标签归档：flavonoids

(+)-Kavain

发表于由

天然产物 黄酮类 Flavonoids

(+)-Kavain  纯度: 99.83%

(+)-Kavain 是从卡瓦胡椒 (Piper methysticum) 中提取的一种主要的卡瓦内酯，具有抗惊厥作用，通过电压依赖性的Na+ 和Ca2+通道相互作用，减弱血管平滑肌的收缩。Kavain 能与α4β2δ GABAA 受体结合，加强GABA的功效。Kavain 可用于炎症疾病研究。

(+)-Kavain

(+)-Kavain Chemical Structure

CAS No. : 500-64-1

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥550 In-stock
5 mg ￥500 In-stock
10 mg ￥700 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

(+)-Kavain 相关产品

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  • Medicine Food Homology Compound Library
  • Neurotransmitter Receptor Compound Library
  • Traditional Chinese Medicine Monomer Library
  • FDA Approved & Pharmacopeial Drug Library
  • Flavonoids Library
  • Anti-Alzheimer’s Disease Compound Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Food-Sourced Compound Library

生物活性

(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4].

IC50 & Target

Na+, Ca2+ channel[1].
α4β2δ GABAA receptor[2].
体外研究
(In Vitro)

(+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM[2]. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

230.26

Formula

C14H14O3
CAS 号

500-64-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (217.15 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3429 mL 21.7146 mL 43.4292 mL
5 mM 0.8686 mL 4.3429 mL 8.6858 mL
10 mM 0.4343 mL 2.1715 mL 4.3429 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (9.03 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (9.03 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (9.03 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Bradić I, et al. [Hirschsprung’s disease — therapy and results]. Acta Chir Iugosl. 1975;22(2):183-95.

    [2]. Chua HC, et al. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLoS One. 2016 Jun 22;11(6):e0157700.

    [3]. G. Boonen, et al. In vivo Effects of the Kavapyrones (+)-Dihydromethysticin and (±)-Kavain on Dopamine, 3,4-Dihydroxyphenylacetic Acid, Serotonin and 5-Hydroxyindoleacetic Acid Levels in Striatal and Cortical Brain Regions. Planta Medica 64 (1998) 507-510.

    [4]. Tang X, et al. Kavain Inhibition of LPS-Induced TNF-α via ERK/LITAF. Toxicol Res (Camb). 2016 Jan 1;5(1):188-196.

5,7-Dimethoxyflavone

发表于由

天然产物 黄酮类 Flavonoids

5,7-Dimethoxyflavone  纯度: 99.86%

5,7-Dimethoxyflavone 是 Kaempferia parviflora 的主要成分之一，具有抗肥胖，抗炎和抗肿瘤作用。5,7-Dimethoxyflavone 抑制细胞色素 P450 (CYP) 3As。5,7-Dimethoxyflavone 也是有效的抗乳腺癌蛋白 (BCRP) 抑制剂。

5,7-Dimethoxyflavone

5,7-Dimethoxyflavone Chemical Structure

CAS No. : 21392-57-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥990 In-stock
25 mg ￥900 In-stock
50 mg ￥1500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

5,7-Dimethoxyflavone 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Antioxidants Compound Library
  • Oxygen Sensing Compound Library
  • Flavonoids Library
  • Anti-Breast Cancer Compound Library
  • Anti-Obesity Compound Library
  • Food-Sourced Compound Library
  • Targeted Diversity Library

生物活性

5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor[1][2].

IC50 & Target[1][2]

CYP3A

 

Breast Cancer Resistance Protein (BCRP)

 

分子量

282.29

Formula

C17H14O4
CAS 号

21392-57-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (354.25 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5425 mL 17.7123 mL 35.4246 mL
5 mM 0.7085 mL 3.5425 mL 7.0849 mL
10 mM 0.3542 mL 1.7712 mL 3.5425 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.86 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.86 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.86 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Ochiai W, et al. Effect of the active ingredient of Kaempferia parviflora, 5,7-dimethoxyflavone, on the pharmacokinetics of midazolam. J Nat Med. 2018 Jun;72(3):607-614.

    [2]. Bae S, et al. Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice. Eur J Pharm Sci. 2018 May 30;117:27-34.

Cowaxanthone B

发表于由

天然产物 黄酮类 Flavonoids

Cowaxanthone B 

Cowaxanthone B 是从小叶藤黄果实中分离出的一种氧杂蒽酮。Cowaxanthone B 具有较弱的抗菌活性。

Cowaxanthone B

Cowaxanthone B Chemical Structure

CAS No. : 212842-64-3

规格 价格 是否有货
5 mg ￥3430 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Cowaxanthone B is a xanthone isolated from the fruits of Garcinia cowa. Cowaxanthone B has weak antibacterial activity[1].

分子量

424.49

Formula

C25H28O6
CAS 号

212842-64-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Panthong K, et al. Tetraoxygenated xanthones from the fruits of Garcinia cowa. Phytochemistry. 2006 May;67(10):999-1004.

3′-Methoxyflavonol

发表于由

天然产物 黄酮类 Flavonoids

3′-Methoxyflavonol  纯度: 99.79%

3′-Methoxyflavonol 是神经介肽 U 2 受体 (NMU2R) 的选择性激动剂。

3

3′-Methoxyflavonol Chemical Structure

CAS No. : 76666-32-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥550 In-stock
50 mg ￥500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

3′-Methoxyflavonol 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Flavonoids Library
  • Microbial Metabolite Library

生物活性

3′-Methoxyflavonol is a selective agonist of neuromedin U 2 receptor (NMU2R).

IC50 & Target

NMU2R[1]
体外研究
(In Vitro)

3′-Methoxyflavonol (NRA 10) is a selective agonist of neuromedin U 2 receptor (NMU2R)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

268.26

Formula

C16H12O4
CAS 号

76666-32-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 155 mg/mL (577.80 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7277 mL 18.6386 mL 37.2773 mL
5 mM 0.7455 mL 3.7277 mL 7.4555 mL
10 mM 0.3728 mL 1.8639 mL 3.7277 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ma ML, et al. Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. Bioorg Med Chem. 2014 Nov 1;22(21):6117-23.

Comanthoside A

发表于由

天然产物 黄酮类 Flavonoids

Comanthoside A 

Comanthoside A 是一种从 Comanthosphace japonica 中提取的植物源性天然黄酮苷。Comanthoside A 也是合成 Comanthoside B 和 Linaroside 的关键中间体。

Comanthoside A

Comanthoside A Chemical Structure

CAS No. : 70938-59-9

规格 价格 是否有货
1 mg ￥1000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Comanthoside A is a plant derived natural flavonoid glycoside isolated from the leaves of Comanthosphace japonica. Comanthoside A also serves as a key intermediate for the synthesis of Comanthoside B and Linaroside[1][2].

分子量

504.44

Formula

C24H24O12
CAS 号

70938-59-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. ARISAWA, M., et al. The constituents of the leaves of Comanthosphace japonica S. Moore (Labiatae): Isolation of two new flavone glycosides, comanthosides A and B. CHEMICAL & PHARMACEUTICAL BULLETIN, 27(5), 1252–1254.

    [2]. Yan, S., et al. Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin. Tetrahedron, 76(8), 130950.

3′,​4′,​5′,​5,​7-​Pentamethoxyflavone

发表于由

天然产物 黄酮类 Flavonoids

3′,​4′,​5′,​5,​7-​Pentamethoxyflavone 

3′,4′,5′,5,7-Pentamethoxyflavone 是从 Rutaceae 中提取得到的一种天然黄铜类化合物，通过抑制Nrf2 通路克服化疗药物对癌细胞的导致的耐药性。

3

3′,​4′,​5′,​5,​7-​Pentamethoxyflavone Chemical Structure

CAS No. : 53350-26-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

3′,4′,5′,5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic drugs by inhibition of Nrf2 pathway[1].

分子量

372.37

Formula

C20H20O7
CAS 号

53350-26-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hou X, et al. 3′,4′,5′,5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway. Mol Cells. 2015 May;38(5):396-401.

6”-Acetylhyperin

发表于由

天然产物 黄酮类 Flavonoids

6”-Acetylhyperin 

6”-Acetylhyperin 是可存在于 Nymphaea odorata 中的天然生物碱。

6

6”-Acetylhyperin Chemical Structure

CAS No. : 72659-75-7

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

6”-Acetylhyperin is a natural phenolic compounds that could be found in Nymphaea odorata[1].

分子量

506.41

Formula

C23H22O13
CAS 号

72659-75-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhizhen Zhang, et al. Phenolic compounds from Nymphaea odorata. J Nat Prod. 2003 Apr;66(4):548-50.

3,8”-Biapigenin

发表于由

天然产物 黄酮类 Flavonoids

3,8”-Biapigenin 

3,8”-Biapigenin 是存在于贯叶连翘中的双黄酮。

3,8

3,8”-Biapigenin Chemical Structure

CAS No. : 101140-06-1

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

3,8”-Biapigenin is a biflavone in Hypericum perforatum L.[1].

分子量

538.46

Formula

C30H18O10
CAS 号

101140-06-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bagdonait E, et al. Variation in concentrations of major bioactive compounds in Hypericum perforatum L. from Lithuania[J]. Industrial Crops & Products, 2012, 35(1):302-308.

Ladanein

发表于由

天然产物 黄酮类 Flavonoids

Ladanein 

Ladanein 是一种从 Thymus piperella 中分离出来的黄酮类化合物。

Ladanein

Ladanein Chemical Structure

CAS No. : 10176-71-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ladanein is a flavonoids compound isolated from Thymus piperella[1].

分子量

314.29

Formula

C17H14O6
CAS 号

10176-71-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Barberán FA, et al. Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella. Planta Med. 1985;51(5):452-454.

Latinone

发表于由

天然产物 黄酮类 Flavonoids

Latinone 

Latinone 是一种从黄檀中分离出的新黄酮，具有抗骨质疏松活性。

Latinone

Latinone Chemical Structure

CAS No. : 79157-36-1

规格 价格 是否有货
5 mg ￥14000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Latinone, a neoflavonoid isolated from Dalbergia cochinchinensis, has antiosteoporotic activity[1].

分子量

360.36

Formula

C22H16O5
CAS 号

79157-36-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Padam Kumar, et al. Neoflavonoids as Potential Osteogenic Agents From Dalbergia Sissoo Heartwood. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2664-8.