HANNA哈纳 pH221台式酸度计系列具有GLP功能的酸度离子测量仪

发表于2023年5月29日由Whatman官网

HANNA哈纳 pH221台式酸度计系列具有GLP功能的酸度离子测量仪

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品牌：HANNA哈纳
生产厂家：HANNA哈纳
需求数量：

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校准测量功能:
＊更多校准信息：在校准时，当一个或多个参数不合适时仪器会显示错误信息提醒用户
＊显示电极状态：通过检测电极零点或斜率判断电极状态
＊显示电极响应时间：通过校准时检测电极性能判断电极响应时间
＊校准报警：可编程设定报警间隔为1到7天
●其它特点：
＊数据存贮功能，HI221可存贮100个数据，HI223可存贮500个数据
＊记录上一次准的时间和日期
＊可设定中的特征号
＊仪器内置实时时钟
＊RS232接口

GLP 除了可存贮校准数据，可对仪器进行编程当需要进行新的校准时报警

仪器具有存贮测量结果的功能，HI221可存贮100个结果，HI223可存贮500个结果

HI221和HI223可随后调出仪器内部存贮的测量结果

GLP-1(32-36)amide

发表于2023年5月15日由Whatman官网

GLP-1(32-36)amide; 纯度: 98.43%

GLP-1(32-36)amide，一种衍生自糖调节激素 GLP-1 的 C 末端的五肽。GLP-1(32-36)amide 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。

GLP-1(32-36)amide Chemical Structure

CAS No. : 1417302-71-6

规格	价格	是否有货	数量
5 mg	￥2750	In-stock
10 mg	￥4650	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

GLP-1(32-36)amide 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Diabetes Related Compound Library
Peptide Library

生物活性

GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice^[1]^[2].

体外研究
(In Vitro)

GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS‐1 cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	INS‐1 cells
Concentration:	0.1, 1, 10 μM
Incubation Time:	24 hours
Result:	Decreased cell viability only approximately 30% in 0.1 μM and approximately 20% in ≥1 μM while approximately 45% in saline-treated controls.

体内研究
(In Vivo)

GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice^[2].
GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice^[2].
GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male KM mice (6-8 weeks; 18-22 g) injected with STZ^[2]
Dosage:	1 μmol/kg
Administration:	I.p. once daily for 21 days
Result:	Signiﬁcantly lowered the cumulative values of food and water intake. Lowered fasting glucose. Reduced the level of Hemoglobin A1c (HbA1c). Improved glucose tolerance. Suppressed body weight gain.

分子量

570.73

Formula

C₂₅H₅₀N₁₀O₅

CAS 号

1417302-71-6

Sequence

Leu-Val-Lys-Gly-Arg-NH2

Sequence Shortening

LVKGR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 250 mg/mL (438.04 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7521 mL	8.7607 mL	17.5214 mL
5 mM	0.3504 mL	1.7521 mL	3.5043 mL
10 mM	0.1752 mL	0.8761 mL	1.7521 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.64 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.64 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.64 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Elahi D, et, al. GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep;59:20-4.

[2]. Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015 Dec;86(6):1482-90.

[3]. Tomas E, et, al. GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul;64(7):2409-19.

GLP-1(28-36)amide

发表于2023年4月24日由Whatman官网

GLP-1(28-36)amide; 纯度: 96.08%

GLP-1(28-36)amide 是一段 GLP-1 的 C-端九肽，是一种中性内肽酶 (NEP) 裂解 GLP-1 的主要产物。GLP-1(28-36)amide 是一种抗氧化剂，靶向线粒体，抑制线粒体通透性转变 (MPT)。GLP-1(28-36)amide 具有抗糖尿病和心脏保护作用。

GLP-1(28-36)amide Chemical Structure

CAS No. : 1225021-13-5

规格	价格	是否有货	数量
5 mg	￥2850	In-stock
10 mg	￥4850	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

GLP-1(28-36)amide 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Diabetes Related Compound Library
Anti-Cardiovascular Disease Compound Library
Peptide Library

生物活性

GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide has anti-diabetic and cardioprotection effects^[1].

体外研究
(In Vitro)

Different from DPP-IV, NEP, which cleaves GLP-1(7-36)amide or GLP-1(9-36)amide to generate GLP-1(28-36)amide, is widely distributed in endothelial cells, vascular smooth muscle cells, cardiac cells and renal epithelial cells^[1].
GLP-1(28-36)amide (100 nM) treatment on hepatocytes for 24 hours directly modulates mitochondrial oxidative metabolism, such as gluconeogenesis in mitochondria of hepatocytes^[1].
The plasma half-life of GLP-1(28-36)amide is longer in human hepatocytes (t_1/2 = 24 min) than that in mouse hepatocytes (t_1/2 = 13 min)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

The administration of GLP-1(28-36)amide at a rate of 18.5 nmol/kg BW/day for 9 weeks to diet-induced obese mice diminishes the development of hepatic steatosis^[1].
The intraperitoneal injection of 18 nmol/kg GLP-1(28-36)amide once daily for 9 weeks show cytoprotective effect on pancreatic β cells by increasing mass and promoting proliferation in a β-cell injury diabetic mouse model^[1].
An in vivo study in high-fat diet-fed mice indicates that a six-week administration of 18.5 nmol/kg GLP-1(28-36)amide improved hepatic glucose disposal, which is associated with increased cAMP levels and phosphorylation of PKA target^[1].
Administered GLP-1(28-36)amide for 20 min to male C57BL6/J mice (10-12 week old), then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure (LVDP) is significantly greater in GLP-1(28-36)amide group compared to vehicle-treated hearts^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1088.35

Formula

C₅₄H₈₅N₁₅O₉

CAS 号

1225021-13-5

Sequence

Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Sequence Shortening

FIAWLVKGR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (91.88 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9188 mL	4.5941 mL	9.1882 mL
5 mM	0.1838 mL	0.9188 mL	1.8376 mL
10 mM	0.0919 mL	0.4594 mL	0.9188 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (2.30 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.30 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.30 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.30 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Bilan Zhou, et al. GLP-1(28-36)amide, a Long Ignored Peptide Revisited. Open Biochem J. 2014 Dec 31;8:107-11.

HAEGTFTSD

发表于2023年4月20日由Whatman官网

HAEGTFTSD; 纯度: 98.04%

HAEGTFTSD 是 GLP-1 肽或 GLP-1(7-36), amide (HY-P0054A) 的 9 个残基的肽段。GLP-1(7-36), amide 是一种生理促胰岛素激素，以葡萄糖依赖式，刺激胰岛素分泌的方式。

HAEGTFTSD Chemical Structure

CAS No. : 926018-45-3

规格	价格	是否有货	数量
1 mg	￥1600	In-stock
5 mg	￥5000	In-stock
10 mg	￥8000	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

HAEGTFTSD 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptidomimetic Library
Peptide Library

生物活性

HAEGTFTSD is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide (HY-P0054A). GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretionin a glucose-dependant manner^[1]

体外研究
(In Vitro)

The GLP-1 (7-36) amide is a product of the preproglucagon gene, which is secreted from intestinal L-cells, in response to the ingestion of food. GLP-1 exerts multiple actions by stimulating insulin secretion from pancreatic β-cells, in a glucose dependent manner (insulinotropic action). GLP-1 lowers circulating plasma glucagon concentration, by inhibiting its secretion (production) from α-cells. GLP-1 also exhibits properties like stimulation of β-cell growth, appetite suppression, delays gastric emptying and stimulation of insulin sensitivity^[1]. The peptide analogs of GLP-1 are useful as glucagon-like peptide 1 receptor agonists^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

963.94

Formula

C₄₀H₅₇N₁₁O₁₇

CAS 号

926018-45-3

Sequence Shortening

HAEGTFTSD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

参考文献

[1]. K Hupe-Sodmann, et al. Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides. Regul Pept. 1995 Aug 22;58(3):149-56.

GLP-2(rat) TFA

发表于2023年2月2日由Whatman官网

GLP-2(rat) TFA;

GLP-2(rat) TFA 是一种肠道生长因子。GLP-2(rat) TFA 刺激细胞增殖并抑制细胞凋亡。在大肠小肠切除术 (MSBR) 后，GLP-2(rat) TFA 可以增强残留小肠的粘膜质量和功能。

GLP-2(rat) TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

GLP-2(rat) TFA is an intestinal growth factor. GLP-2(rat) TFA stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) TFA enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR)^[1]^[2].

Clinical Trial

分子量

3910.16

Formula

C₁₆₈H₂₅₇F₃N₄₄O₅₈S

Sequence

His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Thr-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp

Sequence Shortening

HADGSFSDEMNTILDNLATRDFINWLIQTKITD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Avik K, et, al. Is OM-3 synergistic with GLP-2 in intestinal failure. J Surg Res. 2017 Jan; 207: 7-12.

[2]. Flavio GR, et, al. Glucagon-like peptide-2: divergent signaling pathways. J Surg Res. 2004 Sep; 121(1): 5-12.

GLP-1(9-36)amide TFA

发表于2023年1月31日由Whatman官网

GLP-1(9-36)amide TFA;

GLP-1(9-36)amide TFA 是胰高血糖素样肽-1 (7-36)）amide 的主要代谢产物。GLP-1(9-36)amide TFA 是一种人胰腺 GLP-1 受体的拮抗剂。

GLP-1(9-36)amide TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

GLP-1(9-36)amide TFA 的其他形式现货产品:

GLP-1(9-36)amide

生物活性	GLP-1(9-36)amide TFA is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide TFA acts as an antagonist to the human pancreatic GLP-1 receptor^[1]^[2].
分子量	3203.43
Formula	C₁₄₂H₂₁₅F₃N₃₆O₄₅
Sequence	Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Sequence Shortening	EGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Knudsen LB, et al. Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol. 1996;318(2-3):429-435. [2]. Elahi D, et al. GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring). 2008;16(7):1501-1509.

GLP-1(32-36)amide TFA

发表于2023年1月23日由Whatman官网

GLP-1(32-36)amide TFA;

GLP-1(32-36)amide TFA，一种衍生自糖调节激素 GLP-1 的 C 末端的五肽。GLP-1(32-36)amide TFA 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。

GLP-1(32-36)amide TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

GLP-1(32-36)amide TFA 的其他形式现货产品:

GLP-1(32-36)amide

生物活性

GLP-1(32-36)amide TFA, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide TFA could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice^[1]^[2].

体外研究
(In Vitro)

GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS‐1 cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	INS‐1 cells
Concentration:	0.1, 1, 10 μM
Incubation Time:	24 hours
Result:	Decreased cell viability only approximately 30% in 0.1 μM and approximately 20% in ≥1 μM while approximately 45% in saline-treated controls.

体内研究
(In Vivo)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male KM mice (6-8 weeks; 18-22 g) injected with STZ^[2]
Dosage:	1 μmol/kg
Administration:	1 μmol/kg
Result:	Signiﬁcantly lowered the cumulative values of food and water intake. Lowered fasting glucose. Reduced the level of Hemoglobin A1c (HbA1c). Improved glucose tolerance. Suppressed body weight gain.

分子量

684.75

Formula

C₂₇H₅₁F₃N₁₀O₇

Sequence

Leu-Val-Lys-Gly-Arg-NH2

Sequence Shortening

LVKGR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Elahi D, et, al. GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep;59:20-4.

[2]. Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015 Dec;86(6):1482-90.

[3]. Tomas E, et, al. GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul;64(7):2409-19.

GLP-1(28-36)amide TFA

发表于2023年1月19日由Whatman官网

GLP-1(28-36)amide TFA;

GLP-1(28-36)amide TFA 是一段 GLP-1 的 C-端九肽，是一种中性内肽酶 (NEP) 裂解 GLP-1 的主要产物。GLP-1(28-36)amide TFA 是一种抗氧化剂，靶向线粒体，抑制线粒体通透性转变 (MPT)。GLP-1(28-36)amide TFA 具有抗糖尿病和心脏保护作用。

GLP-1(28-36)amide TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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GLP-1(28-36)amide TFA 的其他形式现货产品:

GLP-1(28-36)amide

生物活性	GLP-1(28-36)amide TFA, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide TFA is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide TFA has anti-diabetic and cardioprotection effects^[1].
体外研究 (In Vitro)	Different from DPP-IV, NEP, which cleaves GLP-1(7-36)amide or GLP-1(9-36)amide to generate GLP-1(28-36)amide, is widely distributed in endothelial cells, vascular smooth muscle cells, cardiac cells and renal epithelial cells^[1]. GLP-1(28-36)amide (100 nM) treatment on hepatocytes for 24 hours directly modulates mitochondrial oxidative metabolism, such as gluconeogenesis in mitochondria of hepatocytes^[1]. The plasma half-life of GLP-1(28-36)amide is longer in human hepatocytes (t_1/2 = 24 min) than that in mouse hepatocytes (t_1/2 = 13 min)^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	The administration of GLP-1(28-36)amide at a rate of 18.5 nmol/kg BW/day for 9 weeks to diet-induced obese mice diminishes the development of hepatic steatosis^[1]. The intraperitoneal injection of 18 nmol/kg GLP-1(28-36)amide once daily for 9 weeks show cytoprotective effect on pancreatic β cells by increasing mass and promoting proliferation in a β-cell injury diabetic mouse model^[1]. An in vivo study in high-fat diet-fed mice indicates that a six-week administration of 18.5 nmol/kg GLP-1(28-36)amide improved hepatic glucose disposal, which is associated with increased cAMP levels and phosphorylation of PKA target^[1]. Administered GLP-1(28-36)amide for 20 min to male C57BL6/J mice (10-12 week old), then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure (LVDP) is significantly greater in GLP-1(28-36)amide group compared to vehicle-treated hearts^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1202.37
Formula	C₅₆H₈₆F₃N₁₅O₁₁
Sequence	Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Sequence Shortening	FIAWLVKGR-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Bilan Zhou, et al. GLP-1(28-36)amide, a Long Ignored Peptide Revisited. Open Biochem J. 2014 Dec 31;8:107-11.

Ecnoglutide

发表于2023年1月16日由Whatman官网

Ecnoglutide;

Ecnoglutide 是胰高血糖素样肽 1 (GLP-1) 受体激动剂。

Ecnoglutide Chemical Structure

CAS No. : 2459531-73-6

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Ecnoglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist^[1].
分子量	4284.76
Formula	C₁₉₄H₃₀₄N₄₈O₆₁
CAS 号	2459531-73-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. WHO Drug Information, Vol. 35, No. 4, 2021. Geneva: World Health Organization; 2022.

Utreglutide

发表于2023年1月16日由Whatman官网

Utreglutide;

Utreglutide 是一种有效的胰高血糖素样肽 1 (GLP-1) 受体激动剂。

Utreglutide Chemical Structure

CAS No. : 2460862-12-6

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Utreglutide is a potent glucagon-like peptide 1 (GLP-1) receptor agonit^[1].
分子量	4166.67
Formula	C₁₉₁H₂₉₈N₄₆O₅₈
CAS 号	2460862-12-6
Sequence Shortening	Chain 1:H{Aib}EGTFTSDVSSYLEGQAAKEFIAWLVRGRGL; Chain 2:{Ggu}{Aib}{Oaa} (Amide bridge:Lys20-{Oaa})
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. WHO Drug Information, Vol. 35, No. 4, 2021. Geneva: World Health Organization; 2022.

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标签归档：glp

HANNA哈纳 pH221台式酸度计系列具有GLP功能的酸度离子测量仪

HANNA哈纳 pH221台式酸度计系列具有GLP功能的酸度离子测量仪

GLP-1(32-36)amide

GLP-1(32-36)amide 相关产品

bull;相关化合物库:

GLP-1(28-36)amide

GLP-1(28-36)amide 相关产品

bull;相关化合物库:

HAEGTFTSD

HAEGTFTSD 相关产品

bull;相关化合物库:

GLP-2(rat) TFA

GLP-1(9-36)amide TFA

GLP-1(32-36)amide TFA

GLP-1(28-36)amide TFA

Ecnoglutide

Utreglutide

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