HS014

HS014;

HS014 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂,对人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM。HS014 调节吗啡对小鼠行为的影响。HS014 增加自由喂养大鼠的食物摄取量。

HS014amp;;

HS014 Chemical Structure

CAS No. : 207678-81-7

规格 价格 是否有货
1 mg ¥4500 询问价格 货期
5 mg ¥13500 询问价格 货期

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HS014 的其他形式现货产品:

HS014 TFA

生物活性

HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats[1][2][3].

体内研究
(In Vivo)

The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively[2].
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1563.76

Formula

C71H94N20O17S2

CAS 号

207678-81-7

Sequence

Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)

Sequence Shortening

Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82.

    [2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285.

    [3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93.

荧光染料HS-131

荧光染料Dye Reagents HS-131;

HS-131 是一种近红外 Hsp90 的染料抑制剂,能够检测原癌基因驱动的乳腺癌,并能识别不同的人类乳腺癌分子亚型。

HS-131

HS-131 Chemical Structure

CAS No. : 2084850-40-6

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生物活性

HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers[1].

体外研究
(In Vitro)

Immunofluorescence[1]

Cell Line: Tumor cells.
Concentration: 10 µM.
Incubation Time: 30 min.
Result: Tissues/organs, including eyes, brain, heart, lung, liver, spleen, kidney, gut, urinary bladder and skin, were imaged ex vivo by the IVIS imager machine, an imaging modality that detects IR at 640 nm.

体内研究
(In Vivo)

HS131 (10 nmol/mouse) could label breast cancers with different molecular subtypes, including MCF-7 and T-47D for luminal type, BT474M1 and KPL-4 for HER2+ subtype, MDA-MB-231 and MDA-MB-468 for triple negative subtype were chosen after considering the tumorigenic capacities of breast cancer cell lines in SCID mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID-beige mice bearing human breast cancer xenografts of different molecular subtypes[1].
Dosage: 10 nmol/mouse.
Administration: Injected intravenously.
Result: All breast cancer xenografts with different molecular subtypes showed stronger nIR signals in tumor by intravenous administration of HS131 compared to HS152, and the retention of the nIR signals was detectable even at the 24 h time point in HS131 injected mice.

分子量

1318.68

Formula

C71H95N7O13S2

CAS 号

2084850-40-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Takuya Osada, et al. In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior. Clin Cancer Res. 2017 Dec 15;23(24):7531-7542.

HS014 TFA

HS014 TFA; 纯度: 98.81%

HS014 TFA 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂,对人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM。HS014 TFA 调节吗啡对小鼠行为的影响。HS014 TFA 增加自由喂养大鼠的食物摄取量。

HS014 TFAamp;;

HS014 TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥4500 In-stock
5 mg ¥13500 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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HS014 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library
  • Peptide Library

生物活性

HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA modulates the behavioral effects of morphine in mice. HS014 TFA increases food intake in free-feeding rats[1][2][3].

体内研究
(In Vivo)

The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 TFA and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 TFA and in A(y) mice, respectively[2].
Pretreatment with HS014 TFA blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1677.78

Formula

C73H95F3N20O19S2

Sequence

Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)

Sequence Shortening

Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

参考文献
  • [1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82.

    [2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285.

    [3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93.

CAY10731

CAY10731;

CAY10731 (compound 3) 是一种用于检测硫化氢 (H2S) 的高选择性荧光探针。CAY10731 用于监测癌细胞和正常细胞中的外源性和内源性 H2S。CAY10731 用于对不同深度的活组织和线虫中的 H2S 进行成像。

CAY10731amp;;

CAY10731 Chemical Structure

CAS No. : 2119597-33-8

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生物活性

CAY10731 (compound 3) is a highly selective fluorescent probe for detection of hydrogen sulfide (H2S). CAY10731 is used to monitor exo- and endogenous H2S in both cancer and normal cells. CAY10731 is applied for imaging of H2S in living tissues at variable depths and in nematodes[1].

分子量

497.29

Formula

C24H17BrO7

CAS 号

2119597-33-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shahi Imam Reja, et al.A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications. Chemistry. 2017 Jul 21;23(41):9872-9878.

HS024 TFA

HS024 TFA; 纯度: 99.63%

HS024 是一种选择性的 MC4 受体拮抗剂,对 MC4、MC5、MC3 和 MC1 的 Ki 分别为 0.29、3.29、5.45 和 18.6 nM。HS024 增加食物摄入。

HS024 TFAamp;;

HS024 TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥1400 In-stock
5 mg ¥3200 In-stock
10 mg ¥5200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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HS024 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Peptide Library

生物活性

HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].

分子量

1380.52

Formula

C60H80F3N19O12S2

Sequence Shortening

Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 50 mg/mL (36.22 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7244 mL 3.6218 mL 7.2436 mL
5 mM 0.1449 mL 0.7244 mL 1.4487 mL
10 mM 0.0724 mL 0.3622 mL 0.7244 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.

EyelaHS-1温水循环装置

EyelaHS-1温水循环装置

EyelaHS-1温水循环装置

产品编号:
市场价:¥0.00
会员价:¥0.00
品牌:中文
生产厂家:Eyela
需求数量:

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HS系列温水循环装置用于外部温水循环保温及加热,适用于薄膜式蒸发仪。

型号

HS-1

HS-6

HS-8

HS-12

循环方式

密闭式循环

温度范围及精度

室温+15~90℃±2℃(液体膨胀式温度传感器)

最大流量及扬程

流量22.5L/min 扬程9.5m 

流量60L/min 扬程6m

加热功率

1.3KW+0.75KW

2KW×3

2KW×4

3KW×4

纯水机  超纯水机

HS024

HS024;

HS024 是一种选择性的 MC4 受体拮抗剂,对 MC4、MC5、MC3 和 MC1 的 Ki 分别为 0.29、3.29、5.45 和 18.6 nM。HS024 增加食物摄入。

HS024amp;;

HS024 Chemical Structure

CAS No. : 212370-59-7

规格 是否有货
5 mg 询价
10 mg 询价

* Please select Quantity before adding items.

生物活性

HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].

分子量

1266.50

Formula

C58H79N19O10S2

CAS 号

212370-59-7

Sequence Shortening

Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.