Uty HY Peptide (246-254),一种 H-Y 表位 H-YDb,来源于 UTY 蛋白,可作为男性特异性移植抗原 H-Y。
Uty HY Peptide (246-254) Chemical Structure
CAS No. : 261172-28-5
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是否有货
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Uty HY Peptide (246-254) 的其他形式现货产品:
Uty HY Peptide (246-254) (TFA)
生物活性
Uty HY Peptide (246-254), derived from the ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome (UTY) protein as an H-Y epitope, H-YDb, is a male-specific transplantation antigen H-Y[1].
分子量
1196.40
Formula
C53H77N15O13S2
CAS 号
261172-28-5
Sequence
Trp-Met-His-His-Asn-Met-Asp-Leu-Ile
Sequence Shortening
WMHHNMDLI
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Greenfield A, et al. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. Nat Genet. 1996 Dec;14(4):474-8.
Hyp-Phe-Phe is a tripeptide that forms helical-like sheets via aromatic interactions of the Phe rings to comprise a cross helical architecture. Hyp-Phe-Phe possesses a high shear piezoelectricity and acts as piezoelectric material[1].
分子量
425.48
Formula
C23H27N3O5
CAS 号
2493080-84-3
Sequence
Hyp-Phe-Phe
Sequence Shortening
Hyp-FF
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Ehud Gazit, et al. Piezoelectric peptide-based materials and piezoelectric devices containing same. WO2020194304A1.
Cyclosporin H 是 FPR-1 (甲酰肽受体 1) 的选择性强效抑制剂。Cyclosporin H 是一种病毒转导 (viral transduction) 增强剂,可使人脐带血来源的造血干细胞和祖细胞 (HSPCs) 中慢病毒转导增强 10 倍。Cyclosporin H 与雷帕霉素 (HY-10219) 或前列腺素 E2 (HY-101952) 联合使用时表现出累加效应。Cyclosporin H 缺乏 Cyclosporin A 具有的免疫抑制活性。
Cyclosporin H Chemical Structure
CAS No. : 83602-39-5
规格
价格
是否有货
数量
5 mg
¥3800
In-stock
10 mg
¥6500
In-stock
50 mg
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100 mg
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Cyclosporin H 相关产品
bull;相关化合物库:
Bioactive Compound Library Plus
Anti-Infection Compound Library
Immunology/Inflammation Compound Library
Peptide Library
生物活性
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
体外研究 (In Vitro)
The cyclic undecapeptide, cyclosporin H, is a potent inhibitor of formyl-Met-Leu-Phe (FMLP)-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibits FMLP binding in HL-60 membranes with a Ki of 0.1 μM. Cyclosporin H inhibits activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a Ki of 0.79 μM. Cyclosporin H inhibits the stimulatory effects of FMLP on cytosolic Ca2+ concentration ([Ca2+]i), O2- formation, and beta-glucuronidase release with Ki values of 0.08, 0.24, and 0.45 μM, respectively[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
Cyclosporin H (5 mg/kg; i.p.; before LPS or HCl challenge) attenuats lung injury induced by LPS or HCl (a lung injurymodel)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
[1]. Zhang X, et al. Mitochondrial peptides cause proinflammatory responses in the alveolar epithelium via FPR-1, MAPKs, and AKT: a potential mechanism involved in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2018;315(5):L775-L786.
[2]. Wenzel-Seifert K, et al. Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. J Immunol. 1993;150(10):4591-4599.