Protein E7(43-62)

Protein E7(43-62);

Protein E7(43-62) 是一种具有抗肿瘤作用的 E7 衍生肽 (即在 E7 蛋白中跨越 43 到 62 个氨基酸残基的短肽)。

Protein E7(43-62)amp;;

Protein E7(43-62) Chemical Structure

CAS No. : 143853-58-1

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Protein E7(43-62) is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein)[1].

体内研究
(In Vivo)

Using an E7-derived peptide Protein E7(43-62), 50% of mice (C57BL/6 mice bearing human papilloma virus (HPV) E6/7 TC-1 tumors) are tumor free 60 days after treatment with Protein E7(43-62)-polymeric nanoparticle (PC7A NP)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2270.52

Formula

C95H144N28O31S3

CAS 号

143853-58-1

Sequence

Gly-Gln-Ala-Glu-Pro-Asp-Arg-Ala-His-Tyr-Asn-Ile-Val-Thr-Phe-Cys-Cys-Lys-Cys-Asp

Sequence Shortening

GQAEPDRAHYNIVTFCCKCD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Min Luo, et al. A STING-activating Nanovaccine for Cancer Immunotherapy. Nat Nanotechnol. 2017 Jul;12(7):648-654.

OVA-E1 peptide

OVA-E1 peptide;

OVA-E1 peptide 是SIINFEKL [OVA (257-264)拮抗突变体。OVA-E1 peptide在突变型和野生型胸腺细胞中激活 p38 和 JNK 级联。

OVA-E1 peptideamp;;

OVA-E1 peptide Chemical Structure

CAS No. : 153316-01-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes[1].

分子量

1005.16

Formula

C47H76N10O14

CAS 号

153316-01-9

Sequence

Glu-Ile-Ile-Asn-Phe-Glu-Lys-Leu

Sequence Shortening

EIINFEKL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Leandro J Carreño, et al. The Half-Life of the T-cell receptor/peptide-major Histocompatibility Complex Interaction Can Modulate T-cell Activation in Response to Bacterial Challenge. Immunology. 2007 Jun;121(2):227-37.

Guangxitoxin 1E

Guangxitoxin 1E;

Guangxitoxin 1E 是 KV2.1KV2.2 通道的有效选择性阻断剂。Guangxitoxin 1E 抑制 KV2, 其 IC50 值为 1-3 nM,KV2 通道是各种神经元中延迟整流器钾电流的基础。

Guangxitoxin 1Eamp;;

Guangxitoxin 1E Chemical Structure

CAS No. : 1233152-82-3

规格 是否有货
100 μg 询价

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生物活性

Guangxitoxin 1E is a potent and selective blocker of KV2.1 and KV2.2 channels. Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM. KV2 channels underlie delayed-rectifier potassium currents in various neurons[1][2].

IC50 Target

IC50: 1-3 nM (KV2 channels); 24-54 nM (KV4.3 channels)[2]

体外研究
(In Vitro)

Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM[2].
In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3948.61

Formula

C178H248N44O45S7

CAS 号

1233152-82-3

Sequence Shortening

EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP(Disulfide bridge:Cys4-Cys19;Cys11-Cys24;Cys18-Cys31)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hönigsperger C, et al. Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. J Physiol. 2017 Feb 1;595(3):739-757.

    [2]. Herrington J, et al. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. 2006 Apr;55(4):1034-42.

HPV16-E711-20 epitope

HPV16-E711-20 epitope;

HPV16-E711-20 epitope 是 HLA-A*0201 限制性人细胞毒性T淋巴细胞 (CTL) 表位的 HPV16 E7 蛋白,在体外显示了与 HLA-A2 的高亲和力结合。HPV16 CTL 表位可能是开发有效肽基抗肿瘤疫苗的良好候选。

HPV16-E711-20 epitopeamp;;

HPV16-E711-20 epitope Chemical Structure

CAS No. : 160040-04-0

规格 是否有货
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生物活性

HPV16-E711-20 epitope is a well-known HLA-A*0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein that shows high-affinity binding to HLA-A2 in vitro. HPV16 CTL epitopes may be good candidates for the development of an effective peptide-based antitumor vaccine[1].

分子量

1210.35

Formula

C53H83N11O19S

CAS 号

160040-04-0

Sequence

Tyr-Met-Leu-Asp-Leu-Gln-Pro-Glu-Thr-Thr

Sequence Shortening

YMLDLQPETT

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ding Z, et al. Cytolytic activity of the human papillomavirus type 16 E711-20 epitope-specific cytotoxic T lymphocyte is enhanced by heat shock protein 110 in HLA-A*0201 transgenic mice. Clin Vaccine Immunol. 2013 Jul;20(7):1027-33.

HPV16 E7 (86-93)

HPV16 E7 (86-93);

HPV16 E7 (86-93) 是人类白细胞抗原 (HLA)-A2.1 限制的 HPV16 E7 衍生肽。HPV16 E7 (86-93) 在宫颈癌中具有免疫原性。

HPV16 E7 (86-93)amp;;

HPV16 E7 (86-93) Chemical Structure

CAS No. : 160212-93-1

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HPV16 E7 (86-93) 的其他形式现货产品:

HPV16 E7 (86-93) (TFA)

生物活性

HPV16 E7 (86-93) is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) is immunogenic in cervical carcinomas[1][2].

体外研究
(In Vitro)

HPV16 E7 (86-93) specific T cells are expandable upon IVS (in vitro stimulation) with cognate peptide-pulsed dendritic cells (DCs) and are reactive against peptide-pulsed targets or, in case of the E711-20 epitope-specific T cells, against HPV16 E7 expressing CaSki cell line[1].
For peptide HPV16 E7 (86-93), the only response against K562 cells pulsed with the corresponding peptide was significantly blocked by anti-HLA class I Ab w6/32, which was not the case for HPV16 E7 expressing tumor cell line CaSki. Precursor T cells specific for HPV16 E7 (86-93) peptide is able to differentiate, at least in vitro, into HPVspecific effector cells[1].
HPV16 E7 peptide-loaded autologous dendritic cells (DCs) are able to stimulate a specific cytotoxic CD8+ T-cell response[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

HPV16 E7 (86-93) peptide in IVS culture has specific T cell expansion. The HPV16 E7 (86-93) specific T cells produced does not recognize naturally HPV16 E7 expressing cell line CaSki. HPV16 E7 (86-93) peptides also has similar observations in transgenic mice. The HPV16 E7 (86-93) peptide is able to induce cytotoxic T lymphocyte (CTL) responses if loaded on the antigen presenting HLA class I molecules, but that the peptide appears not to be processed or presented by HPV16 infected cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

815.03

Formula

C37H66N8O10S

CAS 号

160212-93-1

Sequence

Thr-Leu-Gly-Ile-Val-Cys-Pro-Ile

Sequence Shortening

TLGIVCPI

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Cheng WF, et al. Induction of human papillomavirus type 16-specific immunologic responses in a normal and an human papillomavirus-infected populations. Immunology. 2005 May;115(1):136-49.

    [2]. Hoffmann TK, et al. T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx. Int J Cancer. 2006 Apr 15;118(8):1984-91.

Human Papillomavirus (HPV) E7 protein (49-57)

Human Papillomavirus (HPV) E7 protein (49-57);

Human Papillomavirus (HPV) E7 protein (49-57) 是 H-2d 限制性人乳头瘤病毒 (HPV) E749-57 表位(即在 E7 蛋白中跨越 49 到 57 个氨基酸残基的短肽)。

Human Papillomavirus (HPV) E7 protein (49-57)amp;;

Human Papillomavirus (HPV) E7 protein (49-57) Chemical Structure

CAS No. : 151812-18-9

规格 是否有货
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250 mg ; 询价 ;
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生物活性

Human Papillomavirus (HPV) E7 protein (49-57) is the H-2d-restricted human papillomavirus (HPV) E749-57 epitope (short peptide spanning the 49th to 57th amino acid residues in the E7 protein)[1].

分子量

1120.26

Formula

C52H77N15O13

CAS 号

151812-18-9

Sequence

Arg-Ala-His-Tyr-Asn-Ile-Val-Thr-Phe

Sequence Shortening

RAHYNIVTF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ding Z, et al. Cytolytic activity of the human papillomavirus type 16 E711-20 epitope-specific cytotoxic T lymphocyte is enhanced by heat shock protein 110 in HLA-A*0201 transgenic mice. Clin Vaccine Immunol. 2013 Jul;20(7):1027-33.

OVA-E1 peptide TFA

OVA-E1 peptide TFA;

OVA-E1 peptide TFA 是SIINFEKL [OVA (257-264)拮抗突变体。OVA-E1 peptide在突变型和野生型胸腺细胞中激活 p38 和 JNK 级联。

OVA-E1 peptide TFAamp;;

OVA-E1 peptide TFA Chemical Structure

CAS No. : 1262750-80-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes[1].

分子量

1119.19

Formula

C49H77F3N10O16

CAS 号

1262750-80-0

Sequence

Glu-Ile-Ile-Asn-Phe-Glu-Lys-Leu

Sequence Shortening

EIINFEKL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Leandro J Carreño, et al. The Half-Life of the T-cell receptor/peptide-major Histocompatibility Complex Interaction Can Modulate T-cell Activation in Response to Bacterial Challenge. Immunology. 2007 Jun;121(2):227-37.

Protein E7(43-62) TFA

Protein E7(43-62) TFA;

Protein E7(43-62) TFA 是一种具有抗肿瘤作用的 E7 衍生肽 (即在 E7 蛋白中跨越 43 到 62 个氨基酸残基的短肽)。

Protein E7(43-62) TFAamp;;

Protein E7(43-62) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Protein E7(43-62) TFA is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein)[1].

体内研究
(In Vivo)

Using an E7-derived peptide Protein E7(43-62), 50% of mice (C57BL/6 mice bearing human papilloma virus (HPV) E6/7 TC-1 tumors) are tumor free 60 days after treatment with Protein E7(43-62)-polymeric nanoparticle (PC7A NP)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2384.54

Formula

C97H145N28F3O33S3

Sequence Shortening

GQAEPDRAHYNIVTFCCKCD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Min Luo, et al. A STING-activating Nanovaccine for Cancer Immunotherapy. Nat Nanotechnol. 2017 Jul;12(7):648-654.

Specnuezhenide(Synonyms: 特女贞苷; (8E)-Nuezhenide)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Specnuezhenide (Synonyms: 特女贞苷; (8E)-Nuezhenide) 纯度: 98.55%

Specnuezhenide ((8E)-Nuezhenide) 是从女贞子的果实中分离出来的。Specnuezhenide ((8E)-Nuezhenide) 可通过抑制 NF-κBwnt/β-catenin 信号传导来抑制 IL-1β 诱导的软骨细胞炎症。Specnuezhenide ((8E)-Nuezhenide) 可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。

Specnuezhenide(Synonyms: 特女贞苷; (8E)-Nuezhenide)

Specnuezhenide Chemical Structure

CAS No. : 39011-92-2

规格 价格 是否有货 数量
5 mg ¥1500 In-stock
10 mg ¥2400 In-stock
25 mg ¥3800 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Specnuezhenide 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • NF-κB Signaling Compound Library
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  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Anti-Obesity Compound Library
  • Transcription Factor Targeted Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library

生物活性

Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].

体外研究
(In Vitro)

Specnuezhenide (0.2-5.0 μg/mL) significantly decreases the mRNA expression of VEGFA induced by CoCl2 as a dose-dependent manner in ARPE-19 cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

686.66

Formula

C31H42O17

CAS 号

39011-92-2

中文名称

特女贞苷;女贞子甙

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : 250 mg/mL (364.08 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4563 mL 7.2816 mL 14.5632 mL
5 mM 0.2913 mL 1.4563 mL 2.9126 mL
10 mM 0.1456 mL 0.7282 mL 1.4563 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (9.10 mM); Clear solution

    此方案可获得 ≥ 6.25 mg/mL (9.10 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (9.10 mM); Clear solution

    此方案可获得 ≥ 6.25 mg/mL (9.10 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (9.10 mM); Clear solution

    此方案可获得 ≥ 6.25 mg/mL (9.10 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Ma C, et al. Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.Front Pharmacol. 2018 Jun 28;9:700.

    [2]. Wu J, et al. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.Molecules. 2016 Dec 21;21(12). pii: E1756.

Mogroside I E1(Synonyms: 罗汉果苷 I E1;罗汉果甜苷 I E1;罗汉果甙 I E1;罗汉果甜甙 I E1)

天然产物 糖类和糖苷 Saccharides and Glycosides

Mogroside I E1 (Synonyms: 罗汉果苷 I E1;罗汉果甜苷 I E1;罗汉果甙 I E1;罗汉果甜甙 I E1) 纯度: 99.11%

Mogroside I E1 是一种三萜糖苷。Mogroside I E1 是一种非糖类甜味剂。Mogroside 比蔗糖更甜。Mogroside 具有抗氧化,抗糖尿病和抗癌活性。

Mogroside I E1(Synonyms: 罗汉果苷 I E1;罗汉果甜苷 I E1;罗汉果甙 I E1;罗汉果甜甙 I E1)

Mogroside I E1 Chemical Structure

CAS No. : 88901-39-7

规格 价格 是否有货 数量
5 mg ¥3360 In-stock
10 mg ¥5710 In-stock
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100 mg   询价  

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Mogroside I E1 相关产品

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生物活性

Mogroside I E1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities[1].

分子量

638.87

Formula

C36H62O9

CAS 号

88901-39-7

中文名称

罗汉果苷 I E1;罗汉果甜苷 I E1;罗汉果甙 I E1;罗汉果甜甙 I E1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 33.33 mg/mL (52.17 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5653 mL 7.8263 mL 15.6526 mL
5 mM 0.3131 mL 1.5653 mL 3.1305 mL
10 mM 0.1565 mL 0.7826 mL 1.5653 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.91 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.91 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.91 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.91 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.91 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.91 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.