GRGDSPC

GRGDSPC;

GRGDSPC 是一种含 7 个氨基酸的多肽,是一种末端巯基化的细胞粘附肽。

GRGDSPCamp;;

GRGDSPC Chemical Structure

CAS No. : 91575-26-7

规格 价格 是否有货
1 mg ¥700 询问价格 货期
5 mg ¥2100 询问价格 货期
10 mg ¥3100 询问价格 货期

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生物活性

GRGDSPC, a 7-amino acid peptide, is a thiolated cell adhesion peptide[1].

体外研究
(In Vitro)

GRGDSPC is conjugated to acrylated dextran via thiol-acrylate reaction to regulate the interactions of human mesenchymal stem cells (hMSCs) with the photocrosslinkable hydrogels. To determine the conjugation kinetics and efficiency of GRGDSPC peptide to DEX-MAES16, various GRGDSPC concentrations (i.e., 5, 10 and 20 mg/1 g DEX-MAES16) are conjugated to the acrylated Dextran (DEX) macromer over time (0.25, 0.5, 1 and 3h) in PBS at pH 7.8 and the free thiol groups of unreacted peptides are quantified using Ellman’s assay. In addition, the reaction kinetics of the thiol-peptide to acrylated (DEX-MAES16) and methacrylated (DEX-HEMA16) macromers are compared. As early as 15 min conjugation, with 5, 10 and 20 mg of GRGDSPC peptide/1 g modified DEX, the peptide conjugation efficiencies with DEX-MAES are 105.40, 94.10 and 87.45%, respectively, while for the reaction with the DEX-HEMA they are 0.73, 15.78 and 18.42%, respectively. After 1h, the GRGDSPC conjugation with DEX-MAES is completed with the peptide concentration of 10 mg, but only 35.66% of the thiol groups of the peptide react with DEX-HEMA. The reaction kinetics are also monitored at 3 h of conjugation, and all of the 20 mg GRGDSPC peptide reacts with acrylated DEX compared to only 32.53% for the methacrylated DEX at this time point[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

690.73

Formula

C25H42N10O11S

CAS 号

91575-26-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Nguyen MK, et al. Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNAdelivery to hMSCs to enhance their osteogenic differentiation. J Mater Chem B. 2017 Jan 21;5(3):485-495.

Endomorphin 2(Synonyms: 内吗啡肽 2)

Endomorphin 2;(Synonyms: 内吗啡肽 2)

Endomorphin 2,一种高度选择性的高亲和力μ-opioid受体激动剂 , 对kappa3结合位点具有高亲和力 ,Ki为 20 到 30 nM 之间。

Endomorphin 2amp;;(Synonyms: 内吗啡肽 2)

Endomorphin 2 Chemical Structure

CAS No. : 141801-26-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Endomorphin 2 的其他形式现货产品:

Endomorphin 2 TFA

生物活性

Endomorphin 2, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.

IC50 Target

Ki: 20-30 nM (kappa3 opioid receptor)[1]

体外研究
(In Vitro)

Endomorphin 2 is an endogenous opioid peptide and one of the two Endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with Endomorphin 1 (EM-2). The two Endomorphins display reasonable affinities for kappa3 binding sites, with Ki values between 20 and 30 nM. Endomorphin 1 and Endomorphin 2 compete both μ1 and μ2 receptor sites quite potently. Endomorphins have little appreciable affinity for either delta or kappa1 binding sites, with Ki values greater than 500 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Both Endomorphin 1 and Endomorphin 2 are potent analgesics with peak effects seen at 10 and 15 min, respectively. All subsequent studies are performed at peak effect. Both compounds are fully active supraspinally and spinally, with no indication of ceiling effects. Endomorphin 1 is significantly more potent spinally than supraspinally and, at the spinal level, it is significantly more potent than Endomorphin 2. The response of both agents are readily reversed by naloxone. β-FNA, a highly selective μ antagonist, effectively reverses the actions of both Endomorphins. Both Endomorphin 1 and Endomorphin 2 display a profile similar to morphine. Neither compound have analgesic activity in CXBK mice at a dose which produced over 70% analgesia in control CD-1 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

571.67

Formula

C32H37N5O5

CAS 号

141801-26-5

Sequence

Tyr-Pro-Phe-Phe-NH2

Sequence Shortening

YPFF-NH2

中文名称

内吗啡肽 2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Goldberg IE, et al. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J Pharmacol Exp Ther. 1998 Aug;286(2):1007-13.

Kinase Assay
[1]

125I-Endomorphin 1 or 125I-Endomorphin 2 binding (0.2 nM) is performed in potassium phosphate buffer (50 mM, pH 7.4; 0.5 mL) with MgCl2 (5 mM) at a tissue concentration of 10 mg wet weight/mL for brains or 0.06 mg protein/mL for MOR-1/CHO cells. Specific binding is determined in the presence and absence of either 1 μM of the corresponding unlabeled peptide. The entire mixture is then incubated at 25°C for 1 hr and filtered over no. 32 glass fiber filters which have been presoaked for 1 hr in 0.5% polyethylenimine and washed twice with ice cold Tris buffer using a Brandel cell harvester. The filters are then counted on a Packard Cobra gamma counter. The other opioid receptor binding assays are performed[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Mice[1]
Groups of mice are treated i.c.v. with Endomorphin 1 (12 μg) or Endomorphin 2 (3 μg) 15 min before a 0.5-cc charcoal meal (2.5% gum tragacanth,10% activated charcoal in water). The mice are killed 30 min later and the distance the charcoal traveled is measured.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Goldberg IE, et al. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J Pharmacol Exp Ther. 1998 Aug;286(2):1007-13.

Platycodin D3(Synonyms: 桔梗皂苷 D3)

天然产物 糖类和糖苷 Saccharides and Glycosides

Platycodin D3 (Synonyms: 桔梗皂苷 D3) 纯度: ≥98.0%

Platycodin D3 是桔梗中的三萜皂苷类化合物,具有抗 HCV 活性。

Platycodin D3(Synonyms: 桔梗皂苷 D3)

Platycodin D3 Chemical Structure

CAS No. : 67884-03-1

规格 价格 是否有货 数量
1 mg ¥3430 In-stock
5 mg ¥10290 In-stock
10 mg   询价  
50 mg   询价  

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Platycodin D3 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Platycodin D3 is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity[1].

IC50 & Target

HCV[1]

分子量

1387.46

Formula

C63H102O33

CAS 号

67884-03-1

中文名称

桔梗皂苷 D3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Kim JW, et al. Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication. Evid Based Complement Alternat Med. 2013;2013:560417.

PMX-53(Synonyms: 3D53)

PMX-53;(Synonyms: 3D53) 纯度: 98.85%

PMX-53 (3D53) 是一种合成肽,也是一种有效的,具有口服活性的补体 C5a 受体 (CD88) 拮抗剂,IC50 为 20 nM。PMX-53 还是一种低亲和力的 MrgX2 激动剂,可刺激 MrgX2 介导的肥大细胞脱颗粒。PMX-53 特异性结合 C5aR1,不结合第二个 C5aR (C5L2) 和 C3aR。PMX-53 具有抗炎,抗癌和抗动脉粥样硬化作用。

PMX-53amp;;(Synonyms: 3D53)

PMX-53 Chemical Structure

CAS No. : 219639-75-5

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ¥6900 In-stock
1 mg ¥2000 In-stock
5 mg ¥4500 In-stock
10 mg ¥7000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

PMX-53 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Anti-Cancer Compound Library
  • Macrocyclic Compound Library
  • Anti-Cardiovascular Disease Compound Library
  • Peptide Library

生物活性

PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects[1][2][3][4][5][6].

IC50 Target

IC50: 20 nM (Complement C5a receptor)[4]
MrgX2[1]

体外研究
(In Vitro)

PMX-53 is a potent CD88 antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively[1].
PMX-53 (10 nM) inhibits C5a-induced Ca2+ mobilization in HMC-1 cells, but at higher concentrations( ≥30 nM) it causes degranulation in LAD2 mast cells, CD34+ cell-derived mast cells, and RBL-2H3 cells stably expressing MrgX2. Replacement of Trp with Ala and Arg with dArg abolishes the ability of PMX-53 to inhibit C5a-induced Ca2+ mobilization in HMC-1 cells and to cause degranulation in RBL-2H3 cells expressing MrgX2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

PMX-53 (0.3-3 mg/kg; subcutaneous injection; once; male Wistar rats) treatment inhibits the hypernociception induced by zymosan-activated serum and C5a but not by the direct-acting hypernociceptive mediators, prostaglandin E2 and dopamine[2].
Local pretreatment of rats with PMX-53 (60-180 μg per paw) inhibits zymosan-, carrageenan-, lipopolysaccharide (LPS)- and antigen-induced hypernociception[2].
Pharmacokinetic analyses have shown that PMX-53 (3D53) appears in the plasma within 5 min of oral administration (3 mg/kg) to rats, with peak blood levels of approximately 0.3 µM beingreached within 20 min The plasma elimination half-life wasapproximately 70 min in this case[3].
The non-acetylated version of PMX-53 (3D53) binds to isolated mouse neutrophils with a Kd value of 30 nM (mouse C5a binds with a Kd value of 0.3 nM) and inhibits mouse C5a-induced chemotaxis with an IC50 value of 0.5 nM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (weighing 180-200 g) injected with zymosan[2]
Dosage: 0.3 mg/kg, 1 mg/kg or 3 mg/kg
Administration: Subcutaneous injection; once
Result: Inhibited the hypernociception induced by zymosan-activated serum and C5a.

分子量

896.09

Formula

C47H65N11O7

CAS 号

219639-75-5

Sequence Shortening

F-{Orn}-P-{d-Cha}-WR (Lactam bridge: Orn2- Arg6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro:;

DMSO : 125 mg/mL (139.49 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1160 mL 5.5798 mL 11.1596 mL
5 mM 0.2232 mL 1.1160 mL 2.2319 mL
10 mM 0.1116 mL 0.5580 mL 1.1160 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (2.32 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (2.32 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.32 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (2.32 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.32 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (2.32 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Subramanian H, et al. PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Mol Pharmacol. 2011 Jun;79(6):1005-13.

    [2]. Ting E, et al. Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain. Br J Pharmacol. 2008 Mar;153(5):1043-53.

    [3]. Holland MC, et al. Synthetic small-molecule complement inhibitors. Curr Opin Investig Drugs. 2004 Nov;5(11):1164-73.

    [4]. Finch AM, et al. Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J Med Chem. 1999 Jun 3;42(11):1965-74.

    [5]. Manthey HD, et al. Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. FASEB J. 2011 Jul;25(7):2447-55.

    [6]. Vadrevu SK, et al. Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche. Cancer Res. 2014 Jul 1;74(13):3454-65.

Deapi-platycodin D3(Synonyms: 去芹糖桔梗皂苷D3)

天然产物 糖类和糖苷 Saccharides and Glycosides

Deapi-platycodin D3 (Synonyms: 去芹糖桔梗皂苷D3) 纯度: 98.17%

Deapi-platycodin D3 是从桔梗根中提取的一种三萜皂苷。

Deapi-platycodin D3(Synonyms: 去芹糖桔梗皂苷D3)

Deapi-platycodin D3 Chemical Structure

CAS No. : 67884-05-3

规格 价格 是否有货 数量
1 mg ¥2860 In-stock
5 mg ¥8570 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Deapi-platycodin D3 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Deapi-platycodin D3 is a triterpenoid saponin from the roots of Platycodon grandiflorum[1].

分子量

1255.35

Formula

C58H94O29

CAS 号

67884-05-3

中文名称

去芹糖桔梗皂苷D3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Li W, et al. Platycoside N: a new oleanane-type triterpenoid saponin from the roots of Platycodon grandiflorum. Molecules. 2010 Nov 30;15(12):8702-8.

Virtis15Dx14通用型冻干机

Virtis15Dx14通用型冻干机

Virtis 15D x 14通用型冻干机

产品编号:
市场价:¥0.00
会员价:¥0.00
品牌:中文
生产厂家:Virtis
需求数量:

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

具有高效预冷功能,并有多阶段冻干程序

Virtis15Dx14通用型冻干机

标准冷凝舱温度:- 50 ℃,并可选择 – 85 ℃

Virtis15Dx14通用型冻干机

可选择 Wizard 自动控制系统

通用型冻干机规格:

型号

15D x 14

24D x 24

24D x 48

36D x 66

36D x D72

36D x 84

48D x 108

62D x 108

层板数

1

2 – 5

2 – 5

2 – 9

5 – 8

2 – 9

7 – 11

11

最大面积 m2

0.82

1.36

2.78

8.24

12.6

9.21

19.5

34.6

最小间距 mm

2.87

98

98

85

69

85

87

95

最小面积 m2

0.82

0.64

1.23

2.08

7.89

7.38

12.3

34.6

最大间距 mm

287

198

198

295

127

117

147

95

WIGGENSWH-210D/WH-410D/WH610D数字式多位搅拌器

WIGGENSWH-210D/WH-410D/WH610D数字式多位搅拌器

WIGGENS WH-210D/WH-410D/WH610D 数字式多位搅拌器

产品编号:
市场价:¥0.00
会员价:¥0.00
品牌:WIGGENS
生产厂家:WIGGENS
需求数量:

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

主要特点:

1. 直流电机驱动,确保在高粘度状态下,仍然安静平稳运行
2. 不锈钢工作面,坚固耐用,耐化学试剂腐蚀
3. 1, 4, 6三个搅拌位的型号可供选择
4. 特别适合实验室常规实验和教学使用

型号

WH-210D

WH-410D

WH-610D

定货号

400214

400215

400216

显示方式

LCD显示

转速范围(rpm)

1001500

搅拌位数

1

4

6

单个搅拌位最大搅拌量(mL)

503000

502000

502000

搅拌台面尺寸(mm)

158×143

313×303

473×303

外形尺寸(mm)

189×215×48

344×377×48

504×377×48

 

金畔生物

5-PAHSA-d9

生化分析试剂 Biochemical Assay Reagents
5-PAHSA-d9;

5-PAHSA-d9 是氘标记的 5-PAHSA. 5-PAHSA 是一种连接糖脂代谢的抗炎、抗糖尿病脂质因子。

5-PAHSA-d9

5-PAHSA-d9 Chemical Structure

CAS No. : 1809226-17-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

5-PAHSA-d9 is the deuterium labeled 5-PAHSA. 5-PAHSA is a kind of anti-inflammatory and antidiabetic lipokines that connect glucose and lipid metabolism[1].

分子量

547.94

Formula

C34H57D9O4

CAS 号

1809226-17-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Veronika Paluchova, et al. Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice. Diabetes. 2020 Mar;69(3):300-312.

Platycodin D2(Synonyms: 桔梗皂苷 D2)

天然产物 糖类和糖苷 Saccharides and Glycosides

Platycodin D2;(Synonyms: 桔梗皂苷 D2) 纯度: 99.36%

Platycodin D2 是桔梗中的皂苷类物质,具有抗癌活性。

Platycodin D2(Synonyms: 桔梗皂苷 D2)

Platycodin D2 Chemical Structure

CAS No. : 66663-90-9

规格 价格 是否有货 数量
5 mg ¥2350 In-stock
10 mg ¥4000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Platycodin D2 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Glycoside Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library

生物活性

Platycodin D2 is a saponin isolated from Platycodon grandiflorum, with anti-cancer activity[1].

分子量

1387.46

Formula

C63H102O33

CAS 号

66663-90-9

中文名称

桔梗皂苷 D2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (72.07 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7207 mL 3.6037 mL 7.2074 mL
5 mM 0.1441 mL 0.7207 mL 1.4415 mL
10 mM 0.0721 mL 0.3604 mL 0.7207 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (1.80 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.80 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.80 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.80 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.80 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (1.80 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Kim YS, et al. Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines. Planta Med. 2005 Jun;71(6):566-8.

D149 Dye(Synonyms: D149 Indoline dye D149)

D149 Dye;(Synonyms: D149; Indoline dye D149) 纯度: ge;95.0%

D149 Dye 是一种二氢吲哚类染料,是一种具有高消光系数的非金属有机敏化剂。

D149 Dyeamp;;(Synonyms: D149;  Indoline dye D149)

D149 Dye Chemical Structure

CAS No. : 786643-20-7

规格 价格 是否有货 数量
50 mg ¥1800 In-stock
100 mg ¥2930 In-stock
500 mg ¥5800 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

* Please select Quantity before adding items.

D149 Dye 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

D149 Dye is an indoline-based dye, which is a high-extinction-coefficient metal-free organic sensitizer.

体外研究
(In Vitro)

D149 is a metal-free organic dye, which is promising all-organic alternatives. D149 displays power conversion efficiency of up to 9%. Furthermore, D149 has a peak extinction co-efficient of 68700 M-1 cm-1 at 540 nm, significantly higher than 13900 M-1cm-1 at 535 nm for N719[1]. D149, a metal-free indoline dye, is one of the most promising sensitizers for dye-sensitized solar cells (DSSCs) and has shown very high solar energy conversion efficiencies of 9%. D149 shows a large number of unresolved aromatic and olefinic signals between 7 and 7.5 ppm[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

741.94

Formula

C42H35N3O4S3

CAS 号

786643-20-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 1 mg/mL (1.35 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3478 mL 6.7391 mL 13.4782 mL
5 mM
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Lin J, et al. 3D hierarchical rutile TiO2 and metal-free organic sensitizer producing dye-sensitized solar cells 8.6% conversion efficiency. Sci Rep. 2014 Aug 29;4:5769.

    [2]. El-Zohry A, et al. Isomerization and Aggregation of the Solar Cell Dye D149. J Phys Chem C Nanomater Interfaces. 2012 Dec 20;116(50):26144-26153.

Cell Assay
[1]

The porous TiO2 films are immersed in a 0.5 mM D149 (1-material) dye solution in a 1:1 (v/v) mixture of acetonitrile (HPLC) and tert-butanol (LR) overnight once their temperature decreased to approximately 110°C. The samples are then taken out of the dye bath, washed with acetonitrile, and dried. The working electrode and Pt counter electrode [produced using a pre-drilled piece of 2.3 mm FTO glass, coated with one drop of 10 mM platinic acid solution [H2PtCl6] and heated to 400°C for 20 min] are assembled into a sandwich type cell and sealed with a spacer of 25 μm Surlyn. An I-1/I3-1 organic solvent based electrolyte solution [50 mM iodine, 0.6 M 1,2-dimethyl-3-propylimidazelium iodide, 0.1 M lithium iodide in methoxypropionitrile] is introduced via vacuum back-filling. The hole is sealed with a piece of aluminium foil-backed Surlyn[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Lin J, et al. 3D hierarchical rutile TiO2 and metal-free organic sensitizer producing dye-sensitized solar cells 8.6% conversion efficiency. Sci Rep. 2014 Aug 29;4:5769.

    [2]. El-Zohry A, et al. Isomerization and Aggregation of the Solar Cell Dye D149. J Phys Chem C Nanomater Interfaces. 2012 Dec 20;116(50):26144-26153.