上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Euphol acetate
Euphol acetate 是一种三萜烯类化合物,可以从 Euphorbia broteri 中提取得到。Euphol acetate 是肝转运蛋白 OATP1B1/3 的抑制剂。
Euphol acetate Chemical Structure
CAS No. : 13879-04-4
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3)[1][2].
IC50 & Target
OATP1B1/3[2]
体外研究 (In Vitro)
Euphol acetate (10 μM) suppresses the uptake of the OATP1B substrate sodium fluorescein in OATP1B1 (29.2%)- or 1B3 (40.2%)-transfected CHO cells[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
468.75
Formula
C32H52O2
CAS 号
13879-04-4
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. DePascual Teresa, et al. Triterpenes from Euphorbia broteri. Phytochemistry. 1987. 26(6): 1767-1776.
[2]. Tom De Bruyn, et al. Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol. 2013 Jun;83(6):1257-67.
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain[1].
IC50 & Target
Human Endogenous Metabolite
体外研究 (In Vitro)
Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively[2]. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[2]
Cell Line:
T47D cells
Concentration:
0.01, 0.03, 0.1 and 0.3 mM
Incubation Time:
24, 48 and 72 hours
Result:
Decreased the percentage of viable cells.
Western Blot Analysis[2]
Cell Line:
T47D cells
Concentration:
0.03 mM
Incubation Time:
48 and 72 hours
Result:
Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D.
分子量
426.72
Formula
C30H50O
CAS 号
514-47-6
中文名称
大戟二烯醇
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Dutra RC, et al. Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. Neuropharmacology. 2012 Sep;63(4):593-605.
[2]. Wang L, et al. Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression. Mol Med Rep. 2013 Oct;8(4):1279-85.