Chrysophanol triglucoside(Synonyms: 大黄酚-1-O-Β-三葡萄糖苷)

天然产物 糖类和糖苷 Saccharides and Glycosides

Chrysophanol triglucoside;(Synonyms: 大黄酚-1-O-Β-三葡萄糖苷)

Chrysophanol triglucoside 是一种从决明子中分离出的蒽醌类化合物,可抑制蛋白酪氨酸磷酸酶 1B (PTP1B)α-glucosidaseIC50 值分别为80.17 和 197.06 µM。Chrysophanol triglucoside 具有糖尿病研究的潜力。

Chrysophanol triglucoside(Synonyms: 大黄酚-1-O-Β-三葡萄糖苷)

Chrysophanol triglucoside Chemical Structure

CAS No. : 120181-07-9

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生物活性

Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC50s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research[1].

IC50 Target

IC50: 80.17 µM (PTP1B), 197.06 µM (α-glucosidase)[1]

分子量

740.66

Formula

C33H40O19

CAS 号

120181-07-9

中文名称

大黄酚-1-O-Β-三葡萄糖苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jung HA, et, al. Promising Inhibitory Effects of Anthraquinones, Naphthopyrone, and Naphthalene Glycosides, from Cassia obtusifolia on α-Glucosidase and Human Protein Tyrosine Phosphatases 1B. Molecules. 2016 Dec 27; 22(1): 28.

Chrysophanol(Synonyms: 大黄酚; Chrysophanic acid)

天然产物醌类Quinones

Chrysophanol (Synonyms: 大黄酚; Chrysophanic acid) 纯度: 99.34%

Chrysophanol (Chrysophanic acid) 是一种天然蒽醌,抑制EGF-诱导的 EGFR 磷酸化,且抑制 AKTmTOR/p70S6K 激活。

Chrysophanol(Synonyms: 大黄酚; Chrysophanic acid)

Chrysophanol Chemical Structure

CAS No. : 481-74-3

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生物活性

Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.

IC50 & Target[1]

EGFR

 

体外研究
(In Vitro)

Chrysophanol (Chrysophanic Acid) blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Chrysophanol, a natural anthraquinone, has anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanol treatment in SNU-C5 cells inhibits EGF-induced phosphorylation of EGFR and suppresses activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of Rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanol (80 and 120 μM) significantly blocks cell proliferation when combined with the mTOR inhibitor, Rapamycin. Chrysophanol inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K, and significantly blocks cell proliferation. Chrysophanol dose dependently decreases CCK-8 and the viability of EGFR-overexpressing SNU-C5 cells. Chrysophanol treatment dose-dependently decreases EGF induced phosphorylation of EGFR at Tyr1068. Chrysophanol (80 and 120 μM) reduces the phosphorylation levels of mTOR at Ser2448. Chrysophanol (80 and 120 μM) also decreases the phosphorylation levels of p70S6K at Thr389. Chrysophanol inhibits EGF-induced EGFR activation and suppresses activation of the downstream signaling molecules, AKT and mTOR/p70S6K[1]. Chrysophanol (CA) inhibits lipid accumulation in 3T3-L1 adipocytes. Chrysophanol down-regulates adipogenic factors in 3T3-L1 adipocytes. Chrysophanol induces thermogenic factors in primary cultured brown adipocytes. Chrysophanol suppresses adipogenesis and induces thermogenesis via activation of AMPK pathway[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Chrysophanol (CA) improves HFD-induced obesity in C57BL/6 Mice. The in vivo performance of Chrysophanol is performed in male C57BL/6J mice to determine the efficacy of administered Chrysophanol. Mice fed the HFD gained significantly more weight than those fed the standard diet mice. On the other hand, weight gain of Chrysophanol group is significantly less than with the untreated HFD. Mice in the HFD-group gained 23.92 ± 1.74 g of weight, while those in the Chrysophanol group gained 16.72±2 g of weight after 16 weeks[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

254.24

Formula

C15H10O4

CAS 号

481-74-3

中文名称

大黄酚;大黄根酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 2 mg/mL (7.87 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9333 mL 19.6665 mL 39.3329 mL
5 mM 0.7867 mL 3.9333 mL 7.8666 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Lee MS, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25(6):833-7.

    [2]. Lim H, et al. Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol. 2016 Dec 8;7:476.

Cell Assay
[1]

The cells are seeded at 5×103 cells/mL in 96-well microplates and allowed to attach for 24 h. Chrysophanol (20, 50, 80 and 120 μM) is added to the medium at various concentrations up to 120 μM and for different durations. After treatment, cell cytotoxicity and/or proliferation is assessed by a Cell Counting Kit-8 (CCK-8). Briefly, highly water-soluble tetrazolium salt, WST-8, produces an orange colored water-soluble product, formazan. The amount of formazan dye generated by dehydrogenases in cells is directly proportional to the number of living cells.CCK-8 (10 μL) is added to each well and incubated for 3 h at 37°C, then cell proliferation and cytotoxicity are assessed by measuring the absorbance at 450 nm using a microplate reader.Three replicated wells are used for each experimental condition[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Mice[2]
Male 4-week-old C57BL/6J mice are maintained for 1 week prior to experiments. Mice are maintained on a 12-h light/dark cycle in a pathogen-free animal facility, provided with laboratory diet and water ad libitum. To induce obesity, the mice are fed a HFD with 60% kcal% fat. Control group (C) are fed a commercial standard chow diet. HFD group (HFD) mice are fed with HFD only. HFD plus CA group (CA) Mice are fed with HFD for 4 weeks before administration of Chrysophanol (5 mg/kg/day). The mice are divided into three groups (n = 5) that are fed chow diet, HFD, and HFD plus Chrysophanol for 16 weeks. Body weight and food intake are measured three times per week.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Lee MS, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25(6):833-7.

    [2]. Lim H, et al. Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol. 2016 Dec 8;7:476.

8-Methyl Chrysophanol(Synonyms: Chrysophanol 8-methyl ether)

天然产物醌类Quinones

8-Methyl Chrysophanol (Synonyms: Chrysophanol 8-methyl ether)

8-Methyl Chrysophanol 是从Senna macranth 树皮中分离得到的一种蒽醌。

8-Methyl Chrysophanol(Synonyms: Chrysophanol 8-methyl ether)

8-Methyl Chrysophanol Chemical Structure

CAS No. : 3300-25-2

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生物活性

8-Methyl Chrysophanol is an anthraquinone isolated from the bark of Senna macranth[1].

分子量

268.26

Formula

C16H12O4

CAS 号

3300-25-2

中文名称

8-甲基大黄酚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Alexsandro Branco, et al. Anthraquinones from the bark of Senna macranthera. An Acad Bras Cienc. 2011 Dec;83(4):1159-64.

Chrysophanol 8-O-glucoside(Synonyms: 大黄酚-8-O-葡萄糖苷)

天然产物醌类Quinones

Chrysophanol 8-O-glucoside (Synonyms: 大黄酚-8-O-葡萄糖苷)

Chrysophanol 8-O-glucoside 来自 Rumex acetosa 根部,具有中等的弹性蛋白酶抑制活性。

Chrysophanol 8-O-glucoside(Synonyms: 大黄酚-8-O-葡萄糖苷)

Chrysophanol 8-O-glucoside Chemical Structure

CAS No. : 13241-28-6

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生物活性

Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity[1].

分子量

416.38

Formula

C21H20O9

CAS 号

13241-28-6

中文名称

大黄酚-8-O-葡萄糖苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. T. Annamalai, et al. Pulmatin from the roots of Rumex acetosa. Scholars Research Library. Der Pharmacia Lettre, 2013, 5 (5):116-119.

Chrysophanol tetraglucoside

天然产物 糖类和糖苷 Saccharides and Glycosides

Chrysophanol tetraglucoside;

Chrysophanol tetraglucoside possesses 具有抗血脂和抗细菌的活性。

Chrysophanol tetraglucoside

Chrysophanol tetraglucoside Chemical Structure

CAS No. : 120181-08-0

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生物活性

Chrysophanol tetraglucoside possesses anti-hypolipidemic and antibacterial activities[1][2].

分子量

902.80

Formula

C39H50O24

CAS 号

120181-08-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. T Hatano, et al. Phenolic constituents of Cassia seeds and antibacterial effect of some naphthalenes and anthraquinones on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull (Tokyo). 1999 Aug;47(8):1121-7.

    [2]. Umesh K Patil, et al. Hypolipidemic activity of seeds of Cassia tora Linn. J Ethnopharmacol. 2004 Feb;90(2-3):249-52.