Guangxitoxin-1E 品牌:Peptide


Guangxitoxin-1E

品牌:Peptide
CAS No.:
储存条件:-20°C
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

334-44331

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Guangxitoxin 1E

Guangxitoxin 1E;

Guangxitoxin 1E 是 KV2.1KV2.2 通道的有效选择性阻断剂。Guangxitoxin 1E 抑制 KV2, 其 IC50 值为 1-3 nM,KV2 通道是各种神经元中延迟整流器钾电流的基础。

Guangxitoxin 1Eamp;;

Guangxitoxin 1E Chemical Structure

CAS No. : 1233152-82-3

规格 是否有货
100 μg 询价

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生物活性

Guangxitoxin 1E is a potent and selective blocker of KV2.1 and KV2.2 channels. Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM. KV2 channels underlie delayed-rectifier potassium currents in various neurons[1][2].

IC50 Target

IC50: 1-3 nM (KV2 channels); 24-54 nM (KV4.3 channels)[2]

体外研究
(In Vitro)

Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM[2].
In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3948.61

Formula

C178H248N44O45S7

CAS 号

1233152-82-3

Sequence Shortening

EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP(Disulfide bridge:Cys4-Cys19;Cys11-Cys24;Cys18-Cys31)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hönigsperger C, et al. Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. J Physiol. 2017 Feb 1;595(3):739-757.

    [2]. Herrington J, et al. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. 2006 Apr;55(4):1034-42.