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加拿大Silicycle硅胶填料SiliaMetS DOTA (R91030B)

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SiliaMetS DOTA (R91030B)

SiliaMetS DOTA (R91030B)

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Product Number Quantity  
R91030B-10G 10 g

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R91030B-25G 25 g

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R91030B-50G 50 g

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R91030B-100G 100 g

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R91030B-250G 250 g

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R91030B-500G 500 g

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R91030B-1KG 1 kg

SiliaMetS DOTA (R91030B)   Loading…  

Details

SiliaMetS DOTA metal scavenger (Si-DOTA) is a silica-supported tetracarboxylic acid and its various conjugate bases.

DOTA molecule is a well-adopted complexing agent.

Linked to various metals, so formed-complexes are used as contrast agents in cancer treatments or other medical applications.

Metals Removed

  • Best scavenger for: As, Ca, Cu, Gd, La, Ni, Se & Zn
  • Good scavenger for: Co, Fe, Mg, Pd, Pt & Rh

Documentations

SPECIFICATION SHEET

Download the Specification Sheet for SiliaMetS DOTA

APPLICATION NOTE

Application Note for SiliaMetS DOTA

Additional Information

Particle Shape Irregular
Array DOTA
Family / Formats SiliaMetS® (Metal Scavengers)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Endcapped
Storage Condition Keep dry
Solvent Compatibility All solvents, aqueous and organic
Typical Density 0.681 g/mL
Molecular Loading ≥ 0.38 mmol/g
Color Light Yellow

DOTATATE

发表于由

DOTATATE;

DOTATATE 是一种 DOTA 偶联肽，可以被放射性核素标记以用于正电子发射断层扫描 (PET) 成像和肽受体放射性核素治疗 (PRRT)。

DOTATATEamp;;

DOTATATE Chemical Structure

CAS No. : 177943-88-3

规格 是否有货
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DOTATATE 的其他形式现货产品:

DOTATATE acetate

生物活性

DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide therapy (PRRT)[1][2][3][4].

体内研究
(In Vivo)

177Lu-DOTATATE shows excellent antitumor effects in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1435.62

Formula

C65H90N14O19S2
CAS 号

177943-88-3
Sequence Shortening

{D-Phe}-CY-{D-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S.

    [2]. Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10.

    [3]. Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):917-20.

    [4]. Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27(3):273-82.