[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA

发表于2024年4月9日由Whatman官网

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA; 纯度: 99.38%

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 是一种特定的神经肽 Y Y₁ 受体激动剂。[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 也激活 Y₄，Y₅。[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 可以增加麻醉大鼠的血压，也增加饮食摄入量。

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFAamp;;

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA Chemical Structure

规格	价格	是否有货	数量
5 mg	￥4000	In-stock
10 mg	￥6800	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake^[1]^[2].

IC₅₀ Target^[1]^[2]

NPY Y₁ receptor

;

NPY Y₄ receptor

;

NPY Y₅ receptor

;

体外研究
(In Vitro)

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA has K_i values of 0.39 nM, 0.499 nM, 0.31 nM for Y₁, Y₄, Y₅ in HEK cell lines. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA has a K_i of >1000 for Y₂ in HEK cell lines^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g)^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4354.76

Formula

C₁₉₁H₂₈₅F₃N₅₄O₅₈S

Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

H₂O : 50 mg/mL (11.48 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2296 mL	1.1482 mL	2.2963 mL
5 mM	0.0459 mL	0.2296 mL	0.4593 mL
10 mM	0.0230 mL	0.1148 mL	0.2296 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. K McCrea, et al. 2-36[K4,RYYSA(19-23)]PP a novel Y₅-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept. 2000 Feb 8;87(1-3):47-58.

[2]. J Fuhlendorff, et al. [Leu31, Pro34]neuropeptide Y: a specific Y₁ receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6.

[3]. A Kask, et al. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y₁-selective antagonist BIBP3226. Br J Pharmacol. 1998 Aug;124(7):1507-15.