Wako Biostir-过敏性皮炎诱发试剂Biostir AD、研究用过敏原


Wako Biostir-过敏性皮炎诱发试剂Biostir AD、研究用过敏原

Biostir AD 是与人类过敏性皮炎发病有关的含有粉尘螨虫体成分的软膏。同时,作为研究用过敏原,有来源于植物的过敏原和来源于昆虫的过敏原系列。


Biostir AD

用来源于粉尘螨的过敏性皮炎诱发软膏,为 NC/Nga 小鼠一周涂抹2次,共涂抹6次,第1~2周过敏性皮炎发病。



◆特点


● 可引发类似于过敏性皮炎的症状

● 可确认现在治疗时使用的甾族化合物软膏及专业软膏的效果

● 皮炎发病后,中止诱发,皮炎仍持续,可作为医药品的评价系使用

● 在小鼠标背部的逗留性优秀,少量就能诱发皮炎

● 皮炎的发病率高,无反应的小鼠极少

● 皮炎发病时间比之前方法(抗原液的反复涂抹)短



◆诱发方法


用 4% SDS 破坏皮肤防御后,向小鼠背部及耳廓部进行一周2次,每次涂抹 100 mg/mouse 本品。诱发期间的目标是3周(共计6次)。最终共计涂抹 600 mg 本品。模型动物表现涂药开始后,第 1~2 周发病,3~4 周约80%的发病率。

Wako Biostir-过敏性皮炎诱发试剂Biostir AD、研究用过敏原



◆产品列表

产品编号

产品名称

包装

参考

309-34133

Biostir AD

5 g

——

303-34131

15g

约25只的用量

307-34134

30 g

——



其他产品系列:来源于植物的过敏原和来源于昆虫的过敏原等


种类

产品编号

产品名称

包装

306-34143

Mite body

粉尘螨虫体(Dermatophagoides farinae)

1g

300-34141

2 g

308-35183

Mite body Dp

屋尘螨虫体(Dermatophagoides pteronyssinus)

1 g

302-35181

2 g

303-34153

Mite extract Dfb

粉尘螨提取物

来源于粉尘螨虫体粗纯化的过敏原

50 mg

307-34151

100 mg

304-35163

Mite Extract Dpb

屋尘螨提取物

来源于屋尘螨虫体粗纯化的抗原(Dpb)

50 mg

308-35161

100 mg

300-34163

Mite extrtact Dff

粉尘螨排泄物提取物

来源于粉尘螨排泄物粗纯化的过敏原

50 mg

304-34161

100 mg

301-35173

Mite Extract Dpf

屋尘螨排泄物提取物

来源于屋尘螨排泄物粗纯化的抗原(Dpf)

50 mg

305-35171

100 mg

种类

产品编号

产品名称

包装

木本花粉

304-35141

Japanese cedar pollen

日本雪松花粉

5 g

301-35151

Japanese cedar pollen extract

日本雪松花粉提取物

100 mg

307-35153

50 mg

304-84611

Japanese cypress pollen

日本柏树花粉

5 g

309-89281

Japanease red pine pollen

日本赤松花粉

5 g

308-89131

Black pine pollen

日本黑松花粉

5 g

305-89141

Ginkgo pollen

银杏花粉

5 g

种类

产品编号

产品名称

包装

草本花粉

308-89251

Mugwort pollen

蒿花粉

1 g

306-89291

Solidago serotina pollen

一枝黄花花粉

1 g

305-89261

Japanese pampas grass pollem

日本芒草花粉

1 g

309-89161

Japanese hop pollen

日本路草花粉

1 g

种类

产品编号

产品名称

包装

昆虫

309-89301

Silk moth

家蚕(冻干粉碎虫体)

1g

304-89231

Periplaneta fuliginosa

黑胸大蠊(冻干粉碎虫体)

1g

302-89151

German cockroach

德国小蠊(冻干粉碎虫体)

1g

种类

产品编号

产品名称

包装

输入型花粉

307-89221

white birch pollen import

输入型白桦花粉

1g

300-89191

ryegrass pollen import

输入型黑麦草花粉

1g

303-89201

imothy pollen import

输入型梯牧草花粉

1g

300-89211

Tvernalgrass pollen import

输入型欧洲香草花粉

1g

306-89171

Dactylis glomerata pollen import

输入型野茅花粉

1g

303-89181

Ragweed pollen import

输入型美洲豚草花粉

1g



Astrea Bioseparations AD200100-PCXXXX-G/N Evolve®D AD200100 Column Packing – Astrea

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品牌 货号 产品名称 规格 价格

Astrea Bioseparations AD200100-PCXXXX-G/N Evolve®D AD200100 Column Packing – Astrea 0.00

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Astrea Bioseparations AS025100-CSXXXX 50 mL Evolve®S Column Packing – Third party 42752.00

Astrea Bioseparations AS025100-PCXXXX 50 mL Evolve®S Column Packing – Astrea 40893.00

Astrea Bioseparations AS025100-PC3250 EtoxiClear® 50 mL Evolve®S 65719.00

Astrea Bioseparations 4300-0050-CSXXXX Evolve®R 50 mL Column Packing – Third Party 20628.00

Astrea Bioseparations 4300-0005-CSXXXX Evolve®R 5 mL Column Packing – Third Party 19521.00

Astrea Bioseparations 4300-0050-PCXXXX Evolve®R 50 mL Column Packing – Astrea 19731.00

shimadzu岛津On-lineTOC-VCSH在线高灵敏度独立控制型

shimadzu岛津On-lineTOC-VCSH在线高灵敏度独立控制型

shimadzu 岛津On-line TOC-V CSH 在线高灵敏度独立控制型

产品编号:
市场价:¥0.00
会员价:¥0.00
品牌:SHIMADZU 岛津
生产厂家:shimadzu 岛津

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

岛津的总有机碳分析仪是世界著名的品牌。TOC-V系列共八个型号:TOC-V CPH、CSH、CPN、CSN、WP、WS、E、online CSH。氧化原理有催化燃烧法,也有湿化学法。主机有计算机控制型,也有单机型。既有经济型号TOC-V E,也有具备高灵敏度的适用在线监测的型号TOC-V online CSH。
      一应俱全的选配件:自动进样器、八通进样器、总氮测定附件、固体样品测定附件、气体样品进样组件、POC组件、载气纯化组件等。
      岛津独特的680℃固定温度铂金催化燃烧法,无需根据样品易氧化程度调节温度,保证完全的氧化效率。大幅降低了样品中盐分对燃烧管、催化剂的腐蚀,提高了燃烧管、催化剂的寿命,为高盐分样品的测定,提供了根本的解决方案。
      主机进样部分采用八通道的注射泵,结构简单,功能丰富。通过此注射泵,可自动完成无机碳IC的预去除功能(NPOC法),无需任何手工操作。
      主机可自动制作不含碳的空白零水,从而可以确认仪器空白,对超纯水的检测提供重要的误差信息参考。

主机特点

在TOC-V CSH的基础上,增加在线检测功能,适于超纯水、制药用水、自来水等高灵敏度的TOC自动监测。

  • 测定原理:680℃催化燃烧氧化/非色散红外检测(NDIR)
  • 操作方式:单机独立控制
  • 测定项目:TC、IC、TOC(TC-IC)、NPOC、POC(选配)、TN(选配)
  • 测定范围(mg/L):TC 0-25000  IC 0-30000
  • 检测限:4  μg/L
  • 测定时间:约3-4分钟
  • 进样方式:自动吸样
  • 进样量:10-2000 μL 可变
  • IC预去除法:主机内自动加酸并气体吹扫

Everest Biotech EB09909 Goat anti-ADAMTS8 (aa176-185) 100ug

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Everest Biotech EB09909 Goat anti-ADAMTS8 (aa176-185) 100ug 3224.00

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Everest Biotech EB10915-B Goat anti-ACPP / PAP (aa269-282), Biotinylated 100ug 5096.00

Biostir® 特应性皮炎诱导剂AD Biostir® AD

 Biostir® 特应性皮炎诱导剂AD

 

产品编号 产品名称 中文名称 包装 备注
309-34133 Biostir® AD Biostir® 特应性皮炎诱导剂AD 5 g 软膏包括来自粉尘螨的螨过敏原,-30℃
303-34131 Biostir® AD Biostir® 特应性皮炎诱导剂AD 15 g
项目 方法 动物
特应性皮炎模型服务和药理学测试  1. 在D粉尘螨具有高含量螨变应原的NC / Nga小鼠中通过Biostir® AD

诱导特应性皮炎样损伤。

2. 经皮致敏/免疫小鼠。

3. 高概率获得特应性皮炎模型。

4. 评估测试物质对疾病模型的效力。

5. 评价项目:症状评分,IgE,组织病理学,搔抓行为等。

小鼠
(NC/Nga)

 

◆特征

● 是特应性皮炎相关的房尘螨提取物成分之一

● Biostir® AD能够在NC/Nga小鼠诱导特应性皮炎样皮肤损伤

● 在该模型中观察到他克莫司软膏和皮质类固醇软膏的功效

● Biostir® AD能高概率在NC/Nga小鼠引起皮炎

● Biostir® AD节省时间和精力,与重复应用螨过敏原悬浮液相比较直到观察到皮炎发病

● 现今还没有类似概念的产品

 

◆操作流程

用 4% 十二烷基硫酸钠(SDS)破坏屏障后,每周两次在剃毛的背部皮肤和两耳廓部涂抹100 mg的AD。
重复此步骤3周。共涂抹6次完成。

 

◆应用实例

 

动物 雌性NC / Nga小鼠
 

特应性皮炎样皮肤损伤的临床方面

 

 

在皮肤上观察到搔抓行为,红斑,丘疹,鳞屑,疮痂和苔藓病变

 

组织学评价 损伤皮肤表现在真皮和表皮显著增厚,角化过度和角化不全。
在损伤小鼠中观察到包括肥大细胞和嗜酸性粒细胞在内的皮肤炎症细胞数量的增加。
损伤小鼠中总数和脱颗粒的肥大细胞的数量多于正常小鼠。
 

血清总IgE

 

 

显著升高

 

 

■ 7周龄无毛雄性小鼠用Biostir AD处理诱发皮炎模型

141573705409.png

形态学表现

■ 苏木精和曙红对皮肤组织(5 μm)染色(1:500)

141573705463.png

产品列表

产品编号 产品名称 产品规格 产品等级 备注
309-34133 Biostir® AD
Biostir®特应性皮炎诱导剂AD
5 g
303-34131 Biostir® AD
Biostir®特应性皮炎诱导剂AD
15 g

 

 

Anti-Glyoxalase 1 (GLO1) antibody; rat monoclonal (6F10) 品牌:Bio Academia


Anti-Glyoxalase 1 (GLO1) antibody; rat monoclonal (6F10)

品牌:Bio Academia
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

74-001

100 ug 咨询


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Biostir® 特应性皮炎诱导剂AD Biostir® AD

Biostir® 特应性皮炎诱导剂AD
Biostir® AD

  • 产品特性
  • 相关资料
  • Q&A
  • 参考文献

Biostir® 特应性皮炎诱导剂AD                              Biostir® AD

Biostir® 特应性皮炎诱导剂AD

 


产品编号

产品名称

中文名称

包装

备注

309-34133

Biostir® AD

Biostir® 特应性皮炎诱导剂AD

5 g

软膏包括来自粉尘螨的螨过敏原,-30℃

303-34131

Biostir® AD

Biostir® 特应性皮炎诱导剂AD

15 g

项目

方法

动物

特应性皮炎模型服务和药理学测试

 1. 在D粉尘螨具有高含量螨变应原的NC / Nga小鼠中通过Biostir® AD

     诱导特应性皮炎样损伤。

    
 2. 经皮致敏/免疫小鼠。
    
 3. 高概率获得特应性皮炎模型。
    
 4. 评估测试物质对疾病模型的效力。
    
 5. 评价项目:症状评分,IgE,组织病理学,搔抓行为等。

小鼠
(NC/Nga)



◆特征


 ● 是特应性皮炎相关的房尘螨提取物成分之一

 ● Biostir® AD能够在NC/Nga小鼠诱导特应性皮炎样皮肤损伤

 ● 在该模型中观察到他克莫司软膏和皮质类固醇软膏的功效

 ● Biostir® AD能高概率在NC/Nga小鼠引起皮炎

 ● Biostir® AD节省时间和精力,与重复应用螨过敏原悬浮液相比较直到观察到皮炎发病

 ● 现今还没有类似概念的产品

 


◆操作流程


  用 4% 十二烷基硫酸钠(SDS)破坏屏障后,每周两次在剃毛的背部皮肤和两耳廓部涂抹100 mg的AD。
  重复此步骤3周。共涂抹6次完成。



◆应用实例


动物

雌性NC / Nga小鼠


特应性皮炎样皮肤损伤的临床方面



在皮肤上观察到搔抓行为,红斑,丘疹,鳞屑,疮痂和苔藓病变


组织学评价

损伤皮肤表现在真皮和表皮显著增厚,角化过度和角化不全。
在损伤小鼠中观察到包括肥大细胞和嗜酸性粒细胞在内的皮肤炎症细胞数量的增加。
损伤小鼠中总数和脱颗粒的肥大细胞的数量多于正常小鼠。


血清总IgE



显著升高


■ 7周龄无毛雄性小鼠用Biostir AD处理诱发皮炎模型

Biostir® 特应性皮炎诱导剂AD                              Biostir® AD

形态学表现

■ 苏木精和曙红对皮肤组织(5 μm)染色(1:500)


Biostir® 特应性皮炎诱导剂AD                              Biostir® AD


参考文献


 1.

Kang, R. Y., Park, B. K., Gim, S. B., Choi, H. J., & Kim, D. H. (2009). The effects of HYT on various immunological factors related to pathogenesis of allergic dermatitis in NC/Nga mice induced by Biostir AD. Journal of Haehwa Medicine, 18(2), 47-62.


 2.

Lee, J. K., Ha, H., Lee, H. Y., Park, S. J., Jeong, S. L., Choi, Y. J., & SHIN, H. K. (2010). Inhibitory effects of heartwood extracts of Broussonetia kazinoki Sieb on the development of atopic dermatitis in NC/Nga mice. Bioscience, biotechnology, and biochemistry, 1007282075-1007282075.


 3.

Lim, H. S., Ha, H., Lee, H., Lee, J. K., Lee, M. Y., & Shin, H. K. (2014). Morus alba L. suppresses the development of atopic dermatitis induced by the house dust mite in NC/Nga mice. BMC complementary and alternative medicine, 14(1), 139.


 4.

Aktar, M. K., Kido‐Nakahara, M., Furue, M., & Nakahara, T. (2015). Mutual upregulation of endothelin‐1 and IL‐25 in atopic dermatitis. Allergy, 70(7), 846-854.

 5.

Joo, S. S., Won, T. J., Nam, S. Y., Kim, Y. B., Lee, Y. C., Park, S. Y., … & Lee, D. I. (2009). Therapeutic advantages of medicinal herbs fermented with Lactobacillus plantarum, in topical application and its activities on atopic dermatitis. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(7), 913-919.


 6.

Lim, H. S., Seo, C. S., Ha, H., Lee, H., Lee, J. K., Lee, M. Y., & Shin, H. (2012). Effect of Alpinia katsumadai Hayata on house dust mite-induced atopic dermatitis in NC/Nga mice. Evidence-Based Complementary and Alternative Medicine, 2012.


 7.

Lim, H. S., Ha, H., Lee, M. Y., Jin, S. E., Jeong, S. J., Jeon, W. Y., … & Shin, H. K. (2014). Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice. Food and chemical toxicology, 63, 212-220.


 8.

Kim, M. C., Lee, C. H., & Yook, T. H. (2013). Effects of anti-inflammatory and Rehmanniae radix pharmacopuncture on atopic dermatitis in NC/Nga mice. Journal of acupuncture and meridian studies, 6(2), 98-109.


 9.

Lee, J. N., Lee, C. H., & Kim, Y. S. (2015). Protective effects of Opuntia humifusa cladode extracts against biostir AD-induced atopic dermatitis in NC/Nga mice. Food Science and Biotechnology, 24(3), 1123-1130.


10.

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Ha, H., Lee, J. K., Lee, M. Y., Lim, H. S., & Shin, H. (2013). Galgeun-tang, an Herbal Formula, Ameliorates Atopic Dermatitis Responses in Dust Mite Extract-treated NC/Nga Mice. Journal of Korean Medicine, 34(4), 1-11.


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产品列表
产品编号 产品名称 产品规格 产品等级 备注
309-34133 Biostir® AD
Biostir®特应性皮炎诱导剂AD
5 g
303-34131 Biostir® AD
Biostir®特应性皮炎诱导剂AD
15 g

GV-58 品牌:Adipogen


GV-58

品牌:Adipogen
CAS No.:1402821-41-3
储存条件:-20°C
纯度:>97% (NMR)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-MR-C0035-M001

1 mg 720.00


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小型红外线温度计(AD-5617)

小型红外线温度计(AD-5617)

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小型红外线温度计(AD-5617)小型红外线温度计(AD-5617)

小型红外线温度计(AD-5617)

  无需接触就能测试温度的小型红外线温度计

  适用于蓄热材料表面温度管理



◆特点

● 测试范围:-33℃~+180℃

● 本体外尺寸:17(W)×86(H)mm

● 自动关机功能

产品列表
产品编号 产品名称 产品规格 产品等级 备注
27833 AD-5617

加拿大Silicycle硅胶填料SiliCycle SiliaSphere PC, 200-500 µm, 300 Å

上海金畔生物科技有限公司代理加拿大Silicycle硅胶填料色谱柱层析板金属离子清除剂全线产品,欢迎访问官网了解更多产品信息和订购。

SiliaSphere PC Spherical Silica Gel, 200 – 500 µm, 300 Å (S10070M)

SiliCycle SiliaSphere PC, 200-500 µm, 300 Å

Prices do not include applicable taxes, customs, duties and/or shipping.

Product Number Quantity  
S10070M-250G 250 g

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S10070M-500G 500 g

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S10070M-1KG 1 kg

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SiliCycle SiliaSphere PC, 200-500 µm, 300 Å   Loading…  

Details

SiliaSphere PC materials differs from other spherical particles due to it’s increased efficiency for the eluent’s flow characteristics, an improved resolution between sample compounds and it packs with great ease.

Additional Information

Particle Shape Spherical
Array Silica
Family / Formats SiliaSphere™ (Spherical Silicas)
Particle Size 250 – 500 µm / 35 – 60 mesh
Pore Size 300 Å
Storage Condition Keep dry
Solvent Compatibility All solvents, aqueous and organic