IYPTNGYTR acetate

IYPTNGYTR acetate; 纯度: 99.41%

IYPTNGYTR acetate,一种脱酰胺敏感的特征肽,是曲妥珠单抗 (Trastuzumab) 的脱酰胺产物。 IYPTNGYTR acetate 可用于监测体内曲妥珠单抗的代谢。

IYPTNGYTR acetateamp;;

IYPTNGYTR acetate Chemical Structure

规格 价格 是否有货 数量
5 mg ¥2500 In-stock
10 mg ¥4500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

IYPTNGYTR acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Drug Metabolite Library
  • Peptide Library

生物活性

IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism[1].

体外研究
(In Vitro)

IYPTNGYTR is deamidated at pH 7.5 and above, with a higher deamidation rate when the pH increases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1144.23

Formula

C51H77N13O17

Sequence Shortening

IYPTNGYTR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 125 mg/mL (109.24 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8740 mL 4.3698 mL 8.7395 mL
5 mM 0.1748 mL 0.8740 mL 1.7479 mL
10 mM 0.0874 mL 0.4370 mL 0.8740 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Bults P, et, al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016 Feb 2;88(3):1871-7.

IYPTNGYTR

IYPTNGYTR;

IYPTNGYTR,一种脱酰胺敏感的特征肽,是曲妥珠单抗 (Trastuzumab) 的脱酰胺产物。 IYPTNGYTR 可用于监测体内曲妥珠单抗的代谢。

IYPTNGYTRamp;;

IYPTNGYTR Chemical Structure

CAS No. : 1431957-72-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

IYPTNGYTR 的其他形式现货产品:

IYPTNGYTR acetate

生物活性

IYPTNGYTR, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR can be used to monitor in vivo Trastuzumab metabolism[1].

体外研究
(In Vitro)

IYPTNGYTR is deamidated at pH 7.5 and above, with a higher deamidation rate when the pH increases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1084.18

Formula

C49H73N13O15

CAS 号

1431957-72-0

Sequence Shortening

IYPTNGYTR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Bults P, et, al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016 Feb 2;88(3):1871-7.