Des-Arg9-Bradykinin 品牌:Peptide


Des-Arg9-Bradykinin

品牌:Peptide
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

334-40671

0.5mg 咨询


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Anti Arg1, Rabbit Arg1抗体, 兔源 品牌:FUJIFILM Wako


Anti Arg1, Rabbit

Arg1抗体, 兔源

品牌:FUJIFILM Wako
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

018-28361

for Immunochemistry 100uL 4,940.00


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D-Arg-[Hyp3,Thi5,8,D-Phe7]-Bradykinin 品牌:Peptide


D-Arg-[Hyp3,Thi5,8,D-Phe7]-Bradykinin

品牌:Peptide
CAS No.:103412-42-6
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

337-42023

25mg 咨询


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Pyr-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu 品牌:Peptide


Pyr-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu

品牌:Peptide
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

334-42371

5mg 咨询


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anti-Monomethyl-Histone H4 (Arg3), Rabbit Monoclonal (RM195) 抗单甲基化组蛋白 H4 (Arg3), 兔单克隆抗体 (RM195) 品牌:RevMab


anti-Monomethyl-Histone H4 (Arg3), Rabbit Monoclonal (RM195)

抗单甲基化组蛋白 H4 (Arg3), 兔单克隆抗体 (RM195)

品牌:RevMab
CAS No.:
储存条件:-20°C
纯度:Protein A purified.
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

REV-31-1080-00-C100

100 µg 6,570.00


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(Arg)9 TFA(Synonyms: Nona-L-arginine TFA Peptide R9 TFA)

(Arg)9 TFA;(Synonyms: Nona-L-arginine TFA; Peptide R9 TFA) 纯度: 96.80%

(Arg)9 TFA (Nona-L-arginine TFA)是可渗透细胞的多肽,在谷氨酸模型实验模型中保护神经的IC50值为0.78 μM。

(Arg)9 TFAamp;;(Synonyms: Nona-L-arginine TFA; Peptide R9 TFA)

(Arg)9 TFA Chemical Structure

CAS No. : 2283335-13-5

规格 价格 是否有货 数量
1 mg ¥1300 In-stock
5 mg ¥4900 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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(Arg)9 TFA 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

(Arg)9 TFA (Nona-L-arginine TFA), a cell-penetrating peptide, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.

IC50 Target

IC50: 0.78 μM (neuroprotection)[1].

体外研究
(In Vitro)

Poly-arginine (e.g. (Arg)9) and arginine-rich peptides (e.g. TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. (Arg)9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect[2]. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

1537.71

Formula

C56H111N36F3O12

CAS 号

2283335-13-5

Sequence

Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Sequence Shortening

RRRRRRRRR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Meloni BP, et al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81.

    [2]. Meloni BP, et al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004.

    [3]. Milani D, et al. Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat strokemodel. BMC Neurosci. 2016 May 3;17(1):19.

Tos-Arg-OMe.HCl 品牌:Peptide


Tos-Arg-OMe.HCl

品牌:Peptide
CAS No.:1784-03-8
储存条件:2-10℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

335-30032

25g 咨询


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[Arg8]-Vasotocin TFA

[Arg8]-Vasotocin TFA; 纯度: 99.87%

[Arg8]-Vasotocin (TFA) 是加压素/催产素激素家族的脊椎动物神经垂体肽。

[Arg8]-Vasotocin TFAamp;;

[Arg8]-Vasotocin TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ¥1400 In-stock
10 mg ¥2400 In-stock
25 mg ¥4800 询价
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

[Arg8]-Vasotocin (TFA) is a vertebrate neurohypophyseal peptide of the vasopressin/oxytocin hormone family[1].

体外研究
(In Vitro)

[Arg8]-Vasotocin occurs throughout the vertebrate phyla, being present in primitive fish, the cyclostomes, and remaining unchanged in vertebrates up to and including birds[1].

[Arg8]-Vasotocin excites neurones in the dorsal vagal complex in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1164.24

Formula

C45H68F3N15O14S2

Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

Sequence Shortening

CYIQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 50 mg/mL (42.95 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8589 mL 4.2946 mL 8.5893 mL
5 mM 0.1718 mL 0.8589 mL 1.7179 mL
10 mM 0.0859 mL 0.4295 mL 0.8589 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Ingram CD, et al [Arg8]vasotocin excites neurones in the dorsal vagal complex in vitro: evidence for an action through novel class(es) of CNS receptors. J Neuroendocrinol. 1994 Aug;6(4):415-22.

    [2]. Mihai R, et al. The effects of [Arg8]vasotocin on the firing rate of suprachiasmatic neurons in vitro. Neuroscience. 1994 Oct;62(3):783-92.

Bz-L-Arg-p-NA.HCl 品牌:Peptide


Bz-L-Arg-p-NA.HCl

品牌:Peptide
CAS No.:21653-40-7
储存条件:2-10℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

335-30571

0.1g 咨询


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Bz-Gly-Arg 品牌:Peptide


Bz-Gly-Arg

品牌:Peptide
CAS No.:744-46-7
储存条件:2-10℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

335-30593

1g 咨询


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