Histone H4 (2-21)

发表于2023年4月28日由Whatman官网

Histone H4 (2-21); 纯度: 99.61%

Histone H4 (2-21) 是一组与单纯疱疹病毒1 (HSV-1) 基因组染色化相关的核心组蛋白。

Histone H4 (2-21) Chemical Structure

CAS No. : 667899-73-2

规格	价格	是否有货	数量
1 mg	￥1200	In-stock
5 mg	￥3600	In-stock
10 mg	￥5760	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

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Histone H4 (2-21) 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes^[1].

分子量

1992.33

Formula

C₈₂H₁₅₀N₃₆O₂₂

CAS 号

667899-73-2

Sequence

Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys

Sequence Shortening

SGRGKGGKGLGKGGAKRHRK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

H₂O : 100 mg/mL (50.19 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.5019 mL	2.5096 mL	5.0192 mL
5 mM	0.1004 mL	0.5019 mL	1.0038 mL
10 mM	0.0502 mL	0.2510 mL	0.5019 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Conn KL, et al. Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1. J Virol. 2011 Dec;85(24):13234-52.

Histone H3 (1-35) (TFA)

发表于2023年3月25日由Whatman官网

Histone H3 (1-35) (TFA); 纯度: 99.85%

Histone H3 (1-35) TFA 是含 35 个氨基酸的组蛋白 H3 肽片段。Histone H3 是参与真核细胞染色质结构的五个主要组蛋白之一。

Histone H3 (1-35) (TFA) Chemical Structure

规格	价格	是否有货	数量
5 mg	￥4000	In-stock
10 mg	￥7000	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

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Histone H3 (1-35) (TFA) 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

Histone H3 (1-35) TFA is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells^[1].

体外研究
(In Vitro)

Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3665.15

Formula

C₁₅₁H₂₇₀F₃N₅₅O₄₇

Sequence Shortening

ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGV

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

H₂O : 50 mg/mL (13.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2728 mL	1.3642 mL	2.7284 mL
5 mM	0.0546 mL	0.2728 mL	0.5457 mL
10 mM	0.0273 mL	0.1364 mL	0.2728 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Manoj Bhasin, et al. Recognition and classification of histones using support vector machine. J Comput Biol. Jan-Feb 2006;13(1):102-12.

Histone H3 (1-25), amide

发表于2023年2月20日由Whatman官网

Histone H3 (1-25), amide;

Histone H3 (1-25), amide 是组蛋白H3的一个N端肽段。Histone H3 (1-25), amide 可以用来鉴定组蛋白甲基转移酶 (HMTs) 的底物。Histone H3 (1-25), amide，作为 HMT G9a 的底物，比组蛋白 H3 (15-39)和全长组蛋白 H3 更有效。

Histone H3 (1-25), amide Chemical Structure

CAS No. : 1373320-65-0

规格		是否有货
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250 mg	;	询价	;
500 mg	;	询价	;

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生物活性	Histone H3 (1-25), amide is an N-terminal peptide fragment of histone H3. Histone H3 (1-25), amide can be used to identify the substrate for histone methyltransferases (HMTs). Histone H3 (1-25), amide, as a substrate for HMT G9a, shows more efficient than histone H3 (15-39) and full-length histone H3^[1].
分子量	2625.10
Formula	C₁₁₀H₂₀₂N₄₂O₃₂
CAS 号	1373320-65-0
Sequence Shortening	ARTKQTARKSTGGKAPRKQLATKAA-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Kumar M, et al. Biochemical Assay Development for Histone Methyltransferases Using a Transcreener-Based Assay for S-Adenosylhomocysteine. Assay Drug Dev Technol. 2015;13(4):200-209.

Histone H1-derived Peptide

发表于2023年2月17日由Whatman官网

Histone H1-derived Peptide;

Histone H1-derived Peptide 是一种磷酸肽，肽底物包含 CDK 最佳识别基序的序列。

Histone H1-derived Peptide Chemical Structure

CAS No. : 889112-06-5

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性

Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDKs^[1].

分子量

1252.51

Formula

C₅₆H₁₀₁N₁₇O₁₅

CAS 号

889112-06-5

Sequence

Gly-Gly-Gly-Pro-Ala-Thr-Pro-Lys-Lys-Ala-Lys-Lys-Leu

Sequence Shortening

GGGPATPKKAKKL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Roderick G Walker, et al. High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase. PLoS Negl Trop Dis. 2011 Apr 5;5(4):e1033.

Histone H3 (1-35)

发表于2023年2月7日由Whatman官网

Histone H3 (1-35);

Histone H3 (1-35) 是含 35 个氨基酸的组蛋白 H3 肽片段。Histone H3 是参与真核细胞染色质结构的五个主要组蛋白之一。

Histone H3 (1-35) Chemical Structure

CAS No. : 135990-31-7

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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Histone H3 (1-35) 的其他形式现货产品:

Histone H3 (1-35) (TFA)

生物活性

Histone H3 (1-35) is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells^[1].

体外研究
(In Vitro)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3551.13

Formula

C₁₄₉H₂₆₉N₅₅O₄₅

CAS 号

135990-31-7

Sequence Shortening

ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGV

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Manoj Bhasin, et al. Recognition and classification of histones using support vector machine. J Comput Biol. Jan-Feb 2006;13(1):102-12.

Histone H2A (1-20)

发表于2023年2月4日由Whatman官网

Histone H2A (1-20); 纯度: 99.49%

Histone H2A (1-20) 是一种含 35 个氨基酸的组蛋白 H2A 肽片段，是甲基转移酶/脱甲基酶 (methyltransferase/demethylase enzymes) 的底物。

Histone H2A (1-20) Chemical Structure

规格	价格	是否有货	数量
1 mg	￥1600	In-stock
5 mg	￥4400	In-stock
10 mg	￥7000	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Histone H2A (1-20) 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

Histone H2A (1-20), a 35-residue a peptide of histone H2A, is a substrate for methyltransferase/demethylase enzymes^[1].

分子量

2087.40

Formula

C₈₃H₁₅₅N₃₇O₂₆

Sequence

Ser-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Ala-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser-Arg

Sequence Shortening

SGRGKQGGKARAKAKTRSSR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

H₂O : 100 mg/mL (47.91 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.4791 mL	2.3953 mL	4.7906 mL
5 mM	0.0958 mL	0.4791 mL	0.9581 mL
10 mM	0.0479 mL	0.2395 mL	0.4791 mL

参考文献

[1]. Burgos ES, et, al. Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase. J Biol Chem. 2015 Apr 10; 290(15): 9674-89.

Histone H3 (5-23)

发表于2023年2月4日由Whatman官网

Histone H3 (5-23);

Histone H3 (5-23)，来源于氨基酸组蛋白 H3 5-23 个氨基酸，可作为组蛋白乙酰转移酶 (HAT) 检测的底物。

Histone H3 (5-23) Chemical Structure

CAS No. : 330198-01-1

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性	Histone H3 (5-23), derived from histone H3 5-23 amino acids, can be used as a substrate for histone acetyltransferase (HAT) assays^[1].
分子量	2013.30
Formula	C₈₄H₁₅₃N₃₁O₂₆
CAS 号	330198-01-1
Sequence Shortening	QTARKSTGGKAPRKQLASK
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Holbert MA, et al. The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. J Biol Chem. 2007;282(50):36603-36613.

Histone H3 (1-34)

发表于2023年1月25日由Whatman官网

Histone H3 (1-34);

Histone H3 (1-34) 是一种来源于组蛋白 3.1 亚型中的多肽。组蛋白是真核细胞染色质的主要蛋白质组分。组蛋白变体和组蛋白修饰调节染色质结构，确保与基因组 DNA 相关的细胞过程的精确调节。

Histone H3 (1-34) Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
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生物活性	Histone H3 (1-34) is a peptide derived from human histone isotype 3.1. Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA^[1]^[2].
分子量	3452.00
Formula	C₁₄₄H₂₆₀N₅₄O₄₄
Sequence	Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly
Sequence Shortening	ARTKQTARKSTGGKAPRKQLATKAARKSAPATGG
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Hake SB, Allis CD. Histone H3 variants and their potential role in indexing mammalian genomes: the “H3 barcode hypothesis”. Proc Natl Acad Sci U S A. 2006;103(17):6428-6435. [2]. Xiong C, et al. Histone Variant H3.3: A versatile H3 variant in health and in disease. Sci China Life Sci. 2016;59(3):245-256. [3]. Mulder KW, et al. Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Res. 2007;35(7):2428-2439.

Histone H3 (23-34)

发表于2023年1月23日由Whatman官网

Histone H3 (23-34);

Histone H3 (23-34) 是组蛋白 H3 的氨基酸残基 23 到 34。Histone H3 (23-34) 在 23 位和 27 位含有赖氨酸残基，这些残基可被甲基化和乙酰化。

Histone H3 (23-34) Chemical Structure

CAS No. : 2130981-29-0

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
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生物活性	Histone H3 (23-34) is the histone H3 amino acid residues 23 to 34. Histone H3 (23-34) contains lysine residues at positions 23 and 27 that are subject to methylation and acetylation^[1].
分子量	1114.30
Formula	C₄₆H₈₃N₁₇O₁₅
CAS 号	2130981-29-0
Sequence Shortening	KAARKSAPATGG
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Santos-Rosa H, Caldas C. Chromatin modifier enzymes, the histone code and cancer. Eur J Cancer. 2005;41(16):2381-2402.

Histone H3 (21-44)

发表于2023年1月12日由Whatman官网

Histone H3 (21-44);

Histone H3 (21-44)，源于组蛋白 H 3的 21-44 个氨基酸，通常用作甲基化检测的底物 (如蛋白质精氨酸甲基转移酶)。

Histone H3 (21-44) Chemical Structure

CAS No. : 1373516-71-2

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性	Histone H3 (21-44), derived from histone H3 21-44 amino acids, is usually used as a substrate (such as protein arginine methyltransferases) for methylation assays^[1].
分子量	2505.90
Formula	C₁₀₉H₁₈₅N₉O₂₉
CAS 号	1373516-71-2
Sequence Shortening	ATKAARKSAPATGGVKKPHRYRPG
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Santos-Rosa H, Caldas C. Chromatin modifier enzymes, the histone code and cancer. Eur J Cancer. 2005;41(16):2381-2402.

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标签归档：histone

Histone H4 (2-21)

Histone H4 (2-21) 相关产品

bull;相关化合物库:

Histone H3 (1-35) (TFA)

Histone H3 (1-35) (TFA) 相关产品

bull;相关化合物库:

Histone H3 (1-25), amide

Histone H1-derived Peptide

Histone H3 (1-35)

Histone H2A (1-20)

Histone H2A (1-20) 相关产品

bull;相关化合物库:

Histone H3 (5-23)

Histone H3 (1-34)

Histone H3 (23-34)

Histone H3 (21-44)

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