Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC₅₀ value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis ^[1][2].

Icariside D2 3 induces apoptosis via alteration of expression of apoptosis-related proteins and decreases phosphorylation of AKT in HL-60 cells^[1].
Icariside D2 exhibits anti-inflammatory and anti-HIV activity^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

300.30

C₁₄H₂₀O₇

38954-02-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nguyen Thi Thu Hien, et al. Chemical Constituents of the Annona Glabra Fruit and Their Cytotoxic Activity. Pharm Biol. 2015;53(11):1602-7.

  [2]. Xue Liu, et al. Metabolic Engineering Escherichia coli for Efficient Production of Icariside D2. Biotechnol Biofuels. 2019 Nov 6;12:261.

  [3]. Jin-YuLi, et al. Three new acylated prenylflavonol glycosides from Epimedium koreanum. Phytochemistry Letters Volume 17, September 2016, Pages 206-212.