Isorhamnetin 3-O-galactoside(Synonyms: 异鼠李素-3-O-半乳糖苷; Cacticin)

天然产物 糖类和糖苷 Saccharides and Glycosides

Isorhamnetin 3-O-galactoside;(Synonyms: 异鼠李素-3-O-半乳糖苷; Cacticin) 纯度: ge;98.0%

Isorhamnetin 3-O-galactoside (Cacticin) 是从 Artemisia capillaris Thunberg 中分离出的一种黄酮苷,通过增强抗氧化防御系统和减少炎症信号通路来改善 CCl4-诱导的肝损伤。Isorhamnetin 3-O-galactoside (Cacticin) 具有抗血栓和抗炎作用。

Isorhamnetin 3-O-galactoside(Synonyms: 异鼠李素-3-O-半乳糖苷; Cacticin)

Isorhamnetin 3-O-galactoside Chemical Structure

CAS No. : 6743-92-6

规格 价格 是否有货 数量
5 mg ¥5710 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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生物活性

Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities[1][2][3].

分子量

478.40

Formula

C22H22O12

CAS 号

6743-92-6

中文名称

异鼠李素-3-O-半乳糖苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

参考文献
  • [1]. Kim DW, et al. Isorhamnetin-3-O-galactoside Protects against CCl4-Induced Hepatic Injury in Mice. Biomol Ther (Seoul). 2012 Jul;20(4):406-12.

    [2]. Kim TH, et al. Anti-inflammatory activities of isorhamnetin-3-O-galactoside against HMGB1-induced inflammatory responses in both HUVECs and CLP-induced septic mice. J Cell Biochem. 2013 Feb;114(2):336-45.

    [3]. Ku SK, et al. Antithrombotic and profibrinolytic activities of isorhamnetin-3-O-galactoside and hyperoside. Food Chem Toxicol. 2013 Mar;53:197-204.

Isorhamnetin-3-O-sophoroside-7-O-rhamnoside

天然产物 糖类和糖苷 Saccharides and Glycosides

Isorhamnetin-3-O-sophoroside-7-O-rhamnoside;

Isorhamnetin-3-O-sophoroside-7-O-rhamnoside 是一种从 Hippophaë rhamnoides 中分离出的的黄酮醇苷。Isorhamnetin-3-O-sophoroside-7-O-rhamnoside 具有抗有害微藻生长的杀藻活性。

Isorhamnetin-3-O-sophoroside-7-O-rhamnoside

Isorhamnetin-3-O-sophoroside-7-O-rhamnoside Chemical Structure

CAS No. : 41328-75-0

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Isorhamnetin-3-O-sophoroside-7-O-rhamnoside, the major flavonol glycoside, is isolated from sea buckthorn (Hippophaë rhamnoides). Isorhamnetin-3-O-sophoroside-7-O-rhamnoside has the algicidal activity against the growth of the harmful microalgae[1][2].

分子量

786.68

Formula

C34H42O21

CAS 号

41328-75-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang B, et, al. Flavonol glycosides in wild and cultivated berries of three major subspecies of Hippophaë rhamnoides and changes during harvesting period. Food Chemistry. Food Chemistry. 2009 Jul 15, 115 (2): 657-664.

    [2]. Xu NJ, et, al. [Inhibitory effects of Spartina anglica on Heterosigma akashiwo and Prorocenrum micans and the isolation and identification of the algicidal compounds]. Ying Yong Sheng Tai Xue Bao. 2009 Oct;20(10):2563-8.

Isorhamnetin 3-glucoside-7-rhamnoside(Synonyms: Luteoside)

天然产物 糖类和糖苷 Saccharides and Glycosides

Isorhamnetin 3-glucoside-7-rhamnoside;(Synonyms: Luteoside)

Isorhamnetin 3-glucoside-7-rhamnoside (Luteoside) 是一种黄酮化合物,可以从 B. tripartita 中提取得到。

Isorhamnetin 3-glucoside-7-rhamnoside(Synonyms: Luteoside)

Isorhamnetin 3-glucoside-7-rhamnoside Chemical Structure

CAS No. : 17331-71-4

规格 是否有货
5 mg 询价
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生物活性

Isorhamnetin 3-glucoside-7-rhamnoside (Luteoside) is a flavonoid that can be isolated from the aerial parts of B. tripartita[1].

分子量

624.54

Formula

C28H32O16

CAS 号

17331-71-4

中文名称

异鼠李亭 7-鼠李糖苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jie-Li Lv, et al. Flavonoids and polyacetylenes from the aerial parts of Bidens tripartite. June 2013Biochemical Systematics and Ecology 48:42-44.

Isorhamnetin(Synonyms: 异鼠李素; 3′-Methylquercetin)

天然产物 黄酮类 Flavonoids

Isorhamnetin (Synonyms: 异鼠李素; 3′-Methylquercetin) 纯度: 99.30%

Isorhamnetin 是从中草药沙棘 (Hippophae rhamnoides L.) 中提取的类黄酮化合物。Isorhamnetin 可通过直接抑制 MEK1PI3K 来抑制皮肤癌。

Isorhamnetin(Synonyms: 异鼠李素; 3

Isorhamnetin Chemical Structure

CAS No. : 480-19-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥880 In-stock
5 mg ¥800 In-stock
10 mg ¥1400 In-stock
25 mg ¥2800 In-stock
50 mg ¥5000 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

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生物活性

Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.

IC50 & Target

PI3-K

 

MEK1

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Isorhamnetin is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin binds directly to MEK1 in an ATP-noncompetitive manner and to PI3-K in an ATP-competitive manner. In vitro and ex vivo kinase assay data show that Isorhamnetin inhibits the kinase activity of MAP/ERK kinase (MEK) 1 and PI3-K and the inhibition is due to direct binding with Isorhamnetin[1]. Isorhamnetin inhibits the Akt/mTOR and MEK/ERK signaling pathways, and promotes the activity of the mitochondrial apoptosis signaling pathway. The inhibitory effects of Isorhamnetin on breast cancer cells are determined using the CCK-8 method. Isorhamnetin inhibits the proliferation of numerous breast cancer cells (IC50, ~10 µM), including MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468, whereas less inhibitory activity is observed in the MCF10A normal breast epithelial cell line (IC50, 38 µM)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Photographic data shows that Isorhamnetin treatment suppresses tumor development in mice. The average volume of tumors in untreated mice increases over time and reaches a volume of 623 mm3 at 4 weeks post-inoculation; however, at this time, in mice treated with 1 or 5 mg/kg Isorhamnetin, the average tumor volume is only 280 or 198 mm3, respectively. At the end of the study, Isorhamnetin treatment (1 or 5 mg/kg) reduces tumor weight compared with the untreated control group[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

316.26

Formula

C16H12O7

CAS 号

480-19-3

中文名称

异鼠李素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (316.20 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1620 mL 15.8098 mL 31.6196 mL
5 mM 0.6324 mL 3.1620 mL 6.3239 mL
10 mM 0.3162 mL 1.5810 mL 3.1620 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (6.58 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.08 mg/mL (6.58 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Kim JE, et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila). 2011 Apr;4(4):582-91.

    [2]. Hu S, et al. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen activated protein kinase kinase signaling pathways. Mol Med Rep. 2015 Nov;12(5):6745-51.

Cell Assay
[2]

MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468 breast cancer cell lines, as well as a MCF10A normal breast epithelial cell line (control) are seeded into 96-well plates at a density of 5×103 cells/well in 100 µL DMEM and placed in cell incubator for 12 h at 37°C in an atmosphere containing 5% CO2. The cells are then treated with various concentrations of Isorhamnetin (100, 33.3, 11.1, 3.7, 1.2, 0.4 and 0 µM) for 48 h, and cell proliferation rates are determined by adding 10 µL CCK-8 solution prior to incubation at 37°C for 2 h. The absorbance is measured at a wavelength of 450 nm using a SpectraMax 190 Microplate Reader. For each assay, four parallel wells are included, and the half maximal inhibitory concentration (IC50) is measured using the inhibition curve and presented as the mean of three independent experiments[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Mice[1]
Female athymic nude mice are injected subcutaneously in the flank with A431 cells (1×106 cells in 50 μL of medium and 50 μL of Matrigel). Cells are allowed to form tumors, and once the tumors reach a size of 40 mm3, the mice are randomly assigned into groups (6 mice/group) and treated with (1 or 5 mg/kg body weight) or without Isorhamnetin in 40% DMSO/PBS buffer, administered intraperitoneally every other day for 28 days. Tumor size is measured every week with calipers, and the tumor volume is calculated. Mice are sacrificed after 28 days of treatment when the control tumors reach approximately 600 mm3. The tumors are harvested, photographed, and weighed. Tumor tissues are used for western blot analysis and immunohistochemical analysis.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Kim JE, et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila). 2011 Apr;4(4):582-91.

    [2]. Hu S, et al. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen activated protein kinase kinase signaling pathways. Mol Med Rep. 2015 Nov;12(5):6745-51.

Isorhamnetin-3-O-neohespeidoside(Synonyms: 异鼠李素-3-O-新橙皮苷)

天然产物 糖类和糖苷 Saccharides and Glycosides

Isorhamnetin-3-O-neohespeidoside;(Synonyms: 异鼠李素-3-O-新橙皮苷) 纯度: 99.09%

Isorhamnetin-3-O-neohespeidoside 是一种从 Pollen typhae 分离的黄酮类化合物。

Isorhamnetin-3-O-neohespeidoside(Synonyms: 异鼠李素-3-O-新橙皮苷)

Isorhamnetin-3-O-neohespeidoside Chemical Structure

CAS No. : 55033-90-4

规格 价格 是否有货 数量
5 mg ¥800 In-stock
10 mg ¥1400 In-stock
20 mg ¥2300 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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生物活性

Isorhamnetin-3-O-neohespeidoside is a flavonoid isolated from Pollen typhae[1].

分子量

624.54

Formula

C28H32O16

CAS 号

55033-90-4

中文名称

异鼠李素-3-O-新橙皮苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

DMSO : 250 mg/mL (400.29 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6012 mL 8.0059 mL 16.0118 mL
5 mM 0.3202 mL 1.6012 mL 3.2024 mL
10 mM 0.1601 mL 0.8006 mL 1.6012 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (3.33 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.33 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.33 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.33 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.33 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.33 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Wang X, et al. A rapid and efficient extraction method based on industrial MCM-41-miniaturized matrix solid-phase dispersion extraction with response surface methodology for simultaneous quantification of six flavonoids in Pollen typhae by ultra-high-performance liquid chromatography. J Sep Sci. 2019 Jul;42(14):2426-2434.

Isorhamnetin-3-O-glucoside

天然产物 糖类和糖苷 Saccharides and Glycosides

Isorhamnetin-3-O-glucoside; 纯度: 99.95%

Isorhamnetin-3-O-glucoside 是一种广泛存在于蔬菜和水稻中的天然化合物,经消化后可在肠道菌群中代谢。

Isorhamnetin-3-O-glucoside

Isorhamnetin-3-O-glucoside Chemical Structure

CAS No. : 5041-82-7

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ¥2090 In-stock
5 mg ¥1900 In-stock
10 mg ¥2800 In-stock
25 mg ¥5600 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Isorhamnetin-3-O-glucoside 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Food-Sourced Compound Library

生物活性

Isorhamnetin-3-O-glucoside, a natural compound widely contained in many vegetables and rice, could be metabolized in intestinal microbiota after digestion[1].

分子量

478.40

Formula

C22H22O12

CAS 号

5041-82-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 250 mg/mL (522.58 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0903 mL 10.4515 mL 20.9030 mL
5 mM 0.4181 mL 2.0903 mL 4.1806 mL
10 mM 0.2090 mL 1.0452 mL 2.0903 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (4.35 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.35 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.35 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.35 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.35 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.35 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Le-yue Du, et al. Analysis of the Metabolites of Isorhamnetin 3-O-Glucoside Produced by Human Intestinal Flora in Vitro by Applying Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry. J Agric Food Chem. 201462122489-2495.