标签归档：apelin

Apelin-17(human, bovine) TFA

发表于由

Apelin-17(human, bovine) TFA;

Apelin-17(human, bovine) TFA是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-17(human, bovine) TFA 与在 HEK 293 细胞中表达的人 APJ 受体结合 (pIC50)。Apelin-17(human, bovine) TFA 阻断 HIV-1 和 HIV-2 毒株进入表达 APJ 的 NP-2/CD4 细胞。

Apelin-17(human, bovine) TFAamp;;

Apelin-17(human, bovine) TFA Chemical Structure

规格 是否有货
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250 mg ; 询价 ;
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Apelin-17(human, bovine) TFA 的其他形式现货产品:

Apelin-17(human, bovine)

生物活性

Apelin-17(human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

IC50 Target[3]

HIV-1

;

HIV-2

;

分子量

2252.57

Formula

C98H157F3N34O22S
Sequence

Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

KFRRQRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476.

    [2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172.

    [3]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

Apelin-36(human) TFA

发表于由

Apelin-36(human) TFA;

Apelin-36(human) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂，EC50 为 20 nM。Apelin-36(human) TFA 对 HEK 293 细胞表达的人 APJ 受体有很高的亲和力 (pIC50=8.61)。Apelin-36(human) TFA与两种主要的生物活性有关：心血管和代谢。Apelin-36(human) TFA 抑制 HIV-1 和 HIV-2进入表达 APJ 的NP2/CD4细胞。

Apelin-36(human) TFAamp;;

Apelin-36(human) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC50 of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC550=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3][4].

IC50 Target

HIV-1

;

HIV-2

;

分子量

4309.85

Formula

C186H298F3N69O45S
Sequence

Leu-Val-Gln-Pro-Arg-Gly-Ser-Arg-Asn-Gly-Pro-Gly-Pro-Trp-Gln-Gly-Gly-Arg-Arg-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

LVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476.

    [2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172.

    [3]. Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

Apelin-36(human)

发表于由

Apelin-36(human);

Apelin-36(human) 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂，EC50 为 20 nM。Apelin-36(human) 对 HEK 293 细胞表达的人 APJ 受体有很高的亲和力 (pIC50=8.61)。Apelin-36(human) 与两种主要的生物活性有关：心血管和代谢。Apelin-36(human) 抑制 HIV-1 和 HIV-2 进入表达 APJ 的 NP2/CD4 细胞。

Apelin-36(human)amp;;

Apelin-36(human) Chemical Structure

CAS No. : 252642-12-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC50 of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC50=8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3][4].

IC50 Target[3]

HIV-1

;

HIV-2

;

分子量

4195.83

Formula

C184H297N69O43S
CAS 号

252642-12-9
Sequence

Leu-Val-Gln-Pro-Arg-Gly-Ser-Arg-Asn-Gly-Pro-Gly-Pro-Trp-Gln-Gly-Gly-Arg-Arg-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

LVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476.

    [2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172.

    [3]. Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

    [4]. Galon-Tilleman H, Yang H, Bednarek MA, et al. Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling. J Biol Chem. 2017;292(5):1925-1933.

Apelin-36(rat, mouse)

发表于由

Apelin-36(rat, mouse);

Apelin-36(rat, mouse) 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-36(rat, mouse) 与 APJ 受体结合，IC50 为 5.4 nM，显著抑制 cAMP 的产生，EC50 为 0.52 nM。Apelin-36(rat, mouse) 阻断 HIV-1 和 HIV-2 毒株进入表达 APJ 的 NP-2/CD4 细胞。

Apelin-36(rat, mouse)amp;;

Apelin-36(rat, mouse) Chemical Structure

CAS No. : 230299-95-3

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Apelin-36(rat, mouse) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM. Apelin-36(rat, mouse) blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ[1][2].

IC50 Target[2]

HIV-1

;

HIV-2

;

分子量

4200.89

Formula

C185H304N68O43S
CAS 号

230299-95-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kawamata Y, et al. Molecular properties of apelin: tissue distribution and receptor binding. Biochim Biophys Acta. 2001;1538(2-3):162-171.

    [2]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

Apelin-13 TFA

发表于由

Apelin-13 TFA; 纯度: 97.75%

Apelin-13 是 APJ 受体的内源性配体，激活G蛋白偶联受体的 EC 50 值为 0.37 nM。

Apelin-13 TFAamp;;

Apelin-13 TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥550 In-stock
5 mg ￥1650 In-stock
10 mg ￥2800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Apelin-13 TFA 相关产品

bull;相关化合物库:

  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC 50 value of 0.37 nM.

Clinical Trial

分子量

1664.85

Formula

C71H112F3N23O18S
Sequence

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

QRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (60.07 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6007 mL 3.0033 mL 6.0065 mL
5 mM 0.1201 mL 0.6007 mL 1.2013 mL
10 mM 0.0601 mL 0.3003 mL 0.6007 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998).

    [2]. Li M,et al. Apelin 13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high fat diet. Mol Med Rep. 2018 Dec;18(6):5784-5790.

[Pyr1]-Apelin-13(Synonyms: [pGlu1]-Apelin-13)

发表于由

[Pyr1]-Apelin-13;(Synonyms: [pGlu1]-Apelin-13) 纯度: 98.76%

[Pyr1]-Apelin-13 是一种高效的，选择性的内源性 apelin 受体激动剂。

[Pyr1]-Apelin-13amp;;(Synonyms: [pGlu1]-Apelin-13)

[Pyr1]-Apelin-13 Chemical Structure

CAS No. : 217082-60-5

规格 价格 是否有货 数量
1 mg ￥1000 In-stock
5 mg ￥4000 In-stock
10 mg ￥7500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

[Pyr1]-Apelin-13 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cardiovascular Disease Compound Library
  • Peptide Library

生物活性

[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

体外研究
(In Vitro)

[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1533.80

Formula

C69H108N22O16S
CAS 号

217082-60-5
Sequence Shortening

{Glp}-RPRLSHKGPMPF
中文名称

[Pyr1]-爱帕琳肽-13
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (65.20 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6520 mL 3.2599 mL 6.5198 mL
5 mM 0.1304 mL 0.6520 mL 1.3040 mL
10 mM 0.0652 mL 0.3260 mL 0.6520 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98.

    [2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22.

Apelin-17(human, bovine)

发表于由

Apelin-17(human, bovine); 纯度: 98.86%

Apelin-17(human, bovine) 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-17(human, bovine) 与在 HEK 293 细胞中表达的人 APJ 受体结合 (pIC50=9.02)。Apelin-17(human, bovine) 阻断 HIV-1 和 HIV-2 毒株进入表达 APJ 的 NP-2/CD4 细胞。

Apelin-17(human, bovine)amp;;

Apelin-17(human, bovine) Chemical Structure

CAS No. : 217082-57-0

规格 价格 是否有货 数量
1 mg ￥700 In-stock
5 mg ￥2100 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Apelin-17(human, bovine) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

IC50 Target[3]

HIV-1

;

HIV-2

;

分子量

2138.55

Formula

C96H156N34O20S
CAS 号

217082-57-0
Sequence

Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

KFRRQRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476.

    [2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172.

    [3]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

Apelin-12

发表于由

Apelin-12; 纯度: 99.17%

Apelin-12 是多肽中最有效的 C 端片段之一，对孤儿受体 APJ 受体具有很高的亲和力。Apelin-12 参与体液平衡的调节和摄食的中枢控制。Apelin-12 阻断HIV-1通过 APJ 受体进入。Apelin-12 具有神经保护作用。

Apelin-12amp;;

Apelin-12 Chemical Structure

CAS No. : 229961-08-4

规格 价格 是否有货 数量
5 mg ￥3500 In-stock
10 mg ￥5500 询价
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Apelin-12 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Neuroprotective Compound Library

生物活性

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3].

体外研究
(In Vitro)

Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse[1].
Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents[2].
Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1422.70

Formula

C64H103N21O14S
CAS 号

229961-08-4
Sequence Shortening

RPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 100 mg/mL (70.29 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7029 mL 3.5144 mL 7.0289 mL
5 mM 0.1406 mL 0.7029 mL 1.4058 mL
10 mM 0.0703 mL 0.3514 mL 0.7029 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203.

    [2]. Pisarenko OI, et al. Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2014;391(1-2):241-250.

    [3]. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895.

    [4]. Ohno S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept. 2012;174(1-3):71-78.

Apelin-16 (Human, Bovine) 品牌：Anygen

发表于由

Apelin-16 (Human, Bovine)

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

307-36013

 – 0.5 mg – 咨询 – –


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抗Apelin，单克隆抗体（4G5） Anti Apelin, Monoclonal Antibody (4G5)

发表于由

抗Apelin，单克隆抗体（4G5）
Anti Apelin, Monoclonal Antibody (4G5)

  • 产品特性
  • 相关资料
  • Q&A
  • 参考文献

抗Apelin，单克隆抗体（4G5） Anti Apelin, Monoclonal Antibody (4G5)抗Apelin，单克隆抗体（4G5）

Anti Apelin, Monoclonal Antibody (4G5)

孤儿配体Apelin水平中和抗体

产品编号

产品名称【中文名称】

规格

包装

013-25871 

Anti Apelin, Monoclonal Antibody (4G5)

【抗Apelin，单克隆抗体（4G5）】

免疫化学用

100 μL

抗体信息

抗原名

Apelin

适用实验

中和实验，免疫染色、ELISA

同种型

IgG1

—

抗原信息

pGlu65-Apelin13  (QRPRLSHKGPMPF)

物种交叉反应性

人，小鼠，大鼠

标签

非标签

抗原别名

APLN, APEL, XNPEP2, AGTRL1 Ligand

免疫动物

小鼠

克隆号

4G5

详细信息

Apelin是由36个氨基酸组成的生理活性肽配体。与APJ受体结合从而激活APJ受体。显示血压下降作用，血管重生作用，动脉硬化作用。Apelin也存在于神经系统。近年来有报道称用于ALS小鼠模型神经保护作用。

本产品是针对Apelin相关的抗体。结合Apelin的活性部位表现中和活性。

使用文献

1. Kidoya, H. et al.: EMBO. J., 27, 522 (2008).
  2. Kawamata, Y. et al.: Biochimica. et. Biophysica. Acta.,1538, 162 (2001).

 

 

产品列表
产品编号 产品名称 产品规格 产品等级 备注
013-25871 Anti Apelin, Monoclonal Antibody (4G5) 
抗Apelin，单克隆抗体（4G5）		 100 μL 免疫化学用