。

Acetyl tetrapeptide-15amp;;

Acetyl tetrapeptide-15 Chemical Structure

CAS No. : 928007-64-1

规格 价格 是否有货 数量
10 mg ¥500 In-stock
25 mg ¥1000 In-stock
50 mg ¥1500 In-stock
100 mg ¥2500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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Acetyl tetrapeptide-15 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Neurotransmitter Receptor Compound Library
  • Peptide Library

生物活性

Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway[1].

分子量

613.70

Formula

C34H39N5O6

CAS 号

928007-64-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

参考文献
  • [1]. Resende DISP, et al. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021;14(8):702.

Acetyl-Calpastatin(184-210)(human)

Acetyl-Calpastatin(184-210)(human);

Acetyl-Calpastatin(184-210)(human) 是一种有效,选择性和可逆的钙蛋白酶 (calpain) 抑制剂,对 μ-钙蛋白酶和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。

Acetyl-Calpastatin(184-210)(human)amp;;

Acetyl-Calpastatin(184-210)(human) Chemical Structure

CAS No. : 123714-50-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively[1][2].

体外研究
(In Vitro)

Acetyl-Calpastatin(184-210)(human) (peptide 1; 12.5-100 μM) inhibits calpains in LCLC 103H cells with an IC50 of 27 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3177.63

Formula

C142H230N36O44S

CAS 号

123714-50-1

Sequence

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

Sequence Shortening

Ac-DPMSSTYIEELGKREVTIPPKYRELLA-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3.

    [2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355.

Argireline acetate(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate;(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate (Acetyl hexapeptide-3 acetate) 是一种无毒,可渗透皮肤的抗皱肽。Argireline acetate 可显着抑制神经肌肉接头处依赖 Ca2+ 的神经递质释放。Argireline acetate 具有抗皱和抗衰老的作用。

Argireline acetateamp;;(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Argireline acetate 的其他形式现货产品:

Argireline

生物活性

Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity[1][2][3].

体外研究
(In Vitro)

The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

949.04

Formula

C36H64N14O14S

Sequence

N-acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2

Sequence Shortening

Ac-EEMQRR-NH2

中文名称

醋酸阿基瑞林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Blanes-Mira C, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002 Oct;24(5):303-10.

    [2]. Grosicki M, et al. The study of cellular cytotoxicity of argireline – an anti-aging peptide. Acta Biochim Pol. 2014;61(1):29-32.

    [3]. Wang Y, et al. The anti-wrinkle efficacy of Argireline. J Cosmet Laser Ther. 2013 Aug;15(4):237-41.

Acetyl-pepstatin(Synonyms: 乙酰胃泌素)

Acetyl-pepstatin;(Synonyms: 乙酰胃泌素)

Acetyl-pepstatin 是一种有效的天冬氨酸蛋白酶抑制剂(PRs),其 XMRV PR 和 HIV-1 PR Ki 值分别为 712 nM 和 13 nM。

Acetyl-pepstatinamp;;(Synonyms: 乙酰胃泌素)

Acetyl-pepstatin Chemical Structure

CAS No. : 11076-29-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR Ki values of 712 nM and 13 nM[1].

IC50 Target

Ki: 13 nM (XMRV PR) and 712 nM (XMRV PR)[1]

分子量

643.81

Formula

C31H57N5O9

CAS 号

11076-29-2

中文名称

乙酰胃泌素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Matúz K, et al. Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin. FEBS J. 2012;279(17):3276-3286.

N-Acetyl-Ser-Asp-Lys-Pro(Synonyms: Ac-SDKP)

N-Acetyl-Ser-Asp-Lys-Pro;(Synonyms: Ac-SDKP)

N-Acetyl-Ser-Asp-Lys-Pro 是来自骨髓的内源性四肽,是 ACE 的N-末端位点的特异性底物。

N-Acetyl-Ser-Asp-Lys-Proamp;;(Synonyms: Ac-SDKP)

N-Acetyl-Ser-Asp-Lys-Pro Chemical Structure

CAS No. : 127103-11-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

N-Acetyl-Ser-Asp-Lys-Pro 的其他形式现货产品:

N-Acetyl-Ser-Asp-Lys-Pro acetate

生物活性

N-Acetyl-Ser-Asp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

体外研究
(In Vitro)

N-Acetyl-Ser-Asp-Lys-Pro is degraded specifically by ACE, and its plasma level rises substantially during ACE inhibitor therapy. Flow cytometry of rat cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro shows significant inhibition of the progression of cells from G0/G1 phase to S phase of the cell cycle. Moreover, phosphorylation and nuclear translocation of Smad2 is decreased in cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro[1]. N-acetyl-seryl-aspartyl-lysyl-proline appears to exert this function by blocking the action of a stem cell-specific proliferation stimulator and acts selectively on quiescent progenitors[2]. N-Acetyl-Ser-Asp-Lys-Pro inhibits collagenase expression and activation is associated with increased expression of TIMP-1 and TIMP-2. N-Acetyl-Ser-Asp-Lys-Pro normalizes the IL-1β-mediated increase in MMP-2 and MMP-9 activities and MMP-13 expression[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

N-Acetyl-Ser-Asp-Lys-Pro prevents hypertension-induced inflammatory cell infiltration, collagen deposition, nephrin downregulation and albuminuria, which could lead to renoprotection in hypertensive mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

487.50

Formula

C20H33N5O9

CAS 号

127103-11-1

Sequence

Ac-Ser-Asp-Lys-Pro

Sequence Shortening

Ac-SDKP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Rousseau A, et al. The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specificsubstrate of the N-terminal active site of human angiotensin-converting enzyme. J Biol Chem. 1995 Feb 24;270(8):3656-61.

    [2]. Pokharel S, et al. N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts. Hypertension. 2002 Aug;40(2):155-61.

    [3]. Rhaleb NE, et al. N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1β-mediated matrix metalloproteinase activation in cardiac fibroblasts. Pflugers Arch. 2013 Oct;465(10):1487-95.

    [4]. Rhaleb NE, et al. Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in deoxycorticosterone acetate-salt hypertensive mice. J Hypertens. 2011 Feb;29(2):330-8.