Kanamycin sulfate;(Synonyms: 硫酸卡那霉素; Kanamycin A monosulfate) 纯度: ge;98.0%
Kanamycin sulfate是氨基糖苷类杀菌抗生素,其通过与细菌30S核糖体结合起作用。
Kanamycin sulfate Chemical Structure
CAS No. : 25389-94-0
规格
价格
是否有货
数量
Free Sample (0.1-0.5 mg)
;
Apply now
;
10;mM;*;1 mL in Water
¥500
In-stock
200 mg
¥350
In-stock
1 g
¥450
In-stock
5 g
¥880
In-stock
10 g
;
询价
;
50 g
;
询价
;
* Please select Quantity before adding items.
Kanamycin sulfate 相关产品
bull;相关化合物库:
Natural Product Library Plus
Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
FDA-Approved Drug Library Mini
Bioactive Compound Library Plus
Anti-Infection Compound Library
Natural Product Library
FDA-Approved Drug Library
Drug Repurposing Compound Library
Glycoside Compound Library
Antibacterial Compound Library
Anti-COVID-19 Compound Library
NMPA-Approved Drug Library
FDA Approved amp; Pharmacopeial Drug Library
Antibiotics Library
Drug-Induced Liver Injury (DILI) Compound Library
Microbial Metabolite Library
Rare Diseases Drug Library
生物活性
Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic which acts by binding to the bacterial 30S ribosomes.
体外研究 (In Vitro)
Kanamycin sulfate at the concentration above 0.0025% has a significant inhibition on the growth of B. bifidum and has no influence on the other four probiotics at incubation 12 h or 24 h. The optimum selective concentration of kanamycin sulfate in MRS media is 0.005% for selective enumeration of B.bifidum[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
The neurons damage of the DCN caused by kanamycin (500 mg/kg/day) is reversible and autophagy is upregulated in the neurotoxic course of kanamycin on DCN through JNK1-mediated phosphorylation of Bcl-2 pathway in rats. The serum BUN and Cr levels are both increased at the 1st day after the period of kanamycin administration. The neurons expressing LC3 are increased at 1, 7 and 14 days after kanamycin administration in comparison to the control group. Kanamycin treatment results in the increase of autophagy in a time-dependent manner[1]. Kanamycin sulfate (5 mg/kg) and sodium ampicillin (10 mg/kg) administered intramuscularly (i.m.) separately, and then together, to five pony mares, and the ampicillin concentration exceeds 5 mg/mL in inflamed synovial fluid for some 2.5 h after injection, and kanamycin sulfate concentration exceeds 2 mg/mL for 7 h in the pony[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量
582.58
Formula
C18H38N4O15S
CAS 号
25389-94-0
中文名称
硫酸卡那霉素;单硫酸卡那霉素;硫酸卡那辛
运输条件
Room temperature in continental US; may vary elsewhere.
Solubility: 50 mg/mL (85.83 mM); Clear solution; Need ultrasonic
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
[1]. Fan GR, et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013 Jan 17. pii: S0006-8993(13)00068-1.
[2]. Mohamed el SW, et al. Tongue actinomycetoma due to Actinomadura madurae: a rare clinical presentation. J Oral Maxillofac Surg. 2012 Nov;70(11):e622-4.
[3]. Guo WS, et al. Effect of Kanamycin Sulfate and Gentamicin on Growth of Probiotics. Advanced Materials Research,2011, 366, 490-493.
[4]. Firth EC, et al. Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. J Vet Pharmacol Ther. 1988 Mar;11(1):56-62.
Animal Administration [1]
Sixty-six male Sprague-Dawley rats (initial body weight 125-150 g, 5-6 weeks old) have free access to water and a regular diet, and are allowed 1 week of acclimation before the first treatment. The animals are divided randomly into one control group and seven experimental groups. Control group rats (n=10) are injected subcutaneously with an equal volume of vehicle (0.9% saline) for 10 days as those in the groups of kanamycin treatment, but without kanamycin. The experimental groups (n=56, 8 for each group: 1, 7, 14, 28, 56, 70 and 140 days after kanamycin administration, respectively) receive 500 mg of kanamycin sulfate/kg/day by subcutaneous injection for 10 days. The animal body weight is monitored every day and the injection dosage of kanamycin is adjusted accordingly. Auditory thresholds are tested by ABR. The tests are taken twice for each animal, first prior to the beginning of administration and then at different observing time points after kanamycin treatment. Details for the ABR measurement is described elsewhere.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Fan GR, et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013 Jan 17. pii: S0006-8993(13)00068-1.
[2]. Mohamed el SW, et al. Tongue actinomycetoma due to Actinomadura madurae: a rare clinical presentation. J Oral Maxillofac Surg. 2012 Nov;70(11):e622-4.
[3]. Guo WS, et al. Effect of Kanamycin Sulfate and Gentamicin on Growth of Probiotics. Advanced Materials Research,2011, 366, 490-493.
[4]. Firth EC, et al. Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. J Vet Pharmacol Ther. 1988 Mar;11(1):56-62.
Bekanamycin;(Synonyms: 卡那霉素; Kanamycin B) 纯度: ge;98.0%
Bekanamycin (Kanamycin B) 是一种氨基糖苷类抗生素,提取自 Streptomyces kanamyceticus,抑制一系列革兰氏阳性和阴性细菌。
Bekanamycin Chemical Structure
CAS No. : 4696-76-8
规格
价格
是否有货
数量
Free Sample (0.1-0.5 mg)
;
Apply now
;
10;mM;*;1 mL in Water
¥550
In-stock
100 mg
¥500
In-stock
200 mg
;
询价
;
500 mg
;
询价
;
* Please select Quantity before adding items.
Bekanamycin 相关产品
bull;相关化合物库:
Covalent Screening Library Plus
Natural Product Library Plus
Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
FDA-Approved Drug Library Mini
Bioactive Compound Library Plus
Anti-Infection Compound Library
Natural Product Library
FDA-Approved Drug Library
Drug Repurposing Compound Library
Covalent Screening Library
Glycoside Compound Library
Antibacterial Compound Library
Anti-COVID-19 Compound Library
FDA Approved amp; Pharmacopeial Drug Library
Antibiotics Library
Microbial Metabolite Library
生物活性
Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain[1][2].
体外研究 (In Vitro)
Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of S. kanamyceticus[2]. Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
483.51
Formula
C18H37N5O10
CAS 号
4696-76-8
中文名称
卡那霉素 B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20deg;C
3 years
4deg;C
2 years
In solvent
-80deg;C
6 months
-20deg;C
1 month
溶解性数据
In Vitro:;
H2O : ≥ 100 mg/mL (206.82 mM)
DMSO : 1 mg/mL (2.07 mM; ultrasonic and warming and heat to 80°C)
[1]. Gao W, et al. Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus viametabolic engineering. PLoS One. 2017 Jul 28;12(7):e0181971.
[2]. Fosso MY, et al. Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. J Med Chem. 2015 Dec 10;58(23):9124-32.
[3]. Uchiyama T, et al. Presynaptic effects of bekanamycin at the frog neuromuscular junction. Reversibility by calcium and aminopyridines. Eur J Pharmacol. 1981 Jul 10;72(4):271-80.