[Arg14,Lys15]Nociceptin TFA

[Arg14,Lys15]Nociceptin TFA;

[Arg14,Lys15]Nociceptin TFA 是一种高效、选择性的 NOP (ORL1; OP4) 受体激动剂,EC50为 1 nM。[Arg14,Lys15]Nociceptin TFA 对阿片受体具有较高的选择性,对 NOP、μ、δ 和 κ 受体的 IC50 值分别为 0.32、280、>10000 和 1500 nM。

[Arg14,Lys15]Nociceptin TFAamp;;

[Arg14,Lys15]Nociceptin TFA Chemical Structure

规格 是否有货
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生物活性

[Arg14,Lys15]Nociceptin TFA is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin TFA displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1].

体外研究
(In Vitro)

[Arg14,Lys15]Nociceptin TFA is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In in vivo experiments, [Arg14,Lys15]Nociceptin TFA mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2023.18

Formula

C84H138F3N31O24

Sequence Shortening

FGGFTGARKSARKRKNQ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498.

    [2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63.

[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P 品牌:FUJIFILM Wako


[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P

品牌:FUJIFILM Wako
CAS No.:84676-91-5
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

017-22971

for Proteome Research 2 nmol本

[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P               品牌:FUJIFILM Wako


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

(Arg)9, FAM-labeled

(Arg)9, FAM-labeled;

(Arg)9, FAM-labeled 是一种带有 FAM 标记的 ARG,属于细胞穿透肽 (CPP)。CPPs 已成为一种强大的工具,用于将生物活性物质输送到完整细胞胞质中。

(Arg)9, FAM-labeledamp;;

(Arg)9, FAM-labeled Chemical Structure

规格 是否有货
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生物活性

(Arg)9, FAM-labeled, a cell-penetrating peptide (CPP), is a nona-arginine (ARG) with FAM label. CPPs have emerged as powerful tools for delivering bioactive cargoes into the cytosol of intact cells[1].

分子量

1782.00

Formula

F

Sequence

FAM-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Sequence Shortening

FAM-RRRRRRRRR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. CPProtectides: Rapid uptake of well-folded β-hairpin peptides with enhanced resistance to intracellular degradation. Pept Sci (Hoboken). 2019 Mar; 111(2): e24092.

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal];

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) 对耐药革兰氏阳性菌和革兰氏阴性菌具有广谱活性,对于 MRSA (ATCC BAA-1556),S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), 和 E. coli (ATCC 25922) 的 MIC 分别为 3.1、3,1、12.5 和 25 μg/mL。

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]amp;;

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] Chemical Structure

CAS No. : 2619854-01-0

规格 是否有货
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生物活性

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].

分子量

1216.44

Formula

C63H81N19O7

CAS 号

2619854-01-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687.

H-D-Phe-Pip-Arg-pNA(Synonyms: S-2238)

H-D-Phe-Pip-Arg-pNA;(Synonyms: S-2238)

H-D-Phe-Pip-Arg-pNA (S-2238) 是一种显色底物,在凝血酶的天然底物纤维蛋白原 α 链的 N 端部分之后形成。H-D-Phe-Pip-Arg-pNA 对凝血酶有特异性,用于测定抗凝血酶肝素辅因子 (AT-III)。使用 H-D-Phe-Pip-Arg-pNA 进行的 AT-III 分析灵敏、准确、易于执行。

H-D-Phe-Pip-Arg-pNAamp;;(Synonyms: S-2238)

H-D-Phe-Pip-Arg-pNA Chemical Structure

CAS No. : 64815-81-2

规格 是否有货
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H-D-Phe-Pip-Arg-pNA 的其他形式现货产品:

H-D-Phe-Pip-Arg-pNA acetate

生物活性

H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform[1][2].

分子量

552.63

Formula

C27H36N8O5

CAS 号

64815-81-2

Sequence Shortening

{D-Phe}-{Pip}-R-pNA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647.

    [2]. Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353.

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip];

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) 对耐药革兰氏阳性菌和革兰氏阴性菌具有广谱活性,对于 MRSA (ATCC BAA-1556),S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), 和 E. coli (ATCC 25922)的 MIC 分别为 3.1、3,1、12.5 和 12.5 μg/mL。

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]amp;;

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] Chemical Structure

CAS No. : 2619853-87-9

规格 是否有货
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250 mg ; 询价 ;
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生物活性

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].

分子量

1294.55

Formula

C69H87N19O7

CAS 号

2619853-87-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687.

Arg-Gly-Asp-Ser (TFA)(Synonyms: RGDS peptide (TFA) Fibronectin tetrapeptide (TFA))

Arg-Gly-Asp-Ser (TFA);(Synonyms: RGDS peptide (TFA); Fibronectin tetrapeptide (TFA))

Arg-Gly-Asp-Ser (TFA) 是整联蛋白结合序列,抑制整联蛋白受体 (integrin receptor) 功能。Arg-Gly-Asp-Ser (TFA) 直接并特异性地结合 pro-caspase-8,pro-caspase-9 和 pro-caspase-3,但不与 pro-caspase-1 结合。

Arg-Gly-Asp-Ser (TFA)amp;;(Synonyms: RGDS peptide (TFA);  Fibronectin tetrapeptide (TFA))

Arg-Gly-Asp-Ser (TFA) Chemical Structure

规格 是否有货
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Arg-Gly-Asp-Ser (TFA) 的其他形式现货产品:

Arg-Gly-Asp-Ser

生物活性

Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1[1].

分子量

547.44

Formula

C17H28F3N7O10

Sequence

Arg-Gly-Asp-Ser

Sequence Shortening

RGDS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Aguzzi MS, et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer. 2010 Apr 22;9:84.

pGlu-Pro-Arg-MNA

pGlu-Pro-Arg-MNA;

pGlu-Pro-Arg-MNA 是一种显色底物。

pGlu-Pro-Arg-MNAamp;;

pGlu-Pro-Arg-MNA Chemical Structure

CAS No. : 130835-45-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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pGlu-Pro-Arg-MNA 的其他形式现货产品:

pGlu-Pro-Arg-MNA monoacetate

生物活性

pGlu-Pro-Arg-MNA is a chromogenic substrate.

体外研究
(In Vitro)

Protein C activity is measured using the reagents, both with a partial thromboplastin time (aPTT) system as well as with a chromogenic substrate (pGlu-Pro-Arg-mNA) in a photometric method[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

532.55

Formula

C23H32N8O7

CAS 号

130835-45-9

Sequence

{pGlu}-Pro-Arg-MNA

Sequence Shortening

{pGlu}-PR-MNA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Girolami A, et al. Heterozygous protein-S deficiency: a study of a large kindred. Acta Haematol. 1990;84(3):162-8.

D-Lys(Z)-Pro-Arg-pNA(Synonyms: Chromozym Pca)

D-Lys(Z)-Pro-Arg-pNA;(Synonyms: Chromozym Pca)

D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) 是 APC (活化蛋白 C ) 的发光底物。

D-Lys(Z)-Pro-Arg-pNAamp;;(Synonyms: Chromozym Pca)

D-Lys(Z)-Pro-Arg-pNA Chemical Structure

CAS No. : 108963-69-5

规格 是否有货
5 mg 询价
10 mg 询价
50 mg 询价
100 mg 询价

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生物活性

D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a luminescent substrate of activated protein C (APC).

分子量

653.73

Formula

C31H43N9O7

CAS 号

108963-69-5

Sequence

{d-Lys(Z)}-Pro-Arg-pNA

Sequence Shortening

{d-Lys(Z)}-PR-pNA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

pGlu-Pro-Arg-MNA monoacetate

pGlu-Pro-Arg-MNA monoacetate; 纯度: ge;99.0%

pGlu-Pro-Arg-MNA monoacetate 是一种显色底物。

pGlu-Pro-Arg-MNA monoacetateamp;;

pGlu-Pro-Arg-MNA monoacetate Chemical Structure

CAS No. : 2070009-26-4

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ¥4563 In-stock
5 mg ¥3500 In-stock
10 mg ¥5000 In-stock
50 mg ¥15000 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

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pGlu-Pro-Arg-MNA monoacetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

pGlu-Pro-Arg-MNA monoacetate is a chromogenic substrate.

体外研究
(In Vitro)

Protein C activity is measured using the reagents, both with a partial thromboplastin time (aPTT) system as well as with a chromogenic substrate (pGlu-Pro-Arg-mNA) in a photometric method[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

592.60

Formula

C25H36N8O9

CAS 号

2070009-26-4

Sequence

{pGlu}-Pro-Arg-MNA

Sequence Shortening

{pGlu}-PR-MNA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : ≥ 25 mg/mL (42.19 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6875 mL 8.4374 mL 16.8748 mL
5 mM 0.3375 mL 1.6875 mL 3.3750 mL
10 mM 0.1687 mL 0.8437 mL 1.6875 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Girolami A, et al. Heterozygous protein-S deficiency: a study of a large kindred. Acta Haematol. 1990;84(3):162-8.