Pall, 离子色谱 (IC) Acrodisc针头过滤器和Supor(PES) 圆盘过滤膜片, 4583, 4783, 4585, 4785

发表于2023年6月5日由Whatman官网

名称：离子色谱 (IC) Acrodisc针头过滤器和Supor(PES) 圆盘过滤膜片

型号：4583, 4783, 4585, 4785

简介：Pall 颇尔, 离子色谱 (IC) Acrodisc针头过滤器和Supor(PES) 圆盘过滤膜片

Pall 颇尔, 离子色谱 (IC) Acrodisc针头过滤器和Supor(PES) 圆盘过滤膜片

产品简介：
最适合在进行分析离子时提供最为一致的结果

．精确结果，用于离子色谱灵敏度分析。认证用于低水平传导可测萃取物。
．优化的Pall Supor 聚醚砜膜，流速高。
．符合离子色谱（IC ）萃取物质量标准。
．大小适宜，用于小量样品。

Pall 颇尔, 离子色谱 (IC) Acrodisc针头过滤器和Supor(PES) 圆盘过滤膜片

应用
．专门用于离子色谱（IC ）应用。
．良好的溶液过滤器选择。
．制药过滤应用时药物和蛋白质吸附。
．Pall Supor ( IC ）圆盘过滤膜仅推荐用于水样样品。
．AutoPack ™ 包装中配有Pall AcrodiscPSF 针头过滤器与Caliper. Prelude' , TPWll , Multi 一Dose ，系统及Sotax ，溶液系统的自动化进样工作站兼容。

Pall 颇尔, 离子色谱 (IC) Acrodisc针头过滤器和Supor(PES) 圆盘过滤膜片

订购信息
Pall 离子色谱Acrodisc^®针头过滤器，13mm

产品编号	说明	包装
4483	0.2µm 3×100个/包	300个/盒
4683	0.2µm	1000个/包装
4685	0.45µm 3×100个/包	300个/盒
4485	0.45µm	1000个/包装

Pall Supor^®（PES ）圆盘过滤膜片，0.2µm

产品编号	说明	包装
60298	13mm	100片/包装
60300	25m	100片/包装
60301	47m	100片/包装
.60334	90m	100片/包装

Pall 离子色谱（PES ) Acrodisc 针头过滤器，25mm

产品编号	说明	包装
4583	0.2µm 4×50个/包	200个/盒
4783	0.2µm	1000个/包装
4585	0.45µm 4×50个/包	200个/盒
4785	0.45µm	1000个/包装

Pall Supor ( PES ) 圆盘过滤膜片，0.45pm

产品编号	说明	包装
60170	13mm	100片/包装
60172	25mm	100片/包装
60173	47mm	100片/包装
60174	50mm	100片/包装
60206	90mm	100片/包装

Pall 离子色谱Acrodisc PSF 针头过滤器，25mm

产品编号	说明	包装
AP-4587	0.45µm autopack™ 标准包装 8×25个/包	200个/盒
AP-4585	0.45µm 4×50个/包	200个/盒
AP-4785	0.45µm	1000个/包装

Pall 颇尔, 离子色谱 (IC) Acrodisc针头过滤器和Supor(PES) 圆盘过滤膜片

IKA仪科 KS 4000ic 控制型摇床-赛恩斯仪器有限公司

发表于2023年4月21日由Whatman官网

IKA仪科 KS 4000ic 控制型摇床

产品编号：
市场价：~~￥0.00~~元
会员价：￥0.00元
品牌：IKA仪科
生产厂家：IKA仪科

产品概览
技术参数
订购信息
相关资料

相关产品

新型控温摇床，可实现控温条件下无人操作，自动化程度高。

– 大屏数显液晶屏，可显示振荡转速和时间设置
– 控制面板采用防菌涂层，可有效减少细菌滋生
– 内置PID温度控制系统(采用两个 PT1000 温度传感器)
– 电子温度和速度控制
– 电子定时功能：0-999 h(可选分钟和小时)
– 可选内置冷却盘管用于连接外部冷却单元，如：KV600
– 振荡过于剧烈时，仪器自动停止运转
– 上盖开启时，仪器自动停止运转
– 仪器尾部配置排水管，用于排出收集盘中洒落的液体
– 操作简单
– 所有功能可通过实验室软件 labworldsoft® 进行纪录和控制
– 夹具为选配件，请单独订购

技术参数：

运行方式	圆周
周转直径	20 mm
允许震荡承重量(含夹具)	20 kg
电机输入功率	82 W
电机输出功率	24 W
允许连续运转时间	100 %
最小转速 (可调节)	10 rpm
速度范围	10 – 500 rpm
转速显示	LED
计时器	是
计时器显示	LED七分区
时间设置范围	1 – 59940 min
运行方式	定时，连续运转
点动功能	不
桌面振荡制动装置	不
用酶标板工作	不
加热温度范围	室温 +5° – 80 °C
加热输出功率	1000 W
温度显示	是
介质温度稳定性 (0,2l H2O; RT 25°C, T=37°C)	0.1 ±K
Temperature range (inlet T>3°C)	12 – 80 °C
外形尺寸	580 x 525 x 750 mm
重量	55 kg
允许环境温度	15 – 32 °C
允许相对湿度	80 %
DIN EN 60529 保护方式	IP 30
RS 232接口	是
电压	230 V
频率	50/60 Hz
仪器输入功率	1120 W

运行方式	圆周
周转直径	20 mm
允许震荡承重量(含夹具)	20 kg
电机输入功率	82 W
电机输出功率	24 W
允许连续运转时间	100 %
最小转速 (可调节)	10 rpm
速度范围	10 – 500 rpm
转速显示	LED
计时器	是
计时器显示	LED七分区
时间设置范围	1 – 59940 min
运行方式	定时，连续运转
点动功能	不
桌面振荡制动装置	不
用酶标板工作	不
加热温度范围	室温 +5° – 80 °C
加热输出功率	1000 W
温度显示	是
介质温度稳定性 (0,2l H2O; RT 25°C, T=37°C)	0.1 ±K
Temperature range (inlet T>3°C)	12 – 80 °C
外形尺寸	580 x 525 x 750 mm
重量	55 kg
允许环境温度	15 – 32 °C
允许相对湿度	80 %
DIN EN 60529 保护方式	IP 30
RS 232接口	是
电压	230 V
频率	50/60 Hz
仪器输入功率	1120 W

Tutuilamide A

发表于2023年2月3日由Whatman官网

Tutuilamide A;

Tutuilamide A 是一种有效的猪胰弹性蛋白酶 (PPE) 抑制剂，IC₅₀ 值为 1.2 nM。Tutuilamide A 还抑制人中性粒细胞弹性蛋白酶 (HNE; IC₅₀=0.73 nM) 和激肽释放酶 7 (KLK7; IC₅₀=5.0 nM)。

Tutuilamide A Chemical Structure

CAS No. : 2756129-42-5

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC₅₀ of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC₅₀=0.73 nM) and kallikrein 7 (KLK7; IC₅₀=5.0 nM)^[1].
IC₅₀ Target	IC50: 1.2 nM (porcine pancreatic elastase), 0.73 nM (human neutrophil elastase), 5.0 nM (kallikrein 7)^[1]
分子量	1021.59
Formula	C₅₁H₆₉ClN₈O₁₂
CAS 号	2756129-42-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Chen QY, et, al. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7. Bioorg Med Chem. 2020 Dec 1;28(23):115756.

PG-931

发表于2023年1月13日由Whatman官网

PG-931;

PG-931 是 SHU 9119 (HY-P0227) 的类似物。PG-931 是一种强效的黑素皮质素 4 (MC4) 受体 (IC₅₀=0.58 nM) 激动剂，比 hMC3R (IC₅₀=55 nM) 或 hMC5R (IC₅₀=2.4 nM) 更具选择性。PG-931 在动物实验模型中，可逆转出血休克，防止体内多器官损伤。

PG-931 Chemical Structure

CAS No. : 667430-81-1

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo^[2].

IC₅₀ Target

IC50: 0.58 nM (melanocortin 4 receptor)
IC50: 2.4 nM (melanocortin 5 receptor)
IC50: 55 nM (melanocortin 3 receptor)^[1]

体内研究
(In Vivo)

PG-931 (intravenous injection; 13-10⁸ nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar rats^[2]
Dosage:	13-10⁸ nmol/kg
Administration:	Intravenous injection; single dose
Result:	Exhibitd an anti-shock effect occurred at nanomolar doses.

分子量

1180.40

Formula

C₅₉H₈₅N₁₅O₁₁

CAS 号

667430-81-1

Sequence Shortening

Ac-{Nle}-DP-{D-Phe}-RWKPV-NH2 (Lactam bridge:Asp2-Lys7)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. D Giuliani, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol

[2]. P Grieco, et al. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J Pept Res

HDAC-IN-30

发表于2023年1月5日由Whatman官网

HDAC-IN-30;

HDAC-IN-30 是一种新颖的多靶点 HDAC 抑制剂，靶点主要有 HDAC1 (IC₅₀=13.4 nM)，HDAC2 (IC₅₀=28.0 nM)， HDAC3 (IC₅₀=9.18 nM)，HDAC6 (IC₅₀=42.7 nM)，HDAC8 (IC₅₀=131 nM)。HDAC-IN-30 表现出非常强大的抗肿瘤作用。

HDAC-IN-30 Chemical Structure

CAS No. : 2756809-34-2

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC₅₀=13.4 nM),HDAC2 (IC₅₀=28.0 nM), HDAC3 (IC₅₀=9.18 nM), HDAC6 (IC₅₀=42.7 nM), HDAC8 (IC₅₀=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy^[1].

IC₅₀ Target

HDAC1

13.4 nM (IC₅₀)

HDAC2

28.0 nM (IC₅₀)

HDAC3

9.18 nM (IC₅₀)

HDAC6

42.7 nM (IC₅₀)

HDAC8

131 nM (IC₅₀)

体外研究
(In Vitro)

HDAC-IN-30 (compound 8 h; 0.5, 1, 2 μM; 48 hours) can effectively activate the p53 pathway by promoting the phosphorylation of p53^[1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours; HepG2 cells) induces cell cycle arrest at the G2 phase in a concentration-dependent manner^[1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours) possesses prominent anticancer activity in HepG2 cells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HepG2 cells
Concentration:	0.5, 1, 2 μM
Incubation Time:	24 hours
Result:	Could effectively activate the p53 pathway by promoting the phosphorylation of p53

Cell Cycle Analysis^[1]

Cell Line:	HepG2 cells
Concentration:	0, 1, 2.5, 5 μM
Incubation Time:	48 hours
Result:	Cells were arrested at the G2 phase in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:	HepG2 cells
Concentration:	0, 1, 2.5, 5 μM
Incubation Time:	24 hours
Result:	Possessed prominent anticancer activity in HepG2 cells.

体内研究
(In Vivo)

HDAC-IN-30 (12, 24 mg/kg; intraperitoneal injection, every two days for 4 weeks) exhibits potent anticancer activity and no side effects even at high dose (24 mg/kg)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HepG2 xenograft mouse model^[1]
Dosage:	12, 24 mg/kg
Administration:	Intraperitoneal injection, every 2 days, 4 weeks
Result:	Exhibited potent anticancer activity

分子量

405.45

Formula

C₂₂H₂₃N₅O₃

CAS 号

2756809-34-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Liu Q, et al. Discovery of phthalazino [1, 2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway. Eur J Med Chem. 2022, 229:114058.

Garcinol(Synonyms: 山竹子素)

发表于2022年11月29日由Whatman官网

天然产物黄酮类 Flavonoids

Garcinol (Synonyms: 山竹子素) 纯度: 98.85%

Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶的特性，IC₅₀ 分别为 0.66 µM 和 7.39 µM。Garcinol 还抑制组蛋白乙酰转移酶 (HATs, IC₅₀=7 μM) 和 p300/CPB 相关因子 (PCAF, IC₅₀=5 μM)。Garcinol 具有抗炎和抗癌活性。

Garcinol Chemical Structure

CAS No. : 78824-30-3

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥3315	In-stock
1 mg	￥800	In-stock
5 mg	￥2500	In-stock
10 mg		询价
50 mg		询价

* Please select Quantity before adding items.

Garcinol 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Epigenetics Compound Library
Immunology/Inflammation Compound Library
Metabolism/Protease Compound Library
Neuronal Signaling Compound Library
Natural Product Library
Histone Modification Research Compound Library
Anti-Cancer Compound Library
Human Endogenous Metabolite Compound Library
Phenols Library
Flavonoids Library
Anti-Alzheimer’s Disease Compound Library
Neurodegenerative Disease-related Compound Library
Food-Sourced Compound Library

生物活性

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively^[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity^[2].

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Garcinol (10-50 µM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner^[3].
Garcinol (10-50 µM; 24-72 hours) induces apoptosis in HNSCC cells^[3].
Garcinol (50 µM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	CAL27 and UMSCC1 cells
Concentration:	10, 25, 50 µM
Incubation Time:	24, 48, and 72 hours
Result:	Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner.

Apoptosis Analysis^[3]

Cell Line:	CAL27 and UMSCC1 cells
Concentration:	10, 25, 50 µM
Incubation Time:	24, 48, and 72 hours
Result:	Induced apoptosis in HNSCC cells.

Western Blot Analysis^[3]

Cell Line:	CAL27 cells
Concentration:	50 µM
Incubation Time:	1, 2, 4, 6 hours
Result:	Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.

体内研究
(In Vivo)

Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors^[3]
Dosage:	1 and 2 mg/kg
Administration:	I.p.; five times/week for 4 consecutive weeks
Result:	Induced significant inhibition of tumor growth.

分子量

602.80

Formula

C₃₈H₅₀O₆

CAS 号

78824-30-3

中文名称

山竹子素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 50 mg/mL (82.95 mM; Need ultrasonic)

Ethanol : 20 mg/mL (33.18 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6589 mL	8.2946 mL	16.5893 mL
5 mM	0.3318 mL	1.6589 mL	3.3179 mL
10 mM	0.1659 mL	0.8295 mL	1.6589 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (4.15 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (4.15 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57.

[2]. Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106(9):3963-86.

[3]. Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 2013 Aug;6(8):843-54.

Icaritin(Synonyms: Anhydroicaritin)

发表于2022年11月28日由Whatman官网

天然产物黄酮类 Flavonoids

Icaritin (Synonyms: Anhydroicaritin) 纯度: 99.27%

Icaritin (Anhydroicaritin) 是 Epimedium Genusis 的异戊二烯类黄酮衍生物，有效抑制 K562 细胞 (IC₅₀ 为 8 µM) 和原代 CML 细胞 (对 CML-CP 的 IC₅₀ 值为 13.4 µM，对 CML-BC 的 IC₅₀ 值为 18 µM) 的增殖。Icaritin 可以调节 MAPK/ERK/JNK 和 JAK2/STAT3/AKT 信号传导，并具有增强成骨的作用。

Icaritin Chemical Structure

CAS No. : 118525-40-9

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥660	In-stock
5 mg	￥600	In-stock
10 mg	￥1100	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

Icaritin 相关产品

•相关化合物库:

Natural Product Library Plus
Drug Repurposing Compound Library Plus
Clinical Compound Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Natural Product Library
Anti-Cancer Compound Library
Clinical Compound Library
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生物活性

Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium Genusis and potently inhibits proliferation of K562 cells (IC₅₀ of 8 µM) and primary CML cells (IC₅₀ of 13.4 µM for CML-CP and 18 µM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis^[1]^[2]^[3.

体外研究
(In Vitro)

Icaritin (4-64 µM; 48 hours; K562, imatinib-resistant cells and primary CML cells) treatment inhibits proliferation of K562, imatinib-resistant cells and primary CML cells ^[1].
Icaritin (0-64 µM; 48 hours; K562 and primary cells) treatment induces K562 or primary cells apoptosis in an concentration dependent manner^[1].
Icaritin (32 µM; K562 cells) treatment increases cell population in the sub-G1 phase in K562 cells^[1].
Icaritin (0-64 µM; 48 hours; K562 cells) treatment inhibits MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. Icaritin treatment also significantly inhibits Bcl-2 protein expression and up-regulated Bax protein expression in K562 with a dose-dependent manner accompanied by the cleavage activation of caspase-3 or caspase-9, and a down-regulated expression of Apaf-1^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	K562, imatinib-resistant cells and primary CML cells
Concentration:	4 µM, 8 µM, 16 µM, 32 µM and 64 µM
Incubation Time:	48 hours
Result:	Inhibited cell proliferation.

Apoptosis Analysis^[1]

Cell Line:	K562 or primary cells
Concentration:	0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM
Incubation Time:	48 hours
Result:	Induced K562 or primary cells apoptosis.

Cell Cycle Analysis^[1]

Cell Line:	K562 cells
Concentration:	32 µM
Incubation Time:
Result:	Cell population in the sub-G1 phase was increased.

Western Blot Analysis^[1]

Cell Line:	K562 cells
Concentration:	0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM
Incubation Time:	48 hours
Result:	Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression.

体内研究
(In Vivo)

Icaritin (4-8 mg/kg; intraperitoneal injection; daily; for 10 weeks; female NOD-SCID nude mice) treatment could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow in mouse leukemia model^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female NOD-SCID nude mice (6-8 weeks old) with K562 cells^[1]
Dosage:	4 mg/kg and 8 mg/kg
Administration:	Intraperitoneal injection; daily; for 10 weeks
Result:	Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow.

Clinical Trial

分子量

368.38

Formula

C₂₁H₂₀O₆

CAS 号

118525-40-9

中文名称

去水淫羊藿黄素；三七淫羊藿素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 15.62 mg/mL (42.40 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7146 mL	13.5729 mL	27.1459 mL
5 mM	0.5429 mL	2.7146 mL	5.4292 mL
10 mM	0.2715 mL	1.3573 mL	2.7146 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 1.56 mg/mL (4.23 mM); Clear solution

此方案可获得 ≥ 1.56 mg/mL (4.23 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 15.6 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 50% PEG300 50% saline

Solubility: 1.51 mg/mL (4.10 mM); Suspended solution; Need ultrasonic

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Zhu Jf, et al. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings. PLoS One. 2011;6(8):e23720.

[2]. Yao D, et al. Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis–an in vitro efficacy study. PLoS One. 2012;7(8):e41264.

[3]. Guo Y, et al. An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells. Eur J Pharmacol. 2011 May 11;658(2-3):114-22.

Momordin Ic(Synonyms: 地肤子皂苷Ic)

发表于2022年11月28日由Whatman官网

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Momordin Ic (Synonyms: 地肤子皂苷Ic) 纯度: 99.71%

Momordin Ic 是山茱萸的主要皂苷成分，具有抗癌活性。Momordin Ic 通过氧化应激调控线粒体功能障碍诱导细胞凋亡。

Momordin Ic Chemical Structure

CAS No. : 96990-18-0

规格	价格	是否有货
5 mg	￥990	In-stock
10 mg	￥1680	In-stock
20 mg	￥2860	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

Momordin Ic 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Natural Product Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Glycoside Compound Library
Oxygen Sensing Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Traditional Chinese Medicine Monomer Library
Anti-Parkinson’s Disease Compound Library
Neurodegenerative Disease-related Compound Library

生物活性

Momordin Ic is a principal saponin constituent of Fructus Kochiae, with with anti-cancer bioactivity. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction^[1]^[2].

分子量

764.94

Formula

C₄₁H₆₄O₁₃

CAS 号

96990-18-0

中文名称

地肤子皂苷Ic

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (130.73 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3073 mL	6.5365 mL	13.0729 mL
5 mM	0.2615 mL	1.3073 mL	2.6146 mL
10 mM	0.1307 mL	0.6536 mL	1.3073 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 6.25 mg/mL (8.17 mM); Clear solution

此方案可获得 ≥ 6.25 mg/mL (8.17 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.27 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.27 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Mi Y, et al. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016 Jan;90:230-42.

[2]. Wang J, et al. Suppressive effects of Momordin Ic on HepG2 cell migration and invasion by regulating MMP-9 and adhesion molecules: Involvement of p38 and JNK pathways. Toxicol In Vitro. 2019 Apr;56:75-83.

Orobol

发表于2022年11月25日由Whatman官网

天然产物黄酮类 Flavonoids

Orobol

Orobol 是一种主要的大豆异黄酮，具有多种药理活性，包括抗皮肤老化和抗肥胖作用。Orobol 抑制 CK1ε、VEGFR2、MAP4K5、MNK1、MUSK、TOPK 和 TNIK (IC₅₀=1.24-4.45 μM)。Orobol 还抑制 PI3K 亚型 (对于 PI3K α/β/γ/K/δ，IC₅₀=3.46-5.27μM)。

Orobol Chemical Structure

CAS No. : 480-23-9

规格		是否有货
5 mg		询价
10 mg		询价
25 mg		询价

* Please select Quantity before adding items.

生物活性

Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ)^[1]^[2].

体外研究
(In Vitro)

Orobol binds to CK1ε in an ATP-competitive manner and exerts anti-obesity effects by targeting casein kinase 1 epsilon^[2].
Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone and insulin (MDI))-induced phosphorylation of 4E-BP1^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HFD-induced obesity in C57BL/6J mice^[2]
Dosage:	10 mg/kg
Administration:	Intragastrically; daily for 23 weeks
Result:	Significantly reduced body weight by 17.3% compared to the HFD group.

分子量

286.24

Formula

C₁₅H₁₀O₆

CAS 号

480-23-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kim MH, et al. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics. 2020;12(9):845. Published 2020 Sep 3.

AF12198

发表于2022年11月19日由Whatman官网

AF12198; 纯度: 99.61%

AF12198 是针对人类I型白介素-1 受体 (IL1R1) (IC₅₀=8 nM) 的有效，选择性和特异性肽拮抗剂，但不是针对人类 II 型受体 (IC₅₀=6.7 µM) 或鼠 I 型受体 (IC₅₀>200 µM)。AF12198 抑制 IL-1 诱导的 IL-8 产生 (IC₅₀=25 nM) 和 IL-1诱导的细胞间粘附分子 1 (ICAM-1) 表达 (IC₅₀=9 nM)。AF12198 具有抗炎活性，并在体内阻断了对 IL-1 的反应。

AF12198 Chemical Structure

CAS No. : 185413-30-3

规格	价格	是否有货	数量
1 mg	￥1200	In-stock
5 mg	￥3500	In-stock
10 mg	;	询价	;
50 mg	;	询价	;

* Please select Quantity before adding items.

AF12198 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo^[1].

IC₅₀ Target^[1]

IL1R1

8 nM (IC₅₀)

体外研究
(In Vitro)

AF12198 competes for binding of ¹²⁵I-IL-1α with an IC₅₀ of 8.0 nM, nearly equal to that of IL-1ra, IC₅₀ of 4.0 nM for the type I receptor^[1].
AF12198 (0-5 ng; 8 hours) inhibits IL-6 induction with an IC₅₀ of 15 μM whereas IL-1ra inhibits with an IC₅₀ of 2 nM in heparinized human primate blood. Meanwhile, With blood from cynomolgus monkeys, the IC₅₀ values are 17 μM for AF12198 and 30 nM for IL-1ra. Additionally, AF12198 or IL-1RA alone does not induce IL-6 in blood from either humans or cynomolgus monkeys^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

AF12198 (intravenous infusion; 16 mg/kg; 30 min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4 h (32.6%), 12 h (50.1%) and 24 h (65.3%) after LPS^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats^[2]
Dosage:	16 mg/kg
Administration:	Intravenous infusion; 30 min before LPS intravenous injection
Result:	Decreased pulmonary microvascular leakage in rats.

分子量

1895.12

Formula

C₉₆H₁₂₃N₁₉O₂₂

CAS 号

185413-30-3

Sequence

Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-{Aze}-Tyr-Ala-Leu-Pro-Leu-NH2

Sequence Shortening

Ac-FEWTPGWYQ-{Aze}-YALPL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 100 mg/mL (52.77 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.5277 mL	2.6384 mL	5.2767 mL
5 mM	0.1055 mL	0.5277 mL	1.0553 mL
10 mM	0.0528 mL	0.2638 mL	0.5277 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (1.32 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (1.32 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (1.32 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (1.32 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. F Aimbire, et al. Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1beta levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation

[2]. A L Akeson, et al.AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J Biol Chem. 1996 Nov 29;271(48):30517-23.

Cytiva思拓凡-Whatman滤纸滤膜滤器

沃特曼官网代理商|Whatman滤纸滤膜中国官网代理商

标签归档：ic

Pall, 离子色谱 (IC) Acrodisc针头过滤器和Supor(PES) 圆盘过滤膜片, 4583, 4783, 4585, 4785

IKA仪科 KS 4000ic 控制型摇床-赛恩斯仪器有限公司

IKA仪科 KS 4000ic 控制型摇床

Tutuilamide A

PG-931

HDAC-IN-30

Garcinol(Synonyms: 山竹子素)

Garcinol 相关产品

•相关化合物库:

Icaritin(Synonyms: Anhydroicaritin)

Icaritin 相关产品

•相关化合物库:

Momordin Ic(Synonyms: 地肤子皂苷Ic)

Momordin Ic 相关产品

•相关化合物库:

Orobol

AF12198

AF12198 相关产品

bull;相关化合物库:

IKA仪科 KS 4000ic 控制型 摇床

Garcinol 相关产品

•相关化合物库:

Icaritin 相关产品

•相关化合物库:

Momordin Ic 相关产品

•相关化合物库:

AF12198 相关产品

bull;相关化合物库:

IKA仪科 KS 4000ic 控制型摇床