标签归档：ic

IC87114 品牌：SynKinase

发表于由

IC87114

品牌：SynKinase
CAS No.：371242-69-2
储存条件：-20°C
纯度：>95%
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

SYN-1045-M050

 – 50 mg – 8,320.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

IC87114 品牌：SynKinase

发表于由

IC87114

品牌：SynKinase
CAS No.：371242-69-2
储存条件：-20°C
纯度：>95%
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

SYN-1045-M100

 – 100 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

IKA仪科 KS 4000ic 控制型 摇床-赛恩斯仪器有限公司

发表于由
IKA仪科 KS 4000ic 控制型 摇床-金畔生物仪器有限公司

IKA仪科 KS 4000ic 控制型 摇床

产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：IKA仪科
生产厂家：IKA仪科

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

新型控温摇床，可实现控温条件下无人操作，自动化程度高。

– 大屏数显液晶屏，可显示振荡转速和时间设置
– 控制面板采用防菌涂层，可有效减少细菌滋生
– 内置PID温度控制系统(采用两个 PT1000 温度传感 器)
– 电子温度和速度控制
– 电子定时功能：0-999 h(可选分钟和小时)
– 可选内置冷却盘管用于连接外部冷却单元，如：KV600
– 振荡过于剧烈时，仪器自动停止运转
– 上盖开启时，仪器自动停止运转
– 仪器尾部配置排水管，用于排出收集盘中洒落的液体
– 操作简单
– 所有功能可通过实验室软件 labworldsoft® 进行纪录和控制
– 夹具为选配件，请单独订购

技术参数：

运行方式 圆周
周转直径 20 mm
允许震荡承重量(含夹具) 20 kg
电机输入功率 82 W
电机输出功率 24 W
允许连续运转时间 100 %
最小转速 (可调节) 10 rpm
速度范围 10 – 500 rpm
转速显示 LED
计时器 是
计时器显示 LED七分区
时间设置范围 1 – 59940 min
运行方式 定时，连续运转
点动功能 不
桌面振荡制动装置 不
用酶标板工作 不
加热温度范围 室温 +5° – 80 °C
加热输出功率 1000 W
温度显示 是
介质温度稳定性 (0,2l H2O; RT 25°C, T=37°C) 0.1 ±K
Temperature range (inlet T>3°C) 12 – 80 °C
外形尺寸 580 x 525 x 750 mm
重量 55 kg
允许环境温度 15 – 32 °C
允许相对湿度 80 %
DIN EN 60529 保护方式 IP 30
RS 232接口 是
电压 230 V
频率 50/60 Hz
仪器输入功率 1120 W
运行方式 圆周
周转直径 20 mm
允许震荡承重量(含夹具) 20 kg
电机输入功率 82 W
电机输出功率 24 W
允许连续运转时间 100 %
最小转速 (可调节) 10 rpm
速度范围 10 – 500 rpm
转速显示 LED
计时器 是
计时器显示 LED七分区
时间设置范围 1 – 59940 min
运行方式 定时，连续运转
点动功能 不
桌面振荡制动装置 不
用酶标板工作 不
加热温度范围 室温 +5° – 80 °C
加热输出功率 1000 W
温度显示 是
介质温度稳定性 (0,2l H2O; RT 25°C, T=37°C) 0.1 ±K
Temperature range (inlet T>3°C) 12 – 80 °C
外形尺寸 580 x 525 x 750 mm
重量 55 kg
允许环境温度 15 – 32 °C
允许相对湿度 80 %
DIN EN 60529 保护方式 IP 30
RS 232接口 是
电压 230 V
频率 50/60 Hz
仪器输入功率 1120 W

 

Tutuilamide A

发表于由

Tutuilamide A;

Tutuilamide A 是一种有效的猪胰弹性蛋白酶 (PPE) 抑制剂，IC50 值为 1.2 nM。Tutuilamide A 还抑制人中性粒细胞弹性蛋白酶 (HNE; IC50=0.73 nM) 和激肽释放酶 7 (KLK7; IC50=5.0 nM)。

Tutuilamide Aamp;;

Tutuilamide A Chemical Structure

CAS No. : 2756129-42-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC50 of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM)[1].

IC50 Target

IC50: 1.2 nM (porcine pancreatic elastase), 0.73 nM (human neutrophil elastase), 5.0 nM (kallikrein 7)[1]
分子量

1021.59

Formula

C51H69ClN8O12
CAS 号

2756129-42-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chen QY, et, al. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7. Bioorg Med Chem. 2020 Dec 1;28(23):115756.

PG-931

发表于由

PG-931;

PG-931 是 SHU 9119 (HY-P0227) 的类似物。PG-931 是一种强效的黑素皮质素 4 (MC4) 受体 (IC50=0.58 nM) 激动剂，比 hMC3R (IC50=55 nM) 或 hMC5R (IC50=2.4 nM) 更具选择性。PG-931 在动物实验模型中，可逆转出血休克，防止体内多器官损伤。

PG-931amp;;

PG-931 Chemical Structure

CAS No. : 667430-81-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2].

IC50 Target

IC50: 0.58 nM (melanocortin 4 receptor)
IC50: 2.4 nM (melanocortin 5 receptor)
IC50: 55 nM (melanocortin 3 receptor)[1]
体内研究
(In Vivo)

PG-931 (intravenous injection; 13-108 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[2]
Dosage: 13-108 nmol/kg
Administration: Intravenous injection; single dose
Result: Exhibitd an anti-shock effect occurred at nanomolar doses.

分子量

1180.40

Formula

C59H85N15O11
CAS 号

667430-81-1
Sequence Shortening

Ac-{Nle}-DP-{D-Phe}-RWKPV-NH2 (Lactam bridge:Asp2-Lys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. D Giuliani, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol

    [2]. P Grieco, et al. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J Pept Res

HDAC-IN-30

发表于由

HDAC-IN-30;

HDAC-IN-30 是一种新颖的多靶点 HDAC 抑制剂，靶点主要有 HDAC1 (IC50=13.4 nM)，HDAC2 (IC50=28.0 nM)， HDAC3 (IC50=9.18 nM)，HDAC6 (IC50=42.7 nM)，HDAC8 (IC50=131 nM)。HDAC-IN-30 表现出非常强大的抗肿瘤作用。

HDAC-IN-30amp;;

HDAC-IN-30 Chemical Structure

CAS No. : 2756809-34-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC50=13.4 nM),HDAC2 (IC50=28.0 nM), HDAC3 (IC50=9.18 nM), HDAC6 (IC50=42.7 nM), HDAC8 (IC50=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy[1].

IC50 Target

HDAC1

13.4 nM (IC50)

HDAC2

28.0 nM (IC50)

HDAC3

9.18 nM (IC50)

HDAC6

42.7 nM (IC50)

HDAC8

131 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-30 (compound 8 h; 0.5, 1, 2 μM; 48 hours) can effectively activate the p53 pathway by promoting the phosphorylation of p53[1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours; HepG2 cells) induces cell cycle arrest at the G2 phase in a concentration-dependent manner[1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours) possesses prominent anticancer activity in HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 0.5, 1, 2 μM
Incubation Time: 24 hours
Result: Could effectively activate the p53 pathway by promoting the phosphorylation of p53

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 0, 1, 2.5, 5 μM
Incubation Time: 48 hours
Result: Cells were arrested at the G2 phase in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 0, 1, 2.5, 5 μM
Incubation Time: 24 hours
Result: Possessed prominent anticancer activity in HepG2 cells.

体内研究
(In Vivo)

HDAC-IN-30 (12, 24 mg/kg; intraperitoneal injection, every two days for 4 weeks) exhibits potent anticancer activity and no side effects even at high dose (24 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HepG2 xenograft mouse model[1]
Dosage: 12, 24 mg/kg
Administration: Intraperitoneal injection, every 2 days, 4 weeks
Result: Exhibited potent anticancer activity

分子量

405.45

Formula

C22H23N5O3
CAS 号

2756809-34-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liu Q, et al. Discovery of phthalazino [1, 2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway. Eur J Med Chem. 2022, 229:114058.

Garcinol(Synonyms: 山竹子素)

发表于由

天然产物 黄酮类 Flavonoids

Garcinol (Synonyms: 山竹子素) 纯度: 98.85%

Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶的特性，IC50 分别为 0.66 µM 和 7.39 µM。Garcinol 还抑制组蛋白乙酰转移酶 (HATs, IC50=7 μM) 和 p300/CPB 相关因子 (PCAF, IC50=5 μM)。Garcinol 具有抗炎和抗癌活性。

Garcinol(Synonyms: 山竹子素)

Garcinol Chemical Structure

CAS No. : 78824-30-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3315 In-stock
1 mg ￥800 In-stock
5 mg ￥2500 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Garcinol 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Epigenetics Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Neuronal Signaling Compound Library
  • Natural Product Library
  • Histone Modification Research Compound Library
  • Anti-Cancer Compound Library
  • Human Endogenous Metabolite Compound Library
  • Phenols Library
  • Flavonoids Library
  • Anti-Alzheimer’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Food-Sourced Compound Library

生物活性

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 µM and 7.39 µM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity[2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Garcinol (10-50 µM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner[3].
Garcinol (10-50 µM; 24-72 hours) induces apoptosis in HNSCC cells[3].
Garcinol (50 µM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: CAL27 and UMSCC1 cells
Concentration: 10, 25, 50 µM
Incubation Time: 24, 48, and 72 hours
Result: Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner.

Apoptosis Analysis[3]

Cell Line: CAL27 and UMSCC1 cells
Concentration: 10, 25, 50 µM
Incubation Time: 24, 48, and 72 hours
Result: Induced apoptosis in HNSCC cells.

Western Blot Analysis[3]

Cell Line: CAL27 cells
Concentration: 50 µM
Incubation Time: 1, 2, 4, 6 hours
Result: Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.

体内研究
(In Vivo)

Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors[3]
Dosage: 1 and 2 mg/kg
Administration: I.p.; five times/week for 4 consecutive weeks
Result: Induced significant inhibition of tumor growth.

分子量

602.80

Formula

C38H50O6
CAS 号

78824-30-3
中文名称

山竹子素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (82.95 mM; Need ultrasonic)

Ethanol : 20 mg/mL (33.18 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6589 mL 8.2946 mL 16.5893 mL
5 mM 0.3318 mL 1.6589 mL 3.3179 mL
10 mM 0.1659 mL 0.8295 mL 1.6589 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.15 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (4.15 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57.

    [2]. Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106(9):3963-86.

    [3]. Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 2013 Aug;6(8):843-54.

Icaritin(Synonyms: Anhydroicaritin)

发表于由

天然产物 黄酮类 Flavonoids

Icaritin (Synonyms: Anhydroicaritin) 纯度: 99.27%

Icaritin (Anhydroicaritin) 是 Epimedium Genusis 的异戊二烯类黄酮衍生物，有效抑制 K562 细胞 (IC50 为 8 µM) 和原代 CML 细胞 (对 CML-CP 的 IC50 值为 13.4 µM，对 CML-BC 的 IC50 值为 18 µM) 的增殖。Icaritin 可以调节 MAPK/ERK/JNK 和 JAK2/STAT3/AKT 信号传导，并具有增强成骨的作用。

Icaritin(Synonyms: Anhydroicaritin)

Icaritin Chemical Structure

CAS No. : 118525-40-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥660 In-stock
5 mg ￥600 In-stock
10 mg ￥1100 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Icaritin 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Autophagy Compound Library
  • Drug Repurposing Compound Library
  • Anti-COVID-19 Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Anti-Blood Cancer Compound Library

生物活性

Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium Genusis and potently inhibits proliferation of K562 cells (IC50 of 8 µM) and primary CML cells (IC50 of 13.4 µM for CML-CP and 18 µM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis[1][2][3.

体外研究
(In Vitro)

Icaritin (4-64 µM; 48 hours; K562, imatinib-resistant cells and primary CML cells) treatment inhibits proliferation of K562, imatinib-resistant cells and primary CML cells [1].
Icaritin (0-64 µM; 48 hours; K562 and primary cells) treatment induces K562 or primary cells apoptosis in an concentration dependent manner[1].
Icaritin (32 µM; K562 cells) treatment increases cell population in the sub-G1 phase in K562 cells[1].
Icaritin (0-64 µM; 48 hours; K562 cells) treatment inhibits MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. Icaritin treatment also significantly inhibits Bcl-2 protein expression and up-regulated Bax protein expression in K562 with a dose-dependent manner accompanied by the cleavage activation of caspase-3 or caspase-9, and a down-regulated expression of Apaf-1[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: K562, imatinib-resistant cells and primary CML cells
Concentration: 4 µM, 8 µM, 16 µM, 32 µM and 64 µM
Incubation Time: 48 hours
Result: Inhibited cell proliferation.

Apoptosis Analysis[1]

Cell Line: K562 or primary cells
Concentration: 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM
Incubation Time: 48 hours
Result: Induced K562 or primary cells apoptosis.

Cell Cycle Analysis[1]

Cell Line: K562 cells
Concentration: 32 µM
Incubation Time:
Result: Cell population in the sub-G1 phase was increased.

Western Blot Analysis[1]

Cell Line: K562 cells
Concentration: 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM
Incubation Time: 48 hours
Result: Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression.

体内研究
(In Vivo)

Icaritin (4-8 mg/kg; intraperitoneal injection; daily; for 10 weeks; female NOD-SCID nude mice) treatment could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow in mouse leukemia model[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD-SCID nude mice (6-8 weeks old) with K562 cells[1]
Dosage: 4 mg/kg and 8 mg/kg
Administration: Intraperitoneal injection; daily; for 10 weeks
Result: Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow.

Clinical Trial

分子量

368.38

Formula

C21H20O6
CAS 号

118525-40-9
中文名称

去水淫羊藿黄素；三七淫羊藿素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 15.62 mg/mL (42.40 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7146 mL 13.5729 mL 27.1459 mL
5 mM 0.5429 mL 2.7146 mL 5.4292 mL
10 mM 0.2715 mL 1.3573 mL 2.7146 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.56 mg/mL (4.23 mM); Clear solution

    此方案可获得 ≥ 1.56 mg/mL (4.23 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 15.6 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 50% PEG300    50% saline

    Solubility: 1.51 mg/mL (4.10 mM); Suspended solution; Need ultrasonic

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Zhu Jf, et al. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings. PLoS One. 2011;6(8):e23720.

    [2]. Yao D, et al. Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis–an in vitro efficacy study. PLoS One. 2012;7(8):e41264.

    [3]. Guo Y, et al. An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells. Eur J Pharmacol. 2011 May 11;658(2-3):114-22.

Momordin Ic(Synonyms: 地肤子皂苷Ic)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Momordin Ic (Synonyms: 地肤子皂苷Ic) 纯度: 99.71%

Momordin Ic 是山茱萸的主要皂苷成分，具有抗癌活性。Momordin Ic 通过氧化应激调控线粒体功能障碍诱导细胞凋亡。

Momordin Ic(Synonyms: 地肤子皂苷Ic)

Momordin Ic Chemical Structure

CAS No. : 96990-18-0

规格 价格 是否有货 数量
5 mg ￥990 In-stock
10 mg ￥1680 In-stock
20 mg ￥2860 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Momordin Ic 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Glycoside Compound Library
  • Oxygen Sensing Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library

生物活性

Momordin Ic is a principal saponin constituent of Fructus Kochiae, with with anti-cancer bioactivity. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction[1][2].

分子量

764.94

Formula

C41H64O13
CAS 号

96990-18-0
中文名称

地肤子皂苷Ic
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (130.73 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3073 mL 6.5365 mL 13.0729 mL
5 mM 0.2615 mL 1.3073 mL 2.6146 mL
10 mM 0.1307 mL 0.6536 mL 1.3073 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (8.17 mM); Clear solution

    此方案可获得 ≥ 6.25 mg/mL (8.17 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.27 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.27 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Mi Y, et al. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016 Jan;90:230-42.

    [2]. Wang J, et al. Suppressive effects of Momordin Ic on HepG2 cell migration and invasion by regulating MMP-9 and adhesion molecules: Involvement of p38 and JNK pathways. Toxicol In Vitro. 2019 Apr;56:75-83.

Orobol

发表于由

天然产物 黄酮类 Flavonoids

Orobol 

Orobol 是一种主要的大豆异黄酮，具有多种药理活性，包括抗皮肤老化和抗肥胖作用。Orobol 抑制 CK1ε、VEGFR2、MAP4K5、MNK1、MUSK、TOPK 和 TNIK (IC50=1.24-4.45 μM)。Orobol 还抑制 PI3K 亚型 (对于 PI3K α/β/γ/K/δ，IC50=3.46-5.27μM)。

Orobol

Orobol Chemical Structure

CAS No. : 480-23-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ)[1][2].

体外研究
(In Vitro)

Orobol binds to CK1ε in an ATP-competitive manner and exerts anti-obesity effects by targeting casein kinase 1 epsilon[2].
Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone and insulin (MDI))-induced phosphorylation of 4E-BP1[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced obesity in C57BL/6J mice[2]
Dosage: 10 mg/kg
Administration: Intragastrically; daily for 23 weeks
Result: Significantly reduced body weight by 17.3% compared to the HFD group.

分子量

286.24

Formula

C15H10O6
CAS 号

480-23-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim MH, et al. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics. 2020;12(9):845. Published 2020 Sep 3.