标签归档：like

Insulin-like Growth factor-I(IGF-I), Human, recombinant, Animal-derived-free 品牌：FUJIFILM Wako

发表于由

Insulin-like Growth factor-I(IGF-I), Human, recombinant, Animal-derived-free

品牌：FUJIFILM Wako
CAS No.：68562-41-4
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

092-05743

 for Cellbiology 1mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Glucagon-like Peptide 1 (7-36 Amide) 品牌：Peptide

发表于由

Glucagon-like Peptide 1 (7-36 Amide)

品牌：Peptide
CAS No.：107444-51-9
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

333-43441

 – 0.5mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Insulin-like Growth Factor Binding Protein 1(IGFBP1), Human, recombinant 品牌：FUJIFILM Wako

发表于由

Insulin-like Growth Factor Binding Protein 1(IGFBP1), Human, recombinant

品牌：FUJIFILM Wako
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

092-06201

 for Cellbiology 25ug – 4,760.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Glucagon-Like Peptide (GLP) II, human

发表于由

Glucagon-Like Peptide (GLP) II, human;

Glucagon-Like Peptide (GLP) II, human 是由原胰高血糖素 C 端衍生的33 氨基酸肽，主要由肠道L细胞产生。Glucagon-Like Peptide (GLP) II 可刺激肠粘膜生长，减少肠细胞的凋亡。

Glucagon-Like Peptide (GLP) II, humanamp;;

Glucagon-Like Peptide (GLP) II, human Chemical Structure

CAS No. : 89750-15-2

规格 价格 是否有货
5 mg ￥3500 询问价格 货期
10 mg ￥5500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Glucagon-Like Peptide (GLP) II, human is a 33-amino acid peptide derived from the C-terminal of proglucagon and mainly produced by the intestinal L cells. Glucagon-Like Peptide (GLP) II, human stimulates intestinal mucosal growth and decreases apoptosis of enterocytes [1].

IC50 Target[1]

Human Endogenous Metabolite

;

分子量

3766.20

Formula

C165H254N44O55S
CAS 号

89750-15-2
Sequence

His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp
Sequence Shortening

HADGSFSDEMNTILDNLAARDFINWLIQTKITD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Drucker DJ, et al. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7911-6.

Anti-Human Chemokine-like factor 1 Polyclonal Antibody 品牌：Transgenic

发表于由

Anti-Human Chemokine-like factor 1 Polyclonal Antibody

品牌：Transgenic
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

KR072

 – 25 ug – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Insulin-like Growth factor-Ⅱ(IGF-Ⅱ), Human, recombinant, Animal-derived-free 品牌：FUJIFILM Wako

发表于由

Insulin-like Growth factor-Ⅱ(IGF-Ⅱ), Human, recombinant, Animal-derived-free

品牌：FUJIFILM Wako
CAS No.：96081-16-2
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

099-06613

 for Cellbiology 1mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Insulin-like Growth factor-Ⅱ(IGF-Ⅱ), Human, recombinant, Animal-derived-free 品牌：FUJIFILM Wako

发表于由

Insulin-like Growth factor-Ⅱ(IGF-Ⅱ), Human, recombinant, Animal-derived-free

品牌：FUJIFILM Wako
CAS No.：96081-16-2
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

093-06611

 for Cellbiology 50ug – 4,760.00 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Bombinin-Like Peptide (BLP-1)

发表于由

Bombinin-Like Peptide (BLP-1);

Bombinin-Like Peptide (BLP-1) 是来自铃蟾属的抗微生物 (antimicrobial) 肽。

Bombinin-Like Peptide (BLP-1)amp;;

Bombinin-Like Peptide (BLP-1) Chemical Structure

CAS No. : 138220-00-5

规格 价格 是否有货
1 mg ￥1600 询问价格 货期
5 mg ￥4800 询问价格 货期
10 mg ￥7600 询问价格 货期

* Please select Quantity before adding items.

生物活性

Bombinin-Like Peptide (BLP-1) is an antimicrobial peptide from Bombina species.

IC50 Target

Bacterial[1]
体外研究
(In Vitro)

Bombinin-like peptides, BLP-1, 2, 3 share considerable, but not complete, homology with bombinin, an antimicrobial, hemolytic peptide first isolated from the skin of Bombina uariegata. The BLPs have been assayed for antibiotic and hemolytic activity and found to be more potent than magainin 2 (a related antimicrobial peptide from Xenopus laeuis) in their ability to kill bacteria[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2580.98

Formula

C115H194N34O33
CAS 号

138220-00-5
Sequence

Gly-Ile-Gly-Ala-Ser-Ile-Leu-Ser-Ala-Gly-Lys-Ser-Ala-Leu-Lys-Gly-Leu-Ala-Lys-Gly-Leu-Ala-Glu-His-Phe-Ala-Asn-NH2
Sequence Shortening

GIGASILSAGKSALKGLAKGLAEHFAN-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gibson BW, et al. Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis. J Biol Chem. 1991 Dec 5;266(34):23103-11.

新型B7-like免疫检查点靶点 VSTM家族蛋白

发表于由

新型B7-like免疫检查点靶点
VSTM家族蛋白

  • 产品特性
  • 相关资料
  • Q&A
  • 参考文献

VSTM家族蛋白新型B7-like免疫检查点靶点 VSTM家族蛋白

新型B7-like免疫检查点靶点

V-set and transmembrane domain-containing protein（VSTM）家族是跨膜免疫球蛋白（Ig）超家族。其在结构上与B7-like免疫调节蛋白相似，并且拥有IgV-like和/或IgC-like胞外域。VSTM家族由8种蛋白组成：VSTM1v1、VSTM1v2、VSTM2a、VSTM2b、VSTM2L、VSTM3、VSTM4和VSTM5。据文献报道，VSTM家族成员与免疫细胞、脂肪细胞和神经元细胞的内在功能调节相关。目前大部分关于VSTM家族的研究都集中于其免疫功能上，例如，已证明VSTM1和VSTM4在巨噬细胞的激活中发挥积极或消极的作用。VSTM3（TIGIT、VSIG9）作为共抑制受体，可抑制T细胞和NK细胞的细胞因子产生。而与其他的免疫调节VSTM家族成员不同，VSTM2与脂肪生成过程中的脂肪前体调节有关。

另外，研究表明VSTM5是在大脑中表达的细胞黏附分子，能够促进树突状丝状伪足的形成，并且其形成过程与大脑中的神经元形态发生和迁移有关。基于VSTM5与其他两个免疫检查点VISTA和TIGIT间密切的系统发育关系，研究人员对VSTM5在T细胞免疫反应中的潜在作用进行了研究。结果显示，VSTM5通过调节T细胞增殖和细胞因子产生，以及通过维持T细胞能量和可能诱导T细胞凋亡产生Treg，来发挥新型免疫检查点的作用。

 

参考文献：VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses: O.E. Oludada, et al.; BBRC 635, 283 (2022)

新型B7-like免疫检查点靶点 VSTM家族蛋白

◆临床前研究用生物活性重组蛋白

产品编号

产品名称

来源

内毒素

物种

AG-40B-0170-3010

 CD112R   (mouse):Fc (human) (rec.)

CD112r抗体（小鼠）：Fc（人）（rec.）包装

HEK293细胞

<0.01 EU/µg

小鼠

AG-40B-0162-C050

TIGIT (human):Fc (human) (rec.)

HEK293细胞

<0.01 EU/µg

人

ANC-556-020

TIGIT (human)-muIg Fusion Protein

CHO细胞

n.d.

人

AG-40B-0237

VSTM5 (human):Fc (human) (rec.) (non-lytic)

HEK293细胞

<0.01 EU/µg

人

点击此处下载产品宣传页：AdipoGen免疫检查点试剂小册子

产品列表
产品编号 产品名称 产品规格 产品等级 备注
AG-40B-0170-3010 CD112R (mouse):Fc (human) (rec.)
CD112r抗体（小鼠）：Fc（人）（rec.）包装		 3×10 μg –
AG-40B-0162-C050 TIGIT (human):Fc (human) (rec.) 50 μg –
ANC-556-020 TIGIT (human)-muIg Fusion Protein 25 μg –
AG-40B-0237 VSTM5 (human):Fc (human) (rec.) (non-lytic) 50 μg –

Glucagon-like peptide 1 (1-37), human TFA(Synonyms: HuGLP-1 TFA)

发表于由

Glucagon-like peptide 1 (1-37), human TFA;(Synonyms: HuGLP-1 TFA) 纯度: 97.18%

Glucagon-like peptide 1 (1-37), human (TFA) 是有效的 GLP-1 受体激动剂。

Glucagon-like peptide 1 (1-37), human TFAamp;;(Synonyms: HuGLP-1 TFA)

Glucagon-like peptide 1 (1-37), human TFA Chemical Structure

规格 价格 是否有货 数量
500 μg ￥2970 In-stock
1 mg ￥4840 In-stock
5 mg ; 询价 ;
10 mg ; 询价 ;

* Please select Quantity before adding items.

Glucagon-like peptide 1 (1-37), human TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor.

IC50 Target

GLP-1 receptor[1].
体外研究
(In Vitro)

Glucagon-like peptide-1 (GLP-1) is produced by the posttranslational processing of proglucagon and acts as a regulator of various homeostatic events. GLP-1(1-37) is more stable than GLP-1(7-37), with 94.7% of the initial amount of peptide left after a 4h exposure to mouse serum. GLP-1(1-37) is confirmed to be a highly potent agonist of the GLP-1 receptor (GLP-1R) by measuring the expression of the luciferase reporter gene expression in transiently transfected human embryonic kidney (HEK293) cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

GLP-1(1–37) decreases glycemic excursion in a dose-dependent. The administration of GLP-1(1–37) or GLP-1(7–37) markedly decrease blood glucose levels at 15 min and 30 min compared with the control group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4283.50

Formula

C188H276N51F3O61
Sequence

His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Sequence Shortening

HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : 25 mg/mL (5.84 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2335 mL 1.1673 mL 2.3345 mL
5 mM 0.0467 mL 0.2335 mL 0.4669 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zhao L, et al. Glucagon-like peptide-1(1-37) can enhance blood glucose homeostasis in mice. Regul Pept. 2012 Oct 10;178(1-3):1-5.
Cell Assay
[1]

HEK293 cells (5×104) are seeded in a 96-well plate and transiently cotransfected with the GLP-1R plasmid and the CRE-luciferase reporter plasmid. After a 48 h transfection, different concentrations of GLP-1(1–37) or GLP-1(7–37) (TFA) are added, and the cells are incubated for 5 h. The cells are harvested for a luciferase assay using a luciferase assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice[1]

The normal KM mice are fasted for 16 h before the administration (i.p.) of GLP-1 and glucose. GLP-1(1-37) (25 nmol/kg) with or without exendin(9-39) (250 nmol/kg) is given in combination with glucose (4 g/kg). GLP-1(7-37) (25 nmol/kg) with or without exendin(9-39) (250 nmol/kg) is also administrated in combination with glucose (4 g/kg). The control group is treated with saline (NaCl, 9 g/L) and glucose (4 g/kg). The IPGTT is carried out at 0, 15, 30 and 60 min after glucose and protein administration, and the blood glucose levels are measured as described above[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Zhao L, et al. Glucagon-like peptide-1(1-37) can enhance blood glucose homeostasis in mice. Regul Pept. 2012 Oct 10;178(1-3):1-5.