Kasugamycin hydrochloride(Synonyms: Ksg hydrochloride)

天然产物 糖类和糖苷 Saccharides and Glycosides

Kasugamycin hydrochloride;(Synonyms: Ksg hydrochloride)

Kasugamycin hydrochloride (Ksg hydrochloride) 是一种既能结合 30s 和 70s 核糖体又不能结合 50s 亚基的抗生素。Kasugamycin hydrochloride (Ksg hydrochloride) 模拟 mRNA 核苷酸破坏 tRNA 结合并抑制典型翻译起始。

Kasugamycin hydrochloride(Synonyms: Ksg hydrochloride)

Kasugamycin hydrochloride Chemical Structure

CAS No. : 19408-46-9

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生物活性

Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation[1][2].

分子量

415.82

Formula

C14H26ClN3O9

CAS 号

19408-46-9

中文名称

春雷霉素盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Schluenzen F, et al. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol. 2006 Oct;13(10):871-8.

    [2]. Schuwirth BS, et al. Structural analysis of kasugamycin inhibition of translation. Nat Struct Mol Biol. 2006 Oct;13(10):879-86.