7-Deaza-2′-deoxy-7-iodoadenosine

生化分析试剂 Biochemical Assay Reagents
7-Deaza-2′-deoxy-7-iodoadenosine;

Deaza-2′-deoxy-7-iodoadenosine 是包含 7-Deazaadenine 的修饰的寡核苷酸。

7-Deaza-2

7-Deaza-2′-deoxy-7-iodoadenosine Chemical Structure

CAS No. : 166247-63-8

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生物活性

7-Deaza-2′-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine[1].

分子量

376.15

Formula

C11H13IN4O3

CAS 号

166247-63-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. Frank Seela, et al. Oligonucleotides Containing 7‐Deazaadenines: The Influence of the 7‐Substituent Chain Length and Charge on the Duplex Stability. Research Article

14-Deoxy-11-oxoandrographolide

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

14-Deoxy-11-oxoandrographolide 

14-Deoxy-11-oxoandrographolide 是一种抗利什曼 (antileishmanial) 试剂。14-Deoxy-11-oxoandrographolide 抑制治愈基孔肯雅病毒 (CHIKV) 的复制,可用于 CHIKV 感染的研究。

14-Deoxy-11-oxoandrographolide

14-Deoxy-11-oxoandrographolide Chemical Structure

CAS No. : 42895-57-8

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生物活性

14-Deoxy-11-oxoandrographolide is an antileishmanial agent[1]. 14-Deoxy-11-oxoandrographolide inhibits the replication of heal chikungunya virus (CHIKV) and can be used for CHIKV infection research[1].

分子量

348.43

Formula

C20H28O5

CAS 号

42895-57-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. S Lala, et al. Delivery in vivo of 14-deoxy-11-oxoandrographolide, an antileishmanial agent, by different drug carriers. Indian J Biochem Biophys. 2003 Jun;40(3):169-74.

    [2]. G Koushik Kumar, et al. Structural basis for complementary and alternative medicine: Phytochemical interaction with non-structural protein 2 protease-a reverse engineering strategy. Chin J Integr Med. 2015 Jun;21(6):445-52.

3-Deoxyglucosone(Synonyms: 3-Deoxy-D-glucosone)

天然产物 糖类和糖苷 Saccharides and Glycosides

3-Deoxyglucosone;(Synonyms: 3-Deoxy-D-glucosone)

3-Deoxyglucosone (3-Deoxy-D-glucosone) 是美拉德反应和多元醇途径的反应中间体 (intermediate)。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化终产物 (AGEs),例如咪唑啉酮,它是 3-DG 的最特异 AGE。3-Deoxyglucosone 可以与低葡萄糖协同作用以增强 GLP-1 分泌,可以作为糖尿病生物学检测的标志物。

3-Deoxyglucosone(Synonyms: 3-Deoxy-D-glucosone)

3-Deoxyglucosone Chemical Structure

CAS No. : 4084-27-9

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生物活性

3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes[1][2][3].

体外研究
(In Vitro)

3-Deoxyglucosone (80 ng/ml-1000 ng/ml; 1 hour) markedly increases GLP-1 secretion by 1.23-folds in 300 ng/ml or 1000 ng/ml 3DG-treated group. But at alower concentration (80 ng/ml) has no effects[1].
3-Deoxyglucosone (300 ng/ml; 1 hour) dramatically increases intracellular Ca2+ levels by Fluo-3/AM determination (2.5 μM for 30 mins). But 3DG does not affect intracellular cAMP levels in a cAMP Elisa assay[1].
3-Deoxyglucosone (300 ng/ml; 1 hour) significantly increases the protein expression levels of TAS1R2, TAS1R3, and TRPM5 under both glucose-free and highconditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: STC-1 cells
Concentration: 300 ng/ml
Incubation Time: 1 hour
Result: Upregulated TAS1R2, TAS1R3, and TRPM5 expression.

体内研究
(In Vivo)

3-Deoxyglucosone (intragastric administration; 20 mg/kg; single dose) impairs glucose tolerance with increased AUC, but the plasma glucagon levels are not significantly different. It developes impaired glucose regulation (IGR) with obviously pancreatic islet cell dysfunction in kunming mice and SD-rats[2].
3-deoxyglucosone (gastric gavage; 5-50 mg/kg; once daily; 2 weeks) is significantly increased in the upper small intestine (1.4-fold), lower small intestine (1.4-fold), ileum (1.4-fold) and colon (two fold) compared with the basal levels in the corresponding control group. In addition, the protein expressions of TAS1R2, TAS1R3 and TRPM5 in both duodenum and colon are significantly decreased[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[3]
Dosage: 5, 20 and 50 mg/kg
Administration: oral administration; once daily; 2 weeks
Result: Was capable of accumulating in intestinal tissue and thereby decreased secretion of GLP-1 and insulin.  

分子量

162.14

Formula

C6H10O5

CAS 号

4084-27-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Song X, et al. 3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions.Int J Endocrinol. 2019 Oct 23;2019:4959646.

    [2]. Wang F, et al. Acute Reduction of Incretin Effect and Glucose Intolerance in Rats by Single Intragastric Administration of 3-deoxyglucosone. Exp Clin Endocrinol Diabetes. 2017 Jan;125(1):4-11.

    [3]. Zhang L, et al. Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats. Diabetol Metab Syndr. 2016 Nov 29;8:78.

    [4]. Niwa T, et al. 3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication.J Chromatogr B Biomed Sci Appl. 1999 Aug 6;731(1):23-36.

2-Deoxy-2-sulfoamino-D-glucose sodium

天然产物 糖类和糖苷 Saccharides and Glycosides

2-Deoxy-2-sulfoamino-D-glucose sodium;

2-Deoxy-2-sulfoamino-D-glucose sodium 是一种内源性代谢产物。

2-Deoxy-2-sulfoamino-D-glucose sodium

2-Deoxy-2-sulfoamino-D-glucose sodium Chemical Structure

CAS No. : 38899-05-7

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10 mg ¥350 询问价格 货期
50 mg ¥890 询问价格 货期
100 mg ¥1000 询问价格 货期
200 mg ¥1500 询问价格 货期

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生物活性

2-Deoxy-2-sulfoamino-D-glucose sodium is an endogenous metabolite.

分子量

281.22

Formula

C6H12NNaO8S

CAS 号

38899-05-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro:;

H2O : 125 mg/mL (444.49 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5559 mL 17.7797 mL 35.5593 mL
5 mM 0.7112 mL 3.5559 mL 7.1119 mL
10 mM 0.3556 mL 1.7780 mL 3.5559 mL

8-Epideoxyloganic acid(Synonyms: 7-Deoxy-8-epiloganic acid)

天然产物 糖类和糖苷 Saccharides and Glycosides

8-Epideoxyloganic acid;(Synonyms: 7-Deoxy-8-epiloganic acid)

8-Epideoxyloganic acid (7-Deoxy-8-epiloganic acid) 是一种环烯醚萜苷,可从 Incarvillea delavayi 中分离得到。8-Epideoxyloganic acid 具有微弱的缓解疼痛活性。

8-Epideoxyloganic acid(Synonyms: 7-Deoxy-8-epiloganic acid)

8-Epideoxyloganic acid Chemical Structure

CAS No. : 88668-99-9

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生物活性

8-Epideoxyloganic acid (7-Deoxy-8-epiloganic acid), an iridoid glucoside, can be found in Incarvillea delavayi. 8-Epideoxyloganic acid exhibits weak antinociceptive activity[1].

分子量

360.36

Formula

C16H24O9

CAS 号

88668-99-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Nakamura M, et, al. Antinociceptive substances from Incarvillea delavayi. Phytochemistry. 2000 Jan;53(2):253-6.