标签归档：arg

[D-Arg25]-Neuropeptide Y (human)

发表于由

[D-Arg25]-Neuropeptide Y (human);

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是 Y1 受体的选择性激动剂。Neuropeptide Y (human) 和阿尔兹海默症相关，能够保护老鼠皮质神经元对抗淀粉样蛋白毒性。

[D-Arg25]-Neuropeptide Y (human)amp;;

[D-Arg25]-Neuropeptide Y (human) Chemical Structure

规格 是否有货
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生物活性

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y1 receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer’s disease (AD) and protects rat cortical neurons against β-Amyloid toxicity[1].

体外研究
(In Vitro)

[D-Arg25]-NPY (1 μM) reversibly hyperpolarizes the membrane potential of hypocretin cells by 9.9 ± 1.4 mV (data not shown; p < 0.01; n = 10[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Intracerebroventricular (icv) administration of [D-Arg25]NPY stimulates food intake in freely-feeding rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4271.68

Formula

C189H285N55O57S
Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSAL-{D-Arg}-HYINLITRQRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kilian Kuhn, et al. Molecular Tools for the NPY Y4 Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y1R Antagonists. zur Erlangung des Doktorgrades der Naturwissenschaften an der Fakultät für Chemie und Pharmazie der Universität Regensburg.

    [2]. Li-Ying Fu, et al. Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci. 2004 Oct 6;24(40):8741-51.

    [3]. Ambikaipakan Balasubramaniam, et al. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Curr Pharm Des. 2003;9(15):1165-75.

[Arg14,Lys15]Nociceptin

发表于由

[Arg14,Lys15]Nociceptin;

[Arg14,Lys15]Nociceptin 是一种高效、选择性的 NOP (ORL1; OP4) 受体激动剂，EC50为 1 nM。[Arg14,Lys15]Nociceptin 对阿片受体具有较高的选择性，对 NOP、μ、δ 和 κ 受体的 IC50 值分别为 0.32、280、>10000 和 1500 nM。

[Arg14,Lys15]Nociceptinamp;;

[Arg14,Lys15]Nociceptin Chemical Structure

CAS No. : 236098-40-1

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1].

体外研究
(In Vitro)

[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1909.16

Formula

C82H137N31O22
CAS 号

236098-40-1
Sequence Shortening

FGGFTGARKSARKRKNQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498.

    [2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63.

Gly-Arg-Gly-Asp-Ser TFA

发表于由

Gly-Arg-Gly-Asp-Ser TFA;

Gly-Arg-Gly-Asp-Ser (TFA) 是一种五肽，构成了糖蛋白，骨桥蛋白与细胞的结合域。Gly-Arg-Gly-Asp-Ser (TFA) 与整合素整联蛋白受体 (integrin receptor) αvβ3 和 αvβ5 结合，IC50 估算值为 ∼5 和 ∼6.5 μM。

Gly-Arg-Gly-Asp-Ser TFAamp;;

Gly-Arg-Gly-Asp-Ser TFA Chemical Structure

规格 是否有货
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Gly-Arg-Gly-Asp-Ser TFA 的其他形式现货产品:

Gly-Arg-Gly-Asp-Ser

生物活性

Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin[1]. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM[2].

IC50 Target

IC50: 5 μM (αvβ3), 6.5 μM (αvβ5)[2]
分子量

604.49

Formula

C19H31F3N8O11
Sequence

Gly-Arg-Gly-Asp-Ser
Sequence Shortening

GRGDS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.

    [2]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997.

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc)

发表于由

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc);

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc) 通过阻断 GRTH/DDX25 磷酸化，为开发非激素性男性避孕药提供了途径。

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc)amp;;

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc) Chemical Structure

规格 是否有货
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生物活性

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc) provides an avenue for developing a nonhormonal male contraceptive by blocking of GRTH/DDX25 phosphorylation.

分子量

946.07

Formula

C40H67N17O10
Sequence Shortening

cyclo(FAGRRRG-{AEEAc})
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Raju M, et al. Blockade of GRTH/DDX25 Phosphorylation by Cyclic Peptides Provides an Avenue for Developing a Nonhormonal Male Contraceptive. J Med Chem. 2021 Oct 14;64(19):14715-14727.

Ac-Arg-Gly-Lys(Ac)-AMC

发表于由

Ac-Arg-Gly-Lys(Ac)-AMC;

Ac-Arg-Gly-Lys(Ac)-AMC 是 HDAC 的一个底物。

Ac-Arg-Gly-Lys(Ac)-AMCamp;;

Ac-Arg-Gly-Lys(Ac)-AMC Chemical Structure

CAS No. : 660846-97-9

规格 是否有货
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生物活性

Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC[1].

体外研究
(In Vitro)

Following initial inhibition of HDACs, the peptide substrate Ac-Arg-Gly-Lys-AMC is added to the reaction tubes for next 30 min and finally the stop solution stopped the reaction mediated by HDAC enzymes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

600.67

Formula

C28H40N8O7
CAS 号

660846-97-9
Sequence Shortening

Ac-RG{K(Ac)}-AMC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Meike Kespohl, et al. The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4 + T Cells Front Immunol. 2017 Aug 28;8:1036.

[Arg14,Lys15]Nociceptin TFA

发表于由

[Arg14,Lys15]Nociceptin TFA;

[Arg14,Lys15]Nociceptin TFA 是一种高效、选择性的 NOP (ORL1; OP4) 受体激动剂，EC50为 1 nM。[Arg14,Lys15]Nociceptin TFA 对阿片受体具有较高的选择性，对 NOP、μ、δ 和 κ 受体的 IC50 值分别为 0.32、280、>10000 和 1500 nM。

[Arg14,Lys15]Nociceptin TFAamp;;

[Arg14,Lys15]Nociceptin TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Arg14,Lys15]Nociceptin TFA is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin TFA displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1].

体外研究
(In Vitro)

[Arg14,Lys15]Nociceptin TFA is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In in vivo experiments, [Arg14,Lys15]Nociceptin TFA mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2023.18

Formula

C84H138F3N31O24
Sequence Shortening

FGGFTGARKSARKRKNQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498.

    [2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63.

(Arg)9, FAM-labeled

发表于由

(Arg)9, FAM-labeled;

(Arg)9, FAM-labeled 是一种带有 FAM 标记的 ARG，属于细胞穿透肽 (CPP)。CPPs 已成为一种强大的工具，用于将生物活性物质输送到完整细胞胞质中。

(Arg)9, FAM-labeledamp;;

(Arg)9, FAM-labeled Chemical Structure

规格 是否有货
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生物活性

(Arg)9, FAM-labeled, a cell-penetrating peptide (CPP), is a nona-arginine (ARG) with FAM label. CPPs have emerged as powerful tools for delivering bioactive cargoes into the cytosol of intact cells[1].

分子量

1782.00

Formula

F
Sequence

FAM-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
Sequence Shortening

FAM-RRRRRRRRR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. CPProtectides: Rapid uptake of well-folded β-hairpin peptides with enhanced resistance to intracellular degradation. Pept Sci (Hoboken). 2019 Mar; 111(2): e24092.

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]

发表于由

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal];

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) 对耐药革兰氏阳性菌和革兰氏阴性菌具有广谱活性，对于 MRSA (ATCC BAA-1556)，S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), 和 E. coli (ATCC 25922) 的 MIC 分别为 3.1、3,1、12.5 和 25 μg/mL。

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]amp;;

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] Chemical Structure

CAS No. : 2619854-01-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].

分子量

1216.44

Formula

C63H81N19O7
CAS 号

2619854-01-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687.

H-D-Phe-Pip-Arg-pNA(Synonyms: S-2238)

发表于由

H-D-Phe-Pip-Arg-pNA;(Synonyms: S-2238)

H-D-Phe-Pip-Arg-pNA (S-2238) 是一种显色底物，在凝血酶的天然底物纤维蛋白原 α 链的 N 端部分之后形成。H-D-Phe-Pip-Arg-pNA 对凝血酶有特异性，用于测定抗凝血酶肝素辅因子 (AT-III)。使用 H-D-Phe-Pip-Arg-pNA 进行的 AT-III 分析灵敏、准确、易于执行。

H-D-Phe-Pip-Arg-pNAamp;;(Synonyms: S-2238)

H-D-Phe-Pip-Arg-pNA Chemical Structure

CAS No. : 64815-81-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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H-D-Phe-Pip-Arg-pNA 的其他形式现货产品:

H-D-Phe-Pip-Arg-pNA acetate

生物活性

H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform[1][2].

分子量

552.63

Formula

C27H36N8O5
CAS 号

64815-81-2
Sequence Shortening

{D-Phe}-{Pip}-R-pNA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647.

    [2]. Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353.

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]

发表于由

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip];

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) 对耐药革兰氏阳性菌和革兰氏阴性菌具有广谱活性，对于 MRSA (ATCC BAA-1556)，S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), 和 E. coli (ATCC 25922)的 MIC 分别为 3.1、3,1、12.5 和 12.5 μg/mL。

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]amp;;

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] Chemical Structure

CAS No. : 2619853-87-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].

分子量

1294.55

Formula

C69H87N19O7
CAS 号

2619853-87-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687.