[1]. Choi MG, et al. A fluorogenic method for measuring enteropeptidase activity: spectral shift in the emission of GD4K-conjugated 7-amino-4-methylcoumarin.BMB Rep. 2011 Jul;44(7):458-61.
Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line[1][2].
分子量
190.15
Formula
C10H6O4
CAS 号
531-81-7
中文名称
香豆素-3-羧酸
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Aimin Song, et al. A convenient synthesis of coumarin-3-carboxylic acids via Knoevenagel condensation of Meldrum’s acid with ortho-hydroxyaryl aldehydes or ketones. Tetrahedron Letters. 2003 Feb;44(9): 1755-1758.
[2]. Kostova I, et al. New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents. Met Based Drugs. 2007;2007:15925.
Coumarin 7 is a coumarin laser dye in plants in the form of glycosides[1][2].
体外研究 (In Vitro)
Coumarin 7 has the maximum CL intensity (Imax=0.39×10-9 photon/s•ml), total amount of light (S=0.07×10-10 photon/ml) and the yield of CL (φCL=0.12×108 Einstein/mol)[2]
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
333.38
Formula
C20H19N3O2
CAS 号
27425-55-4
中文名称
香豆素7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Sowrirajan Chandrasekaran, et al. Interaction of Coumarin 7 and Coumarin 314 with C-hexylpyrogallol[4]arene. 25 January 2014
[2]. Kazakov DV, et al. Chemiluminescence in the reaction of 1,2,4,5-tetraoxanes with ferrous ions in the presence of xanthene dyes: fundamentals and perspectives of analytical applications. Photochem Photobiol Sci. 2019 May 15;18(5):1130-1137.
Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.
分子量
146.14
Formula
C9H6O2
CAS 号
91-64-5
中文名称
香豆素
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Liu M, et al. Quantitative analysis of nine coumarins in rat urine and bile after oral administration of Radix Glehniae extract by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Biomed Chromatogr. 2011 Jul;25(7):783-93.
7-Amino-4-(trifluoromethyl)coumarin Chemical Structure
CAS No. : 53518-15-3
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7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.
体外研究 (In Vitro)
Amino acid and peptide derivatives of 7-amino-4-(trifluoromethyl)coumarin are used to monitor peptidase activities. Caspase activation is measured using the fluorogenic compound N-acetyl-asp-glu-val-asp-7-Amino-4-(trifluoromethyl)coumarin (Ac-DEVD-AFC). This substrate rapidly enters cells where it is efficiently cleaved at the aspartate residue by specific caspases, yielding the fluorescent compound 7-Amino-4-(trifluoromethyl)coumarin (AFC). Following cell disruption, released 7-Amino-4-(trifluoromethyl)coumarin is separated on HPLC and detected by fluorescence. The appearance of 7-Amino-4-(trifluoromethyl)coumarin in cells is blocked by the pancaspase inhibitor benzyloxycarbonyl-val-ala-asp-fluoromethylketone, thus establishing that intracellular caspases are responsible for the cleavage[1]. γ-glutamyl-7-amino-4-(trifluoro-methyl)coumarin is synthesized and used as a substrate for fluirimetric assay of γ-gluta-myltranspeptidase. The reaction product 7-amino-4-(trifluoromethyl)coumarin is fluorescent at neutral pH values and with excitation and emission wavelengths of 400 and 490 nm, respectively, concentration is linearly related to fluorescence over the range of 10 to 300 pmol/3 mL reaction mixture[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
229.16
Formula
C10H6F3NO2
CAS 号
53518-15-3
中文名称
香豆素151;7-氨基-4-氟甲醇
运输条件
Room temperature in continental US; may vary elsewhere.
7-Amino-4-(trifluoromethyl)coumarin Chemical Structure
CAS No. : 53518-15-3
规格
价格
是否有货
数量
Free Sample (0.1-0.5 mg)
;
Apply now
;
100 mg
¥660
In-stock
200 mg
;
询价
;
500 mg
;
询价
;
* Please select Quantity before adding items.
7-Amino-4-(trifluoromethyl)coumarin 相关产品
bull;相关化合物库:
Bioactive Compound Library Plus
Fragment Library
Medicine Food Homology Compound Library
生物活性
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.
体外研究 (In Vitro)
Amino acid and peptide derivatives of 7-amino-4-(trifluoromethyl)coumarin are used to monitor peptidase activities. Caspase activation is measured using the fluorogenic compound N-acetyl-asp-glu-val-asp-7-Amino-4-(trifluoromethyl)coumarin (Ac-DEVD-AFC). This substrate rapidly enters cells where it is efficiently cleaved at the aspartate residue by specific caspases, yielding the fluorescent compound 7-Amino-4-(trifluoromethyl)coumarin (AFC). Following cell disruption, released 7-Amino-4-(trifluoromethyl)coumarin is separated on HPLC and detected by fluorescence. The appearance of 7-Amino-4-(trifluoromethyl)coumarin in cells is blocked by the pancaspase inhibitor benzyloxycarbonyl-val-ala-asp-fluoromethylketone, thus establishing that intracellular caspases are responsible for the cleavage[1]. γ-glutamyl-7-amino-4-(trifluoro-methyl)coumarin is synthesized and used as a substrate for fluirimetric assay of γ-gluta-myltranspeptidase. The reaction product 7-amino-4-(trifluoromethyl)coumarin is fluorescent at neutral pH values and with excitation and emission wavelengths of 400 and 490 nm, respectively, concentration is linearly related to fluorescence over the range of 10 to 300 pmol/3 mL reaction mixture[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
229.16
Formula
C10H6F3NO2
CAS 号
53518-15-3
中文名称
香豆素151;7-氨基-4-氟甲醇
运输条件
Room temperature in continental US; may vary elsewhere.
Coumarin hydrazine is a fluorescent chemical probe (λex=420–450/λem=468 nm) to label cellular protein- and lipid-bound carbonyls[1].
分子量
190.20
Formula
C10H10N2O2
CAS 号
113707-87-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Venukumar Vemula, et al. Fluorescence labeling of carbonylated lipids and proteins in cells using coumarin-hydrazide. Redox Biol. 2015 Aug;5:195-204.
Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems[1].
分子量
350.43
Formula
C20H18N2O2S
CAS 号
38215-36-0
中文名称
香豆素 6
运输条件
Room temperature in continental US; may vary elsewhere.