标签归档：kinase

Protein Kinase C Peptide Substrate(Synonyms: PKCε PRKCE Peptide Epsilon)

发表于由

Protein Kinase C Peptide Substrate;(Synonyms: PKCε; PRKCE ; Peptide Epsilon)

Protein Kinase C Peptide Substrate 依赖于第二信使和特定的适配蛋白靶向特定的细胞间室，接受细胞外信号，激活 G 蛋白偶联受体，酪氨酸激酶受体或酪氨酸激酶偶联受体。Protein Kinase C Peptide Substrate 参与调控多种生理功能，包括神经。内分泌、外分泌、炎症和免疫系统的激活。

Protein Kinase C Peptide Substrateamp;;(Synonyms: PKCε; PRKCE ; Peptide Epsilon)

Protein Kinase C Peptide Substrate Chemical Structure

CAS No. : 120253-69-2

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生物活性

Protein Kinase C Peptide Substrate is targeted to a specific cellular compartment in a manner dependent on second messengers and on specific adapter proteins in response to extracellular signals that activate G-protein-coupled receptors, tyrosine kinase receptors, or tyrosine kinase-coupled receptors. Protein Kinase C Peptide Substrate then regulates various physiological functions including the activation of nervous, endocrine, exocrine, inflammatory, and immune systems[1].

分子量

2067.43

Formula

C83H155N39O21S
CAS 号

120253-69-2
Sequence

Glu-Arg-Met-Arg-Pro-Arg-Lys-Arg-Gln-Gly-Ser-Val-Arg-Arg-Arg-Val
Sequence Shortening

ERMRPRKRQGSVRRRV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Akita Y, et al. Protein kinase C-epsilon (PKC-epsilon): its unique structure and function. J Biochem. 2002 Dec;132(6):847-52.

Protein Kinase C (19-36)

发表于由

Protein Kinase C (19-36);

Protein Kinase C (19-36) 是蛋白激酶 C (PKC) 的伪底物肽抑制剂，其IC50 值为 0.18 μM。Protein Kinase C (19-36) 有效减缓血管增生和肥大，抑制葡萄糖诱导的利钠肽受体反应。

Protein Kinase C (19-36)amp;;

Protein Kinase C (19-36) Chemical Structure

CAS No. : 113731-96-7

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250 mg ; 询价 ;
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生物活性

Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response[1].

IC50 Target

IC50: 0.18 μM (protein kinase C)[1].
分子量

2151.48

Formula

C93H159N35O24
CAS 号

113731-96-7
Sequence

Arg-PheAla-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-His-Glu-Val-Lys-Asn
Sequence Shortening

RFARKGALRQKNVHEVKN
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yasunari K, et al. Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration. Hypertension. 1996 Aug;28(2):159-68.

Casein Kinase Substrates 3

发表于由

Casein Kinase Substrates 3;

Casein Kinase Substrates 3 是酪蛋白激酶的一个底物。

Casein Kinase Substrates 3amp;;

Casein Kinase Substrates 3 Chemical Structure

CAS No. : 154444-97-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Casein Kinase Substrates 3 is a substrate of casein kinase.

分子量

2131.24

Formula

C85H139N27O35S
CAS 号

154444-97-0
Sequence

Arg-Arg-Lys-Asp-Leu-His-Asp-Asp-Glu-Glu-Asp-Glu-Ala-Met-Ser-Ile-Thr-Ala
Sequence Shortening

RRKDLHDDEEDEAMSITA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Syk Kinase Peptide Substrate, Biotin labeled

发表于由

Syk Kinase Peptide Substrate, Biotin labeled;

Syk Kinase Peptide Substrate, Biotin labeled 是生物素标记的、Syk 激酶多肽底物。

Syk Kinase Peptide Substrate, Biotin labeledamp;;

Syk Kinase Peptide Substrate, Biotin labeled Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Syk Kinase Peptide Substrate, Biotin labeled is a biotin-labled Syk kinase peptide substrate.

分子量

1689.90

Formula

C76H108N18O24S1
Sequence

Biotin-Lys-Glu-Asp-Pro-Asp-Tyr-Glu-Trp-Pro-Ser-Ala-Lys-NH2
Sequence Shortening

Biotin-KEDPDYEWPSAK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Tyrosine Kinase Peptide 1

发表于由

Tyrosine Kinase Peptide 1;

Tyrosine Kinase Peptide 1 是用于c-Src 激酶实验的对照底物。

Tyrosine Kinase Peptide 1amp;;

Tyrosine Kinase Peptide 1 Chemical Structure

CAS No. : 173691-86-6

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay[1].

分子量

1669.90

Formula

C77H125N19O22
CAS 号

173691-86-6
Sequence

Lys-Val-Glu-Lys-Ile-Gly-Glu-Gly-Thr-Tyr-Gly-Val-Val-Tyr-Lys
Sequence Shortening

KVEKIGEGTYGVVYK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jiansong Huang, et al. Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy. J Hematol Oncol. 2015 May 30;8:62.

Phosphorylase Kinase β-Subunit Fragment (420-436)

发表于由

Phosphorylase Kinase β-Subunit Fragment (420-436);

Phosphorylase Kinase β-Subunit Fragment (420-436) 是β-亚单位片段(肽430-436)的磷酸化酶激酶。磷酸化酶激酶是一种丝氨酸/苏氨酸特异性蛋白激酶，它激活糖原磷酸化酶，从糖原中释放葡萄糖-1-磷酸。

Phosphorylase Kinase β-Subunit Fragment (420-436)amp;;

Phosphorylase Kinase β-Subunit Fragment (420-436) Chemical Structure

CAS No. : 150829-21-3

规格 是否有货
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250 mg ; 询价 ;
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生物活性

Phosphorylase Kinase β-Subunit Fragment (420-436) is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. Phosphorylase kinase is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen[1].

分子量

1947.14

Formula

C79H131N31O25S
CAS 号

150829-21-3
Sequence

Lys-Arg-Asn-Pro-Gly-Ser-Gln-Lys-Arg-Phe-Pro-Ser-Asn-Cys-Gly-Arg-Asp
Sequence Shortening

KRNPGSQKRFPSNCGRD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Fischer EH, et al. Phosphorylase and the origin of reversible protein phosphorylation. Biol Chem. 2010 Feb-Mar;391(2-3):131-7.

Calmodulin-Dependent Protein Kinase II (281-309)

发表于由

Calmodulin-Dependent Protein Kinase II (281-309);

Calmodulin-Dependent Protein Kinase II (281-309) 是钙/钙调素依赖蛋白激酶 II (CaM kinase II) 多肽片段。

Calmodulin-Dependent Protein Kinase II (281-309)amp;;

Calmodulin-Dependent Protein Kinase II (281-309) Chemical Structure

CAS No. : 116826-37-0

规格 是否有货
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250 mg ; 询价 ;
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生物活性

Calmodulin-Dependent Protein Kinase II (281-309) is a peptide of calcium/calmodulin-dependent protein kinase II (CaM-kinase II)[1].

分子量

3374.06

Formula

C146H254N46O39S3
CAS 号

116826-37-0
Sequence

Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala
Sequence Shortening

MHRQETVDCLKKFNARRKLKGAILTTMLA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Chae YJ, et al. Block of Kv4.3 potassium channel by trifluoperazine independent of CaMKII. Neurosci Lett. 2014 Aug 22;578:159-64.

Syk Kinase Peptide Substrate

发表于由

Syk Kinase Peptide Substrate;

Syk Kinase Peptide Substrate 是Syk 激酶多肽底物。

Syk Kinase Peptide Substrateamp;;

Syk Kinase Peptide Substrate Chemical Structure

CAS No. : 865778-47-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Syk Kinase Peptide Substrate is a Syk kinase peptide substrate.

分子量

1463.60

Formula

C66H94N16O22
CAS 号

865778-47-8
Sequence

Lys-Glu-Asp-Pro-Asp-Tyr-Glu-Trp-Pro-Ser-Ala-Lys-NH2
Sequence Shortening

KEDPDYEWPSAK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.