Kushenol E

天然产物 黄酮类 Flavonoids

Kushenol E  纯度: ≥96.0%

Kushenol E 是从 Sophora flavescens 中分离出的一类类黄酮,是 IDO1 的非竞争性抑制剂,其 IC50 值为 7.7 µM,Ki 值为 9.5 µM,具有抗肿瘤活性。

Kushenol E

Kushenol E Chemical Structure

CAS No. : 99119-72-9

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1 mg ¥3500 In-stock
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Kushenol E 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity[1].

分子量

424.49

Formula

C25H28O6

CAS 号

99119-72-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1481-1488.

Kushenol O(Synonyms: 苦参醇O)

天然产物 糖类和糖苷 Saccharides and Glycosides

Kushenol O;(Synonyms: 苦参醇O)

Kushenol O 是一种黄酮类化合物。

Kushenol O(Synonyms: 苦参醇O)

Kushenol O Chemical Structure

CAS No. : 102390-91-0

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生物活性

Kushenol O is a flavonoid compound[1].

分子量

562.52

Formula

C27H30O13

CAS 号

102390-91-0

中文名称

苦参醇O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lei Zhang, et al. Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry. J Pharm Biomed Anal. 2007 Sep 3;44(5):1019-28.

Kushenol L(Synonyms: 苦参醇L)

天然产物 黄酮类 Flavonoids

Kushenol L (Synonyms: 苦参醇L)

Kushenol L 是苦参乙醇提取物的主要成分之一,苦参是来自 Sophora flavescens Ait 的干燥根。Kushenol L 是一种类黄酮,具有抗糖尿病的作用。

Kushenol L(Synonyms: 苦参醇L)

Kushenol L Chemical Structure

CAS No. : 101236-50-4

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生物活性

Kushenol L is one of the main components of EtOA cextracts from Kushen, a traditional medicinal herb derived from the dried roots of Sophora flavescens Ait. Kushenol L is a flavonoid and plays an important role in anti-diabeticeffects[1].

体内研究
(In Vivo)

Kushenol L (1 mg/kg; oral) has a T1/2 of 2.26 hours, a Cmax of 24.17 μg/L and an AUC of 54035 μg/h•L in adult male Sprague-Dawley rats weighing 300 g[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

440.49

Formula

C25H28O7

CAS 号

101236-50-4

中文名称

苦参醇L

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lei Chen, et al. An accurate and reproducible method for simultaneous determination of four flavonoids in EtOAc extracts from Sophora flavescens Ait. in rat plasma based on UHPLC Q-Exactive Mass spectrometry: Application to a pharmacokinetics study. Biomed Chromatogr. 2019 Mar;33(3):e4447.

Kushenol N(Synonyms: 苦参醇N)

天然产物 黄酮类 Flavonoids

Kushenol N (Synonyms: 苦参醇N)

Kushenol N 是一种异戊烯基黄酮类化合物,能从 Sophora flavescens 中分离得到。Kushenol N 具有抗过敏和血管舒张作用。

Kushenol N(Synonyms: 苦参醇N)

Kushenol N Chemical Structure

CAS No. : 102490-65-3

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生物活性

Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities[1][2].

分子量

454.51

Formula

C26H30O7

CAS 号

102490-65-3

中文名称

苦参醇N

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wenying Quan, et al. Anti-allergic prenylated flavonoids from the roots of Sophora flavescens. Planta Med. 2008 Feb;74(2):168-70.

    [2]. Chul Young Kim, et al. Vasorelaxant prenylated flavonoids from the roots of Sophora flavescens. Biosci Biotechnol Biochem. 2013;77(2):395-7.

Kushenol W(Synonyms: 苦参醇W)

天然产物 黄酮类 Flavonoids

Kushenol W (Synonyms: 苦参醇W)

Kushenol W 是一种黄酮类化合物,在 Sophora flavescens 发现。Kushenol W 具有抗菌作用,对金黄色葡萄球菌的 MIC 为 10 μg/mL。

Kushenol W(Synonyms: 苦参醇W)

Kushenol W Chemical Structure

CAS No. : 254886-76-5

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生物活性

Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus[1].

分子量

386.40

Formula

C21H22O7

CAS 号

254886-76-5

中文名称

苦参醇W

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Motahare Boozari, et al. Biologically active prenylated flavonoids from the genus Sophora and their structure-activity relationship-A review. Phytother Res. 2019 Mar;33(3):546-560.

Kushenol B

天然产物 黄酮类 Flavonoids

Kushenol B 

Kushenol B 是一种从 S. flavescens 中分离得到的异戊二烯类黄酮,具有抗菌、抗炎和抗氧化活性。Kushenol B 对 cAMP 磷酸二酯酶 (cAMP PDE) 有抑制活性,IC50 为 31 µM。

Kushenol B

Kushenol B Chemical Structure

CAS No. : 99217-64-8

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生物活性

Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities[1]. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 µM[1].

IC50 & Target

IC50: 31 µM (cAMP PDE)[1]

分子量

492.60

Formula

C30H36O6

CAS 号

99217-64-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Han-Tian Fan, et al. The rational search for PDE10A inhibitors from Sophora flavescens roots using pharmacophore‑ and docking‑based virtual screening. Mol Med Rep

Kushenol M(Synonyms: 苦参醇M)

天然产物 黄酮类 Flavonoids

Kushenol M (Synonyms: 苦参醇M)

Kushenol M 是一种黄酮类化合物,在 Sophora flavescens 发现。 Kushenol M 是一种细胞色素 P450 (CYP) 抑制剂,对人肝微粒体中 CYP3A4 抑制作用的 IC50 值为 1.29 μM。

Kushenol M(Synonyms: 苦参醇M)

Kushenol M Chemical Structure

CAS No. : 101236-51-5

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生物活性

Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC50 values of 1.29 μM for CYP3A4 in human liver microsomes[1].

分子量

508.60

Formula

C30H36O7

CAS 号

101236-51-5

中文名称

苦参醇M

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xinguang Liu, et al. Advances in Metabolic Profiling and Pharmacokinetics of Herbal Medicinal Products. Evid Based Complement Alternat Med. 2019 May 6;2019:5190972.

Kushenol X(Synonyms: 苦参醇X)

天然产物 黄酮类 Flavonoids

Kushenol X (Synonyms: 苦参醇X)

Kushenol X,一种从 Sophora flavescens 的根中分离出来的类黄酮化合物。Kushenol X 是一种有效的 β-葡萄糖醛酸苷酶 (β-glucuronidase) 和人羧酸酯酶 2 (hCE2) 抑制剂,IC50 分别为 2.07 μM 和 3.05 μM。

Kushenol X(Synonyms: 苦参醇X)

Kushenol X Chemical Structure

CAS No. : 254886-77-6

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生物活性

Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively[1][2].

IC50 & Target

IC50: 2.07 μM (β-glucuronidase)[1] and 3.05 μM (Human carboxylesterase 2 (hCE2))[2]

分子量

440.49

Formula

C25H28O7

CAS 号

254886-77-6

中文名称

苦参醇X

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Cheng-Peng Sun, et al. The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase. Int J Biol Macromol. 2020 Jan 15;143:349-358.

    [2]. Sha-Sha Song, et al. Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations. Int J Biol Macromol. 2019 Jun 15;131:201-208.

Kushenol K(Synonyms: 苦参醇K)

天然产物 黄酮类 Flavonoids

Kushenol K (Synonyms: 苦参醇K)

Kushenol K,一种从 Sophora flavescens 中提取的黄酮类抗氧化剂。Kushenol K 是 CYP3A4 的抑制剂,Ki 值为 1.35 μM。Kushenol K 对 HSV-2 具有较弱的抗病毒活性 (EC50 为 147 μM)。Kushenol K 还抑制 SGLT1SGLT2 的活性。

Kushenol K(Synonyms: 苦参醇K)

Kushenol K Chemical Structure

CAS No. : 101236-49-1

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生物活性

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].

IC50 & Target[1][2][3]

HSV-2

147 μM (EC50)

CYP3A4

1.35 μM (Ki)

SGLT

 

体外研究
(In Vitro)

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1].
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

472.53

Formula

C26H32O8

CAS 号

101236-49-1

中文名称

苦参醇K;苦参醇 K

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.

    [2]. E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4.

    [3]. Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.

Sophoraflavanone G(Synonyms: Kushenol F)

天然产物 黄酮类 Flavonoids

Sophoraflavanone G (Synonyms: Kushenol F) 纯度: 98.30%

Sophoraflavanone G (Kushenol F) 是从苦参中提取得到的,具有抗肿瘤和抗炎特性。Sophoraflavanone G (Kushenol F) 通过抑制 MAPK 相关途径诱导 MDA-MB-231 和 HL-60 细胞凋亡 (apoptosis)。

Sophoraflavanone G(Synonyms: Kushenol F)

Sophoraflavanone G Chemical Structure

CAS No. : 97938-30-2

规格 价格 是否有货 数量
5 mg ¥1190 In-stock
10 mg ¥2020 In-stock
20 mg ¥3430 In-stock
50 mg   询价  
100 mg   询价  

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Sophoraflavanone G 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library

生物活性

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.  Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].

IC50 & Target

IC50: 29.7 μM (MDA-MB-231 cell)[1]

体外研究
(In Vitro)

Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner[1].
Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated “intrinsic” pathway[1]
Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br>

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

424.49

Formula

C25H28O6

CAS 号

97938-30-2

中文名称

苦参总黄酮; 苦参酚 F

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (588.94 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3558 mL 11.7788 mL 23.5577 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL
10 mM 0.2356 mL 1.1779 mL 2.3558 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.90 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.90 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Li ZY, et al. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation.Am J Chin Med. 2016;44(1):165-76.

    [2]. Huang WC, et al. Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells.Phytomedicine. 2019 Aug;61:152852.