[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P 品牌:FUJIFILM Wako


[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P

品牌:FUJIFILM Wako
CAS No.:84676-91-5
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

017-22971

for Proteome Research 2 nmol本

[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P               品牌:FUJIFILM Wako


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Tyrosylleucine(Synonyms: Tyr-Leu)

Tyrosylleucine;(Synonyms: Tyr-Leu)

Tyrosylleucine (Tyr-Leu, YL) 是具有口服活性的二肽,具有类似抗抑郁活性。

Tyrosylleucineamp;;(Synonyms: Tyr-Leu)

Tyrosylleucine Chemical Structure

CAS No. : 17355-10-1

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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Tyrosylleucine 的其他形式现货产品:

Tyrosylleucine TFA

生物活性

Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

体内研究
(In Vivo)

Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice (24-27 g)[1]
Dosage: 0.1-30 mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100 mg/kg, p.o.
Administration: Administered orally, intracerebroventricularly, or intraperitoneally
Result: Decreased immobility time after intraperitoneal (1-30 mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST.
Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice.

分子量

294.35

Formula

C15H22N2O4

CAS 号

17355-10-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro:;

H2O : 250 mg/mL (849.33 mM; Need ultrasonic)

DMSO : 250 mg/mL (849.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3973 mL 16.9866 mL 33.9732 mL
5 mM 0.6795 mL 3.3973 mL 6.7946 mL
10 mM 0.3397 mL 1.6987 mL 3.3973 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.07 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.07 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.07 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257.

    [2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.

[Leu3]-Oxytocin

[Leu3]-Oxytocin;

[Leu3]-Oxytocin,一种催产素类似物,由序列位置3的结构变化衍生而来,被亮氨酸 (Leu) 取代。

[Leu3]-Oxytocinamp;;

[Leu3]-Oxytocin Chemical Structure

CAS No. : 4294-11-5

规格 是否有货
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生物活性

[Leu3]-Oxytocin, an oxytocin analogue, is derived by structural variation in sequence position 3 replaced by leucine (Leu)[1].

分子量

1007.19

Formula

C43H66N12O12S2

CAS 号

4294-11-5

Sequence Shortening

CYLQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Krejcí I, et al. Effect of magnesium on the action of oxytocin and a group of analogues on the uterus in vitro. Eur J Pharmacol. 1968;2(5):393-398.

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH;

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Leu-Thr(psi(Me,Me)pro)-OHamp;;

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 955048-89-2

规格 是否有货
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生物活性

Fmoc-Leu-Thr(psi(Me,Me)pro)-OH is a dipeptide.

分子量

494.58

Formula

C28H34N2O6

CAS 号

955048-89-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA;(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) 是一种甲酰肽受体 (FPR) 激动剂。

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFAamp;;(Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA)

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA Chemical Structure

规格 是否有货
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250 mg ; 询价 ;
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N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA 的其他形式现货产品:

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys

生物活性

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist[1].

IC50 Target

Formyl peptide receptor[1]

分子量

938.04

Formula

C45H66F3N7O11

Sequence

N-Formyl-{NLE}-Leu-Phe-{NLE}-Tyr-Lys

Sequence Shortening

N-Formyl-{NLE}-LF-{NLE}-YK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Stenfeldt AL, et al. The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptidereceptor but not the formyl peptide receptor like 1. Biochem Pharmacol. 2007 Oct 1;74(7):1050-6.

{Boc}-Phe-Leu-Phe-Leu-Phe TFA

{Boc}-Phe-Leu-Phe-Leu-Phe TFA;

{Boc}-Phe-Leu-Phe-Leu-Phe TFA 是一种甲酰肽受体 (FPR) 家族拮抗剂,可优先抑制通过甲酰肽受体触发的活性。

{Boc}-Phe-Leu-Phe-Leu-Phe TFAamp;;

{Boc}-Phe-Leu-Phe-Leu-Phe TFA Chemical Structure

规格 是否有货
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生物活性

{Boc}-Phe-Leu-Phe-Leu-Phe TFA is a formyl peptide receptor (FPR) family antagonist that preferentially inhibits activity triggered through the formyl peptide receptor[1].

分子量

899.99

Formula

C46H60F3N5O10

Sequence Shortening

{Boc}-FLFLF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Anna-Lena Stenfeldt, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9.

{Boc}-Phe-Leu-Phe-Leu-Phe

{Boc}-Phe-Leu-Phe-Leu-Phe;

{Boc}-Phe-Leu-Phe-Leu-Phe ({Boc}-FLFLF) 是一种甲酰肽受体 (FPR) 家族拮抗剂,可优先抑制通过甲酰肽受体触发的活性。

{Boc}-Phe-Leu-Phe-Leu-Pheamp;;

{Boc}-Phe-Leu-Phe-Leu-Phe Chemical Structure

CAS No. : 66556-73-8

规格 价格 是否有货
1 mg ¥2500 询问价格 货期
5 mg ¥6000 询问价格 货期
10 mg ¥10000 询问价格 货期

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生物活性

{Boc}-Phe-Leu-Phe-Leu-Phe ({Boc}-FLFLF) is a formyl peptide receptor (FPR) family antagonist that preferentially inhibits activity triggered through the formyl peptide receptor[1].

分子量

785.97

Formula

C44H59N5O8

CAS 号

66556-73-8

Sequence Shortening

{Boc}-FLFLF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Anna-Lena Stenfeldt, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9.

[D-Leu-4]-OB3

[D-Leu-4]-OB3;

[D-Leu-4]-OB3 抑制促炎、增殖和转移基因的表达以及 PD-L1 的表达。[D-Leu-4]-OB3 刺激促凋亡基因的表达。

[D-Leu-4]-OB3amp;;

[D-Leu-4]-OB3 Chemical Structure

CAS No. : 289056-32-2

规格 是否有货
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生物活性

[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes[1].

分子量

734.82

Formula

C29H50N8O12S

CAS 号

289056-32-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yih Ho,et al. Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells.Food Chem Toxicol. 2019 Nov;133:110808.

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH;

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH 是一种二肽。

Fmoc-Leu-Ser(psi(Me,Me)pro)-OHamp;;

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH Chemical Structure

CAS No. : 339531-50-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH is a dipeptide.

分子量

480.55

Formula

C27H32N2O6

CAS 号

339531-50-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

N-Formyl-Met-Leu-Phe-Lys(Synonyms: fMLFK)

N-Formyl-Met-Leu-Phe-Lys;(Synonyms: fMLFK)

N-Formyl-Met-Leu-Phe-Lys 是一种多肽,为有效、选择性的 FPR1 激动剂,对 FPR1,FPR2 和 FPR2-D2817.32G 的 EC50 值分别为 3.5 nM,6.7 μM 和 0.88 μM。

N-Formyl-Met-Leu-Phe-Lysamp;;(Synonyms: fMLFK)

N-Formyl-Met-Leu-Phe-Lys Chemical Structure

CAS No. : 67247-11-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D2817.32G, respectively[1].

IC50 Target

EC50: 3.5 nM (FPR1), 6.7 μM (FPR2), 0.88 μM (FPR2-D2817.32G)[1]

分子量

565.73

Formula

C27H43N5O6S

CAS 号

67247-11-4

Sequence

Formyl-Met-Leu-Phe-Lys

Sequence Shortening

Formyl-MLFK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. He HQ, et al. Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands. J Biol Chem. 2014 Jan 24;289(4):2295-306.