Lanreotide acetate(Synonyms: BIM 23014 acetate)

发表于2024年4月22日由Whatman官网

Lanreotide acetate;(Synonyms: BIM 23014 acetate) 纯度: 99.91%

Lanreotide acetate (BIM 23014 acetate) 是一种具有抗肿瘤活性的生长抑素类似物。Lanreotide acetate 可用于类癌综合症。

Lanreotide acetateamp;;(Synonyms: BIM 23014 acetate)

Lanreotide acetate Chemical Structure

CAS No. : 2378114-72-6

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥1650	In-stock
5 mg	￥750	In-stock
10 mg	￥1300	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Lanreotide acetate 相关产品

bull;相关化合物库:

Covalent Screening Library Plus
Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
FDA-Approved Drug Library Mini
Bioactive Compound Library Plus
FDA-Approved Drug Library
Anti-Cancer Compound Library
Drug Repurposing Compound Library
Covalent Screening Library
Endocrinology Compound Library
FDA Approved amp; Pharmacopeial Drug Library
Drug-Induced Liver Injury (DILI) Compound Library
Rare Diseases Drug Library
Peptide Library

生物活性

Lanreotide acetate (BIM 23014 acetate) is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for carcinoid syndrome^[1]^[2].

体外研究
(In Vitro)

Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100 nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion^[1].
Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57 nM^[1].
Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice)^[1]
Dosage:	2.5, 5, 10 mg/kg
Administration:	Subcutaneous; daily for 5 days
Result:	Produced tumor growth inhibition.

Clinical Trial

分子量

1156.38

Formula

C₅₆H₇₃N₁₁O₁₂S₂

CAS 号

2378114-72-6

Sequence

{d-2nal}-Cys-Tyr-{d-Trp}-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

{d-2nal}-CY-{d-Trp}-KVCT-NH2 (Disulfide bridge: Cys2-Cys7)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (86.48 mM; Need ultrasonic)

H₂O : 25 mg/mL (21.62 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8648 mL	4.3238 mL	8.6477 mL
5 mM	0.1730 mL	0.8648 mL	1.7295 mL
10 mM	0.0865 mL	0.4324 mL	0.8648 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (2.16 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.16 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (2.16 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.16 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.16 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.16 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Ning S, et al. Lanreotide promotes apoptosis and is not radioprotective in GH3 cells.Endocr Relat Cancer. 2009 Sep;16(3):1045-55.

[2]. Florio T, et al. Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.Clin Endocrinol (Oxf). 2003 Jul;59(1):115-28.

BIM-23190 hydrochloride

发表于2024年4月2日由Whatman官网

BIM-23190 hydrochloride; 纯度: 98.82%

BIM-23190 hydrochloride 是 somatostatin 的类似物，是 SSTR2 和SSTR5 的选择性激动剂，对SSTR2 和SSTR5 的K_i 值分别为 0.34 nM 和 11.1 nM。BIM-23190 可用于糖尿病和癌症研究。

BIM-23190 hydrochloride Chemical Structure

规格	价格	是否有货	数量
5 mg	￥3500	In-stock
10 mg	￥5800	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

BIM-23190 hydrochloride 相关产品

bull;相关化合物库:

Covalent Screening Library Plus
Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Neuronal Signaling Compound Library
Anti-Cancer Compound Library
Covalent Screening Library
Macrocyclic Compound Library
Targeted Diversity Library
Peptide Library

生物活性

BIM-23190 hydrochloride, a somatostatin analog, a selective SSRT2 and SSRT5 agonist, exhibits K_i values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly^[1]^[3].

体外研究
(In Vitro)

BIM-23190 tends to mildly stimulate PRL secretion^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

BIM-23190 (50 μg/mouse, twice a day) exhibits significant anti-tumor (C6 glioma) activity^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male athymic nude (nu/nu) mice, 5-6 wk old (C6 glioma)^[2].
Dosage:	50 μg/mouse.
Administration:	Injected twice a day for 19 days.
Result:	Significantly reduced the tumor growth rate.

分子量

1238.91

Formula

C₅₇H₈₀ClN₁₃O₁₂S₂

Sequence

{4-(2-Hydroxyethyl)-1-piperazinylacetyl}-{D-Phe}-Cys-Tyr-{D-Trp}-Lys-{Abu}-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

{4-(2-Hydroxyethyl)-1-piperazinylacetyl}-{D-Phe}-CY-{D-Trp}-K-{Abu}-CT-NH2 (Disulfide bridge: Cys2-Cys7)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (80.72 mM; Need ultrasonic)

H₂O : 100 mg/mL (80.72 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8072 mL	4.0358 mL	8.0716 mL
5 mM	0.1614 mL	0.8072 mL	1.6143 mL
10 mM	0.0807 mL	0.4036 mL	0.8072 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (2.02 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.02 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (2.02 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.02 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.02 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.02 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. I Shimon, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 1;100(9):2386-92.

[2]. Federica Barbieri, et al. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1078-88.

[3]. T J Gillespie, et al. Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution. J Pharmacol Exp Ther. 1998 Apr;285(1):95-104.

BIM-23056

发表于2024年3月28日由Whatman官网

BIM-23056; 纯度: 99.97%

BIM 23056 是一种线性八肽，是有效的 sst3 和 sst5 生长抑素受体拮抗剂，K_i 值分别为 10.8 和 5.7。

BIM-23056 Chemical Structure

CAS No. : 150155-61-6

规格	价格	是否有货	数量
1 mg	￥2500	In-stock
5 mg	￥7500	In-stock
10 mg	￥12000	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

BIM-23056 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

BIM 23056, a linear octapeptide, is a potent sst3 and sst5 somatostatin receptor antagonist with K_i values of 10.8, 5.7, respectively^[1].

体外研究
(In Vitro)

BIM 23056 has K_i values of 142, 16.6, >1000 for sst1, sst4, sst2 , respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1232.47

Formula

C₇₁H₈₁N₁₁O₉

CAS 号

150155-61-6

Sequence Shortening

FFYWKVF-{D-2-Nal}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (81.14 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8114 mL	4.0569 mL	8.1138 mL
5 mM	0.1623 mL	0.8114 mL	1.6228 mL
10 mM	0.0811 mL	0.4057 mL	0.8114 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (2.03 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.03 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.03 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.03 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Y C Patel, et al. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology. 1994 Dec;135(6):2814-7.

[2]. W Feniuk, et al. Further evidence from functional studies for somatostatin receptor heterogeneity in guinea-pig isolated ileum, vas deferens and right atrium. Br J Pharmacol. 1995 Jul;115(6):975-80.

Bim BH3, Peptide IV

发表于2023年10月31日由Whatman官网

Bim BH3, Peptide IV;

Bim BH3, Peptide IV 是一种来自 BH3-only protein Bim 的 26 个残基肽，属于 Bcl-2 蛋白家族的促凋亡家族。

Bim BH3, Peptide IV Chemical Structure

CAS No. : 721885-31-0

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Bim BH3, Peptide IV is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins^[1]^[2].
分子量	3269.65
Formula	C₁₄₅H₂₂₂N₄₄O₄₁S
CAS 号	721885-31-0
Sequence Shortening	DMRPEIWIAQELRRIGDEFNAYYARR
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhu Y, et al. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondriain T cells. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7681-6. [2]. Lee EF, et al. High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl. 2009;48(24):4318-22.

Onzigolide(Synonyms: BIM-23A760 TBR-760)

发表于2023年10月30日由Whatman官网

Onzigolide;(Synonyms: BIM-23A760; TBR-760)

Onzigolide (BIM-23A760)，一种嵌合多巴胺生长抑素化合物，在 DA2 型 (D2R) 和 SST2 型 (SSTR2) 受体。

Onzigolideamp;;(Synonyms: BIM-23A760; TBR-760)

Onzigolide Chemical Structure

CAS No. : 778630-77-6

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors^[1]^[2].
分子量	1694.20
Formula	C₈₆H₁₁₆N₁₆O₁₂S₄
CAS 号	778630-77-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Halem HA, et al. TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. Endocrinology. 2020 Aug 1;161(8):bqaa101. [2]. Cuny T, et al. Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells. Pituitary. 2021 Jun;24(3):351-358.

Angiopep-Bim BH3 hydrochloride

发表于2023年10月24日由Whatman官网

Angiopep-Bim BH3 hydrochloride;

Angiopep-Bim BH3 hydrochloride 是能透过血脑屏障的多肽，可用于研究中枢神经系统的通透性。

Angiopep-Bim BH3 hydrochloride Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

Angiopep-Bim BH3 hydrochloride, a BBB penetrated peptode, could be used to investigate the permeability of CNS therapeutics^[1].

分子量

6273.28

Formula

C₂₇₇H₄₁₅ClN₈₂O₈₂S

Sequence Shortening

TFFYGGSRGKRNNFKTEEYLPSTGGGGGDMRPEIWIAQELRRIGDEFNAYYARR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Sonja Bergmann, et al. Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics. Nat Protoc. 2018 Dec;13(12):2827-2843.

BIM-26226

发表于2023年10月23日由Whatman官网

BIM-26226;

BIM-26226 是一种胃泌素释放肽，是一种强效选择性的 bombesin receptor 拮抗剂。 BIM-26226 抑制 BN 或 GRP 刺激的淀粉酶释放，IC₅₀ 值在纳摩尔范围内。BIM-26226 可用于癌症研究。

BIM-26226 Chemical Structure

CAS No. : 136207-23-3

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性

BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. BIM-26226 inhibits BN- or GRP-stimulated amylase release with IC₅₀s in the nanomolar range. BIM-26226 can be used for the research of cancer^[1]^[2].

IC₅₀ Target

bombesin receptor^[1]

分子量

1075.09

Formula

C₄₉H₆₃F₅N₁₂O₁₀

CAS 号

136207-23-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Dietrich JB, et, al. Effects of BIM26226, a potent and specific bombesin receptor antagonist, on amylase release and binding of bombesin-like peptides to AR4-2J cells. Regul Pept. 1994 Oct 21;53(3):165-73.

[2]. Damgé C, et, al. Effect of the gastrin-releasing peptide antagonist BIM 26226 and lanreotide on an acinar pancreatic carcinoma. Eur J Pharmacol. 1998 Apr 17;347(1):77-86.

BIM-23056 TFA

发表于2023年10月11日由Whatman官网

BIM-23056 TFA;

BIM 23056 TFA 是一种线性八肽，是有效的 sst3 和 sst5 生长抑素受体拮抗剂，K_i 值分别为 10.8 和 5.7。

BIM-23056 TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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BIM-23056 TFA 的其他形式现货产品:

BIM-23056

生物活性

BIM 23056 TFA, a linear octapeptide, is a potent sst3 and sst5 somatostatin receptor antagonist with K_i values of 10.8, 5.7, respectively^[1].

体外研究
(In Vitro)

BIM 23056 TFA has K_i values of 142, 16.6, >1000 for sst1, sst4, sst2 , respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1346.49

Formula

C₇₃H₈₂F₃N₁₁O₁₁

Sequence Shortening

FFYWKVF-{D-2-Nal}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Y C Patel, et al. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology. 1994 Dec;135(6):2814-7.

[2]. W Feniuk, et al. Further evidence from functional studies for somatostatin receptor heterogeneity in guinea-pig isolated ileum, vas deferens and right atrium. Br J Pharmacol. 1995 Jul;115(6):975-80.

Bim BH3, Peptide IV TFA

发表于2023年10月10日由Whatman官网

Bim BH3, Peptide IV TFA;

Bim BH3, Peptide IV TFA 是一种来自 BH3-only protein Bim 的 26 个残基肽，属于 Bcl-2 蛋白家族的促凋亡家族。

Bim BH3, Peptide IV TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Bim BH3, Peptide IV TFA is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins^[1]^[2].
分子量	3383.67
Formula	C₁₄₇H₂₂₃N₄₄F₃O₄₃S
Sequence	Asp-Met-Arg-Pro-Glu-Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg
Sequence Shortening	DMRPEIWIAQELRRIGDEFNAYYARR
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhu Y, et al. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondriain T cells. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7681-6. [2]. Lee EF, et al. High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl. 2009;48(24):4318-22.

BIM-23190

发表于2023年10月9日由Whatman官网

BIM-23190;

BIM-23190 是 somatostatin 的类似物，是 SSTR2 和 SSTR5 的选择性激动剂，对SSTR2 和SSTR5 的K_i 值分别为 0.34 nM 和 11.1 nM。BIM-23190 可用于糖尿病和癌症研究。

BIM-23190 Chemical Structure

CAS No. : 182153-96-4

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

BIM-23190, a somatostatin analog, a selective SSTR2 and SSTR5 agonist, exhibits K_i values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly^[1]^[3].

体外研究
(In Vitro)

BIM-23190 tends to mildly stimulate PRL secretion^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

BIM-23190 (50 μg/mouse, twice a day) exhibits significant anti-tumor (C6 glioma) activity^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male athymic nude (nu/nu) mice, 5-6 wk old (C6 glioma)^[2].
Dosage:	50 μg/mouse
Administration:	Injected twice a day for 19 days.
Result:	Significantly reduced the tumor growth rate.

分子量

1202.45

Formula

C₅₇H₇₉N₁₃O₁₂S₂

CAS 号

182153-96-4

Sequence

{4-(2-Hydroxyethyl)-1-piperazinylacetyl}-{D-Phe}-Cys-Tyr-{D-Trp}-Lys-{Abu}-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

{4-(2-Hydroxyethyl)-1-piperazinylacetyl}-{D-Phe}-CY-{D-Trp}-K-{Abu}-CT-NH2 (Disulfide bridge: Cys2-Cys7)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. I Shimon, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 1;100(9):2386-92.

[2]. Federica Barbieri, et al. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1078-88.

[3]. T J Gillespie, et al. Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution. J Pharmacol Exp Ther. 1998 Apr;285(1):95-104.

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标签归档：bim

Lanreotide acetate(Synonyms: BIM 23014 acetate)

Lanreotide acetate 相关产品

bull;相关化合物库:

BIM-23190 hydrochloride

BIM-23190 hydrochloride 相关产品

bull;相关化合物库:

BIM-23056

BIM-23056 相关产品

bull;相关化合物库:

Bim BH3, Peptide IV

Onzigolide(Synonyms: BIM-23A760 TBR-760)

Angiopep-Bim BH3 hydrochloride

BIM-26226

BIM-23056 TFA

Bim BH3, Peptide IV TFA

BIM-23190

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