标签归档：acetyl

Acetyl-PHF6 amide TFA(Synonyms: AcPHF6 TFA Ac-VQIVYK-NH2 TFA)

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Acetyl-PHF6 amide TFA;(Synonyms: AcPHF6 TFA; Ac-VQIVYK-NH2 TFA) 纯度: 95.22%

Acetyl-PHF6 amide TFA (AcPHF6 TFA) 是 tau 衍生的六肽。

Acetyl-PHF6 amide TFAamp;;(Synonyms: AcPHF6 TFA; Ac-VQIVYK-NH2 TFA)

Acetyl-PHF6 amide TFA Chemical Structure

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ￥5770 In-stock
1 mg ￥1200 In-stock
5 mg ￥3600 In-stock
10 mg ￥5800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Acetyl-PHF6 amide TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Neurodegenerative Disease-related Compound Library
  • Peptide Library

生物活性

Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau derived hexapeptide.

分子量

903.99

Formula

C40H64F3N9O11
Sequence

Ac-Val-Gln-Ile-Val-Tyr-Lys-NH2
Sequence Shortening

Ac-VQIVYK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

DMSO : 67.5 mg/mL (74.67 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1062 mL 5.5310 mL 11.0621 mL
5 mM 0.2212 mL 1.1062 mL 2.2124 mL
10 mM 0.1106 mL 0.5531 mL 1.1062 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.25 mg/mL (2.49 mM); Clear solution

    此方案可获得 ≥ 2.25 mg/mL (2.49 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 22.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Mohamed T, et al. Tau Derived Hexapeptide AcPHF6 Promotes Beta-Amyloid (Aβ) Fibrillogenesis. ACS Chem Neurosci. 2018 Apr 18;9(4):773-782.

3-O-Acetyl-11-hydroxy-beta-boswellic acid(Synonyms: 3α-O-乙酰基-11α-羟基-β-乳香酸)

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

3-O-Acetyl-11-hydroxy-beta-boswellic acid (Synonyms: 3α-O-乙酰基-11α-羟基-β-乳香酸) 纯度: 98.29%

3-O-Acetyl-11-hydroxy-beta-boswellic acid 是一种5-脂氧合酶 (5-LO) 抑制剂。

3-O-Acetyl-11-hydroxy-beta-boswellic acid(Synonyms: 3α-O-乙酰基-11α-羟基-β-乳香酸)

3-O-Acetyl-11-hydroxy-beta-boswellic acid Chemical Structure

CAS No. : 146019-25-2

规格 价格 是否有货 数量
5 mg ￥3800 In-stock
10 mg ￥6000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

3-O-Acetyl-11-hydroxy-beta-boswellic acid 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Ferroptosis Compound Library
  • Terpenoids Library
  • Lipid Metabolism Compound Library

生物活性

3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor[1].

IC50 & Target[1]

5-LOX

 

分子量

514.74

Formula

C32H50O5
CAS 号

146019-25-2
中文名称

3α-O-乙酰基-11α-羟基-β-乳香酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (242.84 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9427 mL 9.7136 mL 19.4273 mL
5 mM 0.3885 mL 1.9427 mL 3.8855 mL
10 mM 0.1943 mL 0.9714 mL 1.9427 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.04 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.04 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.04 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.04 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Mahe Alam, et al. A review on Phytochemical and Pharmacological studies of Kundur (Boswellia serrata Roxb ex Colebr.) -A Unani drug.

3-Acetyl-beta-boswellic acid

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

3-Acetyl-beta-boswellic acid  纯度: ≥98.0%

3-Acetyl-beta-boswellic acid 是从乳香锯缘胶树脂中分离得到的乳香酸。

3-Acetyl-beta-boswellic acid

3-Acetyl-beta-boswellic acid Chemical Structure

CAS No. : 5968-70-7

规格 价格 是否有货 数量
1 mg ￥1900 In-stock
5 mg ￥5710 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

3-Acetyl-beta-boswellic acid 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Terpenoids Library
  • Food-Sourced Compound Library

生物活性

3-Acetyl-beta-boswellic acid is a boswellic acid isolated from Boswellia serrata gum resin[1].

分子量

498.74

Formula

C32H50O4
CAS 号

5968-70-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Gerbeth K, et al. In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins. Fitoterapia. 2013 Jan;84:99-106.

N-Acetyl-Ser-Asp-Lys-Pro TFA(Synonyms: Ac-SDKP TFA)

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N-Acetyl-Ser-Asp-Lys-Pro TFA;(Synonyms: Ac-SDKP TFA)

N-Acetyl-Ser-Asp-Lys-Pro (TFA) 是来自骨髓的内源性四肽，是 ACE 的N-末端位点的特异性底物。

N-Acetyl-Ser-Asp-Lys-Pro TFAamp;;(Synonyms: Ac-SDKP TFA)

N-Acetyl-Ser-Asp-Lys-Pro TFA Chemical Structure

规格 价格 是否有货
1 mg ￥500 询问价格 货期
5 mg ￥1100 询问价格 货期
10 mg ￥1750 询问价格 货期
25 mg ￥3800 询问价格 货期

* Please select Quantity before adding items.

N-Acetyl-Ser-Asp-Lys-Pro TFA 的其他形式现货产品:

N-Acetyl-Ser-Asp-Lys-Pro acetate

生物活性

N-Acetyl-Ser-Asp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

体外研究
(In Vitro)

N-Acetyl-Ser-Asp-Lys-Pro is degraded specifically by ACE, and its plasma level rises substantially during ACE inhibitor therapy. Flow cytometry of rat cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro shows significant inhibition of the progression of cells from G0/G1 phase to S phase of the cell cycle. Moreover, phosphorylation and nuclear translocation of Smad2 is decreased in cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro[1]. N-acetyl-seryl-aspartyl-lysyl-proline appears to exert this function by blocking the action of a stem cell-specific proliferation stimulator and acts selectively on quiescent progenitors[2]. N-Acetyl-Ser-Asp-Lys-Pro inhibits collagenase expression and activation is associated with increased expression of TIMP-1 and TIMP-2. N-Acetyl-Ser-Asp-Lys-Pro normalizes the IL-1β-mediated increase in MMP-2 and MMP-9 activities and MMP-13 expression[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

N-Acetyl-Ser-Asp-Lys-Pro prevents hypertension-induced inflammatory cell infiltration, collagen deposition, nephrin downregulation and albuminuria, which could lead to renoprotection in hypertensive mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

601.53

Formula

C22H34F3N5O11
Sequence

Ac-Ser-Asp-Lys-Pro
Sequence Shortening

Ac-SDKP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Rousseau A, et al. The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specificsubstrate of the N-terminal active site of human angiotensin-converting enzyme. J Biol Chem. 1995 Feb 24;270(8):3656-61.

    [2]. Pokharel S, et al. N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts. Hypertension. 2002 Aug;40(2):155-61.

    [3]. Rhaleb NE, et al. N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1β-mediated matrix metalloproteinase activation in cardiac fibroblasts. Pflugers Arch. 2013 Oct;465(10):1487-95.

    [4]. Rhaleb NE, et al. Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in deoxycorticosterone acetate-salt hypertensive mice. J Hypertens. 2011 Feb;29(2):330-8.

N-Acetyl-α-Endorphin

发表于由

N-Acetyl-α-Endorphin;

N-Acetyl-α-Endorphin 是α-Endorphin 在N末端乙酰化的形式，α-Endorphin是一种内源性阿片肽。

N-Acetyl-α-Endorphinamp;;

N-Acetyl-α-Endorphin Chemical Structure

CAS No. : 88264-63-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

N-Acetyl-α-Endorphin is an acetylated α-Endorphin at N-terminal. α-Endorphin is an endogenous opioid peptide.

分子量

1787.98

Formula

C79H122N18O27S
CAS 号

88264-63-5
Sequence

Ac-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr
Sequence Shortening

Ac-YGGFMTSEKSQTPLVT
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Acetyl Perisesaccharide C(Synonyms: 乙酰杠柳寡糖 C)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Acetyl Perisesaccharide C;(Synonyms: 乙酰杠柳寡糖 C) 纯度: 98.99%

Acetyl Perisesaccharide C 是一种寡糖。

Acetyl Perisesaccharide C(Synonyms: 乙酰杠柳寡糖 C)

Acetyl Perisesaccharide C Chemical Structure

CAS No. : 110764-09-5

规格 价格 是否有货 数量
1 mg ￥2450 In-stock
5 mg ￥4900 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Acetyl Perisesaccharide C 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Acetyl Perisesaccharide C is an oligosaccharide.

分子量

794.88

Formula

C37H62O18
CAS 号

110764-09-5
中文名称

乙酰杠柳寡糖 C
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

Acetyl-Calpastatin(184-210)(human) TFA

发表于由

Acetyl-Calpastatin(184-210)(human) TFA;

Acetyl-Calpastatin(184-210)(human) TFA 是一种有效，选择性和可逆的钙蛋白酶 (calpain) 抑制剂，对 μ-钙蛋白酶和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。

Acetyl-Calpastatin(184-210)(human) TFAamp;;

Acetyl-Calpastatin(184-210)(human) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Acetyl-Calpastatin(184-210)(human) TFA is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively[1][2].

分子量

3291.65

Formula

C144H231F3N36O46S
Sequence

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2
Sequence Shortening

Ac-DPMSSTYIEELGKREVTIPPKYRELLA-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3.

    [2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355.

N-Acetyl-Ser-Asp-Lys-Pro acetate(Synonyms: Ac-SDKP acetate)

发表于由

N-Acetyl-Ser-Asp-Lys-Pro acetate;(Synonyms: Ac-SDKP acetate) 纯度: 98.93%

N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate 是血管紧张素转换酶 (ACE) N端活性位点的特异性底物。N-Acetyl-Ser-Asp-Lys-Pro acetate是多能干细胞增殖的天然抑制剂。N-Acetyl-Ser-Asp-Lys-Pro acetate 具有抗炎和抗纤维化特性。

N-Acetyl-Ser-Asp-Lys-Pro acetateamp;;(Synonyms: Ac-SDKP acetate)

N-Acetyl-Ser-Asp-Lys-Pro acetate Chemical Structure

规格 价格 是否有货 数量
1 mg ￥500 In-stock
5 mg ￥1000 In-stock
10 mg ￥1750 In-stock
25 mg ￥3800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

N-Acetyl-Ser-Asp-Lys-Pro acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Angiogenesis Related Compound Library
  • Peptide Library

生物活性

N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties[1][2].

分子量

547.56

Formula

C22H37N5O11
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (182.63 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8263 mL 9.1314 mL 18.2628 mL
5 mM 0.3653 mL 1.8263 mL 3.6526 mL
10 mM 0.1826 mL 0.9131 mL 1.8263 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Peng H, et al. Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension. Hypertension. 2003;42(6):1164-1170.

    [2]. Sharma U, et al. Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol. 2008;294(3):H1226-H1232.

Acetyl-Hirudin (54-65) (sulfated)

发表于由

Acetyl-Hirudin (54-65) (sulfated);

Acetyl-Hirudin (54-65) (sulfated) 直接与凝血酶-rHCII(L444R) 结合，破坏 rHCII 的 N 末端酸性结构域与凝血酶的阴离子结合异位点 I 之间的相互作用，有助于稳定复合物。

Acetyl-Hirudin (54-65) (sulfated)amp;;

Acetyl-Hirudin (54-65) (sulfated) Chemical Structure

CAS No. : 125441-00-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1].

分子量

1590.60

Formula

C68H95N13O29S
CAS 号

125441-00-1
Sequence

Ac-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-{Try(SO3H)}-Leu-Gln
Sequence Shortening

Ac-GDFEEIPEE-{Try(SO3H)}-LQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272(13):8243-9.

Acetyl tetrapeptide-15

发表于由

Acetyl tetrapeptide-15;

Acetyl tetrapeptide-15 是一种合成肽，用于敏感皮肤的化妆品中。Acetyl tetrapeptide-15 衍生自 endomorphin-2 (Tyr-Pro-Phe-Phe-NH2)，一种具有选择性镇痛作用的人类 μ-阿片类激动剂。Acetyl tetrapeptide-15 通过内啡肽样通路提高 μ-阿片受体中的神经元兴奋性阈值，降低皮肤高反应性产生的炎症性、慢性和神经性疼痛。

Acetyl tetrapeptide-15amp;;

Acetyl tetrapeptide-15 Chemical Structure

CAS No. : 928007-64-1

规格 价格 是否有货 数量
10 mg ￥500 In-stock
25 mg ￥1000 In-stock
50 mg ￥1500 In-stock
100 mg ￥2500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Acetyl tetrapeptide-15 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Neurotransmitter Receptor Compound Library
  • Peptide Library

生物活性

Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway[1].

分子量

613.70

Formula

C34H39N5O6
CAS 号

928007-64-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
参考文献

  • [1]. Resende DISP, et al. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021;14(8):702.