Lei-Dab7 TFA

Lei-Dab7 TFA;

Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

Lei-Dab7 TFAamp;;

Lei-Dab7 TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

分子量

3506.08

Formula

C143H237F3N46O41S6

Sequence Shortening

AFCNLR{Dab}CQLSCRSLGLLGKCIGDKCECVKH-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11.

Lei-Dab7

Lei-Dab7;

Lei-Dab7 是一种有效的选择性 SK2 (KCa2.2) 通道阻滞剂,Kd 为 3.8 nM。Lei-Dab7 在 KCa1、KCa3、Kv 和 Kir2.1 通道上显示低活性或无活性。

Lei-Dab7amp;;

Lei-Dab7 Chemical Structure

CAS No. : 1061556-49-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a Kd of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels[1][2].

体内研究
(In Vivo)

Intracerebroventricular (9-5 ng) injections of Lei-Dab7 decreases locomotor activity, food intake and body weight in rats deprived of food. A dose of 3 ng Lei-Dab7 has no effect on these types of behavior[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3392.06

Formula

C141H236N46O39S6

CAS 号

1061556-49-7

Sequence Shortening

AFCNLR{Dab}CQLSCRSLGLLGKCIGDKCECVKH-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. V G Shakkottai, et al. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51.

    [2]. Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11.

    [3]. Bedel Mpari, et al. Small-conductance Ca(2+)-activated K(+) channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers. Eur J Pharmacol. 2008 Jul 28;589(1-3):140-8.

荧光染料DAB(Synonyms: 3,3′ Diaminobenzidine Tetrahydrochloride)

荧光染料Dye Reagents DAB;(Synonyms: 3,3′ Diaminobenzidine Tetrahydrochloride) 纯度: ge;99.0%

DAB (3,3′ Diaminobenzidine Tetrahydrochloride) 是有机化合物,具有化学和热力学稳定性,可用于核酸和蛋白的免疫组化染色。

DABamp;;(Synonyms: 3,3

DAB Chemical Structure

CAS No. : 7411-49-6

规格 价格 是否有货 数量
500 mg ¥400 In-stock
1 g ¥650 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

* Please select Quantity before adding items.

生物活性

DAB (3,3′ Diaminobenzidine Tetrahydrochloride) is an organic compound that is both chemically and thermodynamically stable; DAB has been used in immunohistochemical staining of nucleic acids and proteins.

分子量

360.11

Formula

C12H18Cl4N4

CAS 号

7411-49-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

H2O : 60 mg/mL (166.62 mM; Need ultrasonic)

DMSO : ≥ 43 mg/mL (119.41 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7769 mL 13.8846 mL 27.7693 mL
5 mM 0.5554 mL 2.7769 mL 5.5539 mL
10 mM 0.2777 mL 1.3885 mL 2.7769 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Hannetz Roschzttardtz, et al. Plant Cell Nucleolus as a Hot Spot for Iron.

荧光染料DAB(Synonyms: 3,3′ Diaminobenzidine Tetrahydrochloride)

荧光染料Dye Reagents DAB;(Synonyms: 3,3′ Diaminobenzidine Tetrahydrochloride) 纯度: ge;99.0%

DAB (3,3′ Diaminobenzidine Tetrahydrochloride) 是有机化合物,具有化学和热力学稳定性,可用于核酸和蛋白的免疫组化染色。

DAB(Synonyms: 3,3

DAB Chemical Structure

CAS No. : 7411-49-6

规格 价格 是否有货 数量
500 mg ¥400 In-stock
1 g ¥650 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

* Please select Quantity before adding items.

生物活性

DAB (3,3′ Diaminobenzidine Tetrahydrochloride) is an organic compound that is both chemically and thermodynamically stable; DAB has been used in immunohistochemical staining of nucleic acids and proteins.

分子量

360.11

Formula

C12H18Cl4N4

CAS 号

7411-49-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

H2O : 60 mg/mL (166.62 mM; Need ultrasonic)

DMSO : ≥ 43 mg/mL (119.41 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7769 mL 13.8846 mL 27.7693 mL
5 mM 0.5554 mL 2.7769 mL 5.5539 mL
10 mM 0.2777 mL 1.3885 mL 2.7769 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Hannetz Roschzttardtz, et al. Plant Cell Nucleolus as a Hot Spot for Iron.