Forsythoside I 是从Forsythia suspense (Thunb.) Vahl 中分离得到的一种咖啡基苯乙醇苷 (CPG),可能有抗炎作用。
Forsythoside I Chemical Structure
CAS No. : 1177581-50-8
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5 mg
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生物活性
Forsythoside I, a caffeoyl phenylethanoid glycoside (CPG) isolated from the fruits of Forsythia suspense (Thunb.) Vahl, may possesses anti-inflammatory activities[1].
分子量
624.59
Formula
C29H36O15
CAS 号
1177581-50-8
运输条件
Room temperature in continental US; may vary elsewhere.
Forsythoside F 是黄嘌呤氧化酶 (xanthine oxidase) 抑制剂,具有抗高尿酸作用。
Forsythoside F Chemical Structure
CAS No. : 94130-58-2
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25 mg
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生物活性
Forsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo[1].
分子量
756.70
Formula
C34H44O19
CAS 号
94130-58-2
中文名称
连翘酯苷F
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Lee-Chuen Chenga, et al. Developing a Validated HPLC Method for the Phytochemical Analysis of Antihyperuricemic Phenylethanoid Glycosides and Flavonoids in Lippia nodiflora.Natural Product Communications.
Forsythoside H 是从Forsythia suspense (Thunb.) Vahl 中分离得到的一种咖啡基苯乙醇苷 (CPG),可能有抗炎作用。
Forsythoside H Chemical Structure
CAS No. : 1178974-85-0
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5 mg
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生物活性
Forsythoside H, a caffeoyl phenylethanoid glycoside (CPG) isolated from the fruits of Forsythia suspense (Thunb.) Vahl, may possesses anti-inflammatory activities[1].
分子量
624.59
Formula
C29H36O15
CAS 号
1178974-85-0
中文名称
连翘酯苷 H
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Wang FN, et al. New phenylethanoid glycosides from the fruits of forsythia suspense (thunb.) vahl. Molecules. 2009 Mar 25;14(3):1324-31.
Forsythoside B 是传统中药植物独一味的叶子中分离的苯乙醇苷。独一味可用于炎症疾病和促进血液循环的研究。Forsythoside B 可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。
Forsythoside B Chemical Structure
CAS No. : 81525-13-5
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价格
是否有货
数量
10;mM;*;1 mL in DMSO
¥999
In-stock
5 mg
¥900
In-stock
10 mg
¥1200
In-stock
25 mg
¥2400
In-stock
50 mg
¥3800
In-stock
100 mg
¥6400
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200 mg
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500 mg
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Forsythoside B 相关产品
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生物活性
Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
IC50 Target
NF-κB
;
TNF-α
;
体外研究 (In Vitro)
Forsythoside B concentration-dependently down-regulates the levels of TNF-α, IL-6 and high-mobility group-box 1 protein (HMGB1) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, inhibits the IκB kinase (IKK) pathway and modulated nuclear factor (NF)- κB[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Intravenous injection of forsythoside B alone or plus imipenem reduces serum levels of TNF-α, IL-6, HMGB1, triggering receptor expressed on myeloid cells (TREM-1) and endotoxin, while the serum level of IL-10 is up-regulated and myeloperoxidase (MPO) in lung, liver and small intestine is reduced[1]. Forsythoside B at doses higher than 8 mg/kg produces a significant neuroprotective potential in cerebral ischemia and reperfusion rats. Forsythoside B (20 mg/kg) demonstrates significant neuroprotective activity even after delayed administration at 1 h, 3 h and 5 h after cerebral ischemia and reperfusion. Forsythoside B 20 mg/kg attenuates histopathological damage as demonstrated by smaller brain infarct size and brain edema, decreased cerebral Evans blue extravasation and myeloperoxidase activity, inhibited cerebral phosphor-IκB-α and NF-κB expression[2]. Forsythoside B shows a significant recovery in myocardial function with improvement of LVSP and +/-dp/dt(max). The myocardial infarct volume, serum levels of Tn-T, TNF-alpha and IL-6, content of MDA and MPO activity in myocardial tissue are all reduced, protein expression of HMGB1, phosphor-I kappaB-alpha and phosphor-NF-kappaB are down-regulated, while attenuate the decrease of SOD and GPx activities[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
756.70
Formula
C34H44O19
CAS 号
81525-13-5
中文名称
连翘脂苷 B;连翘酯苷 B;连翘酯甙 B
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Jiang WL, et al. Forsythoside B protects against experimental sepsis by modulating inflammatory factors. Phytother Res. 2012 Jul;26(7):981-7.
[2]. Jiang WL, et al. Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury. Eur J Pharmacol. 2010 Aug 25;640(1-3):75-81.
[3]. Jiang WL, et al. Cardioprotection with forsythoside B in rat myocardial ischemia-reperfusion injury: relation to inflammation response. Phytomedicine. 2010 Jul;17(8-9):635-9.
Cell Assay [1]
Forsythoside B is dissolved in sterile saline solution and added to the medium at various concentrations (from 0.1 to 10 μM) and incubated with LPS stimulated RAW264.7 cells. Cell-free supernatants are collected after Forsythoside B treatment for 24 h. Cell viability is assessed by measuring lactate dehydrogenase (LDH) in the medium[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration [2]
Rats: Forsythoside B is dissolved in sterilized saline. For the dose–response study, forsythoside B at doses of 1.3, 3.2, 8, 20 or 50 mg/kg is administered as an intravenous bolus injection at 15 min after reperfusion. The sham or vehicle-treated rats are injected with saline. Neurological deficits are determined at 23 h after reperfusion followed by brain infarct volume examination[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Jiang WL, et al. Forsythoside B protects against experimental sepsis by modulating inflammatory factors. Phytother Res. 2012 Jul;26(7):981-7.
[2]. Jiang WL, et al. Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury. Eur J Pharmacol. 2010 Aug 25;640(1-3):75-81.
[3]. Jiang WL, et al. Cardioprotection with forsythoside B in rat myocardial ischemia-reperfusion injury: relation to inflammation response. Phytomedicine. 2010 Jul;17(8-9):635-9.