CALP3 TFA

CALP3 TFA;

CALP3 TFA 是一种类似于 Ca2+ 的肽,是有效的 Ca2+ 通道阻滞剂,可激活 Ca2+ 结合蛋白的 EF 手。CALP3 TFA 可以通过调节钙调蛋白 (CaM),Ca2+ 通道和泵的活性来模拟增加的 [Ca2+]i。CALP3 TFA 具有控制诸如艾滋病或由于缺血引起的神经元丢失等疾病中细胞凋亡的潜力。

CALP3 TFAamp;;

CALP3 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

CALP3 TFA, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 TFA can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia[1][2].

IC50 Target[1][2]

Ca2+

;

体外研究
(In Vitro)

CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca2+]i in a dose-dependent manner (IC50=37.25 μM) in Fura-2-loaded neuronal cultures[1].
CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate-induced cytotoxicity in a dose-dependent manner (IC50=50.97 μM) in cultured rat neocortical neurons. CALP3 TFA causes dose-dependent inhibition of apoptosis (IC50=33.41 μM)[1].
CALP3 TFA (100 μM) inhibits apoptosis induced by HIV gp120 and SAg in Human T cells[1].
CALP3 TFA (100 μM; 15 min pretreatment) reduces gossypol-induced necrosis and increases the fraction of live cells[2].
Cyclic-CALP3 is synthesized starting from Fmoc-Asp(PEG-PS)-OAl. Cyclic CALP3 is unable to inhibit Ca21 influx, and this peptide served as a negative control. Cyclic CALP3 does not inhibit the effect of glutamate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

995.10

Formula

C46H69F3N10O11

Sequence Shortening

VKFGVGFK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Manion MK, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306.

    [2]. Ferdek PE, et al. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death Dis. 2017 Mar 2;8(3):e2640.

C3a (70-77)(Synonyms: Complement 3a (70-77))

C3a (70-77);(Synonyms: Complement 3a (70-77))

C3a (70-77) 是对应于C3a的COOH末端的八肽,表现出C3a的特异性和1至2%的生物活性。

C3a (70-77)amp;;(Synonyms: Complement 3a (70-77))

C3a (70-77) Chemical Structure

CAS No. : 63555-63-5

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250 mg ; 询价 ;
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C3a (70-77) 的其他形式现货产品:

C3a (70-77) (TFA)

生物活性

C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.

IC50 Target

Complement system[1]

体外研究
(In Vitro)

The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10-7 M or higher and exceeds 75% at 10-6 M, irrespective of the stimulus[1].
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

823.94

Formula

C35H61N13O10

CAS 号

63555-63-5

Sequence

Ala-Ser-His-Leu-Gly-Leu-Ala-Arg

Sequence Shortening

ASHLGLAR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Payan DG, et al. Modulation of human lymphocyte function by C3a and C3a(70-77). J Exp Med. 1982 Sep 1;156(3):756-65.

    [2]. Caporale LH, et al. The active site of C3a anaphylatoxin. J Biol Chem. 1980 Nov 25;255(22):10758-63.

Kinase Assay
[1]

2×105 mononuelear leukocytes in 0.2 mL of M199-HPS containing 15% (vol/vol) AB-positive serum are added to each well of microtiter plates without or with 10 μg/mL of Con A, PHA, or SK-SD and incubated at 37°C in 5% CO2:95% air. C3a or C3a(70-77) is introduced into some suspensions at the same time as the stimulus or buffer. After 3 d for the mitogen-stimulated cultures and 5 d for the SK-SD-stimulated cultures, 1 μCi of [3H]thymidine is added to each well. After an additional 16 h at 37°C, the uptake of [3H]thymidine is analyzed by aspirating the contents of each well with a Mash II harvester that collected and ished the leukocytes on glass fiber filters. The radioactivity in each filter is quantified, and the results for quadruplicate chambers are expressed as mean cpm+SEM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Payan DG, et al. Modulation of human lymphocyte function by C3a and C3a(70-77). J Exp Med. 1982 Sep 1;156(3):756-65.

    [2]. Caporale LH, et al. The active site of C3a anaphylatoxin. J Biol Chem. 1980 Nov 25;255(22):10758-63.

25CS080AS-东洋针头式无菌过滤器 CA膜滤器

  • 型号 25CS080AS
  • 品牌 ADVANTEC东洋
  • 【简单介绍】
    品牌 其他品牌

    东洋针头式无菌过滤器 CA膜滤器,针头过滤器,25mm直径,醋酸纤维素(CA)滤膜,0.8um孔径,白色表面,丙烯酸外壳,灭菌,50PK。

    ADVANTEC无菌醋酸纤维素针头滤器0.8um孔径25mm直径25CS080AS,DISMIC-25CS DISPOSABLE MEMBRANE FILTER UNIT.CELLULOSE ACETATE STERILIZED BY ETO.LOT NO.312171CD,针头过滤器,25mm直径,醋酸纤维素(CA)滤膜,0.8um孔径,白色表面,丙烯酸外壳,灭菌,50PK。

    该针头滤器的膜材质为醋酸纤维素材质,亲水,低蛋白吸附,外壳材料选用苯乙烯 – 丙烯腈材质。直径25mm,孔径有0.2um、0.45um、0.8um可供选择。50个每盒。

    东洋针头式无菌过滤器 CA膜滤器 25CS080AS

    订货信息:

    25CS020AS 针头过滤器,25mm直径,醋酸纤维素(CA)滤膜,0.2um孔径,白色表面,丙烯酸外壳,灭菌,50

    25CS020AN 针头过滤器,25mm直径,醋酸纤维素(CA)滤膜,0.2um孔径,白色表面,丙烯酸外壳,未灭菌,50

    25CS045AS 针头过滤器,25mm直径,醋酸纤维素(CA)滤膜,0.45um孔径,白色表面,丙烯酸外壳,灭菌,50

    25CS045AN 针头过滤器,25mm直径,醋酸纤维素(CA)滤膜,0.45um孔径,白色表面,丙烯酸外壳,未灭菌,50

    25CS080AS 针头过滤器,25mm直径,醋酸纤维素(CA)滤膜,0.8um孔径,白色表面,丙烯酸外壳,灭菌,50

    25CS080AN 针头过滤器,25mm直径,醋酸纤维素(CA)滤膜,0.8um孔径,白色表面,丙烯酸外壳,未灭菌,50

    25AS020AS 针头过滤器,25mm直径,混合纤维素酯(MCE)滤膜,0.2um孔径,白色表面,丙烯酸外壳,灭菌,50

    25AS020AN 针头过滤器,25mm直径,混合纤维素酯(MCE)滤膜,0.2um孔径,白色表面,丙烯酸外壳,未灭菌,50

    25AS045AS 针头过滤器,25mm直径,混合纤维素酯(MCE)滤膜,0.45um孔径,白色表面,丙烯酸外壳,灭菌,50

    25AS045AN 针头过滤器,25mm直径,混合纤维素酯(MCE)滤膜,0.45um孔径,白色表面,丙烯酸外壳,未灭菌,50

    25JP020AN 针头过滤器,25mm直径,聚四氟乙烯(PTFE)-疏水性滤膜,0.2um孔径,白色表面,聚丙烯外壳,未灭菌,50

    25JP020AS 针头过滤器,25mm直径,聚四氟乙烯(PTFE)-疏水性滤膜,0.2um孔径,白色表面,聚丙烯外壳,灭菌,50

     

Fluo-4 AM

Fluo-4 AM;

Fluo-4 AM 是一种常用的检测细胞内 Ca2+ 浓度的探针。

Fluo-4 AMamp;;

Fluo-4 AM Chemical Structure

CAS No. : 273221-67-3

规格 价格 是否有货
100 μg ¥1500 询问价格 货期

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生物活性

Fluo-4 AM is a cell-permeable Ca2+ indicator[1].

体外研究
(In Vitro)

Fluo-4 AM is a fluorescent dye (λex=494 nm, λem=516 nm). Preloaded with Fuo-4 AM, a very bright fluorescence image is observed. In a parallel experiment with fluo-3 AM-loaded cells, the resulting fluorescence image, although clearly discernable in this case, is less bright[1]. Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Count the cells and take 106 cells from each sample (control and experiment/s).
2. Collect the cells (5 min, 3000×g, 4 °C) and wash once in PBS.
3. Resuspend the cells in 0.5-ml PBS and add 0.5 μl of Fluo-4-AM (1 mM stock) to a final concentration of 1 μM. Incubate at 37 °C for 1 h.
4. Wash the cells three times (2 min, 3000×g) with PBS and finally resuspend in 1-ml PBS. Separate into 2 flow cytometry tubes—0.5 ml in each.
5. Evaluate the staining by flow cytometry and analyze the data by a software such as CellQuest software.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1096.94

Formula

C51H50F2N2O23

CAS 号

273221-67-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, sealed storage, away from moisture and light

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

参考文献
  • [1]. Gee KR, et al. Chemical and physiological characterization of fluo-4 Ca(2+)-indicator dyes. Cell Calcium. 2000 Feb;27(2):97-106.

    [2]. Fluo-4.

Cell Assay
[1]

For measuring fluorescence from cells in suspension, dilutions to 2 to 3×106 cells are made, from cultures of rat basophilic leukemia (RBL) cells. Cells are incubated in suspension in 1 μM dye (including Fluo-4 AM) for 30 min at 37°C. Cell suspensions are then transferred to cuvets for measurements of fluorescence emission intensity by spectrofluorometer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Gee KR, et al. Chemical and physiological characterization of fluo-4 Ca(2+)-indicator dyes. Cell Calcium. 2000 Feb;27(2):97-106.

    [2]. Fluo-4.

sartorius醋酸纤维素膜(CA)11107-47N 11107-47n


sartorius醋酸纤维素膜(CA)11107-47N

sartorius醋酸纤维素膜(CA)11107-47N 0.2μm 47mm 100/pk sartorius醋酸纤维素膜(CA)11107-47N 醋酸纤维素膜流速高,热稳定性强,吸附低 应用于膜空气/气体过滤,水溶液过滤

sartorius  醋酸纤维素(CA)膜   11107-47N

醋酸纤维素膜流速高,热稳定性强,吸附低,因此是压式过滤的理想选择.0.2μm的CA膜是水相溶液如缓冲液,血清,培养基chu菌过滤的理想用膜。目前各公司公布的滤膜吸附数据,由于所测试的样品,过滤条件,检测方法的不同,很难具有可比性,而且多数滤膜在测试前并没有经过mie菌处理。

醋酸纤维素过滤膜
与水的反应亲水性
等级11107 
初级产品类型过滤器
颜色| 网格颜色白色(W / O格)
材料醋酸纤维素(CA)膜
过滤器格式盘
过滤器类型滤膜
包装 规格100  非无菌包装

孔径 0.2μm
直径 47mm
流速  24ml/min/cm2 BAR
颜色 白色

MIE菌程序 通过在121°C或134°C高压MIE菌,伽马辐射25 kGy,干热或环氧乙烷

技术属性
厚度 120μm 
爆破压力 0.8 bar 
起泡点 2.9 bar 
应用
空气/气体过滤
水溶液过滤
应用领域
分析样品制备
澄清
无菌过滤

滤器材质醋酸纤维素(CA)

CALP3

CALP3; 纯度: 99.27%

CALP3 是一种类似于 Ca2+ 的肽,是有效的 Ca2+ 通道阻滞剂,可激活 Ca2+ 结合蛋白的 EF 手。CALP3 可以通过调节钙调蛋白 (CaM),Ca2+ 通道和泵的活性来模拟增加的 [Ca2+]i。CALP3 具有控制诸如艾滋病或由于缺血引起的神经元丢失等疾病中细胞凋亡的潜力。

CALP3amp;;

CALP3 Chemical Structure

CAS No. : 261969-05-5

规格 价格 是否有货 数量
1 mg ¥1500 In-stock
5 mg ¥6000 In-stock
10 mg ¥9900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

CALP3 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Membrane Transporter/Ion Channel Compound Library
  • Neuronal Signaling Compound Library
  • Anti-Cancer Compound Library
  • Neuroprotective Compound Library
  • Peptide Library

生物活性

CALP3, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia[1][2].

IC50 Target

Ca2+

;

体外研究
(In Vitro)

CALP3 (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca2+]i in a dose-dependent manner (IC50=37.25 μM) in Fura-2-loaded neuronal cultures[1].
CALP3 (50, 100, 150, 200 μM) inhibits glutamate-induced cytotoxicity in a dose-dependent manner (IC50=50.97 μM) in cultured rat neocortical neurons. CALP3 causes dose-dependent inhibition of apoptosis (IC50=33.41 μM)[1].
CALP3 (100 μM) inhibits apoptosis induced by HIV gp120 and SAg in Human T cells[1].
CALP3 (100 μM; 15 min pretreatment) reduces gossypol-induced necrosis and increases the fraction of live cells[2].
Cyclic-CALP3 is synthesized starting from Fmoc-Asp(PEG-PS)-OAl. Cyclic CALP3 is unable to inhibit Ca21 influx, and this peptide served as a negative control. Cyclic CALP3 does not inhibit the effect of glutamate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

881.07

Formula

C44H68N10O9

CAS 号

261969-05-5

Sequence Shortening

VKFGVGFK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 12.5 mg/mL (14.19 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1350 mL 5.6749 mL 11.3498 mL
5 mM 0.2270 mL 1.1350 mL 2.2700 mL
10 mM 0.1135 mL 0.5675 mL 1.1350 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 1.25 mg/mL (1.42 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (1.42 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (1.42 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (1.42 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 1.25 mg/mL (1.42 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (1.42 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Manion MK, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306.

    [2]. Ferdek PE, et al. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death Dis. 2017 Mar 2;8(3):e2640.

Englerin A

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Englerin A 

Englerin A 是一种有效和选择性的 TRPC4TRPC5 通道的活化剂,EC50 值分别为 11.2 和 7.6 nM。Englerin A 通过增加 Ca2+ 内流和 Ca2+ 细胞超负荷来诱导肾癌细胞死亡。

Englerin A

Englerin A Chemical Structure

CAS No. : 1094250-15-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload[1][2][3].

IC50 & Target[1]

hTRPC4

11.2 nM (EC50)

hTRPC5

7.6 nM (EC50)

体外研究
(In Vitro)

Englerin A (0.15-2500 nM; 48 h) characteristic concentration-dependent suppresses cells growth of the A-498 cells treated with the control siRNA while has little effect on the growth of cells treated with TRPC4 siRNAs[3].
Englerin A (0.001nM-10 μM; 48 h) inhibits cells viability in HEK293T cells overexpressing TRPC5[3].
Englerin A (3 nM; 1-240 s) evokes sustained elevation of the intracellular Ca2+ concentration within 1 min in HEK 293 cells over-expressing human TRPC4[1].
Englerin A (0.1-1000 nM; 1-300 s) evokes intracellular Ca2+ elevations in A498 cells as well with an EC50 of 10 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Englerin A (5 mg/kg; i.p daily except Sunday) markedly inhibits tumor growth during the 2-week treatment period in mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

442.54

Formula

C26H34O6

CAS 号

1094250-15-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Akbulut Y, et, al. (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91.

    [2]. Rubaiy HN, et, al. Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels. Br J Pharmacol. 2018 Mar; 175(5):830-839.

    [3]. Carson C, et, al. Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation. PLoS One. 2015 Jun 22;10(6):e0127498.

    [4]. Sourbier C, et, al. Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. Cancer Cell. 2013 Feb 11;23(2):228-37.

C080A090C-东洋CA膜0.8um醋酸纤维过滤膜

  • 型号 C080A090C
  • 品牌 ADVANTEC东洋
  • 【简单介绍】

    东洋CA膜0.8um醋酸纤维过滤膜 C080A090C孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径90mm,25

     

    东洋ADVANTEC醋酸纤维素滤膜0.8um,孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径90mm,25PK

    东洋CA膜0.8um醋酸纤维过滤膜 C080A090C

    订货信息:

    滤膜 C020A013A 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径13mm,100

    滤膜 C020A025A 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径25mm,100

    滤膜 C020A037A 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径37mm,100

    滤膜 C020A047A 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径47mm,100

    滤膜 C020A050A 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径50mm,100

    滤膜 C020A070C 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径70mm,25

    滤膜 C020A082C 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径82mm,25

    滤膜 C020A090C 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径90mm,25

    滤膜 C020A142C 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径142mm,25

    滤膜 C020A293C 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径293mm,25

    滤膜 C020A293H 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,60mm中孔,直径293mm,25

    滤膜 C020A304C 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径300x300mmmm,25

    滤膜 C020A330R 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,未灭菌,直径330mmx3Mmm,1

    滤膜 C020G047A 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,灭菌1片/包,直径47mm,100

    滤膜 C020G050A 醋酸纤维素(CA),孔径0.2um,白色,无格线,无吸收垫,灭菌1片/包,直径50mm,100

    滤膜 C045A013A 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径13mm,100

    滤膜 C045A025A 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径25mm,100

    滤膜 C045A037A 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径37mm,100

    滤膜 C045A047A 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径47mm,100

    滤膜 C045A050A 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径50mm,100

    滤膜 C045A070C 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径70mm,25

    滤膜 C045A082C 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径82mm,25

    滤膜 C045A090C 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径90mm,25

    滤膜 C045A102C 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径102mm,25

    滤膜 C045A142C 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径142mm,25

    滤膜 C045A293C 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径293mm,25

    滤膜 C045A293H 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,60mm中孔,直径293mm,25

    滤膜 C045A304C 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径300x300mmmm,25

    滤膜 C045A330R 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,未灭菌,直径330mmx3Mmm,1

    滤膜 C045G047A 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,灭菌1片/包,直径47mm,100

    滤膜 C045G085A 醋酸纤维素(CA),孔径0.45um,白色,无格线,无吸收垫,灭菌1片/包,直径85mm,100

    滤膜 C080A013A 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径13mm,100

    滤膜 C080A025A 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径25mm,100

    滤膜 C080A037A 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径37mm,100

    滤膜 C080A047A 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径47mm,100

    滤膜 C080A050A 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径50mm,100

    滤膜 C080A082C 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径82mm,25

    滤膜 C080A090C 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径90mm,25

    滤膜 C080A142C 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径142mm,25

    滤膜 C080A293C 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径293mm,25

    滤膜 C080A293H 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,60mm中孔,直径293mm,25

    滤膜 C080A304C 醋酸纤维素(CA),孔径0.8um,白色,无格线,无吸收垫,未灭菌,直径300x300mmmm,25

    滤膜 C300A013A 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,直径13mm,100

    滤膜 C300A025A 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,直径25mm,100

    滤膜 C300A037A 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,直径37mm,100

    滤膜 C300A047A 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,直径47mm,100

    滤膜 C300A050A 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,直径50mm,100

    滤膜 C300A090C 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,直径90mm,25

    滤膜 C300A142C 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,直径142mm,25

    滤膜 C300A293C 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,直径293mm,25

    滤膜 C300A293H 醋酸纤维素(CA),孔径3um,白色,无格线,无吸收垫,未灭菌,60mm中孔,直径293mm,25

Yangambin

天然产物 天然产物苯丙素类 Phenylpropanoids

Yangambin  纯度: ≥98.0%

Yangambin 是一种呋喃木脂素 (furofuran lignan),已经从诸如番荔枝科 (Annonaceae family) 的植物中分离出来,包括:R. pickeli,R. exalbida 和 R. mucosa 以及 Magnolia biondii。 Yangambin 是一种选择性 PAF 受体拮抗剂,通过调控 Ca2+ 通道抑制 Ca2+ 流入,导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少。Yangambin 表现出对 β-氨基己糖苷酶 (β-hexosaminidase) 的抗过敏活性,IC50 为 33.8 μM,抗炎活性的 IC50 为 37.4 μM。

Yangambin

Yangambin Chemical Structure

CAS No. : 13060-14-5

规格 价格 是否有货 数量
5 mg ¥8800 In-stock
10 mg ¥15000 In-stock
50 mg   询价  
100 mg   询价  

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Yangambin 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2].

IC50 & Target[1]

Ca2+

 

分子量

446.49

Formula

C24H30O8

CAS 号

13060-14-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Araújo IG, et al. Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin. Molecules. 2014 May 23;19(5):6863-76.

    [2]. Jindaporn Puripattanavong, et al. Anti-allergic and anti-inflammatory compounds from Aglaia andamanica leaves. Songklanakarin J. Sci. Technol. 2015,37 (1), 37-41.

sartorius Sartoclean CA 滤芯5622506A1 5622506A1


sartorius Sartoclean CA 滤芯5622506A1

sartorius Sartoclean CA 滤芯5622506A1 蛋白吸附量zui低的预过滤滤芯 sartorius Sartoclean CA 滤芯5622506A1 有标准过滤滤芯,微型滤芯,为工艺放大提供zui全mian的产品规格,方便用于不同的工艺体积 sartorius Sartoclean CA 滤芯 0.45μm 应用于诸如血浆分离,疫苗,纯化蛋白质溶液,或含有保护剂的溶液的膜预过滤。

sartorius Sartoclean CA 过滤器滤芯 5622506A1

Sartoclean CA 过滤器滤芯是生物医药领域颗粒去除和生物负荷减少的预过滤应用的理想选择。它们能够通过体积排阻实现特定截留的性能。

Sartoclean CA 预过滤器的使用能够避免下游chu菌级膜过滤器过早出现堵塞并且对过滤系统的经济设计具有重要作用。

单层的 Sartoclean CA (0.45μm,0.2μm)过滤器为微生物截留过滤提供了*大流速。

具备有多种过滤面积和不同接口形式,可满足您的应用和安装要求。为了线性放大和放宽工艺灵活性, Sartoclean CA 过滤器还可提供Maxicaps,囊式滤器和小型滤芯。

支撑层:聚丙烯

结构化合物:聚丙烯

O形圈:硅胶

xi菌内**:经LAL测试<0.18EU/ml

抽取物:产品达到或超过现行USP关于“注射用无菌水”的质量标准

生物安全性:滤器所有元件的材质都通过目前USP塑料VI及生物反应测试(全身注射,皮内和植入测试)。

mie菌:在线蒸汽mie菌,zui少25次,134°C,20分钟,zui大差压0.5bar/7psi

           高压mie菌 zui少25次,134°C,2bar/29psi,30分钟,或其他确定参数

膜材料:醋酸纤维素

zui大压差:20°C 5bar  80°C 2bar

接合器:25(s-连接头顶部  带226双O形圈底部的锁定卡口适配器)