Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].
IC50 & Target[1]
PI3Kγ
2.4 μM (IC50)
PI3Kβ
5.4 μM (IC50)
PI3Kδ
3.0 μM (IC50)
体外研究 (In Vitro)
Quercetin dihydrate is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits[1].Quercetin dihydrate is a PI3K inhibitor with IC50s of 2.4-5.4 μM. Quercetin dihydrate strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2[1].Quercetin dihydrate inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量
338.27
Formula
C15H14O9
CAS 号
6151-25-3
运输条件
Room temperature in continental US; may vary elsewhere.
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
[1]. Navarro-Núñez L, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80.
[2]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.
[3]. Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277.
Tartaric acid disodium dihydrate Chemical Structure
CAS No. : 6106-24-7
规格
价格
是否有货
数量
Free Sample (0.1-0.5 mg)
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10;mM;*;1 mL in Water
¥550
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500 mg
¥500
In-stock
5 g
¥600
In-stock
10 g
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询价
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50 g
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Tartaric acid disodium dihydrate 相关产品
bull;相关化合物库:
Natural Product Like Compound Library
Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Anti-Cancer Compound Library
FDA Approved amp; Pharmacopeial Drug Library
Gut Microbial Metabolite Library
Phosphatase Inhibitor Library
Microbial Metabolite Library
Food Additive Library
Food-Sourced Compound Library
Inactive Ingredient Library
生物活性
Tartaric acid disodium dihydrate is a Acid phosphatase inhibitor, is a sodium salt used in buffers for molecular biology and cell culture applications. Increases the rate of colchicine binding to tubulin1.
分子量
232.10
Formula
C4H10Na2O8
CAS 号
6106-24-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4deg;C, sealed storage, away from moisture and light
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;
H2O : 100 mg/mL (430.85 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
4.3085 mL
21.5424 mL
43.0849 mL
5 mM
0.8617 mL
4.3085 mL
8.6170 mL
10 mM
0.4308 mL
2.1542 mL
4.3085 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。