Autocamtide-2-related inhibitory peptide

Autocamtide-2-related inhibitory peptide;

Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptideamp;;

Autocamtide-2-related inhibitory peptide Chemical Structure

CAS No. : 167114-91-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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Autocamtide-2-related inhibitory peptide 的其他形式现货产品:

Autocamtide-2-related inhibitory peptide TFA

生物活性

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.

IC50 Target

IC50: 40 nM (CaMKII)[1].

体外研究
(In Vitro)

It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1497.74

Formula

C64H116N22O19

CAS 号

167114-91-2

Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Sequence Shortening

KKALRRQEAVDAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Autocamtide-2-related inhibitory peptide, myristoylated

Autocamtide-2-related inhibitory peptide, myristoylated;

Autocamtide-2-related inhibitory peptide, myristoylated 是Autocamtide-2-related inhibitory peptide 烷基化修饰后的形式。 Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptide, myristoylatedamp;;

Autocamtide-2-related inhibitory peptide, myristoylated Chemical Structure

CAS No. : 201422-04-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM[1].

分子量

1708.10

Formula

C78H142N22O20

CAS 号

201422-04-0

Sequence

{Lys(Myr)}-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Sequence Shortening

{Lys(Myr)}-KALRRQEAVDAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Autocamtide-2-related inhibitory peptide, myristoylated TFA

Autocamtide-2-related inhibitory peptide, myristoylated TFA;

Autocamtide-2-related inhibitory peptide, myristoylated TFA 是Autocamtide-2-related inhibitory peptide 烷基化修饰后的形式。 Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptide, myristoylated TFAamp;;

Autocamtide-2-related inhibitory peptide, myristoylated TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Autocamtide-2-related inhibitory peptide, myristoylated TFA is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM[1].

分子量

1822.12

Formula

C78H142N22O20.C2HF3O2

Sequence

{Lys(Myr)}-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Sequence Shortening

{Lys(Myr)}-KALRRQEAVDAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Autocamtide-2-related inhibitory peptide TFA

Autocamtide-2-related inhibitory peptide TFA  纯度: 95.85%

Autocamtide-2-related inhibitory peptide (TFA) 是高度特异性的、CaMKII 的有效抑制剂,其 IC50 值为 40 nM。

Autocamtide-2-related inhibitory peptide TFA 

Autocamtide-2-related inhibitory peptide TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥2200 In-stock
5 mg ¥8900 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Autocamtide-2-related inhibitory peptide TFA 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.

IC50 & Target

IC50: 40 nM (CaMKII)[1].

体外研究
(In Vitro)

It is found that Autocamtide-2-related inhibitory peptide (TFA) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93, respectively, under the assay condition used[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1611.76

Formula

C66H126N22O21F3

Sequence

Lys-Lys-Ala-Lru-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Sequence Shortening

KKALRRQEAVDAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 110 mg/mL (68.25 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6204 mL 3.1022 mL 6.2044 mL
5 mM 0.1241 mL 0.6204 mL 1.2409 mL
10 mM 0.0620 mL 0.3102 mL 0.6204 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

  • [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Autocamtide 2(Synonyms: Autocamtide II)

Autocamtide 2;(Synonyms: Autocamtide II) 纯度: 98.21%

Autocamtide 2是钙/钙调蛋白依赖的蛋白激酶II (CaMKII)的高选择性肽底物。 它可以用于测定CaMKII的活力。

Autocamtide 2amp;;(Synonyms: Autocamtide II)

Autocamtide 2 Chemical Structure

CAS No. : 129198-88-5

规格 价格 是否有货 数量
1 mg ¥900 In-stock
5 mg ¥3600 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Autocamtide 2 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay.

体外研究
(In Vitro)

The Ca/calmodulin dependent protein kinases (CaMKs) are multifunctional serine/threonine kinases whose activity are regulated through Ca2+ signaling. It is multifunctional best known for its critical role in learning and memory. Recent studies demonstrates that high levels of different isoform of CaMK, especially for CaMKII, expresses in several cancers such as lung, breast, prostate and colon cancer. CaMKII phosphorylates nearly 40 different proteins, including enzymes, ion channels, kinases, and transcription factors and plays a critical role in the regulation of proliferation, differentiation and survival of various cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1527.77

Formula

C65H118N22O20

CAS 号

129198-88-5

Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu

Sequence Shortening

KKALRRQETVDAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 20 mg/mL (13.09 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6545 mL 3.2727 mL 6.5455 mL
5 mM 0.1309 mL 0.6545 mL 1.3091 mL
10 mM 0.0655 mL 0.3273 mL 0.6545 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Wang YY, et al. The emerging role of CaMKII in cancer. Oncotarget. 2015 May 20;6(14):11725-34.