标签归档：ether

Kaempferol 3,7,4′-trimethyl ether(Synonyms: 莰非醇三甲醚)

发表于由

天然产物 黄酮类 Flavonoids

Kaempferol 3,7,4′-trimethyl ether (Synonyms: 莰非醇三甲醚)

Kaempferol 3,7,4′-trimethyl ether 是一种从 Siparuna gigantotepala 中分离的黄酮醇苷元，具有抗氧化活性。

Kaempferol 3,7,4

Kaempferol 3,7,4′-trimethyl ether Chemical Structure

CAS No. : 15486-34-7

规格 价格 是否有货
1 mg ￥1500 询问价格 & 货期
5 mg ￥3750 询问价格 & 货期
10 mg ￥6350 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Kaempferol 3,7,4′-trimethyl ether is a flavonol aglycone isolated from the leaves of Siparuna gigantotepala, has antioxidant activity[1].

分子量

328.32

Formula

C18H16O6
CAS 号

15486-34-7
中文名称

莰非醇三甲醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Torres Castañeda HG, et al. Flavonoid Glycosides from Siparuna gigantotepala Leaves and Their Antioxidant Activity. Chem Pharm Bull (Tokyo). 2016;64(5):502-6.

Quercetin 3,3′-dimethyl ether

发表于由

天然产物 黄酮类 Flavonoids

Quercetin 3,3′-dimethyl ether 

Quercetin 3,3′-dimethyl ether 具有抗氧化活性。

Quercetin 3,3

Quercetin 3,3′-dimethyl ether Chemical Structure

CAS No. : 4382-17-6

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25 mg 询价

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生物活性

Quercetin 3,3′-dimethyl ether possesses antioxidant acticity[1].

分子量

330.29

Formula

C17H14O7
CAS 号

4382-17-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Jun, et al. Antioxidant action of apigenin, quercetin-3,3′-dimethyl etherhe and quercetagetin-3,6-dimethyl ether-7-o-glucoside in vitro. Laboratory Center for Medical Science, Lanzhou Medical College.

Artemether(Synonyms: 蒿甲醚; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Artemether (Synonyms: 蒿甲醚; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224) 纯度: ≥98.0%

Artemether是抗疟疾化合物，可作用于恶性疟疾的耐药株。

Artemether(Synonyms: 蒿甲醚; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224)

Artemether Chemical Structure

CAS No. : 71963-77-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
500 mg ￥990 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

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生物活性

Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria. Target: Antiparasitic Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. Artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. Artemether-integrated with other control strategies-has considerable potential for reducing the current burden of schistosomiasis in different epidemiological settings [1]. There were remarkably inhibitory effects of artmeter on brain glioma growth and angiogenesis in SD rats and the mechanism that artemether inhibited brain glioma growth might be penetrating the blood-brain barrier and inhibiting angiogenesis [2].

Clinical Trial

分子量

298.37

Formula

C16H26O5
CAS 号

71963-77-4
中文名称

蒿甲醚；青蒿醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (335.15 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3515 mL 16.7577 mL 33.5154 mL
5 mM 0.6703 mL 3.3515 mL 6.7031 mL
10 mM 0.3352 mL 1.6758 mL 3.3515 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.38 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.38 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.38 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Xiao, S., et al., Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop, 2002. 82(2): p. 175-81.

    [2]. Wu, Z.P., et al., Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model. Integr Cancer Ther, 2009. 8(1): p. 88-92.

Kaempferol-7,4′-dimethyl ether

发表于由

天然产物 黄酮类 Flavonoids

Kaempferol-7,4′-dimethyl ether 

Kaempferol-7,4′-dimethyl ether 存在于心叶凹唇姜中。

Kaempferol-7,4

Kaempferol-7,4′-dimethyl ether Chemical Structure

CAS No. : 15486-33-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Kaempferol-7,4′-dimethyl ether is found in Boesenbergia longiflora[1].

分子量

314.29

Formula

C17H14O6
CAS 号

15486-33-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Teeratad, et al. Inhibition of nitric oxide production by compounds from Boesenbergia longiflora using lipopolysaccharide-stimulated RAW264.7 macrophage cells.[J]. Songklanakarin Journal of Science & Technology, 2013.

Lawsone methyl ether(Synonyms: 2-​Methoxy-​1,​4-​naphthoquinone)

发表于由

天然产物醌类Quinones

Lawsone methyl ether (Synonyms: 2-​Methoxy-​1,​4-​naphthoquinone) 纯度: 98.95%

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和 Swertia calycina 中分离出的，具有有效的抗真菌和抗菌活性。

Lawsone methyl ether(Synonyms: 2-​Methoxy-​1,​4-​naphthoquinone)

Lawsone methyl ether Chemical Structure

CAS No. : 2348-82-5

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
25 mg ￥500 In-stock
50 mg ￥800 In-stock
100 mg ￥1200 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities[1].

体外研究
(In Vitro)

The value of both minimal inhibitory concentration and minimal fungicidal concentration of Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) against Candida was 1.25 lg⁄ml[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

188.18

Formula

C11H8O3
CAS 号

2348-82-5
中文名称

二氯甲基甲醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (265.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.3141 mL 26.5703 mL 53.1406 mL
5 mM 1.0628 mL 5.3141 mL 10.6281 mL
10 mM 0.5314 mL 2.6570 mL 5.3141 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Sritrairat N, et al. Antifungal activity of lawsone methyl ether in comparison with chlorhexidine. J Oral Pathol Med. 2011 Jan;40(1):90-6.

Rubiadin-1-methyl ether

发表于由

天然产物醌类Quinones

Rubiadin-1-methyl ether 

Rubiadin-1-methyl ether 是巴戟天中的蒽醌类化合物，可抑制破骨细胞性骨吸收，通过抑制 NF-κB p65 磷酸化水平，降解 IκBα 蛋白，以及降低 p65 的核转位起作用。

Rubiadin-1-methyl ether

Rubiadin-1-methyl ether Chemical Structure

CAS No. : 7460-43-7

规格 价格 是否有货
1 mg ￥2000 询问价格 & 货期
5 mg ￥5000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].

IC50 & Target[1]

p65

 

分子量

268.26

Formula

C16H12O4
CAS 号

7460-43-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931.

Quercetin 3,7-dimethyl ether

发表于由

天然产物 黄酮类 Flavonoids

Quercetin 3,7-dimethyl ether 

Quercetin 3,7-dimethyl ether 可从Croton schiedeanus Schlecht 中分离得到，和 NO/cGMP 通路相关，可增加血管舒张活性。

Quercetin 3,7-dimethyl ether

Quercetin 3,7-dimethyl ether Chemical Structure

CAS No. : 2068-02-2

规格 价格 是否有货
1 mg ￥2000 询问价格 & 货期
5 mg ￥5000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Quercetin 3,7-dimethyl ether, isolated from Croton schiedeanus Schlecht, has a NO/cGMP pathway-related profile, with increased vasorelaxant activity[1].

分子量

330.29

Formula

C17H14O7
CAS 号

2068-02-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. M F Guerrero, et al. Quercetin 3,7-dimethyl Ether: A Vasorelaxant Flavonoid Isolated From Croton Schiedeanus Schlecht. J Pharm Pharmacol. 2002 Oct;54(10):1373-8.

Scutellarein tetramethyl ether(Synonyms: 4′,5,6,7-Tetramethoxyflavone)

发表于由

天然产物 黄酮类 Flavonoids

Scutellarein tetramethyl ether (Synonyms: 4′,5,6,7-Tetramethoxyflavone) 纯度: 99.87%

Scutellarein tetramethyl ether (4′,5,6,7-Tetramethoxyflavone) 是暹罗草提取物中的生物活性成分。Scutellarein tetramethyl ether (4′,5,6,7-Tetramethoxyflavone) 通过 NF-κB 通路发挥抗炎活性。Scutellarein tetramethyl ether (4′,5,6,7-Tetramethoxyflavone) 通过外排泵抑制作用调节细菌耐药性。Scutellarein tetramethyl ether (4′,5,6,7-Tetramethoxyflavone) 能增强凝血功能。

Scutellarein tetramethyl ether(Synonyms: 4

Scutellarein tetramethyl ether Chemical Structure

CAS No. : 1168-42-9

规格 价格 是否有货 数量
1 mg ￥1000 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

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  • Flavonoids Library
  • Food-Sourced Compound Library

生物活性

Scutellarein tetramethyl ether (4′,5,6,7-Tetramethoxyflavone) is a bioactive component of Siam weed extract. Scutellarein tetramethyl ether (4′,5,6,7-Tetramethoxyflavone) exhibits anti-inflammatory activity through NF-κB pathway[1]. Scutellarein tetramethyl ether (4′,5,6,7-Tetramethoxyflavone) modulats of bacterial drug resistance via efflux pump inhibition[2]. Scutellarein tetramethyl ether (4′,5,6,7-Tetramethoxyflavone) can enhance blood coagulation[3].

分子量

342.34

Formula

C19H18O6
CAS 号

1168-42-9
中文名称

黄芩四甲基醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 83.33 mg/mL (243.41 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9211 mL 14.6054 mL 29.2107 mL
5 mM 0.5842 mL 2.9211 mL 5.8421 mL
10 mM 0.2921 mL 1.4605 mL 2.9211 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.08 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.08 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.08 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.08 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.08 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.08 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Pandith H, et al. Effect of Siam weed extract and its bioactive component scutellarein tetramethyl ether on anti-inflammatory activity through NF-κB pathway. J Ethnopharmacol. 2013 May 20;147(2):434-41.

    [2]. Maia GL, et al. Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance. Molecules. 2011 Jun 10;16(6):4828-35.

    [3]. Triratana T, et al. Effect of Eupatorium odoratum on blood coagulation. J Med Assoc Thai. 1991 May;74(5):283-7.

Resorufin pentyl ether(Synonyms: 7-羟基吩噁嗪酮二戊醚 Pentoxyresorufin)

发表于由

Resorufin pentyl ether;(Synonyms: 7-羟基吩噁嗪酮二戊醚; Pentoxyresorufin)

Resorufin pentyl ether (Pentoxyresorufin) 是一种 Resazurin (HY-111391) 类似物。Resorufin pentyl ether 能作为底物来区分不同诱导物对细胞色素 P-450 的诱导。Resorufin pentyl ether 对 N. gonorrhoeae 具有杀菌活性。

Resorufin pentyl etheramp;;(Synonyms: 7-羟基吩噁嗪酮二戊醚; Pentoxyresorufin)

Resorufin pentyl ether Chemical Structure

CAS No. : 87687-03-4

规格 是否有货
5 mg 询价
10 mg 询价
50 mg 询价
100 mg 询价

* Please select Quantity before adding items.

生物活性

Resorufin pentyl ether (Pentoxyresorufin) is a Resazurin (HY-111391) analogue. Resorufin pentyl ether can function as a substrate probe to characterize and differentiate between a variety of inducers of cytochromes P-450. Resorufin pentyl ether has bactericidal activity against N. gonorrhoeae[1][2].

分子量

283.32

Formula

C17H17NO3
CAS 号

87687-03-4
中文名称

7-羟基吩噁嗪酮二戊醚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Deanna M. Schmitt, et al. Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo. Int J Antimicrob Agents. 2016 Oct; 48(4): 367–372.

    [2]. M D Burke, et al. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem Pharmacol. 1985 Sep 15;34(18):3337-45.

Resorufin methyl ether(Synonyms: Methoxyresorufin)

发表于由

Resorufin methyl ether;(Synonyms: Methoxyresorufin)

Resorufin methyl ether (Methoxyresorufin) 是一种细胞色素 P450 的荧光底物，是啮齿动物中 CYP1A2 特异性底物。

Resorufin methyl etheramp;;(Synonyms: Methoxyresorufin)

Resorufin methyl ether Chemical Structure

CAS No. : 5725-89-3

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生物活性

Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate[1]. Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents[1][2].

分子量

227.22

Formula

C13H9NO3
CAS 号

5725-89-3
中文名称

甲氧基试卤灵
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. P V Nerurkar, et al. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem Pharmacol. 1993 Sep 1;46(5):933-43.

    [2]. Hansen Murcia, et al. Study on the inhibitory effect of furafylline and troleandomycin in the 7-methoxyresorufin-O-demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescence and ultraviolet detection. J Pharm Biomed Anal. 2019 Feb 5;164:148-154.