标签归档：cyclodextrin

SBE-β-CD(Synonyms: 磺丁基-β-环糊精; Sulfobutylether-β-Cyclodextrin)

发表于由

生化分析试剂 Biochemical Assay Reagents
SBE-β-CD;(Synonyms: 磺丁基-β-环糊精; Sulfobutylether-β-Cyclodextrin) 纯度: ge;98.0%

SBE-β-CD 是磺基丁基醚 β-cyclodextrin 衍生物，其用作赋形剂或助溶剂以增加难溶性药物的溶解度。

SBE-β-CD(Synonyms: 磺丁基-β-环糊精; Sulfobutylether-β-Cyclodextrin)

SBE-β-CD Chemical Structure

CAS No. : 182410-00-0

规格 价格 是否有货 数量
500 mg ￥500 In-stock
1 g ￥880 In-stock
5 g ￥1534 In-stock
10 g ￥2500 In-stock
25 g ￥5000 In-stock
50 g ￥9000 In-stock
> 100 g ; 询价 ;

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生物活性

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents[1].

体外研究
(In Vitro)

SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

20% SBE-β-CD in saline:
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2083-2257

CAS 号

182410-00-0
中文名称

磺丁基-β-环糊精；磺丁基醚-β-环糊精
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture and light
溶解性数据
In Vitro:;

H2O : 125 mg/mL (Need ultrasonic)
参考文献

  • [1]. Fukuda M, et al.Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion.Int J Pharm. 2008 Feb 28;350(1-2):188-196

    [2]. Charman SA, et al. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb;95(2):256-67
Animal Administration
[2]

Rats[2]
A 300 g rat is administered with 1 mL of a 0.1 M SBE-β-CD solution containing 5.64 mg of Compound 1, and assuming an extracellular volume of 90 mL, less than 0.1% of the complex would rapidly dissociate due to the initial effects of dilution. This calculation, combined with the changing blood to plasma ratio in the presence of SBE-β-CD, provides a reasonable explanation for the observed differences in the blood and plasma profiles of Compound 1 after intravenous administration in either the cyclodextrin or cyclodextrin-free formulations. After IV administration of the cyclodextrin formulation, Compound 1 would initially be prevented from distributing into erythrocytes thereby resulting in a whole blood to plasma ratio of less than one. Subsequently, clearance of SBE-β-CD from the circulation would lead to changes in the complexation equilibrium such that the unbound fraction of Compound 1 would increase, thereby reestablishing normal blood to plasma partitioning (i.e. in favour of whole blood) and clearance.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Fukuda M, et al.Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion.Int J Pharm. 2008 Feb 28;350(1-2):188-196

    [2]. Charman SA, et al. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb;95(2):256-67

(2-Hydroxypropyl)-β-cyclodextrin(Synonyms: 羟丙基-β-环糊精; Hydroxypropyl betadex; Hydroxypropyl-β-cyclodextrin; HP-β-CD)

发表于由

生化分析试剂 Biochemical Assay Reagents
(2-Hydroxypropyl)-β-cyclodextrin;(Synonyms: 羟丙基-β-环糊精; Hydroxypropyl betadex; Hydroxypropyl-β-cyclodextrin; HP-β-CD)

(2-Hydroxypropyl)-β-cyclodextrin是广泛使用的药物递送载体，可提高稳定性和利用度。

(2-Hydroxypropyl)-β-cyclodextrin(Synonyms: 羟丙基-β-环糊精; Hydroxypropyl betadex; Hydroxypropyl-β-cyclodextrin; HP-β-CD)

(2-Hydroxypropyl)-β-cyclodextrin Chemical Structure

CAS No. : 128446-35-5

规格 价格 是否有货 数量
500 mg ￥400 In-stock
1 g ￥500 In-stock
5 g ￥880 In-stock
10 g ￥1100 In-stock
50 g ; 询价 ;

* Please select Quantity before adding items.

(2-Hydroxypropyl)-beta;-cyclodextrin 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Drug Repurposing Compound Library
  • Anti-COVID-19 Compound Library
  • Anti-Blood Cancer Compound Library
  • Inactive Ingredient Library
  • Rare Diseases Drug Library
  • Childrenrsquo;s Drug Library

生物活性

(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.

体外研究
(In Vitro)

Cell treatment with (2-Hydroxypropyl)-β-cyclodextrin results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic clearance capacity[1]. (2-Hydroxypropyl)-β-cyclodextrin treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for (2-Hydroxypropyl)-β-cyclodextrin after 72 hours exposure are in the range of 3.86–10.09 mM. (2-Hydroxypropyl)-β-cyclodextrin also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by (2-Hydroxypropyl)-β-cyclodextrin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

(2-Hydroxypropyl)-β-cyclodextrin administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder[1]. Intraperitoneal injection of (2-Hydroxypropyl)-β-cyclodextrin significantly improves survival in leukemia mouse models. Systemic administration of (2-Hydroxypropyl)-β-cyclodextrin to mice has no significant adverse effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

CAS 号

128446-35-5
中文名称

羟丙基-β-环糊精
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 50 mg/mL (Need ultrasonic)

H2O : 50 mg/mL (Need ultrasonic)

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;Saline

    Solubility: 200 mg/mL (Infinity mM); Clear solution; Need ultrasonic

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (Infinity mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (Infinity mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 4.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (Infinity mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (Infinity mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Song W, et al. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4;289(14):10211-22.

    [2]. Yokoo M, et al. 2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. PLoS One. 2015 Nov 4;10(11):e0141946.
Cell Assay
[2]

Cells are incubated with (2-Hydroxypropyl)-β-cyclodextrin at various concentrations (5, 7.5, 10, 15, 20 mM) for 72 hours. Cell viability is assessed using a trypan blue dye exclusion method and cell proliferation is evaluated using a modified methyl-thiazol-diphenyl- tetrazolium (MTT) assay[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Mice: Mice are intraperitoneally injected with 200 μL vehicle (saline) or (2-Hydroxypropyl)-β-cyclodextrin (50 or 150 mM) for 20 consecutive days 3 days after transplantation, and survival is monitored daily. Leukemic cell engraftment is confirmed by detection of GFP-positive cells in the recipient’s BM using flow cytometry[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Song W, et al. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4;289(14):10211-22.

    [2]. Yokoo M, et al. 2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. PLoS One. 2015 Nov 4;10(11):e0141946.

Methyl-β-cyclodextrin(Synonyms: 甲基-β-环糊精; Methyl-beta-cyclodextrin)

发表于由

生化分析试剂 Biochemical Assay Reagents
Methyl-β-cyclodextrin;(Synonyms: 甲基-β-环糊精; Methyl-beta-cyclodextrin) 纯度: 99.91%

Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) 是一种环庚糖，对非极性物质有增溶作用，广泛应用于疏水性药物的释放。Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) 也广泛用作降胆固醇剂。Methyl-β-cyclodextrin 可显著降低网格蛋白依赖性内吞作用。

Methyl-β-cyclodextrin(Synonyms: 甲基-β-环糊精; Methyl-beta-cyclodextrin)

Methyl-β-cyclodextrin Chemical Structure

CAS No. : 128446-36-6

规格 价格 是否有货 数量
500 mg ￥400 In-stock
1 g ￥500 In-stock
5 g ￥700 In-stock
10 g ￥1000 In-stock
25 g ￥1900 In-stock
50 g ￥2400 In-stock
> 100 g ; 询价 ;

* Please select Quantity before adding items.

生物活性

Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic drugs based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent[1]. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis[2].

体外研究
(In Vitro)

Methyl-β-cyclodextrin is extensively used to increase the permeability of cells, and thereby increase the uptake of small molecules such as glucose and nano-particles[3].
Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrins molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs[3].
Methyl-β-cyclodextrin quickly induces caspase-dependent apoptosis in PEL cells via cholesterol depletion from the plasma membrane. Methyl-β-cyclodextrin inhibits the growth of all PEL cell lines in a dose-dependent manner. The IC50 is 3.33-4.23 mM in each cell line[4].
Methyl-β-cyclodextrin is a highly water soluble cyclic heptasaccharide consisting of a β-glucopyranose unit, has been reported as the most effective agent for the depletion of cholesterol from cells among the various cholesterol-depleting agents[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In a PEL xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice[3].
Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. Currently, there are approximately 30 different pharmaceutical products worldwide containing drug/cyclodextrins complexes in the market[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1310 (Average)

CAS 号

128446-36-6
中文名称

甲基-β-环糊精
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
溶解性数据
In Vitro:;

DMSO : ≥ 100 mg/mL

H2O : ≥ 50 mg/mL

* “≥” means soluble, but saturation unknown.
参考文献

  • [1]. Mundhara N, et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638.

    [2]. Rodal SK, et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999;10(4):961-974.

    [3]. Chen X, et al. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20;277(51):49631-7.

    [4]. Gotoh K, et al. The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):285-9.

    [5]. Tiwari G, et al. Cyclodextrins in delivery systems: Applications. J Pharm Bioallied Sci. 2010 Apr;2(2):72-9.
Cell Assay
[1]

PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice: Female NRJ mice are intraperitoneally inoculated with BCBL-1 cells suspended in PBS. The mice are then treated with intraperitoneal injections of PBS or methyl-β-cyclodextrin (500 mg/kg per day). Tumor burdens are evaluated by measuring body weights and ascites[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Mundhara N, et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638.

    [2]. Rodal SK, et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999;10(4):961-974.

    [3]. Chen X, et al. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20;277(51):49631-7.

    [4]. Gotoh K, et al. The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):285-9.

    [5]. Tiwari G, et al. Cyclodextrins in delivery systems: Applications. J Pharm Bioallied Sci. 2010 Apr;2(2):72-9.

6-O-α-Maltosyl-β-cyclodextrin(Synonyms: 6-O-alpha-D-Maltosyl-beta-cyclodextrin)

发表于由

生化分析试剂 Biochemical Assay Reagents
6-O-α-Maltosyl-β-cyclodextrin;(Synonyms: 6-O-alpha-D-Maltosyl-beta-cyclodextrin) 纯度: ge;98.0%

6-O-α-Maltosyl-β-cyclodextrin 是一种环糊精衍生物。6-O-α-Maltosyl-β-cyclodextrin 是一种细胞胆固醇修饰剂，能与胆固醇形成可溶性复合体。

6-O-α-Maltosyl-β-cyclodextrin(Synonyms: 6-O-alpha-D-Maltosyl-beta-cyclodextrin)

6-O-α-Maltosyl-β-cyclodextrin Chemical Structure

CAS No. : 104723-60-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥500 In-stock
500 mg ￥400 In-stock
1 g ￥500 In-stock
5 g ￥1350 In-stock
10 g ; 询价 ;
50 g ; 询价 ;

* Please select Quantity before adding items.

6-O-alpha;-Maltosyl-beta;-cyclodextrin 相关产品

bull;相关化合物库:

  • Natural Product Like Compound Library
  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library
  • Glycoside Compound Library

生物活性

6-O-α-Maltosyl-β-cyclodextrin is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol.

体外研究
(In Vitro)

6-O-α-Maltosyl-β-cyclodextrin (Mal-βCD) removes cellular cholesterol forming inclusion complexes, while 6-O-α-Maltosyl-β-cyclodextrin-induced lack of cellular cholesterol is replenished by the addition of cholesterol/6-O-α-Maltosyl-β-cyclodextrin inclusion complex (CLM) without cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1459.27

Formula

C54H90O45
CAS 号

104723-60-6
中文名称

6-O-α-D-麦芽糖-β-环糊精；6-O-α-麦芽糖基-β-环糊精
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : ≥ 100 mg/mL (68.53 mM)

H2O : ≥ 60.5 mg/mL (41.46 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6853 mL 3.4264 mL 6.8527 mL
5 mM 0.1371 mL 0.6853 mL 1.3705 mL
10 mM 0.0685 mL 0.3426 mL 0.6853 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (1.71 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.71 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.71 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.71 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.71 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.71 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Okada Y, et al. Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. Carbohydr Res. 2012 Aug 1;357:68-74.

β-Cyclodextrin(Synonyms: β-环糊精)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

β-Cyclodextrin;(Synonyms: β-环糊精) 纯度: ge;98.0%

β-Cyclodextrin 是一种环状多糖，由 α-D-吡喃型葡萄糖单元通过 α-(1,4) 糖苷键连接而成。β-Cyclodextrin 通常用于增强药物的溶解度。β-Cyclodextrin 具有抗流感病毒 H1N1 的活性。

β-Cyclodextrin(Synonyms: β-环糊精)

β-Cyclodextrin Chemical Structure

CAS No. : 7585-39-9

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Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in Water ￥500 In-stock
500 mg ￥400 In-stock
1 g ￥500 In-stock
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生物活性

β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of drugs. β-Cyclodextrin has anti-influenza virus H1N1 activities.

体外研究
(In Vitro)

β-Cyclodextrin (Beta-cyclodextrin; β-CD) is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds, which presents a hydrophilic external surface and a hydrophobic internal cavity[1]. In the pharmaceutical industry, β-Cyclodextrin (β-CD) has often been used to enhance the solubility of drugs, such as indomethacin, naringin, celecoxib, and citric acid[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1134.98

Formula

C42H70O35
CAS 号

7585-39-9
中文名称

β-环糊精
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 38.75 mg/mL (34.14 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8811 mL 4.4054 mL 8.8107 mL
5 mM 0.1762 mL 0.8811 mL 1.7621 mL
10 mM 0.0881 mL 0.4405 mL 0.8811 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Campos EVR, et al. Chitosan nanoparticles functionalized with β-cyclodextrin: a promising carrier for botanicalpesticides. Sci Rep. 2018 Feb 1;8(1):2067.

    [2]. Cui L, et al. Effect of β-cyclodextrin complexation on solubility and enzymatic conversion of naringin. Int J Mol Sci. 2012 Nov 5;13(11):14251-61.

    [3]. Goncharova EP, et al. A Novel Sulfonated Derivative of β-Cyclodextrin Effectively Inhibits Influenza A Virus Infection in vitro and in vivo. Acta Naturae. 2019 Jul-Sep;11(3):20-30.

β-Cyclodextrin beta-环化糊精 品牌：FUJIFILM Wako

发表于由

β-Cyclodextrin

beta-环化糊精

品牌：FUJIFILM Wako
CAS No.：7585-39-9
储存条件：室温
纯度：98.0+% (HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

038-08343

 Wako 1st Grade 100g – 490.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

β-Cyclodextrin beta-环化糊精 品牌：FUJIFILM Wako

发表于由

β-Cyclodextrin

beta-环化糊精

品牌：FUJIFILM Wako
CAS No.：7585-39-9
储存条件：室温
纯度：98.0+% (HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

030-08342

 Wako 1st Grade 25g – 300.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

γ-Cyclodextrin 环糊精 品牌：FUJIFILM Wako

发表于由

γ-Cyclodextrin

环糊精

品牌：FUJIFILM Wako
CAS No.：17465-86-0
储存条件：室温
纯度：97.0+% (HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

031-10641

 Wako Special Grade 1g – 420.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

γ-Cyclodextrin 环糊精 品牌：FUJIFILM Wako

发表于由

γ-Cyclodextrin

环糊精

品牌：FUJIFILM Wako
CAS No.：17465-86-0
储存条件：室温
纯度：97.0+% (HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

039-10642

 Wako Special Grade 25g – 1,160.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

α-Cyclodextrin alpha-环化糊精 品牌：FUJIFILM Wako

发表于由

α-Cyclodextrin

alpha-环化糊精

品牌：FUJIFILM Wako
CAS No.：10016-20-3
储存条件：室温
纯度：97.0+% (HPLC)
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

033-08332

 Wako 1st Grade 25g – 930.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。