天然产物 天然产物苯丙素类 Phenylpropanoids
Isofraxidin (Synonyms: 异嗪皮啶) 纯度: 98.14%
Isofraxidin 来自 Acanthopanax senticosus 的一种香豆素成分,抑制 MMP-7 表达和人肝癌细胞侵袭。Isofraxidin 作用于肝癌细胞,抑制 ERK1/2 磷酸化。Isofraxidin 减弱 iNOS 和 COX-2 表达,Isofraxidin 还抑制 TLR4/髓样分化蛋白 2 (MD-2) 复合物的形成。
Isofraxidin Chemical Structure
CAS No. : 486-21-5
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5 mg | ¥600 | In-stock | |
10 mg | ¥1000 | In-stock | |
20 mg | ¥1800 | In-stock | |
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Isofraxidin 相关产品
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生物活性 |
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation[2]. |
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IC50 & Target[1][2] |
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体外研究 (In Vitro) |
Isofraxidin inhibits expression of MMP-7 and in vitro cell invasion at a non-toxic level through inhibiting ERK1/2 phosphorylation in hepatoma cell lines[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
222.19 |
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Formula |
C11H10O5 |
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CAS 号 |
486-21-5 |
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中文名称 |
异嗪皮啶 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (1125.16 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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