标签归档：anemarsaponin

Anemarsaponin B(Synonyms: 知母皂苷 B)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Anemarsaponin B;(Synonyms: 知母皂苷 B)

Anemarsaponin B 是一种甾体皂苷。Anemarsaponin B 降低 iNOS 和 COX-2 的蛋白和 mRNA 水平。Anemarsaponin B 减少促炎细胞因子的表达和产生，包括 TNF-α 和 IL-6。Anemarsaponin B 通过阻断 IκBα 的磷酸化来抑制 NF-κB 的 p65 亚基的核转位。Anemarsaponin B 还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 (MLK3) 的磷酸化。 具有抗炎作用。

Anemarsaponin B(Synonyms: 知母皂苷 B)

Anemarsaponin B Chemical Structure

CAS No. : 139051-27-7

规格 价格 是否有货
5 mg ￥2690 询问价格 货期
10 mg ￥4570 询问价格 货期

* Please select Quantity before adding items.

生物活性

Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect [1].

IC50 Target[1]

COX-2

;

p65

;

iNOS

;

分子量

903.06

Formula

C45H74O18
CAS 号

139051-27-7
中文名称

知母皂苷 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim JY, et al. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem Toxicol. 2009 Jul;47(7):1610-7.

Anemarsaponin E

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Anemarsaponin E; 纯度: ge;99.0%

Anemarsaponin E 是从 Anemarrhena asphodeloides 中提取的皂苷，并具有抗炎活性。

Anemarsaponin E

Anemarsaponin E Chemical Structure

CAS No. : 136565-73-6

规格 价格 是否有货 数量
5 mg ￥3500 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Anemarsaponin E is extracted from Anemarrhena asphodeloides Bunge and has anti-inflammatory activity.

分子量

935.10

Formula

C46H78O19
CAS 号

136565-73-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Yang B, et al. Pharmacokinetic comparison of seven major bioactive components in normal and depression model rats after oral administration of Baihe Zhimu decoction by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2018 Jan 30;148:119-127.