标签归档：leucosceptoside

Leucosceptoside A(Synonyms: 米团花苷A)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Leucosceptoside A;(Synonyms: 米团花苷A)

Leucosceptoside A 是一种苯乙醇苷，具有抗高血糖和抗高血压活性。 Leucosceptoside 抑制 α-葡萄糖苷酶 (α-glucosidase) 和 PKCα 的活性 (IC50 为 19.0 μM)。

Leucosceptoside A(Synonyms: 米团花苷A)

Leucosceptoside A Chemical Structure

CAS No. : 83529-62-8

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生物活性

Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC50 of 19.0 μM)[1][2][3].

IC50 Target[3]

PKCα

19 mu;M (IC50)

体外研究
(In Vitro)

Leucosceptoside A shows weak angiotensin converting enzyme (ACE) inhibitory effect[1].
Leucosceptoside A (4-16 μM) significantly reduces 1-methyl-4-phenylpyridinium ion (MPP+)-induced death of mesencephalic neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

638.61

Formula

C30H38O15
CAS 号

83529-62-8
中文名称

米团花苷A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chika Ifeanyi Chukwuma, et al. Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review. J Ethnopharmacol. 2019 May 10;235:329-360.

    [2]. Yan-Yun Li, et al. Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons. Eur J Pharmacol. 2008 Jan 28;579(1-3):134-40.

    [3]. B N Zhou, et al. Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2.