标签归档：epi

23-epi-26-Deoxyactein(Synonyms: 27-Deoxyactein)

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

23-epi-26-Deoxyactein (Synonyms: 27-Deoxyactein)

23-epi-26-Deoxyactein 是天然的、具有口服活性的抗肥胖和抗肿瘤作用的化合物。

23-epi-26-Deoxyactein(Synonyms: 27-Deoxyactein)

23-epi-26-Deoxyactein Chemical Structure

CAS No. : 501938-01-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound[1][2][3].

体外研究
(In Vitro)

23-epi-26-Deoxyactein (DA :10 μM and 20 μM) inhibits 3T3-L1 adipogenesis through down-regulating the expression of C/ebpα, C/ebpβ, and Pparγ, which are the critical adipogenic transcription factors[1].
23-epi-26-Deoxyactein (DA) promotes mitochondrial biogenesis in pancreatic β-cells preventing methylglyoxal-induced oxidative cell damage and protects osteoblasts against Antimycin A-induced cell damage[2].
23-epi-26-Deoxyactein (DA) inhibits growth of the MCF7 human breast cancer cells and induces cell cycle arrest at G1 (IC50 of 21μM)[3].
23-epi-26-Deoxyactein (0.1-1 μM) protects osteoblasts against Antimycin A-induced cell damage[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[1]

Cell Line: 3T3-L1 preadipocytes.
Concentration: 0-50 μM.
Incubation Time: 8 days.
Result: 10 μM DA inhibited the adipogenesis of 3T3-L1 preadipocytes mainly at the early stage of differentiation.

体内研究
(In Vivo)

23-epi-26-Deoxyactein (DA: 5 and 10 mg/kg/d) significantly lowers body weight gain, fat mass, and liver weight in HFD-fed mice. 23-epi-26-Deoxyactein (DA) also reduces insulin resistance and serum lipoprotein levels in HFD-fed mice[1].
23-epi-26-Deoxyactein (DA) promotes adipocyte lipolysis in mice through activating the AMPK signaling and SIRT1-FOXO1 pathway[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet induced obesity in C57BL/6 mice[1].
Dosage: 1-10 mg/kg.
Administration: Orally, daily for 12 weeks.
Result: Lowered body weight gain, fat mass, and liver weight.
5 mg/kg/d DA significantly improved HFD-induced glucose intolerance.

分子量

660.83

Formula

C37H56O10
CAS 号

501938-01-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jingjing Yuan, et al. Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice. Phytomedicine. 2020 Jun 5;76:153264.

    [2]. Kwang Sik Suh, et al. Deoxyactein protects pancreatic β-cells against methylglyoxal-induced oxidative cell damage by the upregulation of mitochondrial biogenesis. Int J Mol Med. 2017 Aug;40(2):539-548.

    [3]. Einbond, L.S., et al. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Cancer Res. Treat. 83, 221–231. Breast Cancer Res Treat. 2004 Feb;83(3):221-31.

    [4]. Eun Mi Choi, et al. Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity. J Appl Toxicol. 2013 Jun;33(6):488-94.

5-epi-Jinkoheremol

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上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

5-epi-Jinkoheremol 

5-epi-Jinkoheremol 具有比 validamycin 更强的杀真菌活性。

5-epi-Jinkoheremol

5-epi-Jinkoheremol Chemical Structure

CAS No. : 2567930-96-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin.

分子量

222.37

Formula

C15H26O
CAS 号

2567930-96-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liang J, et al. Mining of the Catharanthus roseus Genome Leads to Identification of a Biosynthetic Gene Cluster for Fungicidal Sesquiterpenes. J Nat Prod. 2021 Oct 22;84(10):2709-2716.

epi-Aszonalenin A 品牌：Biolinks

发表于由

epi-Aszonalenin A

品牌：Biolinks
CAS No.：908853-14-5
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

BLK-1150

 – 100 μg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

epi-Aszonalenin A 品牌：Biolinks

发表于由

epi-Aszonalenin A

品牌：Biolinks
CAS No.：908853-14-5
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

BLK-1150-100U

 – 100 μg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

epi-Aszonalenin A 品牌：Biolinks

发表于由

epi-Aszonalenin A

品牌：Biolinks
CAS No.：908853-14-5
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

BLK-1150-1M

 – 1 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

epi-Aszonalenin A 品牌：Biolinks

发表于由

epi-Aszonalenin A

品牌：Biolinks
CAS No.：908853-14-5
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

BLK-1150-5M

 – 5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

11-epi-mogroside V(Synonyms: 11-表-罗汉果皂苷V)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

11-epi-mogroside V;(Synonyms: 11-表-罗汉果皂苷V)

11-epi-mogroside V 是罗汉果中的一种罗汉果苷，在体外能促进人 HepG2 细胞摄取葡萄糖。

11-epi-mogroside V(Synonyms: 11-表-罗汉果皂苷V)

11-epi-mogroside V Chemical Structure

CAS No. : 2146088-12-0

规格 价格 是否有货
1 mg ￥4500 询问价格 货期
5 mg ￥13500 询问价格 货期

* Please select Quantity before adding items.

生物活性

11-epi-mogroside V is a mogroside in the fruit of Siraitia grosvenori. 11-epi-mogroside V exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro[1].

分子量

1287.43

Formula

C60H102O29
CAS 号

2146088-12-0
中文名称

11-表-罗汉果皂苷V
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fu Li, et al. Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro. Food Chem. 2017 Aug 1;228:567-573.

7-epi-Taxol(Synonyms: 7-表紫杉醇; 7-epi-Paclitaxel)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

7-epi-Taxol (Synonyms: 7-表紫杉醇; 7-epi-Paclitaxel) 纯度: 98.01%

7-epi-Taxol 是 taxol 的活性代谢物，在抑制细胞增殖及微管 (microtubule) 解离，诱导微管聚合等方面与 taxol 作用相当。

7-epi-Taxol(Synonyms: 7-表紫杉醇; 7-epi-Paclitaxel)

7-epi-Taxol Chemical Structure

CAS No. : 105454-04-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1033 In-stock
5 mg ￥700 In-stock
10 mg ￥1100 In-stock
25 mg ￥2200 In-stock
50 mg ￥3500 In-stock
100 mg ￥5500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

7-epi-Taxol 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Terpenoids Library
  • Cytoskeleton Compound Library
  • Chemical Probe Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Lung Cancer Compound Library

生物活性

7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

IC50 & Target

Microtubule/Tubulin[2]
体外研究
(In Vitro)

7-epi-Taxol (7-Epitaxol) is a metabolite of taxol[1]. 7-epi-Taxol has activity comparable to that of taxol on cell replication, microtubule bundle formation and in vitro microtubule polymerization[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

853.91

Formula

C47H51NO14
CAS 号

105454-04-4
中文名称

7-表紫杉醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (117.11 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1711 mL 5.8554 mL 11.7108 mL
5 mM 0.2342 mL 1.1711 mL 2.3422 mL
10 mM 0.1171 mL 0.5855 mL 1.1711 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.93 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.93 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.93 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.93 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Royer I, et al. Paclitaxel metabolites in human plasma and urine: identification of 6 alpha-hydroxytaxol, 7-epitaxol and taxol hydrolysis products using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 1995;9(6):495-502.

    [2]. Ringel I, et al. Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther. 1987 Aug;242(2):692-8.